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神戸大学大学院医学研究科 生理学・細胞生物学講座
細胞生理学分野

研究業績 / Publication

原著論文

2016201520142013201220112010200920082007200620052004200320022001200019991987-1998

2017

Takahashi D, Suzuki H, Kakei Y, Yamakoshi K, Minami Y, Komori T, Nishita M.
Expression of Ror2 associated with fibrosis of the submandibular gland.
Cell Struct. Funct. in press

Uehara S, Udagawa N, Mukai H, Ishihara A, Maeda K, Yamashita T, Murakami K, Nshita M, Nakamura T, Kato S, Minami Y, Takahashi N, Kobayashi Y.
Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling.
doi: 10.1126/scisignal.aan0023.
Sci. Signal. 10(494). pii: eaan0023. 2017

Kamizaki K, Doi R, Hayashi M, Saji T, Kanagawa M, Toda T, Fukada SI, Ho HH, Greenberg ME, Endo M, Minami Y.
The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle.
doi: 10.1074/jbc.M117.785709
J. Biol. Chem. 292(38): 15939-159351, 2017

Kessenbrock K., Smith P., Steenbeek S., Pervolarakis N., Kumar R., Minami Y., Goga A., Hinck L., Werb Z.
Diverse regulation of mammary epithelial growth and branching morphogenesis through non-canonical Wnt signaling.
doi: 10.1073/pnas.1701464114
Proc. Natl. Acad. Sci. USA, 114 (12): 3121-3126, 2017

Nishita M, Park SY, Nishio T, Kamizaki K, Wang Z, Tamada K, Takumi T, Hashimoto R, Otani H, Pazour GJ, Hsu VW, Minami Y.
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness.
Sci. Rep. 7(1), 1, 2017

Endo M, Ubulkasim G, Kobayashi C, Onishi R, Aiba A, Minami Y.
Critical role of Ror2 receptor tyrosine kinase in regulating cell cycle progression of reactive astrocytes following brain injury.
Glia. 65(1): 182-197, 2017

2016

Diaz-Horta O1, Abad C1, Sennaroglu L2, Foster J 2nd1, DeSmidt A3, Bademci G1, Tokgoz-Yilmaz S2, Duman D4, Cengiz FB4, Grati M5, Fitoz S6, Liu XZ5, Farooq A7, Imtiaz F8, Currall BB9, Morton CC10, Nishita M11, Minami Y11, Lu Z3, Walz K12, Tekin M13.
ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.
Proc Natl Acad Sci U S A. 113(21): 5993-8, 2016

Qi, X., Okinaka, Y., Nishita, M., and Minami, Y.
Essential role of Wnt5a-Ror1/Ror2 signaling in metanephric mesenchyme and ureteric bud formation.
Genes Cells. 21(4): 325-34, 2016

Takiguchi, G., Nishita, M., Kurita, K., Kakeji, Y., and Minami, Y.
Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis.
Cancer Sci. 107(3): 290-7, 2016

2015

Sato, A., Kayama, H., Shojima, K., Matsumoto, S., Koyama, H., Minami, Y., Nojima, S., Morii, E., Honda, H., Takeda, K., *Kikuchi, A.
The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis.
Sci. Rep. 5: 10536, 2015

2014


Nishita, M., Qiao, S., Miyamoto, M., Okinaka, Y., M., Yamada, M., Hashimoto, R., Iijima, K., Otani, H., Hartmann, C., Nishinakamura, R., and Minami, Y..
Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding.
Mol. Cell. Biol. 34 (16): 3096-3105, 2014.


Mori, K., Kitazawa, R., Kondo, T., Mori, M., Hamada, Y., Nishita, M., Minami, Y., Haraguchi, R., Takahashi, Y., and Kitazawa, S..
Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene.
PLoS One 9 (7): e102797, 2014.


Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., and Kobayashi, Y..
Noncanonical Wnt5a enhances Wnt/ β-catenin signaling during osteogenesis.
Scientific Report 4: 4493, 2014.


Doi, R., Endo, M., Yamakoshi, K., Yamanashi, Y., Nishita, M., Fukada, S-I., and Minami, Y..
Critical role of Frizzled1 in age-related alterations of Wnt/β-catenin signal in myogenic cells during differentiation.
Genes Cells 19 (4): 287-296, 2014.


Fukuyo, S., Yamaoka, K., Sonomoto, K., Oshita, K., Okada, Y., Saito, K., Yoshida, Y., Kanazawa, T., Minami, Y., and Tanaka, Y..
IL-6-accelerated calcification by induction of Ror2 in human adipose tissue-derived mesenchymal stem cells is STAT3-dependent.
Rheumatology 53(7):1282-1290,2014

Homma, Y., Kanno, S., Sasaki, K., Nishita, M., Yasui, A., Asano, T., Ohashi, K., and Mizuno, K.
Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation.
J. Biol. Chem. 289: 26302-26313, 2014.

2013

Li, X., Yamagata, K., Nishita, M., Endo, M., Arfian, N., Rikitake, Y., Emoto, N., Hirata, K., Tanaka, Y., and Minami, Y..
Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells during renal fibrosis.
Genes Cells 18 (7)608-619, 2013


Hayashi M, Majumdar A, Li X, Adler J, Sun Z, Vertuani S, Hellberg C, Mellberg S, Koch S, Dimberg A, Koh GY, Dejana E, Belting H-G, Affolter M, Thurston G, Holmgren L, Vestweber D and Claesson-Welsh L.
VE-PTP Regulates VEGFR2 Activity in Stalk Cells to Establish Endothelial Cell Polarity and Lumen Formation.
Nature Communications 4: 1672 (2013)

2012


Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T. J., Minami, Y., and Takahashi, N..
Wnt5a-Ror2 signaling between osteoblasts and osteoclast precursors enhances osteoclastogenesis.
Nat. Med., 18:405-412,2012


Endo, M., Doi, R., Nishita, M., and Minami, Y..
Ror-family receptor tyrosine kinases regulate maintenance of neural progenitor cells in the developing neocortex.
J. Cell Sci.,125: 2017-2029, 2012.


Yamagata, K., Li, X., Ikegaki, S., Oneyama, C., Okada, M., Nishita, M., and Minami, Y..
Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP)-13 expression.
J. Biol. Chem.287: 1588-1599, 2012.


Endo, M., Nishita, M., and Minami, Y..
Analysis of Wnt/Planar cell polarity pathway in cultured cells.
Methods Mol. Biol.839: 201-214, 2012.


Le Jan S, Hayashi M, Kasza Z, Eriksson I, Bishop JR, Weibrecht I, Heldin J, Holmborn K, Jakobsson L, Söderberg O, Spillmann D, Esko JD,
Claesson-Welsh L, Kjellén L, and Kreuger J. Functional Overlap Between Chondroitin and Heparan Sulfate Proteoglycans During VEGF-Induced Sprouting Angiogenesis.
Arteriosclerosis, Thrombosis, and Vascular Biology 32, no. 5: 1255-1263 (2012)

2011


Takahashi, S., Watanabe, T., Okada, M., Inoue, K., Ueda, T., Takada, I., Watabe, T., Yamamoto, Y., Fukuda, T., Nakamura, T., Akimoto, C., Fujimura, T., Hoshino, M., Imai, Y., Metzger, D., Miyazono, K., Minami, Y., Chambon, P., Kitamura, T., Matsumoto, T., and Kato, S..
Non-canonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer.
Proc. Natl. Acad. Sci. USA, 2011. 108: 4938-4943,


Hagihara, M., Endo, M., Hata, K., Higuchi, C., Takaoka, K., Yoshikawa, H., and Yamashita, T..
Neogenin, a receptor for bone morphogenetic proteins.
J. Biol. Chem.2011. 286: 5157-5165,


Ren, D., Minami, Y.*, and Nishita, M.* (corresponding authors).
Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of epidermoid carcinoma cells following Snail-mediated epithelial-mesenchymal transition.
Genes Cells, 2011.16: 304-315,


Gao, B., Song, H., Bishop, K., Eliott, G., Garrett, L., English, M. A., Andre, P., Robinson, J., Sood, R., Minami, Y., Economedes, A. N., and Yang, Y..
Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2.
Dev. Cell, 2011. 20: 163-176,

2010


Lyashenko N, Weissenbock M, Sharir A, Erben R G, Minami Y, and Hartmann C..
Mice lacking the orphan receptor Ror1 have distinct skeletal abnormalities and are growth retarded.
Dev. Dyn., 2010. 239: 2266-2277,


Nishita M, Itsukushima S, Nomachi A, Endo M, Wang Z-C, Inaba D, Qiao S, Takada S, Kikuchi A, and Minami Y..
Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization.
Mol. Cell. Biol., 2010. Jul;30(14):3610-9


Nakagawa K, Sugahara M, Yamasak T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T, Hata Y, Katada T, and Nishina H..
Filamin associates with stress signaling kinase MKK7 and MKK4 and regulates JNK activation.
Biochem. J.2010. 427: 237-245,


Yamada M, Udagawa J, Matsumoto A, Hashimoto R, Nishita M, Minami Y, and Otani H..
Ror2 is required for midgut elongation during mouse development.
Dev. Dyn.2010. 239 (3): 941-953,

2009


Mikels A, Minami Y, and Nusse R,.
The Ror2 receptor requires tyrosine kinase activity to mediate Wnt5a signaling.
J.Biol.Chem,2009.284:30167-30176.


Enomoto M, Hayakawa S, Itsukushima S, Dayong R, Matsuo M, Tamada K, Oneyama C, Okada M, Takumi T, Nishita M, Minami Y.
Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling.
Oncogene, 2009.28: 3197-3208.


Endo M, Yamashita T.
Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse.
J Neurosci. 2009 May 20;29(20):6649-62.


Kobayashi M, Shibuya Y, Takeuchi J, Murata M, Suzuki H, Yokoo S, Umeda M, Minami Y, Komori T.
Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Mar;107(3):398-406.


Mellberg S, Dimberg A, Bahram F, Hayashi M, Rennel E, Ameur A, Westholm JO, Larsson E, Lindahl P, Cross MJ, and Claesson-Welsh L.
Transcriptional Profiling Reveals a Critical Role for Tyrosine Phosphatase VE-PTP in Regulation of VEGFR2 Activity and Endothelial Cell Morphogenesis.
The FASEB Journal 23, no. 5: 1490-1502 (2009)


Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Miyazawa K, Inazawa J, Miyazono K and Imamura T.
SKI and MEL1 Cooperate to Inhibit Transforming Growth Factor-Beta Signal in Gastric Cancer Cells.
The Journal of Biological Chemistry 284, no. 5: 3334-3344 (2009)

2008


He F, Xiong W, Yu X, Espinoza-Lewis R, Liu C, Gu S, Nishita M, Suzuki K, Yamada G, Minami Y, Chen Y.
Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development.
Development. 2008 Dec;135(23):3871-9. Epub 2008 Oct 23.


Nomachi A, Nishita M, Inaba D, Enomoto M, Hamasaki M, Minami Y.
Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A.
J Biol Chem. 2008 Oct 10;283 41):27973-81. Epub 2008 Jul 30.


Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, Sasaki H.
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
Dev Cell. 2008 Jul;15(1):23-36.


Yoda A, Toyoshima K, Watanabe Y, Onishi N, Hazaka Y, Tsukuda Y, Tsukada J, Kondo T, Tanaka Y, Minami Y.
Arsenic Trioxide Augments Chk2/p53-mediated Apoptosis by Inhibiting Oncogenic Wip1 Phosphatase.
J Biol Chem. 2008 Jul 4;283(27):18969-79. Epub 2008 May 15.


Kubo T, Endo M, Hata K, Taniguchi J, Kitajo K, Tomura S, Yamaguchi A, Mueller BK, Yamashita T.
Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule.
J Neurochem. 2008 Apr;105(1):113-26. Epub 2007 Nov 12.


Taniguchi J, Fujitani M, Endo M, Kubo T, Fujitani M, Miller FD, Kaplan DR, Yamashita T.
Rap1 is involved in the signal transduction of myelin-associated glycoprotein.
Cell Death Differ. 2008 Feb;15(2):408-19. Epub 2007 Nov 30.


Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis MF, Li J, Nishita M, Minami Y, Minoo P.
Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2.
BMC Mol Biol. 2008 Jan 23;9:11.


Mouri F, Tsukada J, Mizobe T, Higashi T, Yoshida Y, Minami Y, Izumi H, Kominato Y, Kohno K, and Tanaka Y.
Intracellular HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1.
Eur J Haematol. 2008 Jan;80(1):10-9.


Tominaga H, Maeda S, Hayashi M, Takeda S, Akira S, Komiya S, Nakamura T, Akiyama H, and Imamura T.
CCAAT/Enhancer-Binding Protein Beta Promotes Osteoblast Differentiation by Enhancing Runx2 Activity with ATF4.
Molecular Biology of the Cell 19, no. 12: 5373-5386 (2008)


Hayashi M, Maeda S, Aburatani H, Kitamura K, Miyoshi H, Miyazono K, and Imamura T.
Pitx2 Prevents Osteoblastic Transdifferentiation of Myoblasts by Bone Morphogenetic Proteins.
The Journal of Biological Chemistry 283, no. 1: 565-571 (2008)

2007


Mizobe T, Tsukada J, Higashi T, Mouri F, Matsuura A, Tanikawa R, Minami Y, Yoshida Y, Tanaka Y.
Constitutive association of MyD88 to IRAK in HTLV-I-transformed T cells.
Exp Hematol. 2007 Oct 5


Yamamoto H, Yoo SK, Nishita M, Kikuchi A, Minami Y.
Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2.
Genes Cells. 2007 Nov;12(11):1215-23.


Matsuura I, Endo M, Hata K, Kubo T, Yamaguchi A, Saeki N, Yamashita T.
BMP inhibits neurite growth by a mechanism dependent on LIM-kinase.
Biochem Biophys Res Commun. 2007 Sep 7;360(4):868-73. Epub 2007 Jul 10.


Kani S, Nakayama E, Yoda A, Onishi N, Sougawa N, Hazaka Y, Umeda T, Takeda K, Ichijo H, Hamada Y, Minami Y.
Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling.
Genes Cells. 2007 Aug;12(8):919-28.


Endo M, Ohashi K, Mizuno K.
LIM kinase and slingshot are critical for neurite extension.
J Biol Chem. 2007 May 4;282(18):13692-702. Epub 2007 Mar 13.


Taniguchi K, Ayada T, Ichiyama K, Kohno R, Yonemitsu Y, Minami Y, Kikuchi A, Maehara Y, Yoshimura A.
Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.
Biochem Biophys Res Commun. 2007 Jan 26;352(4):896-902.


Shogo E, Hanyu A, Hayashi M, Aburatani H, Kato Y, Fujime M, Saitoh M, Miyazawa K, Imamura T, and Miyazono K.
Transforming Growth Factor-Beta Promotes Survival of Mammary Carcinoma Cells Through Induction of Antiapoptotic Transcription Factor DEC1.
Cancer Research 67, no. 20: 9694-9703 (2007)

2006


Nishita M, Yoo SK, Nomachi A, Kani S, Sougawa N, Ohta Y, Takada S, Kikuchi A, Minami Y.
Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration.
J Cell Biol. 2006 Nov 20;175(4):555-62.


Shreeram S, Demidov ON, Hee WK, Yamaguchi H, Onishi N, Kek C, Timofeev ON, Dudgeon C, Fornace AJ, Anderson CW, Minami Y, Appella E, Bulavin DV.
Wip1 phosphatase modulates ATM-dependent signaling pathways.
Mol Cell. 2006 Sep 1;23(5):757-64.


*Yoda A, *Xu XZ, Onishi N, Toyoshima K, Fujimoto H, Kato N, Oishi I, Kondo T, Minami Y.
Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.
J Biol Chem. 2006 Aug 25;281(34):24847-62.


*Fujimoto H, *Onishi N, *Kato N, Takekawa M, Xu XZ, Kosugi A, Kondo T, Imamura M, Oishi I, Yoda A, Minami Y.
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase.
Cell Death Differ. 2006 Jul;13(7):1170-80.


Udagawa J, Hashimoto R, Suzuki H, Hatta T, Sotomaru Y, Hioki K, Kagohashi Y, Nomura T, Minami Y, Otani H.
The role of leptin in the development of the cerebral cortex in mouse embryos.
Endocrinology. 2006 Feb;147(2):647-58.


Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K.
MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration.
EMBO J. 2006 Feb 22;25(4):713-26.


Shirakawa K, Maeda S, Gotoh T, Hayashi M, Shinomiya K, Ehata S, Nishimura R, Mori M, Onozaki K, Hayashi H, Uematsu S, Akira S, Ogata E, Miyazono K and Imamura T.
CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Regulates Osteoblast Differentiation.
Molecular and Cellular Biology 26, no. 16: 6105–6116 (2006)

2005


Higashi T, Tsukada J, Yoshida Y, Mizobe T, Mouri F, Minami Y, Morimoto H, Tanaka Y.
Constitutive tyrosine and serine phosphorylation of STAT4 in T-cells transformed with HTLV-I.
Genes Cells. 2005 Dec;10(12):1153-62.

Nishita M, Tomizawa C, Yamamoto M, Horita Y, Ohashi K, Mizuno K.
Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration.
J Cell Biol. 2005 Oct 24;171(2):349-59.

Sakakida Y, Miyamoto Y, Nagoshi E, Akashi M, Nakamura TJ, Mamine T, Kasahara M, Minami Y, Yoneda Y, Takumi T.
Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal.
J Biol Chem. 2005 Apr 8;280(14):13272-8.

2004


Kato N, Fujimoto H, Yoda A, Oishi I, Matsumura N, Kondo T, Tsukada J, Tanaka Y, Imamura M, Minami Y.
Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines.
Cell Death Differ. 2004 Dec;11 Suppl 2:S153-61.


Sammar M, Stricker S, Schwabe GC, Sieber C, Hartung A, Hanke M, Oishi I, Pohl J, Minami Y, Sebald W, Mundlos S, Knaus P.
Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2.
Genes Cells. 2004 Dec;9(12):1227-38.


Kani S, Oishi I, Yamamoto H, Yoda A, Suzuki H, Nomachi A, Iozumi K, Nishita M, Kikuchi A, Takumi T, Minami Y.
The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon.
J Biol Chem. 2004 Nov 26;279(48):50102-9.


Kondo T, Kobayashi M, Tanaka J, Yokoyama A, Suzuki S, Kato N, Onozawa M, Chiba K, Hashino S, Imamura M, Minami Y, Minamino N, Asaka M.
Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex.
J Biol Chem. 2004 Jun 25;279(26):27315-9.


Tomiyoshi G, Horita Y, Nishita M, Ohashi K, Mizuno K.
Caspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing.
Genes Cells. 2004 Jun;9(6):591-600.


Nagata-Ohashi K, Ohta Y, Goto K, Chiba S, Mori R, Nishita M, Ohashi K, Kousaka K, Iwamatsu A, Niwa R, Uemura T, Mizuno K.
A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.
J Cell Biol. 2004 May 24;165(4):465-71.


Schwabe GC, Trepczik B, Suring K, Brieske N, Tucker AS, Sharpe PT, Minami Y, Mundlos S.
Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome.
Dev Dyn. 2004 Feb;229(2):400-10.


Nishita M, Wang Y, Tomizawa C, Suzuki A, Niwa R, Uemura T, Mizuno K.
Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion.
J Biol Chem. 2004 Feb 20;279(8):7193-8.


Horik Mi, Imamura T, Okamoto M, Hayashi M, Murai J, Myoui A, Ochi T, Miyazono K, Yoshikawa H, and Tsumaki N.
Smad6/Smurf1 Overexpression in Cartilage Delays Chondrocyte Hypertrophy and Causes Dwarfism with Osteopenia.
The Journal of Cell Biology 165, no. 3: 433–445 (2004)


Kahata K, Hayashi M, Asaka M, Hellman U, Kitagawa H, Yanagisawa J, Kato S, Imamura T, and Miyazono K.
Regulation of Transforming Growth Factor-Beta and Bone Morphogenetic Protein Signalling by Transcriptional Coactivator GCN5.
Genes to Cells 9, no. 2: 143–151 (2004)


Maeda S, Hayashi M, Komiya S, Imamura T, and Miyazono K.
Endogenous TGF-Beta Signaling Suppresses Maturation of Osteoblastic Mesenchymal Cells.
The EMBO Journal 23, no. 3: 552–563 (2004)

2003

Suzuki K, Bachiller D, Chen YP, Kamikawa M, Ogi H, Haraguchi R, Ogino Y, Minami Y, Mishina Y, Ahn K, Crenshaw EB 3rd, Yamada G.
Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia development by concerted actions of BMP signaling.
Development. 2003 Dec;130(25):6209-20.


Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y.
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.
Genes Cells. 2003 Jul;8(7):645-54.


*Matsuda T, *Suzuki H, Oishi I, Kani S, Kuroda Y, Komori T, Sasaki A, Watanabe K, Minami Y.
The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distribution.
J Biol Chem. 2003 Aug 1;278(31):29057-64.


Wu D, Tadano M, Edamatsu H, Masago-Toda M, Yamawaki-Kataoka Y, Terashima T, Mizoguchi A, Minami Y, Satoh T, Kataoka T.
Neuronal lineage-specific induction of phospholipase Cepsilon expression in the developing mouse brain.
Eur J Neurosci. 2003 Apr;17(8):1571-80.


Endo M, Ohashi K, Sasaki Y, Goshima Y, Niwa R, Uemura T, Mizuno K.
Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin.
J Neurosci. 2003 Apr 1;23(7):2527-37.


Yoneda O, Imai T, Nishimura M, Miyaji M, Mimori T, Okazaki T, Domae N, Fujimoto H, Minami Y, Kono T, Bloom ET, Umehara H.
Membrane-bound form of fractalkine induces IFN-gamma production by NK cells.
Eur J Immunol. 2003 Jan;33(1):53-8.

2002


Tanaka Y, Nakayamada S, Fujimoto H, Okada Y, Umehara H, Kataoka T, Minami Y.
H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts.
J Biol Chem. 2002 Jun 14;277(24):21446-52.


Hyodo-Miura J, Urushiyama S, Nagai S, Nishita M, Ueno N, Shibuya H.
Involvement of NLK and Sox11 in neural induction in Xenopus development.
Genes Cells. 2002 May;7(5):487-96.


Nishita M, Aizawa H, Mizuno K.
Stromal cell-derived factor 1alpha activates LIM kinase 1 and induces cofilin phosphorylation for T-cell chemotaxis.
Mol Cell Biol. 2002 Feb;22(3):774-83.


Iida T, Mine S, Fujimoto H, Suzuki K, Minami Y, Tanaka Y.
Hypoxia-inducible factor-1alpha induces cell cycle arrest of endothelial cells.
Genes Cells. 2002 Feb;7(2):143-9.


Umehara H, Inoue H, Huang J, Kono T, Minami Y, Tanaka Y, Okazaki T, Mimori T, Bloom ET, Domae N.
Role for adapter proteins in costimulatory signals of CD2 and IL-2 on NK cell activation.
Mol Immunol. 2002 Jan;38(8):587-96.


Iwai K, Oishi I, Xu XZ, Minami Y, Yamamura H.
Physical interactions of Dmnk with Orb: implications in the regulated localization of Orb by Dmnk during oogenesis and embryogenesis.
Biochem Biophys Res Commun. 2002 Jan 11;290(1):225-9.

2001


Nomi M, Oishi I, Kani S, Suzuki H, Matsuda T, Yoda A, Kitamura M, Itoh K, Takeuchi S, Takeda K, Akira S, Ikeya M, Takada S, Minami Y.
Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases.
Mol Cell Biol. 2001 Dec;21(24):8329-35.


Rina-Susilowati, Jusuf AA, Sakagami H, Kikkawa S, Kondo H, Minami Y, Terashima T.
Distribution of Ca(2+)/calmodulin-dependent protein kinase I beta 2 in the central nervous system of the rat.
Brain Res. 2001 Aug 17;911(1):1-11.


*Matsuda T, *Nomi M, Ikeya M, Kani S, Oishi I, Terashima T, Takada S, Minami Y.
Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development.
Mech Dev. 2001 Jul;105(1-2):153-6.


Umehara H, Goda S, Imai T, Nagano Y, Minami Y, Tanaka Y, Okazaki T, Bloom ET, Domae N.
Fractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1.
Immunol Cell Biol. 2001 Jun;79(3):298-302.


Fujimoto H, Tanaka Y, Liu ZJ, Yagita H, Okumura K, Kosugi A, Morinobu A, Umehara H, Yamamura H, Minami Y.
Down-regulation of alpha6 integrin, an anti-oncogene product, by functional cooperation of H-Ras and c-Myc.
Genes Cells. 2001 Apr;6(4):337-43.


Oishi I, Iwai K, Kagohashi Y, Fujimoto H, Kariya K, Kataoka T, Sawa H, Okano H, Otani H, Yamamura H, Minami Y.
Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination.
Mol Cell Biol. 2001 Feb;21(4):1329-35.

2000


Huang JY, Umehara H, Inoue H, Tabassam FH, Okazaki T, Kono T, Minami Y, Tanaka Y, Domae N.
Differential interaction of Cbl with Grb2 and CrkL in CD2-mediated NK cell activation.
Mol Immunol. 2000 Dec;37(17):1057-65.


Tanaka Y, Nomi M, Fujii K, Hubscher S, Maruo A, Matsumoto S, Awazu Y, Saito K, Eto S, Minami Y.
Intercellular adhesion molecule 1 underlies the functional heterogeneity of synovial cells in patients with rheumatoid arthritis: involvement of cell cycle machinery.
Arthritis Rheum. 2000 Nov;43(11):2513-22.


Tanaka Y, Maruo A, Fujii K, Nomi M, Nakamura T, Eto S, Minami Y.
Intercellular adhesion molecule 1 discriminates functionally different populations of human osteoblasts: characteristic involvement of cell cycle regulators.
J Bone Miner Res. 2000 Oct;15(10):1912-23.


Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, Akiyama T.
Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.
Genes Dev. 2000 Jul 15;14(14):1741-9.


Nishita M, Hashimoto MK, Ogata S, Laurent MN, Ueno N, Shibuya H, Cho KW.
Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.
Nature. 2000 Feb 17;403(6771):781-5.


Ishihara I, Minami Y, Nishizaki T, Matsuoka T, Yamamura H.
Activation of calpain precedes morphological alterations during hydrogen peroxide-induced apoptosis in neuronally differentiated mouse embryonal carcinoma P19 cell line.
Neurosci Lett. 2000 Jan 28;279(2):97-100.


Takeuchi S, Takeda K, Oishi I, Nomi M, Ikeya M, Itoh K, Tamura S, Ueda T, Hatta T, Otani H, Terashima T, Takada S, Yamamura H, Akira S, Minami Y.
Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation.
Genes Cells. 2000 Jan;5(1):71-8.

1999


Tanaka Y, Minami Y, Mine S, Hirano H, Hu CD, Fujimoto H, Fujii K, Saito K, Tsukada J, van Kooyk Y, Figdor CG, Kataoka T, Eto S.
H-Ras signals to cytoskeletal machinery in induction of integrin-mediated adhesion of T cells.
J Immunol. 1999 Dec 1;163(11):6209-16.


Ueda T, Sakagami H, Abe K, Oishi I, Maruo A, Kondo H, Terashima T, Ichihashi M, Yamamura H, Minami Y.
Distribution and intracellular localization of a mouse homologue of Ca2+/calmodulin-dependent protein kinase Ibeta2 in the nervous system.
J Neurochem. 1999 Nov;73(5):2119-29.


Liu ZJ, Tanaka Y, Fujimoto H, Mine S, Morinobu A, Yagita H, Okumura K, Oishi I, Udagawa J, Yamamura H, Minami Y.
A novel role for H-Ras in the regulation of very late antigen-4 integrin and VCAM-1 via c-Myc-dependent and -independent mechanisms.
J Immunol. 1999 Nov 1;163(9):4901-8.


Nishita M, Ueno N, Shibuya H.
Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8-mediated signalling.
Genes Cells. 1999 Oct;4(10):583-91.


Hanafusa H, Ninomiya-Tsuji J, Masuyama N, Nishita M, Fujisawa J, Shibuya H, Matsumoto K, Nishida E.
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression.
J Biol Chem. 1999 Sep 17;274(38):27161-7.


Maruo A, Oishi I, Sada K, Nomi M, Kurosaki T, Minami Y, Yamamura H.
Protein tyrosine kinase Lyn mediates apoptosis induced by topoisomerase II inhibitors in DT40 cells.
Int Immunol. 1999 Sep;11(9):1371-80.


Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H, Matsumoto K.
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.
Nature. 1999 Jun 24;399(6738):798-802.


Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K.
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway.
EMBO J. 1999 Jan 4;18(1):179-87.


Oishi I, Takeuchi S, Hashimoto R, Nagabukuro A, Ueda T, Liu ZJ, Hatta T, Akira S, Matsuda Y, Yamamura H, Otani H, Minami Y.
Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system.
Genes Cells. 1999 Jan;4(1):41-56.

1998-1991


Liu ZJ, Tanaka Y, Mine S, Morinobu A, Yagita H, Okumura K, Taniguchi T, Yamamura H, Minami Y.
Functional cooperation of cyclin C and c-Myc in mediating homotypic cell adhesion via very late antigen-4 activation and vascular cell adhesion molecule-1 induction.
Blood. 1998 Dec 15;92(12):4700-11.

Nishita M, Inoue S, Tsuda M, Tateda C, Miyashita T.
Nuclear translocation and increased expression of Bax and disturbance in cell cycle progression without prominent apoptosis induced by hyperthermia.
Exp Cell Res. 1998 Oct 10;244(1):357-66.

Liu ZJ, Ueda T, Miyazaki T, Tanaka N, Mine S, Tanaka Y, Taniguchi T, Yamamura H, Minami Y.
A critical role for cyclin C in promotion of the hematopoietic cell cycle by cooperation with c-Myc.
Mol Cell Biol. 1998 Jun;18(6):3445-54.

Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H.
BRAM1, a BMP receptor-associated molecule involved in BMP signalling.
Genes Cells. 1998 Apr;3(4):257-64.

Oishi I, Sugiyama S, Otani H, Yamamura H, Nishida Y, Minami Y.
A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment.
Mech Dev. 1998 Feb;71(1-2):49-63.

Sada K, Minami Y, Yamamura H.
Relocation of Syk protein-tyrosine kinase to the actin filament network and subsequent association with Fak.
Eur J Biochem. 1997 Sep 15;248(3):827-33.

Chen M, Cheng A, Chen YQ, Hymel A, Hanson EP, Kimmel L, Minami Y, Taniguchi T, Changelian PS, O'Shea JJ.
The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals.
Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6910-5.

Qin S, Minami Y, Kurosaki T, Yamamura H.
Distinctive functions of Syk and Lyn in mediating osmotic stress- and ultraviolet C irradiation-induced apoptosis in chicken B cells.
J Biol Chem. 1997 Jul 18;272(29):17994-9.

Oishi I, Sugiyama S, Liu ZJ, Yamamura H, Nishida Y, Minami Y.
A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling.
J Biol Chem. 1997 May 2;272(18):11916-23.

Ueno N, Oishi I, Sugiyama S, Nishida Y, Minami Y, Yamamura H.
Identification of a novel Drosophila protein kinase highly homologous to protein kinase N (PKN).
Biochem Biophys Res Commun. 1997 Mar 6;232(1):126-9.

Adachi M, Ishino M, Torigoe T, Minami Y, Matozaki T, Miyazaki T, Taniguchi T, Hinoda Y, Imai K.
Interleukin-2 induces tyrosine phosphorylation of SHP-2 through IL-2 receptor beta chain.
Oncogene. 1997 Apr 3;14(13):1629-33.

Qin S, Minami Y, Hibi M, Kurosaki T, Yamamura H.
Syk-dependent and -independent signaling cascades in B cells elicited by osmotic and oxidative stress.
J Biol Chem. 1997 Jan 24;272(4):2098-103.
1996
Adachi M, Sekiya M, Torigoe T, Takayama S, Reed JC, Miyazaki T, Minami Y, Taniguchi T, Imai K.
Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain.
Blood. 1996 Dec 1;88(11):4118-23.

Abe M, Saitoh O, Nakata H, Yoda A, Matsuda R.
Expression of neurofilament proteins in proliferating C2C12 mouse skeletal muscle cells.
Exp Cell Res. 1996 Nov 25;229(1):48-59.

Saitoh S, Kosugi A, Noda S, Yamamoto N, Ogata M, Minami Y, Miyake K, Hamaoka T.
Modulation of TCR-mediated signaling pathway by thymic shared antigen-1 (TSA-1)/stem cell antigen-2 (Sca-2).
J Immunol. 1995 Dec 15;155(12):5574-81.

Adachi M, Torigoe T, Sekiya M, Minami Y, Taniguchi T, Hinoda Y, Yachi A, Reed JC, Imai K.
IL-2-induced gene expression of protein-tyrosine phosphatase LC-PTP requires acidic and serine-rich regions within IL-2 receptor beta chain.
FEBS Lett. 1995 Sep 18;372(1):113-8.

Kawahara A, Minami Y, Miyazaki T, Ihle JN, Taniguchi T.
Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.
Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8724-8.

Asahi M, Tanaka Y, Qin S, Tsubokawa M, Sada K, Minami Y, Yamamura H.
Cyclic AMP-elevating agents negatively regulate the activation of p72syk in N-formyl-methionyl-leucyl-phenylalanine receptor signaling.
Biochem Biophys Res Commun. 1995 Jul 26;212(3):887-93.

Fujii H, Nakagawa Y, Schindler U, Kawahara A, Mori H, Gouilleux F, Groner B, Ihle JN, Minami Y, Miyazaki T, et al.
Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.
Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5482-6.

Miyazaki T, Liu ZJ, Kawahara A, Minami Y, Yamada K, Tsujimoto Y, Barsoumian EL, Permutter RM, Taniguchi T.
Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation.
Cell. 1995 Apr 21;81(2):223-31.

Sugie K, Minami Y, Kawakami T, Uchida A.
Stimulation of NK-like YT cells via leukocyte function-associated antigen (LFA)-1. Possible involvement of LFA-1-associated tyrosine kinase in signal transduction after recognition of NK target cells.
J Immunol. 1995 Feb 15;154(4):1691-8.

Minami Y, Nakagawa Y, Kawahara A, Miyazaki T, Sada K, Yamamura H, Taniguchi T.
Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway.
Immunity. 1995 Jan;2(1):89-100.

Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN, et al.
Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.
Science. 1994 Nov 11;266(5187):1045-7.
Kawahara A, Minami Y, Taniguchi T.
Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling.
Mol Cell Biol. 1994 Aug;14(8):5433-40.

Umehara H, Minami Y, Domae N, Bloom ET.
Increased processing of lymphocyte function-associated antigen-1 in human natural killer cells stimulated with IL-2.
Int Immunol. 1994 Jul;6(7):1071-80.

Minami Y, Oishi I, Liu ZJ, Nakagawa S, Miyazaki T, Taniguchi T.
Signal transduction mediated by the reconstituted IL-2 receptor. Evidence for a cell type-specific function of IL-2 receptor beta-chain.
J Immunol. 1994 Jun 15;152(12):5680-90.

Kobayashi N, Nakagawa S, Minami Y, Taniguchi T, Kono T.
Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor gamma.
Gene. 1993 Aug 25;130(2):303-4.

Kobayashi N, Kono T, Hatakeyama M, Minami Y, Miyazaki T, Perlmutter RM, Taniguchi T.
Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.
Proc Natl Acad Sci U S A. 1993 May 1;90(9):4201-5.

Minami Y, Kono T, Yamada K, Kobayashi N, Kawahara A, Perlmutter RM, Taniguchi T.
Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck.
EMBO J. 1993 Feb;12(2):759-68.

Umehara H, Takashima A, Minami Y, Bloom ET.
Signal transduction via phosphorylated adhesion molecule, LFA-1 beta (CD18), is increased by culture of natural killer cells with IL-2 in the generation of lymphokine-activated killer cells.
Int Immunol. 1993 Jan;5(1):19-27.

Satoh T, Minami Y, Kono T, Yamada K, Kawahara A, Taniguchi T, Kaziro Y.
Interleukin 2-induced activation of Ras requires two domains of interleukin 2 receptor beta subunit, the essential region for growth stimulation and Lck-binding domain.
J Biol Chem. 1992 Dec 15;267(35):25423-7.

Murakawa Y, Minami Y, Strober W, James SP.
Association of human lymph node homing receptor (Leu 8) with the TCR/CD3 complex.
J Immunol. 1992 Mar 15;148(6):1771-6.

Minami Y, Stafford FJ, Lippincott-Schwartz J, Yuan LC, Klausner RD.
Novel redistribution of an intracellular pool of CD45 accompanies T cell activation.
J Biol Chem. 1991 May 15;266(14):9222-30.

Garcia-Morales P, Minami Y, Luong E, Klausner RD, Samelson LE.
Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide.
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9255-9.

Hsi ED, Siegel JN, Minami Y, Luong ET, Klausner RD, Samelson LE.
T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates.
J Biol Chem. 1989 Jun 25;264(18):10836-42.

Minami Y, Samelson LE, Klausner RD.
Internalization and cycling of the T cell antigen receptor. Role of protein kinase C.
J Biol Chem. 1987 Sep 25;262(27):13342-7.

Minami Y, Weissman AM, Samelson LE, Klausner RD.
Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor.
Proc Natl Acad Sci U S A. 1987 May;84(9):2688-92.

Sone T, Yamaoka K, Minami Y, Tsunoo H.
Induction of metallothionein synthesis in Menkes' and normal lymphoblastoid cells is controlled by the level of intracellular copper.
J Biol Chem. 1987 Apr 25;262(12):5878-85.