Kobe Journal of Medical Sciences, 1996

TI: Antibody mediated ligation of platelet/endothelial cell adhesion molecule-1 (PECAM-1) on neutrophils enhances adhesion to cultured human dermal microvascular endothelial cells.

AU: Kuwabara-H; Tanaka-S; Sakamoto-H; Oryu-M; Uda-H

AD: Department of Pathology, Kagawa Medical University, Japan.

SO: Kobe-J-Med-Sci. 1996 Aug; 42(4): 233-41

ISSN: 0023-2513

PY: 1996

LA: ENGLISH

CP: JAPAN

AB: We investigated the effects on leukocyte adhesion to cultured human dermal microvascular endothelial (DMvE) cell by antibody mediated ligation of platelet/endothelial cell adhesion molecule-1 (PECAM-1) on neutrophils. Preincubation of neutrophils with anti-PECAM-1 antibody markedly enhanced their adhesion to DMvE cells, while the adhesion-increasing action was cancelled out by anti-CR3 or anti-LFA-1 beta (CD18) antibody. These findings suggest that ligation of PECAM-1 on neutrophils increases their adhesion to cultured DMvE cells depending on the beta 2 integrin family, and PECAM-1 may have a crucial role in dermal inflammation.