Bibliography of WHHL rabbits


WHHL papers


(1977)

1) Watanabe Y, Ito T, Kondo T
Breeding of a rabbit strain of hyperlipidema and characteristic of these strain.
Exp Anim 1977; 26 (1): 35-42. (in Japanse)           < Full paper > 

2) Watanabe Y
Studies on characteristics of spontaneously hyperlipidemic rabbits and development of the strains with such property.
Bull Azabu Vet Coll 1977; 2(1): 99-124. (in Japanese)           < Full paper > 

Bibliography of WHHL rabbits


(1980)

3) Watanabe Y
Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit).
Atherosclerosis 1980; 36(2): 261-268         < Abstract or Full paper >

4) Tanzawa K, Shimada Y, Kuroda M, Tsujita Y, Arai M, Watanabe Y
WHHL-rabbit: A low density lipoprotein receptor-deficient animal model for familial hypercholesterolemia.
FEBS Lett 1980; 118: 81-84         < Abstract or Full paper >

5) Kawai K, Maruno H, Watanabe Y, Hirohata K
Fat necrosis of osteocytes as a casusative factor in idiopathic osteonecrosis in heritable hyperlipidemic rabbits.
Clin Orthop 1980; 153: 273-282         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1981)

6) Watanabe Y, Ito T, Saeki M, Kuroda M, Tanzawa K, Mochizuki M, Tsujita Y, Arai M
Hypolipidemic effects of CS-500 (ML-236B) in WHHL-rabbit, a heritable animal model for hyperlipidemia.
Atherosclerosis 1981; 38(1-2): 27-31         < Abstract or Full paper >

7) Shimada Y, Tanzawa K, Kuroda M, Tsujita Y, Arai M, Watanabe Y
Biochemical characterization of skin fibroblasts derived from WHHL-rabbit, a notable animal for familial hypercholesterolemia.
Eur J Biochem 1981; 118: 557-564         < Abstract or Full paper >

8) Kita T, Brown MS, Watanabe Y, Goldstein JL
Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia.
Proc Natl Acad Sci USA 1981; 78: 2268-2272         < Abstract or Full paper >

9) Attie AD, Pittman RC, Watanabe Y, Steinberg D
Low density lipoprotein receptor deficiency in cultured hepatocytes of the WHHL rabbit.
J Biol Chem 1981; 256(18): 9789-9792         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1982)

10) Havel RJ, Kita T, Kotite L, Kane JP, Hamilton RL, Goldstein JL, Brown MS
Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia.
Arteriosclerosis 1982; 2: 467-474         < Abstract or Full paper >

11) Tsukitani M, Okamoto R, Suehiro A, Hatani M, Fujino M, Imai N, Takano S, Watanabe Y, Fukuzaki H
LDL receptor activity of cultured arterial smooth muscle cells from genetically hyperlipidemic rabbits (WHHL-rabbit).
Kobe J Med Sci 1982; 28: 171-179         < Full paper > 

12) Bilheimer DW, Watanabe Y, Kita T
Impaired receptor-mediated catabolism of low density lipoprotein in the WHHL rabbit, an animal model of familial hypercholesterolemia.
Proc Natl Acad Sci USA 1982; 79(10): 3305-3309         < Abstract or Full paper >

13) Kita T, Goldstein JL, Brown MS, Watanabe Y, Hornick CA, Havel RJ
Hepatic uptake of chylomicron remnants in WHHL rabbits: A mechanism genetically distinct from the low density lipoprotein receptor.
Proc Natl Acad Sci USA 1982; 79(11): 3623-3627         < Abstract or Full paper >

14) Kita T, Brown MS, Bilheimer DW, Goldstein JL
Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.
Proc Natl Acad Sci USA 1982; 79(18): 5693-5697         < Abstract or Full paper >

15) Pittman RC, Carew TE, Attie AD, Witztum JL, Watanabe Y, Steinberg D
Receptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits.
J Biol Chem 1982; 257(14): 7994-8000         < Abstract or Full paper >

16) Ito T, Watanabe Y, Shiomi M.
Spontaneous coronary atherosclerosis in immature stage of WHHL rabbit.
Jpn Coll Angiol. 1982; 22(4):229-232. (in Japanese)        < Full paper > 

Bibliography of WHHL rabbits


(1983)

17) Van Niekerk JLM, Demacker PNM, Hendriks T, Boer HHMD
A comparative study on serum lipids and atherosclerotic plaque formation in diet-induced and familial hypercholesterolemia in rabbits, and the effect of partial ileal bypass.
< Abstract or Full paper >

18) Buja LM, Kita T, Goldstein JL, Watanabe Y, Brown MS
Cellular pathology of progressive atherosclerosis in the WHHL rabbit, an animal model of familial hypercholesterolemia
Arterioscl Thromb Vasc Biol 1983; 3(1): 87-101       < Abstract or Full paper >

19) Okamoto R, Hatani M, Tsukitani M, Suehoro A, Fujino M, Imai N, Takano S, Watanabe Y, Fukuzaki H
The effect of oxygen on the development of atherosclerosis in WHHL rabbits.
Atherosclerosis 1983; 47(1): 47-53       < Abstract or Full paper >

20) Van Niekerk JLM, Demacker PNM, Hendriks T, Boer HHMD
Partial ileal bypass inhibits atherosclerosis in WHHL rabbits.
Atherosclerosis 1983; 48(3): 243-252       < Abstract or Full paper >

21) Yokoyama M, Akita H, Mizutani T, Fukuzaki H, Watanabe Y
Hyperreactivity of coronary arterial smooth muscles in response to ergonovine from rabbits with hereditary hyperlipidemia.
Circ Res 1983; 53(1): 63-71       < Abstract or Full paper >

22) Steinbrecher P, Witztum JL, Kesaniemi YA, Elam RL
Comparison of glucosylated low density lipoprotein with methylated or cyclohexanedione-treated low density lipoprotein in the measurement of receptor-independent low density lipoprotein catabolism.
J Clin Invest 1983; 71(4): 960-964       < Abstract or Full paper >

23) Dietschy JM, Kita T, Suckling KE, Goldstein JL, Brown MS
Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors.
J Lipid Res 1983; 24: 469-480       < Abstract or Full paper >

24) Goldstein JL, Kita T, Brown MS
Defective lipoprotein receptors and atherosclerosis: Lessons from an animal counterpart of familial hypercholesterolemia.
N Engl J Med 1983; 309: 288-296       < Abstract or Full paper >

25) Schneider WJ, Brown MS, Goldstein JL
Kinetic defects in the processing of the low density lipoprotein receptor in fibroblasts from WHHL rabbits and a family with familial hypercholesterolemia.
Mol Biol Med 1983; 1(3): 353-367       < Abstract or Full paper >

26) Hornick CA, Kita T, Hamilton RL, Kane JP, Havel RJ
Secretion of lipoproteins from the liver of normal and Watanabe heritable hyperlipidemic rabbits.
Proc Natl Acad Sci USA 1983: 80: 6096-6100       < Abstract or Full paper >

27) Kolata G
Cholesterol-heart disease link illuminated.
Science 1983; 221 (4616): 1164-1166         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1984)

28) Baker DP, Lenten BJV, Fogelman AM, Edwards PA, Kean C, Berliner JA
LDL, scavenger, and b-VLDL receptors on aortic endothelial cells.
Arterioscler Thromb Vasc Biol 1984; 4(3): 248-255         < Abstract or Full paper >

29) Yokoyama S, Hayashi R, Kikkawa T, Tani N, Takada S, Hatanaka K, Yamamoto A
Specific sorbent of apolipoprotein B-containing lipoproteins for plasmapheresis: characterization and experimental use in hypercholesterolemic rabbits.
Arterioscler Thromb Vasc Biol 1984; 4(3): 276-282         < Abstract or Full paper >

30) Niekerk JLMV, Hendriks T, Boer HHMD, Laar AV
Does nifedipine suppress atherogenesis in WHHL rabbits?
Atherosclerosis 1984; 53(1): 91-98         < Abstract or Full paper >

31) Niekerk JLMV, Hendriks T, Leuven JAG, Havekes L, Boer HHMD
The lipid-lowering effects of 3-hydroxy-3-methylglutaryl acid and bile acid drainage in WHHL rabbits.
Clin Sci 1984; 67(4): 439-444         < Abstract or Full paper >

32) Morii H, Nishizawa Y, Okui Y, Miki T, Inaba M, Kikkawa T, Yamamoto A, Watanabe Y
Effect of calcitonin on lipid metabolism in experimental animals.
Endocrine Control of Bone and Calcium Metabolism 1984; 365-368   

33) Niekerk JLMV, Hendriks T, Boer HHMD
Bile acid drainage by partial small bowel bypass or cholestyramine: Effects on serum cholesterol in Watanabe heritable hyperlipidemic rabbits.
Eur Surg Res 1984; 16(5): 282-287         < Abstract or Full paper >

34) Huettinger M, Schneider WJ, Ho YK, Goldstein JL, Brown MS
Use of monoclonal anti-receptor antibodies to probe the expression of the low density lipoprotein receptor in tissues of normal and Watanabe heritable hyperlipidemic rabbits.
J Clin Invest 1984; 74(3): 1017-1026         < Abstract or Full paper >

35) Wakasugi T, Mabuchi H, Sakai Y, Sakai T, Yoshimura A, Watanabe A, Koizumi J, Miyamoto S, Takeda R, Watanabe Y
ApoVLDL of the Watanabe heritable hyperlipidemic rabbit and the cholesterol-fed rabbit.
J Lipid Res 1984; 25(3): 246-253         < Abstract or Full paper >

36) Naruszewicz M, Carew TE, Pittman RC, Witztum JL, Steinberg D
A novel mechanism by which probucol lowers low density lipoprotein levels demonstrated in the LDL receptor-deficient rabbit.
J Lipid Res 1984; 25(11): 1206-1213         < Abstract or Full paper >

37) Stalenhoef AFH, Niekerk JLMV, Demacker PNM, Laar AV
Partial ileal bypass reduces the production rate of low density lipoproteins in Watanabe heritable hyperlipidemic rabbits.
J Lipid Res 1984; 25(12): 1350-1357         < Abstract or Full paper >

38) Huettinger M, Corbett JM, Schneider WJ, Willerson JT, Brown MS, Goldstein JL
Imaging of hepatic low density lipoprotein receptors by radionuclide scintiscanning in vivo.
Proc Natl Acad Sci USA 1984; 81(23): 7599-7603         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1985)

39) Watanabe Y, Ito T, Shiomi M
The effect of selective breeding on the development of coronary atherosclerosis in WHHL rabbits, an animal model for familial hypercholesterolemia.
Atherosclerosis 1985; 56(1): 71-79         < Abstract or Full paper >

40) Tilton GD, Buja LM, Bilheimer DW, Apprill P, Ashton J, Mcnatt J, Kita T, Willerson JT
Failure of a slow channel calcium antagonist, verapamil, to retard atherosclerosis in the Watanabe heritable hyperlipidemic rabbit, an animal model of familial hypercholesterolemia.
J Am Coll Cardiol 1985; 6: 141-144         < Abstract or Full paper >

41) Phelan JP, Lenten BJV, Fogelman AM, Kean C, Haberland ME, Edwards PA
Notes on the breeding of the WHHL rabbit, an animal model of familial hypercholesterolemia.
J Lipid Res 1985; 26(6): 776-778         < Abstract or Full paper >

42) Hoeg JM, Loriaux L, Gregg RE, Green WR, Brewer GH
Impaired adrenal reserve in the Watanabe heritable hyperlipidemic Rabbit: Implications for LDL-receptor function in steroidogenesis.
Metabolism 1985; 34(2): 194-197         < Abstract or Full paper >

43) Takashima S
Pathological changes in the cochlea of heritable hyperlipidemic (WHHL) rabbits.
The Oto-rhino-and laryngological clinic 1985; 78(12): 1-17 (in Japanese)

Bibliography of WHHL rabbits


(1986)

44) Takano T, Amanuma K, Kimura J, Kanaseki T, Ohkuma S
Involvement of macrophages in accumulation and elimination of cholesterol ester in atherosclerotic aorta.
Acta Histochem Cytochem 1986; 19: 135-143

45) Son YC, Zilversmit DB
Increased lipid transfer activities in hyperlipidemic rabbit plasma.
Arterioscler Thromb Vasc Biol 1986; 6(3): 345-351         < Abstract or Full paper >

46) Tsukada T, Rosenfeld M, Ross R, Gown AM
Immunocytochemical analysis of cellular components in atherosclerotic lesions: Use of monoclonal antibodies with the Watanabe and fat-fed rabbit.
Arterioscler Thromb Vasc Biol 1986; 6(6): 601-613         < Abstract or Full paper >

47) Richards T, Horlock H, Gallagher P
Atherosclerosis in modified WHHL rabbits.
Animal Technology 1986; 37: 1-6

48) Mowri H, Chinen k Ohkuma S, Takano T
Peroxidized lipid isolated by HPLC from atherosclerotic aorta.
Biochem Int 1986; 12: 437-352         < Abstract or Full paper >

49) Tsujita Y, Kuroda M, Shimada Y, Tanzawa K, Arai M, Kaneko I, Tanaka M, Masuda H, Tarumi C, Watanabe Y, Fujii S
CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: Tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species.
Biochim Biophys Acta 1986; 877(1): 50-60         < Abstract or Full paper >

50) Hosomi H, Katsuda S, Watanabe Y
Effect of atherosclerosis on the responsiveness of the rapidly acting arterial pressure control system in WHHL rabbits.
Cardiovasc Res 1986; 20(3): 195-200         < Abstract or Full paper >

51) Wade DP, Knight BL, Soutar K
Binding of low-density lipoprotein and chylomicron remnants to the hepatic low-density lipoprotein receptor of dogs, rats and rabbits demonstrated by ligand blotting: Failure to detect a distinct chylomicron-remnant- binding protein by ligand blotting.
Eur J Biochem 1986; 159(2): 334-340         < Abstract or Full paper >

52) Kita T, Yokode M, Watanabe Y, Narumiya S, Kawai
Stimulation of cholesteryl ester synthesis in mouse peritoneal macrophages by cholesterol-rich very low density lipoproteins from the Watanabe heritable hyperlipidemic rabbit, an animal model of familial hypercholesterolemia.
J Clin Invest 1986; 77(5): 1460-1465         < Abstract or Full paper >

53) Navab M, Hough GP, Berline JA, Frank JA, Fogelman AM, Haberland ME, Edwards PA
Rabbit beta-migrating very low density lipoprotein increases endothelial macromolecular transport without altering electrical resistance.
J Clin Invest 1986; 78(2): 389-397         < Abstract or Full paper >

54) Ecsedi GG, Virag S
Accumulation of cholesterol ester in cultured smooth muscle cells of congenital hypercholesterolemic (WHHL) rabbits treated with normal and WHHL rabbit plasma LDL.
Methods Find Exp Clin Pharmacol 1986; 8(9): 535-542         < Abstract or Full paper >

55) Ma PTS, Gil G, Sudhof TC, Billheimer DW, Goldstein JL, Brown MS
Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits.
Proc Natl Acad Sci USA 1986; 83: 8370-8374         < Abstract or Full paper >

56) Yamamoto T, Bishop RW, Brown MS, Goldstein JL, Russell DW
Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit.
Science 1986; 232: 1230-1237         < Abstract or Full paper >

57) Kutsumi Y, Fujiwara R, Tamai T, Takai H, Nakai T, Miyabo S
Long-tern repetitive plasmapheresis in hypercholesterolemic rabbits.
ASIO Trans 1986; 32: 163-167

58) Kimura J, Nakagami K, Amanuma K, Ohkuma S, Yoshida Y, Takano T
Monoclonal antibodies recognizing lipid-laden cells and extracellular regions with lipid-deposits in atherosclerotic aorta.
Virchows Arch A 1986; 410(2): 159-164         < Abstract or Full paper >

59) Amanuma K, Kanaseki T, Ikeuchi Y, Ohkuma S, Takano T
Studies on fine structure and location of lipids in quick-freeze replicas of atherosclerotic aorta of WHHL rabbits.
Virchows Arch A 1986; 410(3): 231-238         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1987)

60) Hatanaka K, Ito T, Shiomi M, Yamamoto A, Watanabe Y
Ischemic heart disease in the WHHL rabbit: A model for myocardial injury in genetically hyperlipidemic animals.
Am Heart J 1987; 113: 280-288         < Abstract or Full paper >

61) Kovanen PT
Regulation of plasma cholesterol by hepatic low-density lipoprotein receptors.
Am Heart J 1987; 113: 464-469         < Abstract or Full paper >

62) Rosenfeld ME, Tsukada T, Gown AM, Ross R
Fatty streak initiation in Watanabe heritable hyperlipidemic and comparably hypercholesterolemic fat-fed rabbits.
Arterioscler Thromb Vac Biol 1987; 7(1): 9-23         < Abstract or Full paper >

63) Rosenfeld ME, Tsukada T, Chait A, Bierman EL, Gown AM, Ross R
Fatty streak expansion and maturation in Watanabe heritable hyperlipidemic and comparably hypercholesterolemic fat-fed rabbits.
Arterioscler Thromb Vac Biol 1987; 7(1): 24-34         < Abstract or Full paper >

64) Kano M, Koizumi J, Jadhav A, Thompson GR
Plasma exchange and low density lipoprotein apheresis in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vac Biol 1987; 7(3): 256-261         < Abstract or Full paper >

65) Watanabe N, Ishikawa Y, Okamoto R, Watanabe Y, Fukuzaki H
Nifedipine suppressed atherosclerosis in cholesterol-fed rabbits but not in Watanabe heritable hyperlipidemic rabbits.
Artery 1987; 14(5): 283-294         < Abstract or Full paper >

66) Niekerk JLMV, Hendriks T, Boer HHMD
Effect of partial ileal bypass on the progression of atherosclerosis lesions in WHHL rabbits.
Atherosclerosis 1987; 63(2-3): 225-230         < Abstract or Full paper >

67) Ishikawa Y Watanabe N, Okamoto R, Watanabe Y, Fukuzaki H
Nifedipine-suppressed atherosclerosis in cholesterol-fed rabbits but not in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1987; 64(1): 79-80         < Abstract or Full paper >

68) Shiomi M, Ito T, Watanabe Y
Increase in hepatic low-density lipoprotein receptor activity during pregnancy in Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia.
Biochim Biophys Acta 1987; 917(1): 92-100         < Abstract or Full paper >

69) Subbiah MTR, Yunker RL, Rymaszewski Z, Kottke BA, Bale LK
Cholestyramine treatment in early life of low-density lipoprotein receptor deficient Watanabe rabbits: Decreased aortic cholesteryl ester accumulation and atherosclerosis in adult life.
Biochim Biophys Acta 1987; 920(3): 251-258         < Abstract or Full paper >

70) Bell FP, Raymond TL, Patnode CL
The influence of diet and carnitine supplementation on plasma carnitine, cholesterol and triglyceride in WHHL (Watanabe-heritable hyperlipidemic), Netherlands dwarf and New Zealand rabbits (oryctolagus cuniculus).
Comp Biochem Physiol. 1987; 87B: 587-591         < Abstract or Full paper >

71) Raymond TL, Reynilds SA, Swanson JA, Patnode CA, Bell FP
The effect of oral 1-carnitine on lipoprotein composition in the Watanabe heritable hyperlipidemic rabbit (oryctolagus cuniculus).
Comp Biochem Physiol. 1987; 88A: 503-506         < Abstract or Full paper >

72) Hara A, Taketomi T
Occurrence of sulfatide as a major glycosphingolipid in WHHL rabbit serum lipoproteins.
J Biochem 1987; 102(1): 83-92         < Abstract or Full paper >

73) Tsukitani M, Okamoto R, Ishikawa Y, Mukodani J, Watanabe N, Suehiro A, Hatani M, Fujino M, Takano S, Watanabe Y, Fukuzaki H
Effect of hypoxia on lipid accumulation in cultured fibroblasts from normal rabbit and Watanabe heritable hyperlipidemic rabbit.
J Clin Biochem Nutr 1987; 2(3): 279-286         < Abstract or Full paper >

74) Yamada N, Shames DM, Havel RJ
Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma.
J Clin Invest 1987; 80(2): 507-515         < Abstract or Full paper >

75) Ikeda M, Kodama H, Nohara N
Process of foam cell formation in diet-induced hypercholesterolemic rabbit and the Watanabe heritable hyperlipidemic rabbit.
J Dermatol 1987; 14: 305-312

76) Spady DK, Huettinger M, Bilheimer DW, Dietschy JM
Role of receptor-independent low density lipoprotein transport in the maintenance of tissue cholesterol balance in the normal and WHHL rabbit.
J Lipid Res 1987; 28: 32-41         < Abstract or Full paper >

77) Shiomi M, Ito T, Watanabe Y
Effects of hyperlipidemia on the nursing ability of WHHL rabbits.
Lab Anim Sci 1987; 84-88         < Abstract or Full paper >

78) Kita T, Nagano Y, Yokode M, Ishii K, Kume N, Ooshima A, Yoshida H, Kawai C
Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.
Proc Natl Acad Sci USA 1987; 84(16): 5928-5931         < Abstract or Full paper >

79) Hofmann SL, Russell DW, Goldstein JL, Brown MS
mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits.
Proc Natl Acad Sci USA 1987; 84(17): 6312-6316         < Abstract or Full paper >

80) Carew TE, Schwenke DC, Steinberg D
Antiatherogenic effect of probucol unrelated to its hypercholesterolemic effect: Evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbits.
Proc Natl Acad Sci USA 1987; 84(21): 7725-7729         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1988)

81) Steinberg D, Parthasarathy S, Carew TE
In vivo inhibition of form cell development by probucol in Watanabe rabbits.
Am J Cardiol 1988; 62: 6B-12B         < Abstract or Full paper >

82) Kita T, Nagano Y, Yokode M, Ishii K, Kume N, Narumiya S, Kawai C
Prevention of atherosclerotic progression in Watanabe rabbits by probucol.
Am J Cardiol 1988; 62: 13B-19B         < Abstract or Full paper >

83) Clozel JP, Lengsfeld H, Kuhn H, Baumgartner HR
Decreased coronary vascular reserve in Watanabe heritable hyperlipidemic rabbits.
Arterioscler thromb Vasc Biol 1988; 8(3): 310-320         < Abstract or Full paper >

84) Rosenfeld ME, Chait A, Bierman EL, King W, Goodwin P, Walden CE, Ross R
Lipid composition of aorta Watanabe heritable hyperlipidemic and comparably hypercholesterolemic fad-fed rabbits: Plasma lipid composition determines aortic lipid composition of hypercholesterolemic rabbits.
Arterioscler thromb Vasc Biol 1988; 8(4): 338-347         < Abstract or Full paper >

85) Daugherty A, Zweifel BS, Sobel BE, Schonfeld G
Isolation of low density lipoprotein from atherosclerotic vascular tissue of Watanabe heritable hyperlipidemic rabbits.
Arterioscler thromb Vasc Biol 1988; 8(6): 768-777         < Abstract or Full paper >

86) Rall CJN, Hong JM, Gregg RE, Law SW, Monge JC, ME, Meng MS, Zech LA, Brewer HB
Enhanced apolipoprotein E production with normal hepatic mRNA levels in the Watanabe heritable hyperlipidemic rabbit.
Arterioscler thromb Vasc Biol 1988; 8(6): 804-809         < Abstract or Full paper >

87) Olsson G, Ostlund-lindquist AM, Bondjers G, Wiklund O, Olofsson SO
Quantification of plasma lipids and apolipoproteins in British Halflop rabbits: A comparison between normocholesterolemic rabbits, hypercholesterolemic rabbits (modified WHHL rabbits) and rabbits fed an atherogenic diet.
Atherosclerosis 1988; 70(1-2): 81-94         < Abstract or Full paper >

88) Gallagher PJ, Nanjee MN, Richards T, Roche ER, Miller NE
Biochemical and pathological features of a modified strain of Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1988; 71(2-3): 173-183         < Abstract or Full paper >

89) Watanabe Y, Ito T, Shiomi M, Tsujita Y, Kuroda M, Arai M, Fukami M, Tamura A
Preventive effect of pravastatin sodium, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on coronary atherosclerosis and xanthoma in WHHL rabbits.
Biochim Biophys Acta 1988; 960(3): 294-302         < Abstract or Full paper >

90) Ishii K, Kita T, Kume N, Nagano Y, Kawai C
Uptake of acetylated LDL by peritoneal macrophages obtained from normal and Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia.
Biochim Biophys Acta 1988; 962(3): 387-389         < Abstract or Full paper >

91) Mowri H, Ohkuma S, Takano T
Monoclonal DLR1a/104G antibody recognizing peroxidized lipoproteins in atherosclerotic lesions.
Biochim Biophys Acta 1988; 963(2): 208-214         < Abstract or Full paper >

92) Hasegawa M, Watanabe Y
Rheological properties of the thoracic aorta in normal and WHHL rabbits.
Biorheology 1988; 25: 147-156         < Abstract or Full paper >

93) Morita H, Nishida Y, Motochigawa H, Watanabe Y, Hosomi H
Depressed baroreflex control of renal nerve activity in conscious WHHL rabbits.
Cardiovasc Res 1988; 22(10): 679-685         < Abstract or Full paper >

94) Uchida T, Tsuchiya R, Harada N, Tsunoda T, Yamaguchi T, Eto T, Furukawa M
Ischemic changes in the pancreas of Watanabe heritable hyperlipidemic (WHHL) rabbits.
Int J Pancreatol 1988; 3: 261-272         < Abstract or Full paper >

95) Wu D, Fujiwara H, Tanaka M, Onodera T, Matsuda M, Ishida M, Kawamura A, Takemura G, Fujiwara T, Nagano Y, Ishii K, Kita T, Kawai C, Hamashima Y
Distribution and progression of coronary arterial and aortic lesions in the conventional Watanabe heritable hyperlipidemic rabbit.
Jpn Circ J 1988; 52(4): 327-340         < Abstract or Full paper >

96) Yokoyama S
Treatment of hypercholesterolemia by chemical absorption of lipoproteins.
J Clin Apheresis 1988; 4(2-3): 66-71         < Abstract or Full paper >

97) Nishizawa Y, Okui Y, Inaba M, Okuno S, Yukioka K, Miki T, Watanabe Y, Morii H
Calcium/ calmodulin-mediated action of calcitonin on lipid metabolism in rats.
J Clin Invest 1988; 82(4): 1165-1172         < Abstract or Full paper >

98) Yamada N, Shames DM, Takahashi K, Havel RJ
Metabolism of apolipoprotein B-100 in large very low density lipoproteins of blood plasma.
J Clin Invest 1988; 82(6): 2106-2113         < Abstract or Full paper >

99) Williams KJ, Vallabhajosula S, Rahman IU, Donnelly TM, Parker T, Weinrauch M, Goldsmith SJ
Low density lipoprotein receptor-independent hepatic uptake of a synthetic, cholesterol-scavenging lipoprotein: Implications for the treatment of receptor-deficient atherosclerosis.
Proc Natl Acad Sci USA 1988; 85(1): 242-246         < Abstract or Full paper >

100) Wilson JM, Johnston DE, Jefferson DM, Mulligan RC
Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit.
Proc Natl Acad Sci USA 1988; 85(12): 4421-4425         < Abstract or Full paper >

101) Miyanohara A, Sharkey MF, Witztum,JL, Steinberg D, Friendmann T
Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vivo.
Proc Natl Acad Sci USA 1988; 85(17): 6538-6542         < Abstract or Full paper >

102) Haberland ME, Fong D, Cheng L
Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits.
Science 1988; 241: 215-218         < Abstract or Full paper >

103) Garibaldi BA, Goad MEP
Lipid keratopathy in the Watanabe (WHHL) rabbit.
Vet Pathol 1988; 25(2): 173-174         < Abstract or Full paper >

104) Pfister SL, Schmitz JM, Willerson JT, Cambell WB
Characterization of arachidonic acid metabolism in Watanabe heritable hyperlipidemic (WHHL) and New Zealand white (NZW) rabbit aortas.
Prostaglandins 1988; 36(4): 515-532         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1989)

105) Nakagami K, Shimazaki O, Sato R, Komine Y, Ohkuma S, Takano T
Monoclonal antibody EMR1a/212D recognizing site of deposition of extracellular lipid in atherosclerosis: purification and characterization of the antigen.
Am J Pathol 1989; 135: 93-100         < Abstract or Full paper >

106) Boyd HC, Gown AM, Wolfbaur G, Chait A
Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit.
Am J Pathol 1989; 135: 815-825         < Abstract or Full paper >

107) Cohn W, Kuhn H
The role of the low density lipoprotein receptor for a-tocopherol delivery to tissues.
Ann N Y Acad Sci 1989; 570: 61-71         < Abstract or Full paper >

108) Rich S, Miller JM, Charous S, Davis HR, Shanks P, Glagov S, Lands WEM
Development of atherosclerosis in genetically hyperlipidemic rabbits during chronic fish-oil ingestion.
Arterioscler Thromb Vasc Biol 1989; 9(2): 189-194         < Abstract or Full paper >

109) Wines PA, Schmitz JM, Pfister SL, Clubb FJ, Buja LM, Wilson JT, Campbell WB
Augmented vasoconstrictor responses to serotonin precede development of atherosclerosis in aorta of WHHL rabbit.
Arterioscler Thromb Vasc Biol 1989; 9(2): 195-202         < Abstract or Full paper >

110) Nagano Y, Kita T, Yokode M, Ishii K, Kume N, Otani H, Arai H, Kawai C
Probucol does not affect lipoprotein metabolism in macrophages of Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1989; 9(4): 453-461         < Abstract or Full paper >

111) Wernette-Hammond ME, Garcia Z, Arnold KS, Innerarity TL
b-very low density lipoprotein uptake in cultured fibroblasts and smooth muscle cells from Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1989; 9(4): 501-510         < Abstract or Full paper >

112) Clubb FJ, Schmitz JM, Butler MM, Buja LM, Willerson JT, Campbell WB
Effect of dietary omega-3 fatty acid on serum lipids, platelet function, and atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1989; 9(4): 529-537         < Abstract or Full paper >

113) Havel RJ, Yamada N, Shames DM
Watanabe heritable hyperlipidemic rabbit: animal model for familial hypercholesterolemia.
Arterioscler Thromb Vasc Biol 1989; 9(Suppl I): I-33 -I-38         < Abstract or Full paper >

114) Simon TC, Makheja AN, Bailey JM
Formation of 15-hydroxyeicosatetraenoic acid (15-HETE) as the predominant eicosanoid in aortas from Watanabe heritable hyperlipidemic and cholesterol-fed rabbits.
Atherosclerosis 1989; 75(1): 31-38         < Abstract or Full paper >

115) Makheja AN, Bloom S, Muesing R, Simon T, Bailey JM
Anti-inflammatory drugs in experimental atherosclerosis 7. Spontaneous atherosclerosis in WHHL rabbits and inhibition by cortisone acetate.
Atherosclerosis 1989; 76(2-3): 155-161         < Abstract or Full paper >

116) Atkinson JB, Hoover RL, Berry KK, Swift LL
Cholesterol-fed heterozygous Watanabe heritable hyperlipidemic rabbits: A new model for atherosclerosis.
Atherosclerosis 1989; 78(2-3): 123-136         < Abstract or Full paper >

117) Saku K, Yamamoto K, Sakai T, Yanagida T, Hidaka K, Sasaki J, Arakawa K
Kinetics of HDL-apoA-1 in the WHHL rabbit, an animal model of familial hypercholesterolemia.
Atherosclerosis 1989; 79(2-3): 225-230         < Abstract or Full paper >

118) Ragazzi E, Chinellato A, Biasi MD, Pandolfo L, Proadocimi M, Norido F, Caparrotta L, Fassina G
Endothelium-dependent relaxation, cholesterol content and high energy metabolite balance in Watanabe hyperlipidemic rabbit aorta.
Atherosclerosis 1989; 80(2): 125-134         < Abstract or Full paper >

119) Mol MJTM, Stalenhoef FH, Demacker PNM, Laar AV
Low-density lipoprotein catabolism in WHHL rabbits after partial ileal bypass surgery.
Biochim Biophys Acta 1989; 1003(2): 167-174         < Abstract or Full paper >

120) Allain P, Krari N, Chaleil D, Balanant Y, Bled F, Girault M
The distribution of elements in the tissues of Watanabe heritable hyperlipidemic rabbits.
Biol Trace Elem Res 1989; 19(3): 153-160         < Abstract or Full paper >

121) Tsujita Y, Watanabe Y
Pravastatin sodium: A novel cholesterol-lowering agent that inhibits HMG-CoA reductase.
Cardiovasc Drug Rev 1989; 7: 110-126         < Abstract or Full paper >

122) Kume N, Kita T, Mikami A, Yokode M, Ishii K, Nagano Y, Kawai C
Induction of mRNA for low-density lipoprotein receptor in heterozygous Watanabe heritable hyperlipidemic rabbits treated with CS-514 (Pravastatin) and cholestyramine.
Circulation 1989; 79(5): 1084-1090         < Abstract or Full paper >

123) Shiomi M, Ito T, Watanabe Y, Tsujita Y, Kuroda M, Arai M, Fukami M, Fukushige J
Suppressive effect of the combination treatment with pravastatin sodium and cholestyramine on the progression of atherosclerosis and xanthoma in mature WHHL rabbits.
Clin Ter Cardiovasc 1989; 8: 281-283

124) Pfister S, Rosolowsky M, Schmitz JM, Clubb FJ, Campbell WB
Eicosapentaenoic acid alters reactivity and platelet adhesion in Watanabe heritable hyperlipidemic rabbits.
Eur J Pharmacol 1989; 161: 85-89         < Abstract or Full paper >

125) Chobanian AV, Lichtenstein AH, Nilakhe V, Haudenschild CC, Drago R, Nickerson C
Influence of hypertension on aortic atherosclerosis in the Watanabe rabbit.
Hypertension 1989; 14(2): 203-209         < Abstract or Full paper >

126) Taketomi T, Hara A, Uemura K, Kyogashima N
Effect of long-tern treatment on hyperlipidemia and progression of atherosclerosis in WHHL rabbits.
Jpn J Exp Med 1989; 59: 221-231         < Abstract or Full paper >

127) Kono K, Iwata Y, Tajima T, Kuzuya F
Effect of AJ814 on lipid metabolism and atherosclerotic lesions in cholesterol-fed rabbits, Triton- injected rabbits and WHHL rabbit.
J Jpn Atheroscler Soc 1989; 17(1): 97-99         < Abstract or Full paper >

128) Hofmann SL, Brown MS, Lee E, Pathak RK, Anderson RGW, Goldstein JL
Purification of a sarcoplasmic reticulum protein that bonds Ca2+ and plasma lipoproteins.
J Biol Chem 1989; 264(14): 8260-8270         < Abstract or Full paper >

129) Mahley RW, Weisgraber KH, Hussein MM, Greenman B, Fisher M, Vogel T, Goreck M
Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits.
J Clin Invest 1989; 83: 2125-2130         < Abstract or Full paper >

130) Dalessandri KM, Lantz BMT, Tsukamoto H, Link DP, Brock J
Superior mesenteric artery vasoactivity in hyperlipidemic Watanabe rabbits versus normal lipidemic New Zealand controls.
J Invest Surg 1989; 2(4): 471-477         < Abstract or Full paper >

131) Ishii K, Kita T, Yokode M, Kume N, Nagano Y, Otani H, Yamamura T, Murayama S, Morimoto Y, Teranishi Y, Kawai C
Characterization of very low density lipoprotein from Watanabe heritable hyperlipidemic rabbits.
J Lipid Res 1989; 30(1): 1-7         < Abstract or Full paper >

132) Frank JS, Fogelman AM
Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching.
J Lipid Res 1989; 30(7): 967-978         < Abstract or Full paper >

133) Lichtenstein AH, Drago R, Nickerson C, Prescott MF, Lee SQ, Chobanian AV
Effect of propranolol on atherogenesis in the Watanabe heritable hyperlipidemic rabbit.
J Vasc Med Biol 1989; 1: 248-254

134) Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JM
Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenecity.
N Engl J Med 1989; 320: 915-924         < Abstract or Full paper >

135) Mori Y
A study on coagulability in Watanabe heritable hyperlipidemic rabbits and patients with familial hypercholesterolemia.
Mie Med J 1989; 36: 83-97

136) Udom C, Barnard D, Smoth T
Serum cholinesterase isoenzymes and the WHHL rabbit: the relationship between the activity of cholinesterase not bound to low-density-lipoprotein and lipoprotein titer.
Mol Cell Biochem 1989; 90(2): 121-125         < Abstract or Full paper >

137) Pandolfo L, Chinellato A, Zambonin M, Biasi MD, Ragazzi E, Caparrotta L
Influence of the age on energy metabolism and purines turnover in Watanabe hyperlipidemic (WHHL) rabbit aorta.
Pharmacol Res 1989; 21(Suppl 1): 115-116         < Abstract or Full paper >

138) Yamada N, Shimano H, Mokuno H, Ishibashi S, Gotohda T, Kawakami M, Watanabe Y, Akanuma Y, Murase T, Takaku F
Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits.
Proc Natl Acad Sci USA 1989; 86(2): 665-669         < Abstract or Full paper >

139) Palinski W, Rosenfeld ME, Yla-herttuala S, Gurtner GC, Socher SS, Bulter SW, Partharathy S, Carew TE, Steinberg D, Witztum JL
Low density lipoprotein undergoes oxidative modification in vivo.
Proc Natl Acad Sci USA 1989; 86(4): 1372-1376         < Abstract or Full paper >

140) Mathe D, Baudet MF, Boisnier C, Jacotot B
Le lapin WHHL et l'therosclerose experimentale: caracteristiques et utilisation.
Sci Tech Anim Lab 1989; 14: 65-71 (in French)

141) Mori Y, Wada H, Nagano Y, Deguchi K, Kita T, Shirakawa S
Hypercoagulable state in the Watanabe heritable hyperlipidemic rabbit, an animal model for the progression of atherosclerosis: effect of probucol on coagulation.
Thromb Haemostasis 1989; 61: 140-143         < Abstract or Full paper >

142) Lawrence JB, Prevosti LG, Kramer WS, Lu DY, Leon MB
Platelet adherence and thrombus formation with flowing human blood on atherosclerotic plaque: reduced thrombogenecity of Watanabe-heritable hyperlipidemic rabbit aortic subendothelium.
Thromb Res 1989; 54: 99-114         < Abstract or Full paper >

143) Simon TC, Makheja AN, Bailey JM
The induced lipoxygenase in atherosclerotic aorta converts linoleic acid to the platelet chemorepellant factor 13-HODE.
Thromb Res 1989; 55: 171-178         < Abstract or Full paper >

144) Komiyama Y, Masuda M, Murakami T, Nishikado H, Egawa H, Nishimura T, Morii S, Murata K
Accumulation of 125I-factor XI in atheroma of rabbit with hereditary hyperlipidemia (WHHL-rabbit).
Thromb Res 1989; 56: 49-58         < Abstract or Full paper >

145) Ishikawa Y, Watanae N, Miyazaki N, Tanjguchi T, Watsnabe Y, Fukuzaki H
Effects of nifedipine on atherosclerosis in cholesterol-fed rabbits and Watanabe herirable hyperlipidemic rabbits.
Adalat in the Asian Pacific Region ed by Kelly DT. 1989; 47-59

Bibliography of WHHL rabbits


(1990)

146) Workman JR, Schmidt SP, Donovan DL, Clarke R
The effects of heparin upon atherogenesis in the Watanabe heritable hyperlipidemic rabbit.
Ann Vasc Surg 1990; 4(4): 344-350         < Abstract or Full paper >

147) Rosenfeld ME, Palinski W, Yla-Herttuala S, Bulter S, Witztum JL
Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.
Arterioscler Thromb Vasc Biol 1990; 10(3): 336-349         < Abstract or Full paper >

148) Tsunemitsu M, Ishikawa Y, Taniguchi T, Fukuzaki H
Heterogeneity of n-linked sugar chains of apolipoprotein B-100 in Watanabe heritable hyperlipidemic and fasting rabbits.
Arterioscler Thromb Vasc Biol 1990; 10(3): 386-393         < Abstract or Full paper >

149) Lichtenstein AH, Chobanian AV
Effect of fish oil on atherogenesis in Watanabe heritable hyperlipidemic rabbit.
Arterioscler Thromb Vasc Biol 1990; 10(4): 597-606         < Abstract or Full paper >

150) Rosenfeld ME, Ross R
Macrophage and smooth muscle cell proliferation in atherosclerotic lesions of WHHL and comparably hypercholesterolemic fat-fed rabbits.
Arterioscler Thromb Vasc Biol 1990; 10(5): 680-687         < Abstract or Full paper >

151) Saku K, Fujino M, Yamamoto K, Ying H, Tashiro N, Harada R, Okabe M, Arakawa K
Cardiac function of WHHL rabbit, an animal model of familial hypercholesterolemia.
Artery 1990; 17: 271-280         < Abstract or Full paper >

152) Beaumont JL, Vivier P
Circulating IgA-Lp complexes in Watanabe heritable hyperlipidemic and cholesterol fed NZW rabbit.
Atherosclerosis 1990; 82(3): 227-235         < Abstract or Full paper >

153) Shiomi M, Ito T, Watanabe Y, Tsujita Y, Kuroda M, Arai M, Fukami M, Fukushige J, Tamura A
Suppression of established atherosclerosis and xanthomas in mature WHHL rabbits by keeping their serum cholesterol levels extremely low: Effect of pravastatin sodium in combination with cholestyramine.
Atherosclerosis 1990; 83: 69-80         < Abstract or Full paper >

154) Saku K, Harada R, Yamamoto K, Ying H, Ozaki I, Arakawa K
Apolipoprotein AI mRNA levels in WHHL rabbits.
Atherosclerosis 1990; 84(1): 73-74         < Abstract or Full paper >

155) Atkinson JB, Swift LL
Nifedipine reduces atherogenesis in cholesterol-fed heterozygous WHHL rabbits.
Atherosclerosis 1990; 84(2-3): 195-201         < Abstract or Full paper >

156) Armstrong ML, Heistad DD
Animal model of atherosclerosis.
Atherosclerosis 1990; 85(1): 15-23         < Abstract or Full paper >

157) Beaumont J, Assadollahi F
Retinyl palmitate labeled intestinally derived lipoproteins accumulate in the circulation of WHHL rabbits.
Atherosclerosis 1990; 85(2-3): 103-111         < Abstract or Full paper >

158) Demacker NM, Mol MJT, Stalenhoef FH
Increased hepatic lipase activity and increased direct removal of very-low-density lipoprotein remnants in Watanabe heritable hyperlipidemic (WHHL) rabbits treated with ethinyl oestradiol.
Biochem J 1990; 272(3): 647-651         < Abstract or Full paper >

159) Kolodgie FD, Virmani R, Rice HE, Mergner WJ
Vascular reactivity during the progression of atherosclerotic plaque: a study in Watanabe heritable hyperlipidemic rabbits.
Circ Res 1990; 66(4): 1112-1126         < Abstract or Full paper >

160) Chobanian AV
The effect of ACE inhibitors and other antihypertensive drugs on cardiovascular risk factors and atherogenesis.
Clin Cardiol 1990; 13(Suppl-S7): VII-43-48         < Abstract or Full paper >

161) St John LC, Bell FP
Arterial fatty acid-binding protein activity associated with dietary-induced and spontaneously occurring atherosclerosis in the rabbit (oryctolagug cuniculus).
Comp Biochem Physiol 1990; 97B(1): 123-127         < Abstract or Full paper >

162) Buja LM, Clubb FJ, Bilheimer DW, Willerson JT
Pathobiology of human familial hypercholesterolemia and a related animal model, the Watanabe heritable hyperlipidemic rabbit.
Eur Heart J 1990; 11(Suppl-E): 41-52         < Abstract or Full paper >

163) Kita T, Ishii K, Yokode M, Kume N, Nagano Y, Arai H, Kawai C
The role of oxidized low density lipoprotein in the pathogenesis of atherosclerosis.
Eur Heart J 1990; 11(Suppl-E): 122-127         < Abstract or Full paper >

164) Mokuno H, Ishibashi S, Shimano H, Gotohda T, Takaku F, Yamada N
Effect of exogenous apo E on the cellular binding of lipoproteins.
Gerontology 1990; 36(Suppl-1): 42-48         < Abstract or Full paper >

165) Chobanian AV, Haudenschild CC, Nickerson C, Drago R
Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit.
Hypertension 1990; 15(3): 327-331         < Abstract or Full paper >

166) Chobanian AV
1989 Corcoran lecture: Adaptive and maladaptive responses of the arterial wall to hypertension.
Hypertension 1990; 15: 666-674         < Abstract or Full paper >

167) Shimamura T, Amorosa LF, Wilson AC, Lelkes L, Khachadurian AK
Atherosclerosis and glomerulosclerosis in WHHL rabbits and obese Zucker rats.
Japan J Exp Med 1990; 60: 105-109         < Abstract or Full paper >

168) Hara A, Taketomi T
Characterization and change of phospholipids in the aorta of Watanabe heritable hyperlipidemic rabbit.
Japan J Exp Med 1990; 60: 311-318         < Abstract or Full paper >

169) Shimano H, Yamada N, Ishibashi S, Harada K, Matsumoto A, Mori N, Inaba T, Motoyoshi K, Itakura H, Takaku F
Human monocyte colony-stimulating factor enhances the clearance of lipoproteins containing apolipoprotein B-100 via both low density lipoprotein receptor-dependent and-independent pathways in rabbits.
J Biol Chem 1990; 265(22): 12869-12875         < Abstract or Full paper >

170) Sato R, Komine Y, Imanaka T, Takano T
Monoclonal antibody EMR1a/212D recognizing site of deposition of extracellular lipid in atherosclerosis: isolation and characterization of a cDNA clone for the antigen.
J Biol Chem 1990; 265: 21232-21236         < Abstract or Full paper >

171) Herz J, Kowal RC, Ho YK, Brown MS, Goldstein JL
Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver.
J Biol Chem 1990; 265(34): 21355-21362         < Abstract or Full paper >

172) Tsujita Y
A potent HMG-CoA reductase inhibitor, pravastatin sodium-tissue-selective inhibition of cholesterogenesis and preventive effect on atherosclerosis in WHHL rabbits.
J Drug Dev 1990; 3: 155-159

173) Dalessandri KM, Bogren H, Lantz BMT, Tsukamoto H, Bjorkerud S, Brock J
Aortic compliance in hypercholesterolemic Watanabe rabbits compared to normal New Zealand controls.
J Invest Surg 1990; 3(3): 245-251         < Abstract or Full paper >

174) Shames DM, Yamada N, Havel RJ
Metabolism of apoB-100 in lipoproteins separated by density gradient ultracentrifugation in normal and Watanabe heritable hyperlipidemic rabbits.
J Lipid Res 1990; 31(5): 753-762         < Abstract or Full paper >

175) Sharkey MF, Miyanohara A, Elam RL, Friedmann T, Witztum JL
Post-transcriptional regulation of retroviral vector-transduced low density lipoprotein receptor activity.
J Lipid Res 1990; 31(12): 2167-2178         < Abstract or Full paper >

176) Nolte CJM, Tercyak AM, Wu HM, Small DM
Chemical and physicochemical comparison of advanced atherosclerotic lesions of similar size and cholesterol content in cholesterol-fed New Zealand white and Watanabe heritable hyperlipidemic rabbits.
Lab Invest 1990; 62: 213-222         < Abstract or Full paper >

177) Wilson JM, Chowdhury NR, Grossman M, Wajsman R, Epstein A, Mulligan RC, Chowdhury JR
Temporary amelioration of hyperlipidemia in low density lipoprotein receptor-deficient rabbits transplanted with genetically modified hepatocytes.
Proc Natl Acad Sci USA 1990; 87(21): 8437-8441         < Abstract or Full paper >

178) Wiederkehr JC, Kondos GT, Pollak R
Hepatocyte transplantation for the low-density lipoprotein receptor-deficient state: a study in Watanabe rabbit.
Transplantation 1990; 50(3): 466-476         < Abstract or Full paper >

179) Dichek DA, Bratthauer GL, Beg ZH, Newman KD, Anderson KD, Zwiebel JA, Hoeg JM, Anderson EF
A genetic therapy for familial hypercholesterolemia.
Trans Assoc Am Physicians 1990; 103: 73-79         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1991)

180) Havel RJ, Shames DM
Kinetic studies of the origin of apolipoprotein (Apo) B-100 in low density lipoproteins of normal and Watanabe heritable hyperlipidemic (WHHL) rabbits.
Adv Exp Med Biol 1991; 285: 245-255

181) Gross PL, Rand ML, Barrow DV, Packman MA
Platelet function in Watanabe heritable hyperlipidemic rabbits: Decreased sensitivity to thromboxane A2.
Arterioscler Thromb Vasc Biol 1991; 11(3): 610-616         < Abstract or Full paper >

182) O'Brien K, Nagano Y, Gown A, Kita T, Chait A
Probucol treatment affects the cellular composition but not anti-oxidized low density lipoprotein immunoreactivity of plaques from Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1991; 11(3): 751-759         < Abstract or Full paper >

183) Stewart-Lee AL, Burnstock G
Changes in vasoconstrictor and vasodilator responses of the basilar artery during maturation in the Watanabe heritable hyperlipidemic rabbit differ from those in the New Zealand white rabbit.
Arterioscler Thromb Vasc Biol 1991; 11(5): 1147-1155         < Abstract or Full paper >

184) Mao SJT, Yates MT, Parker RA, Chi EM, Jackson RL
Attenuation of atherosclerosis in a modified strain of hypercholesterolemic Watanabe rabbits with use of a probucol analogue (MDL29, 311) that does not lower serum cholesterol.
Arterioscler Thromb Vasc Biol 1991; 11(5): 1266-1275         < Abstract or Full paper >

185) Demacker PNM, Staels B, Stalenhoef AFH, Auwerx J
Increased removal of b-very low density lipoproteins after ethinyl estradiol is associated with increased mRNA levels for hepatic lipase, lipoprotein lipase, and the low density lipoprotein receptor in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1991; 11(6): 1652-1659         < Abstract or Full paper >

186) Chinellato A, Banchineri N, Pandoifo L, Ragazzi E, Froldi G, Norido F, Caparrotta L, Fassina G
Aortic response to relaxing agents in Watanabe heritable hyperlipidemic (WHHL) rabbits of different age.
Atherosclerosis 1991; 89(2-3): 223-230         < Abstract or Full paper >

187) Oguchi A, Ikeda U, Miyashita H, Ohara T, Tsuruya Y, Natsume T, Yaginuma T, Shimada K
Vascular smooth muscle cells from genetically hyperlipidemic rabbit (WHHL rabbit) exhibit decreased growth response.
Atherosclerosis 1991; 90(2-3): 101-108         < Abstract or Full paper >

188) Zhang B, Saku K, Hirata K, Liu R, Tateishi K, Yamamoto K, Arakawa K
Insulin resistance observed in WHHL rabbits.
Atherosclerosis 1991; 91(3): 277-278         < Abstract or Full paper >

189) Bowler A, Redgrave TG, Mamo JCL
Chylomicron-remnant clearance in homozygote and heterozygote Watanabe-heritable-hyperlipidemic rabbit is defective.
Biochem J 1991; 276(Pt 2): 381-386         < Abstract or Full paper >

190) Mol MJT, Stalenhoef FH, Demacker PNM, Laar AV
Alteration in the metabolism of very-low-and low-density lipoproteins after partial ileal-bypass surgery in the Watanabe heritable hyperlipidemic rabbit.
Biochem J 1991; 278(Pt 3): 651-657         < Abstract or Full paper >

191) Mamo JCL, Boelwe A, Elsegood CL, Redgrave TG
Defective plasma clearance of chylomicron-like lipid emulsions in Watanabe heritable hyperlipidemic rabbits.
Biochim Biophys Acta. 1991; 1081(3): 241-245         < Abstract or Full paper >

192) Mokuno H, Yamada N, Shimano H, Ishibashi S, Mori N, Takahashi K, Oka T, Yoon TH, Takaku F
The enhanced cellular uptake of very-low-density lipoprotein enriched in apolipoprotein E.
Biochim Biophys Acta 1991; 1082(1): 63-70         < Abstract or Full paper >

193) Carlson TL, Kottke A
Effect of coconut oil on plasma apoA-1 levels in WHHL and NZW rabbits.
Biochim Biophys Acta 1991; 1083(3): 221-229         < Abstract or Full paper >

194) Stoudemire JB, Garnick MB
Effects of recombinant human macrophage colony- stimulating factor on plasma cholesterol levels.
Blood 1991; 77: 750-755         < Abstract or Full paper >

195) Daugherty A, Zweifel BS, Schonfeld G
The effects of probucol on the progression of atherosclerosis in mature Watanabe heritable hyperlipidemic rabbits.
Br J Pharmacol 1991; 103(1): 1013-1018         < Abstract or Full paper >

196) Stewart-Lee AL, Aberdeen J, Burnstock G
Sympathetic neurotransmission in the Watanabe heritable hyperlipidemic rabbit mesentery artery.
Cardiovasc Res 1991; 25(12): 1035-1041         < Abstract or Full paper >

197) Demer LL
Effect of calcification on in vivo mechanical response of rabbit arteries to balloon dilation.
Circulation 1991; 83(6): 2083-2093         < Abstract or Full paper >

198) Tagawa H, Tomoike H, Nakamura M
Putative mechanisms of the impairment of endothelium-dependent relaxation of the aorta with atheromatous plaque in heritable hyperlipidemic rabbits.
Circ Res 1991; 68(2): 330-337         < Abstract or Full paper >

199) Fukuo Y, Nagashima M, Saitoh A, Kobayashi Y, Terashi A, Nakama K, Kameyama K, Asano G
Effects of simvastatin on serum lipids and atherosclerosis in WHHL rabbits.
Clin Ther 1991; 13(3): 417-424         < Abstract or Full paper >

200) Daugherty A, Rateri DL
Heterogeneity of very low density lipoproteins: Factors influencing the ability of specific subfractions to modulate cholesterol metabolism in macrophages in vitro.
Coron Artery Dis 1991; 2(7): 775-787         < Abstract or Full paper >

201) Finckh B, Niendorf A, Rath M, Beisiegel U
Antiatherosclerotic effect of probucol in WHHL rabbits: are there plasma parameters to evaluate this effect ?
Eur J Clin Pharmacol 1991; 40(Suppl-1): S77-S80         < Abstract or Full paper >

202) Hara A, Taketomi T
Characterization and changes of glycosphingolipids in the aorta of the Watanabe heritable hyperlipidemic rabbit.
J Biochem 1991; 109(6): 904-908         < Abstract or Full paper >

203) Daugherty A, Rateri DL
Failure of the intracellular itinerary of b-very low density lipoproteins to augment cholesterol esterification in macrophages from Watanabe heritable hyperlipidemic rabbits.
J Biol Chem 1991; 266(26): 17269-17275         < Abstract or Full paper >

204) Donnelly TM, Kelsey SF, Levine DM, Parker TS
Control of variance in experimental studies of hyperlipidemia using the WHHL rabbit.
J Lipid Res 1991; 32(7): 1089-1098         < Abstract or Full paper >

205) Mao STJ, Yates MT, Rechtin AE, Jackson RL, Sickle WAV
Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits.
J Med Chem 1991; 34(1): 298-302         < Abstract or Full paper >

206) Moerlein SM, Daugherty A, Sobel BE, Welch MJ
Metabolic imaging with gallium-68- and indium-111- labeled low-density lipoprotein.
J Nucl Med 1991; 32(2): 300-307         < Abstract or Full paper >

207) Kim SS, Kutsumi Y, Nakai T, Miyabo S
In vitro characterization of two types of LDL apheresis module and effect of repetitive LDL apheresis on plasma cholesterol levels and aortic atherosclerosis in heterozygous WHHL rabbits.
Jpn Circ J 1991; 55(1): 68-80         < Abstract or Full paper >

208) Khachadurian AK, Shimamura T, Rozovski SJ, Ananthakrisnan R, Armenian B, Coly E, Alhinai A, Martucci C, Schneider SH, Amorosa JF
Pravastatin decreases serum lipids and vascular cholesterol deposition in Watanabe heritable hyperlipidemic (WHHL) rabbits.
Jpn Heart J 1991; 32(5): 675-685         < Abstract or Full paper >

209) Carlson TL, Kottke BA
ApoA-1 secretion by rabbit intestinal mucosa cell cultures.
Lipids 1991; 26(9): 684-688         < Abstract or Full paper >

210) Tanganelli P, Bianciardi G, Barbagli L, Centi L, Resi L, Salvi M, Weber G
Some aspects of the evolution with age of arterial lesions in Watanabe heritable hyperlipidemic rabbits: Morphological and morphometrical observations of aortic thoracic lesions.
Nutr Metab Cardiovasc Dis 1991; 1: 31-36

211) Cybulsky MI, Gimbrone MA
Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis.
Science 1991; 251: 788-791         < Abstract or Full paper >

212) Chowdhury JR, Grossman M, Gupta S, Chowdhury NR, Baker JR, Wilson JM
Long-term improvement of hypercholesterolemia after ex vivo gene therapy LDLR-deficient rabbits.
Science 1991; 254: 1802-1805         < Abstract or Full paper >

213) Dichek D, Bratthauer GL, Beg ZH, Anderson KD, Newman KD, Zwiebel JA, Hoeg JM, Anderson WF
Retroviral vector-mediated in vivo expression of low-density-lipoprotein receptors in the Watanabe heritable hyperlipidemic rabbit.
Somat Cell Mol Genet 1991; 17(3): 287-301         < Abstract or Full paper >

214) Bianciardi G, Tanganelli P, Palummo N, Zatta A, Prosdocimi M, Weber G
Platelet function abnormalities in 6-12 month-old Watanabe heritable hyperlipidemic (WHHL) rabbits.
Thromb Res 1991; 64(1): 109-115         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1992)

215) Takano T
Accumulation of cholesteryl ester in atherosclerotic lesions.
Acta Pathol Jpn 1992; 42: 625-631         < Abstract or Full paper >

216) Rosenfeld ME, Yla-Herttuala S, Lipton BA, Ord VA, Witztum JL, Steinberg D
Macrophage colony-stimulating factor mRNA and protein in atherosclerotic lesions of rabbits and humans.
Am J Pathol 1992; 140(2): 291-300         < Abstract or Full paper >

217) Atkinson JB, Swift LL, Virmani R
Watanabe heritable hyperlipidemic rabbits. Familial hypercholesterolemia.
Am J Pathol 1992; 140(3): 749-753         < Abstract or Full paper >

218) Hirata K, Akita H, Yokoyama M, Watanabe Y
Impaired vasodilatory response to arterial natriuretic peptide during atherosclerosis progression.
Arterioscler Thromb Vasc Biol 1992; 12(1): 99-105         < Abstract or Full paper >

219) Rand ML ,Gross PL, Barrow DV, Packhan MA
Acute in vitro effects of ethanol on responses of platelets from cholesterol-fed and Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1992; 12(4): 437-445         < Abstract or Full paper >

220) Rosenfeld ME, Carew TE, Hodenberg EV, Pittman RC, Ross R, Steinberg D
Autoradiographic analysis of the distribution of 125I-tyramine-cellobiose-LDL in atherosclerotic lesions of the WHHL rabbit.
Arterioscler Thromb Vasc Biol 1992; 12(8): 985-995         < Abstract or Full paper >

221) Chinellato A, Ragazzi E, Pandolfo L, Froldi G, Bevilacqua C, Prosdocimi M, Caparrota L, Fassina G
Protective role of heparin on in vitro functional aortic response in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1992; 92(1): 17-24         < Abstract or Full paper >

222) Nagano Y, Nakamura T, Matsuzawa Y, Cho M, Ueda Y, Kita T
Probucol and atherosclerosis in the Watanabe heritable hyperlipidemic rabbit: Long-term antiatherogenic effect and effects on established plaques.
Atherosclerosis 1992; 92(2-3): 131-140         < Abstract or Full paper >

223) Ikeda U, Ikeda M, Seino Y, Takahashi M, Kano S, Shimada K
Interleukin 6 gene transcripts are expressed in atherosclerotic lesions of genetically hyperlipidemic rabbits.
Atherosclerosis 1992; 92(2-3): 213-218         < Abstract or Full paper >

224) Roux SP, Kuhn H, Lengsfeld H, Morand OH
Effects of chronic aortic coarctation on atherosclerosis and arterial lipid accumulation in the Watanabe heritable hyperlipidemic (WHHL) rabbit.
Atherosclerosis 1992; 93(1-2); 123-132         < Abstract or Full paper >

225) Cirillo R, Aliev G, Italiano G, Prosdocimi M
Functional responses of hindlimb circulation in aged normal and WHHL rabbits.
Atherosclerosis 1992; 93(1-2): 133-144         < Abstract or Full paper >

226) Tsunemitsu M, Ishikawa Y, Taniguchi T, Fukuzaki H, Yokoyama M
Association of N-glycosylation of apolipoprotein B-100 with plasma cholesterol levels in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1992; 1992: 93(3): 229-235         < Abstract or Full paper >

227) Inoue I, Inaba T, Motoyoshi K, Harada K, Shimano H, Kawamura M, Gotoda T, Oka T, Shiomi M, Watanabe Y, Tsukada T, Yazaki Y, Takaku F, Yamada N
Macrophage colony stimulating factor prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic abbits.
Atherosclerosis 1992; 93(3); 245-254         < Abstract or Full paper >

228) Williams RJ, Motteram JM, Sharp CH, Gallagher PJ
Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits.
Atherosclerosis 1992; 94(2-3): 153-159         < Abstract or Full paper >

229) Shiomi M, Ito T, Shiraishi M, Watanabe Y
Inheritability of atherosclerosis and the role of lipoproteins as risk factors in the development of atherosclerosis in WHHL rabbits: Risk factors related to coronary atherosclerosis are different from those related to aortic atherosclerosis.
Atherosclerosis 1992; 96(1): 43-52         < Abstract or Full paper >

230) Demacker PN, van Heijst PJ, Stalenhoef AF
A study of the chylomicron metabolism in WHHL rabbits after fat loading. Discrepancy between results based on measurement of apoprotein B-48 or retinyl palmitate.
Biochem J 1992; 285(2): 641-646         < Abstract or Full paper >

231) Cohn W, Goss-Sampson MA, Grun H, Muller DPR
Plasma clearance and net uptake of a-tocopherol and low density lipoprotein by tissues in WHHL and control rabbits.
Biochem J 1992; 287(1): 247-254         < Abstract or Full paper >

232) Mezdour H, Nomura S, Yamamura T, Yamamoto A
Concentration and distribution of apolipoproteins A-1 and E in normolipidemic, WHHL and diet-induced hyperlipidemic rabbit sera.
Biochim Biophys Acta 1992; 1127(2): 116-123         < Abstract or Full paper >

233) Okutomi T, Nishizawa T, Inagawa H, Takano T, Morikawa A, Soma G, Mizuno D
Homeostasis as regulated by activated macrophage. VII. Suppression of serum cholesterol level by LPSw (a lipopolysaccharide from wheat flour) in WHHL (Watanabe heritable hyperlipidemic) rabbit.
Chem Pharm Bull 1992; 40(5): 1268-1270         < Abstract or Full paper >

234) Ambrosioni E, Bacchelli S, Esposti D, Borghi C
ACE-inhibitors and atherosclerosis.
Eur J Epidemiol 1992; 8(Suppl 1): 129-133         < Abstract or Full paper >

235) Stewart- Lee AL, Aberdeen J, Burnstock G
The effect of atherosclerosis on neuromodulation of sympathetic neurotransmission by neuropeptide Y and calcitonin gene-related peptide in the rabbit mesenteric artery.
Eur J Pharmacol 1992; 216(2): 167-174         < Abstract or Full paper >

236) Ebbe S, Dalal K, Forte T, Tablin F
Microcytic thrombocytosis, small megakaryocytes, platelet lipids and hyperreactivity to collagen, lymphocytopenia, eosinophilia, and low blood volume in genetically hyperlipidemic rabbits.
Exp Hematol 1992; 20(4): 486-493         < Abstract or Full paper >

237) Nickerson CJ, Haudenschild CC, Chobanian AV
Effects of hypertension and hyperlipidemia on the myocardium and coronary vasculature of the WHHL rabbit.
Exp Mol Pathol 1992; 56(3): 173-185         < Abstract or Full paper >

238) Chobanian AV, Haudenschild CC, Nickerson C, Hope S
Trandolapril inhibits atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.
Hypertension 1992; 20(4): 473-477         < Abstract or Full paper >

239) Kuroda M, Matsumoto A, Itakura H, Watanabe Y, Ito T, Shiomi M, Fukushige J, Nara F, Fukami M, Tsujita Y
Effects of pravastatin sodium alone and in combination with cholestyramine on hepatic, intestinal and adrenal low density lipoprotein receptors in homozygous Watanabe heritable hyperlipidemic rabbits.
Japan J Phamacol 1992; 59: 65-70         < Abstract or Full paper >

240) Lawrence JB, Prevosti LG, Kramer WS, Smith PD, Bonner RF, Lu DV, Leon MB
Pulsed laser and thermal ablation of atherosclerotic plaque: morphometrically defined surface thrombogenecity in studies using an annular perfusion chamber.
J Am Coll Cardiol. 1992; 19(5): 1091-1100         < Abstract or Full paper >

241) Wilson J, Grossman M, Wu CH, Chowdhury NR, Wu GY Chowdhury JRC
Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits.
J Biol Chem 1992; 267(2): 963-967         < Abstract or Full paper >

242) Brizzolara AL, Tomlinson A, Aberdeen J, Gourdie RG, Burnstock G
Sex and age as factors influencing the vascular reactivity in Watanabe heritable hyperlipidemic (WHHL) rabbits: a pharmacological and morphological study of the hepatic artery.
J Cardiovasc Pharmacol 1992; 19(1): 86-95         < Abstract or Full paper >

243) Nomura H, Maichesky PS, Goldcamp JB, Yamashita M, Werynski A, Nose Y
Selective removal of cholesterol by plasmapheresis and the progression of atherosclerosis.
J Clin Apheresis 1992; 7(4): 194-200         < Abstract or Full paper >

244) Amorosa LF, Rozovski SJ, Ananthakrishnan A, Coly E, Alhinai A, Martucci C, Scheider SH, Shimamura T, Khachadurian AK
Effects of pravastatin on cholesterol metabolism in Watanabe heritable hyperlipidemic rabbits.
Jpn Heart J 1992; 33(4): 451-463         < Abstract or Full paper >

245) Yamada N, Inoue I, Kawamura M, Harada K, Watanabe Y, Shimano H, Gotoda T, Shimada M, Kohzaki K, Tsukada T, Shiomi M, Yatanabe Y, Yazaki Y
Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
J Clin Invest. 1992; 89: 706-711         < Abstract or Full paper >

246) Delessandri KM, Wedemeyer W, Tsukamoto H
Watanabe hyperlipidemic rabbit as a model of aortic degeneration of the medial lamella elastin unit.
J Invest Surg 1992; 5(1): 19-23         < Abstract or Full paper >

247) Irie T, Fukunaga K, Garwood MK, Carpenter TO, Pitha J, Pitha J
Hydroxypropylcyclodextrins in parental use. II: Effects on transport and disposition of lipids in rabbit and humans.
J Pharm Sci 1992; 81(6): 524-528         < Abstract or Full paper >

248) Katsuda S, Hosomi H, Shiomi M, Watanabe Y
Effects of atherosclerosis on mean and daily variation of arterial pressure in conscious WHHL rabbits.
J Vet Med Sci 1992; 54: 669-673         < Abstract or Full paper >

249) Katsuda S, Hosomi H, Shiomi M, Watanabe Y
Impaired baroreflex control of arterial pressure in WHHL rabbits.
J Vet Med Sci 1992; 54: 983-987         < Abstract or Full paper >

250) Mizuno D, Soma G
Oral or percutaneous administration of lipopolysaccharide of small molecular size may cure various intractable diseases: A new version of coley's toxin.
Mol Biother 1992; 4(4): 166-169         < Abstract or Full paper >

251) Libby P, Clinton SK
Cytokines as mediators of vascular pathology.
Nouv Rev Fr Hematol 1992; 34: 47-53         < Abstract or Full paper >

252) Chinellato A, Ragazzi E, Laureto PPD, Fassina G
Reduced L-arginine/lysine and L-arginine /aspartic acid rations in aorta from Watanabe heritable hyperlipidemic (WHHL) rabbit.
Pharmacol Res 1992; 25(3): 255-258         < Abstract or Full paper >

253) Ragazzi E, Chinellato A
Purinergic receptors, prostacyclin and atherosclerosis.
Pharmacol Res 1992; 26(2): 123-129         < Abstract or Full paper >

254) Yamada N, Ishibashi S, Shimano H, Inaba T, Gotoda T, Harada K, Shimada M, Shiomi M, Watanabe Y, Kawakami M, Yazaki Y, Takaku F
Role of monocyte colony-stimulating factor in form cell generation.
Proc Soc Exp Biol Med 1992; 200: 240-244         < Abstract or Full paper >

255) Tejera ML, Cienfuegos JA, Maganto P, Pardo F, Santamaria LL, Codesal J, Andres SD, Hernandez JL, Castillo-olivares JL
Reduction of cholesterol levels following liver cell grafting in hyperlipidemic (WHHL) rabbits.
Transplant Proc 1992; 24(1): 160-161

Bibliography of WHHL rabbits


(1993)

256) Caparrota l, Pandolfo L, Chinellato A, Ragazzi E, Froldi G, Aliev G, Fassina G
L-arginine does not improved endothelium-dependent relaxation in in vitro Watanabe rabbits thoracic aorta.
Amino Acids 1993; 5(3): 403-411         < Abstract or Full paper >

257) Giuriato L, Scatena M, Chiavegato A, Zanellato AMC, Guidolin D, Pauletto P, Sartore S
Localization and smooth muscle cell composition of atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1993; 13(3): 347-359         < Abstract or Full paper >

258) Aliev G, Mironov A, Cirillo R, Mironov A, Gorelova E, Prosdocimi M
Evidence for the presence of early vascular lesions in newborn Watanabe heritable hyperlipidemic (WHHL) rabbits.
Atherosclerosis 1993; 101(1): 17-24         < Abstract or Full paper >

259) Demacker PNM, Hijmans AGM, Kleinveld HA, Stalenhoef AFH
Indications for the presence of circulating peroxidized low density lipoproteins in WHHL rabbits treated with antioxidants.
Atherosclerosis 1993; 102(1): 69-77         < Abstract or Full paper >

260) Liu R, Saku K, Zhang B, Hirata K, Shiomi M, Arakawa K
In vivo kinetics of oxidatively modified HDL.
Biochem Med Metab Biol 1993; 49(3): 392-397         < Abstract or Full paper >

261) Bell FP
Effect of the lipid-lowering drug lifibrol on lipid metabolism in rat macrophages and in atherosclerotic arteries from swine and WHHL rabbits, in vitro: Implications in atherogenesis.
Biochem Pharmacol 1993; 46(8): 1475-1480         < Abstract or Full paper >

262) Raper SE, Wilson JM
Cell transplantation in liver-directed gene therapy.
Cell Transplant 1993; 2(5): 381-400         < Abstract or Full paper >

263) Liu R, Saku K, Kostner GM, Hirata K, Zhang B, Shiomi M, Arakawa K
In vivo kinetics of lipoprotein(a) in homozygous Watanabe heritable hyperlipidemic rabbits.
Eur J Clin Invest 1993; 23(9): 561-565         < Abstract or Full paper >

264) Hara A, Taketomi T
Sulphatide as a major glycosphingolipid in WHHL rabbit serum lipoproteins and its anticoagulant activity.
Indian J Biochem Biohys 1993; 30(6): 353-357         < Abstract or Full paper >

265) Wanibuchi H, Dingemans KP, Becker AE, Ueda M, Naruko T, Tanizawa S, Nakamura K
Is the Watanabe heritable hyperlipidemic rabbit a suitable experimental model for percutaneous transluminal coronary angioplasty in humans ?
J Am Coll Cardiol 1993; 21(6): 1490-1496         < Abstract or Full paper >

266) Hardoff R, Braegelmann F, Zanzonico P, Herrold EM, Lees RS, Lees AM, Dean RT, James JL, Borer JS
External imaging of atherosclerosis in rabbits using an 123I-labeled synthetic peptide fragment.
J Clin Pharmacol 1993; 33(11): 1039-1047         < Abstract or Full paper >

267) Esper E, Chan EK, Buchwald H
Natural history of atherosclerosis and hyperlipidemia in heterozygous WHHL (WHHL-Hh) rabbits: I. The effects of aging and gender on plasma lipids and lipoproteins.
J Lab Clin Med 1993; 121: 97-102         < Abstract or Full paper >

268) Esper E, Runge WJ, Gunther R, Buchwald H
Natural history of atherosclerosis and hyperlipidemia in heterozygous WHHL (WHHL-Hh) rabbits: II. Morphologic evaluation of spontaneously occurring aortic and coronary lesions.
J Lab Clin Med 1993; 121(1): 103-110         < Abstract or Full paper >

269) Demacker PNM, Dormans TPJ, Koenders EB, Corstens FHM
Evaluation of indium-111-polyclonal immunoglobulin G to quantitate atherosclerosis in Watanabe heritable hyperlipidemic rabbits with scintigraphy: Effect of age and treatment with antioxidants or ethinylestradiol.
J Nucl Med 1993; 34(8): 1316-1321         < Abstract or Full paper >

270) Ragazzi E, Chinellato A, Pandoolfo L, Froldi G, Caparrotta L, Prosdocimi M, Aliev G, Fassina G
Atherosclerosis-related remodeling of aortic relaxation to purines in the Watanabe heritable hyperlipidemic rabbit.
J Pharmacol Exp Ther 1993; 266(2): 1091-1096         < Abstract or Full paper >

271) Norido F, Zatta A, Fiorito C, Prosdocimi M, Weber G
Hematologic and biochemical profiles of selectively bred WHHL rabbits.
Lab Anim Sci 1993; 43: 319-323         < Abstract or Full paper >

272) Chinellato A, Ragazzi E, Pandolfo L, Froldi G, Preosdocimi M, Caparrotta L, Fassina G
Unimpaired adenosine 5'-triphosphate-induced relaxation in in vitro Watanabe heritable hyperlipidemic rabbit aorta.
Nutr Metab Cardiovasc Dis 1993; 3: 5-9

273) Corr L, Buratock G, Pool-Wilson P
Effects of age and hyperlipidemia on rabbit coronary responses to neuropeptide Y and the interaction with norepinephrine.
Peptides 1993; 14(2): 359-364         < Abstract or Full paper >

274) Amin D, Gustafson SK, Weinacht JM, Cornell SA, Neuenschwander K, Kosmider B, Scotese AC, Regan JR, Perrone MH
RG 12561 (dalvastatin): A novel synthetic inhibitor of HGM-CoA reductase and cholesterol-lowering agent.
Pharmacology 1993; 46(1): 13-22         < Abstract or Full paper >

275) Labeque R, Mullon CJP, Ferreira JPM, Lees RS, Langer R
Enzymatic modification of plasma low density lipoproteins in rabbits: a potential treatment for hypercholesterolemia.
Proc Natl Acad Sci USA 1993; 90(8): 3476-3480         < Abstract or Full paper >

276) Kroon AA, Stalenhoef AFH, Buikema H, Demacker PNM, de Wilde PCM, Leijten PA, van Gilst WH
The effect of cholesterol reduction on the endothelial function and progression of atherosclerosis in WHHL rabbits.
Atherosclerosis 1993; 103(2): 221-230         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1994)

277) Ishibashi T, Yokoyama K, Shindo J, Hamazaki Y, Endo Y, Sato T, Takahashi S, Kawarabayasi Y, Shiomi M, Yamamoto T, Maruyama Y
Human granulocyte-macrophage colony-stimulating factor lowers the levels of plasma cholesterol with an increase in mRNA for very low density lipoprotein receptor in rabbits.
Ann N Y Acad Sci 1994; 748: 630-633         < Abstract or Full paper >

278) Watanabe Y, Inaba T, Gotoda T, Harada K, Shimada M, Ohsuga J, Kawamura M, Yazaki Y, Yamada N
Role of macrophage colony-stimulating factor in the initial process of atherosclerosis.
Ann N Y Acad Sci 1994; 748: 357-364         < Abstract or Full paper >

279) Hansen BF, Mortensen A, Hansen JF, Ibsen P, Frandsen H, Nordestgaard BG
Atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
APMIS 1994; 102(1-6): 177-190         < Abstract or Full paper >

280) Yla-Herttuala S, Palinski W, Butler SW, Picard S, Steinberg D, Witztum JL
Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL.
Arterioscler Thromb Vasc Biol 1994; 14(1): 32-40         < Abstract or Full paper >

281) Schaub RG, Bree MP, Hayes LL, Rudd MA, Rabbani L, Loscalzo J, Clinton SK
Recombinant human macrophage colony-stimulating factor reduces plasma cholesterol and carrageenan granuloma foam cell formation in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1994; 14(1): 70-76         < Abstract or Full paper >

282) Fisher WR, Zeeh LA, Stacpoole PW
ApoB metabolism in familial hypercholesterolemia: inconsistencies with the LDL receptor paradigm.
Arterioscler Thromb Vasc Biol 1994; 14(4): 501-510         < Abstract or Full paper >

283) Shiomi M, Ito T, Tsukada T, Yata T Ueda M
Cell compositions of coronary and aortic atherosclerotic lesions in WHHL rabbits differ: an immunohistochemical study.
Arterioscler Thromb Vasc Biol 1994; 14(6): 931-937         < Abstract or Full paper >

284) Kleinveld HA, Demacker PNM, Stalenhoef AFH
Comparative study on the effect of low-dose vitamin E and probucol on the susceptibility of LDL to oxidation and the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1994; 14(8): 1386-1391         < Abstract or Full paper >

285) Ishibashi T, Yokoyama K, Shindo J, Hamazaki Y, Endo Y, Sato T, Takahashi S, Kawabayashi Y, Shiomi M, Yamamoto T, Maruyama Y
Potent cholesterol-lowering effect by human granulocyte-macrophage colony-stimulating factor in rabbits: possible implications of enhancement of macrophage function and an increase in mRNA for VLDL receptor.
Arterioscler Thromb Vasc Biol 1994; 14: 1534-1541         < Abstract or Full paper >

286) Daugherty A, Rateri DL
Presence of LDL receptor-related protein/a2-Macroglobulin receptors in macrophages of atherosclerotic lesions form cholesterol-fed New Zealand and heterozygous Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1994; 14(12): 2017-2024         < Abstract or Full paper >

287) Shiomi M, Shiraishi M, Yata T, Ito T
Effect of fluvastatin sodium on secretion of very low density lipoprotein and serum cholesterol levels: In vivo study using low density lipoprotein receptor deficient Watanabe heritable hyperlipidemic rabbits.
Arzneim Forsch/Drug Res 1994; 44: 1154-1156         < Abstract or Full paper >

288) Tsubamoto Y, Tamada N, Watanabe Y, Inaba T, Shiomi M, Shimano H, Gotoda T, Harada K, Shimada M, Ohsuga J, Kawamura M, Yazaki Y
Dextran sulfate, a competitive inhibitor for scavenger receptor, prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1994; 106: 43-50         < Abstract or Full paper >

289) Fujioka Y, Taniguchi T, Ishikawa Y, Shiomi M, Yokoyama M
Relation of N-glycosylation of apolipoprotein B-100 to cellular metabolism of low density lipoprotein.
Atherosclerosis 1994; 108(1): 91-102         < Abstract or Full paper >

290) Ikeda U, Oguchi A, Okada K, Ishikawa S, Saito T, Ikeda M, Kano S, Takahashi M, Shiomi M, Shimada K
Involvement of LDL receptor in the proliferation of vascular smooth muscle cells.
Atherosclerosis 1994; 110(1): 87-94         < Abstract or Full paper >

291) Kinter M, Robinson CS, Grimminger LC, Gillies PJ, Shimshick EJ, Ayers C
Whole blood and plasma concentrations of 4-hydroxy-2-nonenal in Watanabe heritable hyperlipidemic versus New Zealand white rabbits.
Biochem Biophys Res Commun 1994; 199(2): 671-675         < Abstract or Full paper >

292) Inoue S, Orimo A, Hosoi T, Ikegami A, Kozaki K, Ouchi Y, Nomura S, Muramatsu M, Orimo H
Demonstration of activin-A in arteriosclerotic lesions.
Biochem Biophys Res Commun 1994; 205(1): 441-448         < Abstract or Full paper >

293) Sohma Y, Suzuki T, Sasano H, Nahura H, Nose M, Yamamoto T
Increased mRNA for CD63 antigen in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
Cell Struct Funct 1994; 19(4): 219-225         < Abstract or Full paper >

294) Miwa Y, Hirata K, Matsuda Y, Suematsu M, Kawashima S, Yokoyama M
Augmented receptor-mediated Ca2+ mobilization causes supersensitivity of contractile response to serotonin in atherosclerotic arteries.
Circ Res 1994; 75(6): 1096-1102         < Abstract or Full paper >

295) Mamo JCL, Bowler A, Redgrave TG, Elsegood CL
Clearance of chylomicron-like lipid emulsions is increased in normal rabbits but not in heterozygous Watanabe heritable hyperlipidemic rabbits following treatment with cholestyramine or pravastatin.
Clin Exp Pharmacol Physiol 1994; 21(9): 687-694         < Abstract or Full paper >

296) Ito T, Tsukada T, Ueda M, Wanibuchi H, Shiomi M
Immunohistochemical and quantitative analysis of cellular and extra-cellular components of aortic atherosclerosis in WHHL rabbits.
J Atheroscler Thromb 1994; 1: 45-52         < Abstract or Full paper >

297) Sato R, Mori M, Imanaka T, Takano T
Accumulation of vitronectin in atherosclerotic lesions where lipids deposited.
J Atheroscler Thromb 1994; 1(Suppl-1): S50-S54         < Abstract or Full paper >

298) Sohma Y, Suzuki T, Sasano H, Nagura H, Nose M, Yamamoto T
Expression of mRNA for matrix g-carboxyglutamic acid protein during progression of atherosclerosis in aortas of Watanabe heritable hyperlipidemic rabbits.
J Biochem 1994; 116(4): 747-751         < Abstract or Full paper >

299) Kozarsky KF, Mckinley DR, Austin LL, Raper SE, Perricaudet LDS, Wilson JM
In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses.
J Biol Chem 1994; 269(18): 13695-13702         < Abstract or Full paper >

300) Robins ED, Nelson LM, Hoeg JM
Aberrant hypothalamic-pituitary-ovarian axis in the Watanabe heritable hyperlipidemic rabbit.
J Lipid Res 1994; 35(1): 52-59         < Abstract or Full paper >

301) Chao F, Blanchette-Mackie EJ, Dickens BF, Gamble W, Kruth HS
Development of unesterified cholesterol-rich lipid particles in atherosclerotic lesions of WHHL and cholesterol-fed NZW rabbits.
J Lipid Res 1994; 35(1): 71-83         < Abstract or Full paper >

302) Breugnot C, Privat S, Guillonneau C, Regnier G, Bouzom F, Vilaine J, Lenaers A
S12340: A potent inhibitor of the oxidative modification of low-density lipoprotein in vitro and ex vivo in WHHL rabbits.
J Pharmacol Exp Ther 1994; 269(2): 515-520         < Abstract or Full paper >

303) Brizzolara AL, Stewart- Lee A, Burnstock G
Responses of rabbit basilar arteries to vasoconstrictor and vasodilator agents: the effects of atherosclerosis, age and sex.
J Vasc Res 1994; 31(2): 106-113         < Abstract or Full paper >

304) Calderon TM, Factor SM, Hatcher VB, Berliner JA, Berman JW
An endothelial cell adhesion protein for monocytes recognized by monoclonal antibody IF9.
Lab Invest 1994; 70(6): 836-849         < Abstract or Full paper >

305) Zhang B, Saku K, Hirata K, Liu R, Takeishi K, Shiomi M, Arakawa K
Quantitative characterization of insulin-glucose response in Watanabe heritable hyperlipidemic and cholesterol-fed rabbits and the effect of cilazapril.
Metabolism 1994; 43(3): 360-366         < Abstract or Full paper >

306) Shiomi M, Ito T
Pravastatin sodium, a competitive inhibitor of hepatic 3-hydoroxy-3-methylglutaryl coenzyme A reductase, decreases the cholesterol content of newly secreted very-low-density lipoprotein in Watanabe heritable hyperlipidemic rabbits.
Metabolism 1994; 43: 559-564         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1995)

307) Villeneuve N, Janiak P, Brunel-Jacquemin C, Canovi C, Pillon A, Breugnot C, Vilaine DGJP
La deoxycorticosterone a dose non hypertensive accelere la progression de I'atherosclerose chez le lapin WHHL.
Arch Mal Coeur Vaiss 1995; 88(8): 1197-201         < Abstract or Full paper >

308) Kleinveld HA, Hak-Lemmers HLM, Hectors MPC, Fouw NJ, Demacker PNM, Stalenhoef AFH
Vitamin E and fatty acid intervention does not attenuate the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1995; 15(2): 290-297         < Abstract or Full paper >

309) Dowell FJ, Hamilton CA, Lindop GBM, Reid JL
Development and progression of atherosclerosis in aorta form heterozygous and homozygous WHHL rabbits: effects of simvastatin treatment.
Arterioscler Thromb Vasc Biol 1995; 15(8): 1152-1160         < Abstract or Full paper >

310) Taguchi H, Faraci FM, Kitazono T, Heistad DD
Relaxation of the carotid artery to hypoxia is impaired in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1995; 15(10): 1641-1645         < Abstract or Full paper >

311) Shiomi M, Ito T, Tsukada T, Yata T, Watanabe Y, Tsujita Y, Fukami M, Fukushige J, Hosohawa T, Tamura A
Reduction of serum cholesterol levels alters lesional composition of atherosclerotic plaques: Effect of pravastatin sodium on atherosclerosis in mature WHHL rabbits.
Arterioscler Thromb Vasc Biol 1995; 15(11): 1938-1944         < Abstract or Full paper >

312) Mezdour H, Tamamura T, Nomura S, Yamamoto A
Genetic but not diet-induced hypercholesterolemia causes low apolipoprotein A-IV level in rabbit sera.
Atherosclerosis 1995; 113(2): 171-178         < Abstract or Full paper >

313) Tanaka M, Otani H, Yokode M, Kita T
Regulation of apolipoprotein B secretion in hepatocytes from Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.
Atherosclerosis 1995; 114(1): 73-82         < Abstract or Full paper >

314) Giuriato L, Chiavegato A, Pauletto P, Sartore S
Correlation between the presence of an immature smooth muscle cell population in tunica media and the development of atherosclerotic lesion. A study on different-sized rabbit arteries from cholesterol-fed and Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1995; 116(1): 77-92         < Abstract or Full paper >

315) Kurokawa J, Hayashi K, Toyota Y, Shingu T, Shiomi M, Kajiyama G
High dose of fluvastatin sodium (Xu62-320), a new inhibitor of 3-hydroxy-3-merhylglutaryl coenzyme A reductase, lowers plasma cholesterol levels in homozygous Watanabe-heritable hyperlipidemic rabbits.
Biochim Biophys Acta 1995; 1259(1): 99-104         < Abstract or Full paper >

316) Matsuo M, Ito F, Kondo A, Akita M, Tomoi M, Shimomura K
Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits: Evidence for a direct effect on the arterial wall.
Biochim Biophys Acta 1995; 1259(3): 254-260         < Abstract or Full paper >

317) Hiltunen T, Luoma J, Nikkari T, Yla-Herttuala S
Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions.
Circulation 1995; 92(11): 3297-3303         < Abstract or Full paper >

318) Sobey CG, Brooks RM, Heistad DD
Evidence that expression of inducible nitric oxide synthase in response to endotoxin is augmented in atherosclerotic rabbits.
Circ Res 1995; 77(3): 536-543         < Abstract or Full paper >

319) Lopez-Candales A, Scott MJ, Wickline SA
Cholesterol feeding modulates spatial expression of TGF-b1 and -b2 in aortas of Watanabe rabbits.
Cytokine 1995; 7(6): 554-561         < Abstract or Full paper >

320) Bihain BE, Delplanqe B, Khallou J, Chevreuil O, Troussard AA, Michel L, Mann CJ, Yen FT
Lipolysis-stimulated receptor: a newcomer on the lipoprotein research scene.
Diabetes Metab 1995; 21: 121-126         < Abstract or Full paper >

321) Hata H, Kuga T, Takeshita A
Adherent leukocytes to the aortic wall promotes atherosclerosis in the Watanabe heritable hyperlipidemic rabbits.
Fukuoka Acta Med 1995; 86: 437-442         < Abstract or Full paper >

322) Chobanian AV, Hope S, Brecher P
Dissociation between the antiatherosclerotic effect of trandolapril and suppression of serum and aortic angiotensin-converting enzyme activity in the Watanabe heritable hyperlipidemic rabbit.
Hypertension 1995; 25(6): 1306-1310         < Abstract or Full paper >

323) Simonsen K, Horn T, Mortensen A, Hansen BF, Hansen JF
Liver fibrosis in heterozygous WHHL rabbits fed cholesterol and fats; a new animal model.
Int Hepatol Commun 1995; 3(6): 310-315         < Abstract or Full paper >

324) Hussain MM, Innerarity TL, Brecht WJ, Mahley RW
Chylomicron metabolism in normal, cholesterol-fed, and Watanabe heritable hyperlipidemic rabbits: Saturation of the sequestration step of the remnant clearance pathway.
J Biol Chem 1995; 270(15): 8578-8587         < Abstract or Full paper >

325) Takahashi S, Suzuki J, Kohno M, Oida K, Tamai T, Miyabo S, Yamamoto T, Nakai T
Enhancement of the binding of triglyceride-rich lipoproteins to the very low density lipoprotein receptor by apolipoprotein E and lipoprotein lipase.
J Biol Chem 1995; 270(26): 15747-15754         < Abstract or Full paper >

326) Ragazzi E, Chinellato A, Pandolfo L, Froldi G, Caparrotta L, Aliev G, Prosdocimi M, Fassina G
Endothelial nucleotide-mediated aorta relaxation in aged Watanabe heritable hyperlipidemic rabbits.
J Cadiovasc Pharmacol 1995; 26(1): 119-126         < Abstract or Full paper >

327) Hansen BF, Mortensen A, Hansen JF, Frandsen H
(-)-Anipamil retards atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
J Cardiovasc Pharmacol 1995; 26(3): 485-489         < Abstract or Full paper >

328) Li J, Fang B, Eisensmith RC, Li XHC, Nasonkin I, Lin-Lee Y, Mims MP, Hughes A, Montgomery CD, Roberts JD, Parker TS, Levine DM, Woo SLC
In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene.
J Clin Invest 1995; 95(2): 768-773         < Abstract or Full paper >

329) Xu G, Salen G, Shefer S, Ness GC, Nguyen LB, Parker TS, Chen TS, Zhao Z, Donnelly TM, Tint GS
Unexpected inhibition of cholesterol 7a-hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits.
J Clin Invest 1995; 95(4): 1497-1504         < Abstract or Full paper >

330) Redgrave TG, Martins IJ, Mortimer B
Measurement of expired carbon dioxide to assess the metabolism of remnant lipoproteins.
J Lipid Res 1995; 36(12): 2670-3675         < Abstract or Full paper >

331) Chakrabarti M, Cheg K, Spicer KM, Kirsch WM, Fowler SD, Kelln W, Griende S, Cannarella SN, Willerson R, Spicer SS, Koch T
Biodistribution and radioimmunopharmacokinetics of 131I-AMA monoclonal antibody in atherosclerotic rabbits.
Nucl Med Biol 1995; 22(6): 693-697         < Abstract or Full paper >

332) Chinellato A, Ragazzi E
Receptor-mediated pathways of endothelium activity in experimental atherosclerosis.
Pharmacol Res 1995; 31(3-4): 163-168         < Abstract or Full paper >

333) Sohma Y, Sasano H, Shiga R, Saeki S, Suzuki T, Nagura H, Nose M, Yamamoto T
Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
Proc Natl Acad Sci USA 1995; 92(11): 4937-4941         < Abstract or Full paper >

334) Braesen JH, Beisigel U, Niendorf A
Probucol inhibits not only the progression of atherosclerotic disease, but causes a different composition of atherosclerotic lesions in WHHL-rabbits.
Virchows Arch 1995; 426(2): 179-188         < Abstract or Full paper >

335) Hardoff R, Zanzonico P, Braegelmann F, Herrold EM, Lees RS, Lees AM, Dean RT, Lister-James J, Borer JS.
Localization of (99m)Tc-Labeled apoB synthetic peptide in arterial lesions of an experimental model of spontaneous atherosclerosis.
Am J Ther 1995 2(2): 88-99         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1996)

336) Moazed TC, Kuo CC, Patton DL, Grayston JT, campbell LA
Experimental rabbit models of Chlamydia pneumoniae infection.
Am J Pathol 1996; 148(2): 667-676         < Abstract or Full paper >

337) Kanazawa K, Kawashima S, Mikami S, Miwa Y, Hirata K, Suematsu M, Hayashi Y, Itoh H, Yokoyama M
Endothelial constitutive nitric oxide synthase protein and mRNA increased in rabbit atherosclerotic aorta despite impaired endothelium-dependent vascular relaxation.
Am J Pathol 1996; 148(6): 1949-1956         < Abstract or Full paper >

338) Nakazato K, Ishibashi T, Shindo J, Shiomi M, Maruyama Y
Expression of very low density lipoprotein receptor mRNA in rabbit atherosclerotic lesions.
Am J Pathol 1996; 149(6); 1831-1838         < Abstract or Full paper >

339) O'leary VJ, Tilling L, Fleetwood G, Stone D, Darley-Usmar V
The resistance of low density lipoprotein to oxidation promoted by copper and its use as an index of antioxidant therapy.
Atherosclerosis 1996; 119(2): 169-179         < Abstract or Full paper >

340) Nakamura M, Abe S, Kinukawa N
Casual relationship between occlusive lesions of the coronary artery and myocardial fibrosis in atherosclerotic rabbits: Differences between cholesterol-fed and heritable hyperlipidemic rabbits.
Atherosclerosis 1996; 124(1): 37-47         < Abstract or Full paper >

341) Kogushi M, Tanaka H, Ohtsuka I, Yamada T, Kobayashi H, Saeki T, Takada M, Hiyoshi H, Yanagimachi M, Kimura T, Yoshitake S, Saito I
Anti-atherosclerotic effect of E5324, an inhibitor of acyl-CoA: cholesterol acyltransferase, in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1996; 124(2): 203-210         < Abstract or Full paper >

342) Lei X, Buja LM
Detection and localization of tumor necrosis factor-a in WHHL rabbit arteries.
Atherosclerosis 1996; 125(1): 81-89         < Abstract or Full paper >

343) Sharma HM, Lee JY, Kauffman EM, Hanna AN
In vivo effect of herbal mixture mak-4 on antioxidant capacity of brain microsomes.
Biochem Arch 1996; 12: 181-186

344) Mamo JCL, Elsegood CL, Gennat HC, Yu K
Degradation of chylomicron remnants by macrophages occurs via phagocytosis.
Biochemistry 1996; 35(31): 10210-10214         < Abstract or Full paper >

345) Proctor SD, Mamo JCL
Arterial fatty lesions have increased uptake of chylomicron remnants but not low-density lipoproteins.
Coron Artery Dis 1996; 7: 239-245         < Abstract or Full paper >

346) Xu G, Salen G, Shefer S, Ness GC, Nguyen LB, Tint S, Paker TS, Roberts J, Batta AK, Chen TS, Zhao Z, Kong X
Increasing hepatic cholesterol 7a hydroxylase reduces plasma cholesterol concentrations in normocholesterolemic and hypercholesterolemic rabbits.
Hepatology 1996; 24(4): 882-887         < Abstract or Full paper >

347) Kozarsky KF, Bonen DK, Giannoni F, Funahashi T, Wilson JM, Davidson NO
Hepatic expression of the catalytic subunit of the apolipoprotein B mRNA editing enzyme (apobec-1) ameliorates hypercholesterolemia in LDL receptor-deficient rabbits.
Hum Gene Ther 1996; 7(8): 943-957         < Abstract or Full paper >

348) Shen J, Herderick E, Cornhill JF, Zsigmond E, Kim H, Kuhn H, Guevara NV, Chan L
Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.
J Clin Invest 1996; 98(10): 2201-2208         < Abstract or Full paper >

349) Greeve J, Jona VK, Chowdhury NR, Horwitz MS, Chowdhury JR
Hepatic gene transfer of the catalytic subunit of the apolipoprotein B mRNA editing enzyme results in a reduction of plasma LDL levels in normal and Watanabe heritable hyperlipidemic rabbits.
J Lipid Res 1996; 37(9): 2001-2017         < Abstract or Full paper >

350) Mortensen A, Frandsen H
Reproductive performance and changes in blood lipids in breeding females and in growing Watanabe heritable hyperlipidemic and New Zealand white rabbits.
Lab Anim 1996; 30(3): 252-259         < Abstract or Full paper >

351) Lei X, Buja LM
Measurement by quantitative reverse transcription-polymerase chain reaction of the levels of tumor necrosis factor alpha mRNA in atherosclerotic arteries in Watanabe heritable hyperlipidemic rabbits.
Lab Invest 1996; 74(1): 135-145         < Abstract or Full paper >

352) Brown DR, Brousseau ME, Shamburek RD, Talley GD, Meyn S, Demosky SJ, Santamarina-Fojo S, Brewer HB, Hoeg JM
Adenoviral delivery of low-density lipoprotein receptors to hyperlipidemic rabbits: receptor expression modulates high-density lipoproteins.
Metabolism 1996; 45(12): 1447-1457         < Abstract or Full paper >

353) Matsuo M, Hashimoto M, Suzuki J, Iwanami K, Tomoi M, Shimomura K
Difference between normal and WHHL rabbits in susceptibility to the adrenal toxicity of an acyl-CoA: cholesterol acyltransferase inhibitor, FR145237.
Toxicol Appl Pharmacol 1996; 140(2): 387-392         < Abstract or Full paper >

354) Eguchi S, Rozga J, Lebow LT, Chen SC, Wang C, Rosenthal R, Fogli L, Hewitt WR, Middleton Y, Demetriou AA
Treatment of hypercholesterolemia in the Watanabe rabbit using allogeneic hepatocellular transplantation under a regeneration stimulus.
Transplantation 1996; 62(2): 588-593         < Abstract or Full paper >

355) Li X, Fox G, Erdman SE, Lipman NS
Intestinal plasmacytosis in rabbits: A histologic and ultrastructural study.
Vet Pathol 1996; 33(6): 721-724         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1997)

356) Saku K, Zhang B, Ohta T, Arakawa K
Troglitazone lowers blood pressure and enhances insulin sensitivity in Watanabe heritable hyperlipidemic rabbits.
Am J Hypertens 1997; 10(9): 1027-1033         < Abstract or Full paper >

357) Yin Y, Lim K, Weinbaum S, Chien S, Rumschitzki DS
A model for the initiation and growth of extracellular lipid liposomes in arterial intima.
Am J Physiol 1997; 272(2 Pt 2): H1033-H1046         < Abstract or Full paper >

358) Nakamura M, Abe S
Arteriosclerotic lesions of the distal small coronary artery in cholesterol-fed rabbits differ from those in Watanabe heritable hyperlipidemic rabbits.
Ann N Y Acad Sci 1997; 811: 420-423         < Abstract or Full paper >

359) Nakamura M, Abe S
An experimental induction of acute myocardial infarction and arterial thrombosis in rabbits.
Ann N Y Acad Sci 1997; 811: 424-428         < Abstract or Full paper >

360) Sakai A, Kume N, Nishi E, Tanoue K, Miyasaka M, Kita T
P-selectin and vascular cell adhesion molecule-1 are focally expressed in aortas of hypercholesterolemic rabbits before intimal accumulation of macrophages and T lymphocytes.
Arterioscler Thromb Vasc Biol 1997; 17(2): 310-316         < Abstract or Full paper >

361) Fruebis J, Gonzalez V, Silvestre M, Palinsky W
Effect of probucol treatment on gene expression of VCAM-I, MCP-I, and M-CSF in the aortic wall of LDL receptor-deficient rabbits during early atherosclerosis.
Arterioscler Thromb Vasc Biol 1997; 17(7): 1289-1302         < Abstract or Full paper >

362) Hong MK, Vossoughi J, Mintz GS, Kauffman RD, Hoyt Jr RF, Cornhill JF, Herderick EE, Leon MB, Hoeg JM
Altered compliance and residual strain precede angiographically detectable early atherosclerosis in low-density lipoprotein receptor deficiency.
Arterioscler Thromb Vasc Biol 1997; 17(10): 2209-2217         < Abstract or Full paper >

363) Holvoet P, Collen D
b-VLDL hypercholesterolemia relative to LDL hypercholesterolemia is associated with higher levels of oxidized lipoproteins and a more rapid progression of coronary atherosclerosis in rabbits.
Arterioscler Thromb Vasc Biol 1997; 17(11): 2376-2382         < Abstract or Full paper >

364) Hoshida S, Yamashita N, Igarashi J, Aoki K, Kuzuya T, Hori M
Long-term probucol treatment reverses the severity of myocardial injury in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1997; 17(11): 2801-2807         < Abstract or Full paper >

365) Takagi M, Ueda M, Becker AE, Takeuchi K, Takeda T
The Watanabe heritable hyperlipidemic rabbit is a suitable experimental model to study differences in tissue response between intimal and medial injury after balloon angioplasty.
Arterioscler Thromb Vasc Biol 1997; 17(12): 3611-3619         < Abstract or Full paper >

366) Harsch M, Breaesen JH, Niendorf A
Effects of low-dose pravastatin sodium on plasma cholesterol levels and aortic atherosclerosis of heterozygous WHHL rabbits fed a low cholesterol (0.03%) enriched diet for one year.
Atherosclerosis 1997; 128(2): 139-147         < Abstract or Full paper >

367) Nakamura M, Abe S, Kinukawa M
Aortic medial necrosis with or without thrombosis in rabbits treated with Russell's viper venom and angiotensin II.
Atherosclerosis 1997; 128(2): 149-156         < Abstract or Full paper >

368) Nordestgaard BG, AgerholmLarsen B, Mortensen A, Hansen BF, Ibsen P, Kjeldsen K
Intermediate density lipoprotein cholesterol as the best lipoprotein predictor of atherosclerosis severity in the Watanabe heritable hyperlipidemic rabbit.
Atherosclerosis 1997; 132(1): 119-122         < Abstract or Full paper >

369) Lee Y, Lott JA, Kauffman EM, Sharma HM
Effect of the herbal mixture MAK-4 on organ function in WHHL rabbits.
Biochem Arch 1997; 13: 285-296

370) Yu KC, Mamo JCL
Binding and uptake of chylomicron remnants by cultured arterial smooth muscle cells from normal and Watanabe heritable hyperlipidemic rabbits.
Biochim Biophys Acta 1997; 1346(3): 212-220         < Abstract or Full paper >

371) Igarashi M, Takeda Y, Mori S, Ishibashi N, Komatsu E, Takahashi K, Fuse T, Yamamura M, Kubo K, Sugiyama Y, Saito Y
Suppression of neointimal thickening by a newly developed HMG-CoA reductase inhibitor, BAYw6228, and its inhibitory effect on vascular smooth muscle cell growth.
Br J Pharmacol 1997; 120(6): 1172-1178         < Abstract or Full paper >

372) Liu R, Saku K, Jimi S, Ohta T, Zhang B, Takebayashi S, Arakawa K
Mechanism of action of gemfibrozil on HDL metabolism and atherosclerosis in WHHL rabbits.
Cardiovasc Drug Therapy 1997; 11(5): 659-668         < Abstract or Full paper >

373) Steinberg D
Lewis A. Conner Memorial Lecture: Oxidative modification of LDL and atherogenesis.
Circulation 1997; 95(4): 1062-1071         < Abstract or Full paper >

374) Van Belle E, Rivard A, Chen DH, Silver M, Bunting S, Ferrara N, Symes JF, Bauters C, Isner JM
Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines.
Circulation 1997; 96(8): 2667-2674         < Abstract or Full paper >

375) Stangle K, Dschietzig T, Laule M, Alexiou K, Wernecke KD, Baumann G
Pulmonary big endothelin affects coronary tone and leads to enhanced, ETA-mediated coronary constriction in early endothelial dysfunction.
Circulation 1997; 96(9): 3192-3200         < Abstract or Full paper >

376) Saku K, Zhang B, Ohta T, Arakawa K
Effects of troglitazone on serum lipids, lipoproteins, and hyperinsulinemia in Watanabe heritable hyperlipidemic rabbits.
Curr Ther Res Clin Exper 1997; 58: 876-887         < Abstract or Full paper >

377) Catapano AL
Calcium antagonists and atherosclerosis: experimental evidence.
Eur Heart J 1997; 18(Suppl A): A80-A86         < Abstract or Full paper >

378) Watanabe Y, Inaba T, Shimano H, Gotoda T, Kawamura M, Shiomi M, Yazaki Y, Yamada N
Effect of macrophage colony stimulating factor on the advanced atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Horm Metab Res 1997; 29(10): 507-509         < Abstract or Full paper >

379) Fruebis J, Bird DA, Pattison J, Palinski W
Extent of antioxidant protection of plasma LDL is not a predictor of the antiatherogenic effect of antioxidants.
J Lipid Res 1997; 38(12): 2455-2466         < Abstract or Full paper >

380) Striker GE, Lupia E, Elliot S, Zheng F, McQuinn C, Blagg C, Selim S, Vilar J, Striker LJ
Glomerulosclerosis, arteriosclerosis, and vascular graft stenosis: Treatment with oral heparinoids.
Kidney Int 1997; 52 (Suppl 63): S120-S123         < Abstract or Full paper >

381) Varret M, Rabes JP, Boileau C
Familial hypercholesterolemia 25 years after. 1. LDL receptor defects.
Med Sci 1997; 13: 1399-1408 (in French)

382) Zhang B, Saku K, Arakawa K
Quantification of the effects of troglitazone on insulin sensitivity and b-cell function in Watanabe heritable hyperlipidemic rabbits: an animal model analysis.
Metabolism 1997; 46(3): 273-281         < Abstract or Full paper >

383) Donnelly LH, Bree MP, Hunter SE, Keith JC, Schaub RG
Immunoreactive macrophage colony-stimulating factor is increased in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits after recombinant human macrophage colony-stimulating factor therapy.
Mol Reprod Dev 1997; 46(1): 92-95         < Abstract or Full paper >

384) Gunsalus JR, Brady DA, Cohlter SM, Gray BM, Edge ASB
Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation.
Nat Med 1997; 3(1): 48-53         < Abstract or Full paper >

385) Allison BA, Crespo MT, Jain AK, Richter AM, Hsiang YN, Levy JG
Delivery of benzoporphyrin derivative, a photosensitizer, into atherosclerotic plaque of Watanabe heritable hyperlipidemic rabbits and balloon-injured New Zealand rabbits.
Photochem Photobiol 1997; 65(5): 877-883         < Abstract or Full paper >

386) Zimmermann GG, Quick HH, Hilfiker PR, von Sculthess K, Giovanoli P, Debatin JF
Intravascular MR imaging: The first in vivo experiences in an animal atherosclerosis model.
Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 1997; 167(8): 180-186         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1998)

387) Nagata N, Nishizaki Y, Watanabe N, Tsuda M, Matsuzaki S
An enzyme immune assay for serum anti acetaldehyde adduct antibody using low-density lipoprotein adduct and its significance in alcoholic liver injury.
Alcohol Clin Exp Res 1998; 22: 150S-155S         < Abstract or Full paper >

388) Higaki J, Hara S, Takasu N, Tonda K, Miyata K, Shike T, Nagata K, Mizui T
Inhibition of Ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits.
Arterioscler Thromb Vasc Biol 1998; 18(8): 1304-1311         < Abstract or Full paper >

389) Ooboshi H, Toyoda K, Faraci FM, Lang MG, Heistad DD
Improvement of relaxation in an atherosclerotic artery by gene transfer of endothelial nitric oxide synthase.
Arterioscler Thromb Vasc Biol 1998; 18(11): 1752-1758         < Abstract or Full paper >

390) Miyazaki A, Koga T
Lipid lowering effects of pravastatin in common marmosets.
Arzneim Forsh/Drug Res 1998; 48(2): 154-160         < Abstract or Full paper >

391) Shiomi M, Ito T, Tsukada T, Shiraishi M, Yata T
Effect of fluvastatin sodium on the smooth muscle cells in atherosclerotic plaques: In vivo study using low-density lipoprotein receptor deficient Watanabe heritable hyperlipidemic (WHHL) rabbits.
Arzneim Forsh/Drug Res 1998; 48(6): 680-685         < Abstract or Full paper >

392) Naka Y, Yoshino G, Hirano T, Murata Y, Maeda E, Kazumi T, Kasuga M
Triglyceride metabolism in heterozygote of Watanabe heritable hyperlipidemic rabbit.
Atherosclerosis 1998; 136(2): 325-332         < Abstract or Full paper >

393) Oshima R, Ikeda T, Watansbe K, Itakura H, Sugiyama N
Probucol treatment attenuates the aortic atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1998; 137(1): 13-22         < Abstract or Full paper >

394) Yamaguchi Y, Kagota S, Kunitomo M, Haginaka J
Evidence of modified lipoprotein in the plasma of Watanabe heritable hyperlipidemic rabbits by anion-exchange high-performance liquid chromatographic assay.
Atherosclerosis 1998; 139(2): 323-331         < Abstract or Full paper >

395) Mortensen A, Hansen BF, Hansen JF, Frandsen H, Bartnikowska E, Andersen PS, Bertelsen LS
Comparison of the effects of fish oil and olive oil on blood lipids and aortic atherosclerosis in Watanabe heritable hyperlipidaemic rabbits.
Br J Nutr 1998; 80(6): 565-573         < Abstract or Full paper >

396) Harsch M, Gebhardt A, Reymann A, Lang G, Schliack M, Loser R, Braesen JH, Niendorf A
Effects of pravastatin on cholesterol metabolism of cholesterol-fed heterozygous WHHL rabbits.
Br J Pharmacol 1998; 124(2): 277-282         < Abstract or Full paper >

397) Sullivan ME, Dashwood MR, Thompson CS, Mikhailidis DP, Morgan RJ
Down-regulation of endothelin-B receptor sites in cavernosal tissue of hypercholesterolemic rabbits.
Br J Urology 1998; 81(1): 128-134         < Abstract or Full paper >

398) Hiltunen TP, Luoma JS, Nikkari T, Yla-Herttuala S
Expression of LDL receptor, VLDL receptor, LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions: Marked induction of scavenger receptor and VLDL receptor expression during lesion development.
Circulation 1998; 97(11): 1079-1086         < Abstract or Full paper >

399) Miller FJ, Gutterman DD Jr, Rios CD, Heistad DD, Davidson BL
Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis.
Cir Res 1998; 82(12): 1298-1305         < Abstract or Full paper >

400) Kagota S, Yamaguchi Y, Shinozuka K, Kunitomi M
Mechanisms of impairment of endothelium-dependent relaxation to acetylcholine in Watanabe heritable hyperlipidemic rabbit aortas.
Clin Exp Pharmacol Physiol 1998; 25(2): 104-109         < Abstract or Full paper >

401) Dschietzig T, Laule M, Alexiou K, Schror K, Baumann G, Stangl K
Coronary constriction and consequent cardiodepression in pulmonary embolism are mediated by pulmonary big endothelin and enhanced in early endothelial dysfunction.
Crit Care Med 1998; 26(3): 510-517         < Abstract or Full paper >

402) Roth BD
ACAT inhibitors: evolution from cholesterol-absorption inhibitors to antiatherosclerotic agents.
Drug Discovery Today 1998; 3(1): 19-25         < Abstract or Full paper >

403) Hamilton CA, Howie CA, Jardine E, Reid JL
Endothelium dependent and independent relaxation of aortic rings from Watanabe heritable hyperlipidemic rabbits after exposure to a free radical generating system.
Free Rad Res 1998; 28(3): 251-257         < Abstract or Full paper >

404) Aliev G, Burnstock G
Watanabe rabbits with heritable hypercholesterolemia: a model of atherosclerosis.
Histol Histopathol 1998; 13: 797-817         < Abstract or Full paper >

405) Handy DE, Johns C, Bresnahan MR, Tavares A, Bursztyn M, Gavrasb H
Expression of a2-adrenergic receptors in normal and atherosclerotic rabbit aorta.
Hypertension 1998; 32(2): 311-317         < Abstract or Full paper >

406) Yokouchi T, Iwabuchi S, Tomiyama A, Samejima H, Takahashi K, Shiomi M
Morphological study of carotid artery of WHHL rabbit after balloon dilatation.
Interventional Neuroradiology 1998; 4(Suppl 1): 183-186         < Abstract or Full paper >

407) Ikeno A, Sumiya T, Minato H, Fujitani B, Masuda Y, Hosoki K, Kurono M, Yasuba M
Effects of monatepil maleate, a new Ca2+ channel antagonist with a1-adrenoceptor antagonistic activity, on cholesterol absorption and catabolism in high cholesterol diet-fed rabbits.
Jpn J Pharmacol 1998; 78(3): 303-312         < Abstract or Full paper >

408) Alexiou K, Dschietzig T, Simsch O, Laule M, Hundertmark J, Baumann G, Stangl K
Arrhythmogenic effects induced by coronary conversion of pulmonary big endothelin to endothelin: Aggravation of this phenomenon in heritable hyperlipidemia.
J Am Coll Cardiol 1998; 32(6): 1773-1778         < Abstract or Full paper >

409) Kim DH, Inagaki Y, Suzuki H, Ioka RX, Yoshioka SZ, Magoori K, Kang MJ, Cho Y, Nakano AZ, Liu Q, Fujino T, Suzuki H, Sasano H, Yamamoto TT
A new low density lipoprotein receptor belated protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E.
J Biochem 1998; 124(6): 1072-1076         < Abstract or Full paper >

410) Yamaguchi Y, Kunitomo M, Haginaka J
Anion-exchange high-performance liquid chromatographic assay of plasma lipoproteins of rabbits, rats and mice.
J Chromatog B 1998; 716(1-2): 57-64         < Abstract or Full paper >

411) Brousseau M, Wang J, Demosky SJ Jr, Vaisman BL, Talley GD, Santamarina-Fojo S, Brewer HB jr, Hoeg JM
Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase.
J Lipid Res 1998; 39(8): 1558-1567         < Abstract or Full paper >

412) Aliev G, Ragazzi E, Cirillo R, Bevilacqua C, Mironov A, Prosdocimi M, Paro M
Cryodamage of the vessel wall accelerates the development of atherosclerotic lesions in arterial vessels of Watanabe heritable hyperlipidemic rabbits.
J Submicrosc Cytol Pathol 1998; 30(3): 417-423         < Abstract or Full paper >

413) Corjay MH, Kearney MA, Munzer DA, Diamond SM, Stoltenborg JK
Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human.
Lab Invest 1998; 78(7): 847-858         < Abstract or Full paper >

414) Aliev G, Bodin P, Burnstock G
Free radical generators cause changes in endothelial and inducible nitric oxide synthases and endothelin-1: Immunoreactivity in endothelial cells from hyperlipidemic rabbits.
Mol Genet Metab 1998; 63(3): 191-197         < Abstract or Full paper >

415) Cynshi O, Kawabe Y, Suzuki T, Takashima Y, Kaise H, Nakamura M, Ohba Y, Kato Y, Tamura K, Hayasaka A, Higashida A, Sakaguchi H, Takeya M, Takahashi K, Inoue K, Noguchi N, Niki E, Kodama T
Antiatherogenic effects of the antioxidant BO-653 in three different animal models.
Proc Natl Acad Sci USA 1998; 95(17): 10123-10128         < Abstract or Full paper >

416) Wetterau JR, Gregg RE, Harrity TW, Arbeeny C, Cap M, Connolly F, Chu CH, George RJ, Gordon DA, Jamil H, Jolibois JG, Kunselman LK, Lan AJ, Maccagnan TJ, Ricci B, Yan M, Young D, Chen Y, Fryszman OM, Logan JVH, Musial CL, Poss MA, Robel JA, Simpkins LM, Slusasrchyk WA, Sulsky R, Taunk P, Magnin DR, Tino JA, Lawrence RM, Dickson JK Jr, Viller SA
An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.
Science 1998; 282(5389): 751-754         < Abstract or Full paper >

417) Brasen JH, Harsch M, Miendorf A
Survival and cardiovascular pathology of heterozygous Watanabe heritable hyperlipidemic rabbits treated with pravastatin and probucol on a low cholesterol (0.03%)-enriched diet.
Virchows Arch 1998; 432(6): 557-562         < Abstract or Full paper >

Bibliography of WHHL rabbits


(1999)

418) Lund DD, Faraci FM, Ooboshi H, Davidson BL, Heistad DD
Adenovirus-mediated gene transfer is augmented in basilar and carotid arteries of heritable hyperlipidemic rabbits.
Stroke 1999; 30(1): 120-125         < Abstract or Full paper >

419) Hope S, Brecher P, Chobanian AV
Comparison of the effects of AT(1) receptor blockade and angiotensin converting enzyme inhibition on atherosclerosis.
Am J Hypertens 1999; 12(1): 28-34         < Abstract or Full paper >

420) Hakkinen T, Luoma JS, Hiltunen MO, Macphee CH, Milliner KJ, Patel L, Rice SQ, Tew DG, Karkola K, Yla-Herttunla S
Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase, is expressed by macrophages in human and rabbit atherosclerotic lesions.
Arterioscler Thromb Vasc Biol 1999; 19(12): 2909-2917         < Abstract or Full paper >

421) Lauridsen ST, Mortensen A
Probucol selectively increases oxidation of atherogenic lipoproteins in cholesterol-fed mice and in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1999; 142(1): 169-178         < Abstract or Full paper >

422) Shiomi M, Ito T, Tsukada T, Tsujita Y, Horikoshi H
Combination treatment with troglitazone, an insulin action enhancer, and pravastatin, an inhibitor of HMG-CoA reductase, shows synergistic effect on atherosclerosis of WHHL rabbits.
Atherosclerosis 1999; 142(2): 345-353         < Abstract or Full paper >

423) Pang ZJ, Zhou M, Chen Y, Wan J
Macrophage colony-stimulating factor reduces tetra-butyl hydroperoxide induced oxidative injury to monocytes/macrophages.
Atherosclerosis 1999; 147(1): 33-40         < Abstract or Full paper >

424) Laury-Kleintop LD, Gleason M, Tulenko TN
Expression of the heterogeneous nuclear ribonucleoprotein complex K protein and the prolyl-4-hydroxylase a-subunit in atherosclerotic arterial smooth muscle cells.
Biochem Biophys Res Comm 1999; 260(2): 382-389         < Abstract or Full paper >

425) Shiomi M, Ito T
Effects of cerivastatin sodium, a new inhibitor of HMG-CoA reductase, on plasma lipid levels, progression of atherosclerosis, and the lesional composition in the plaques of WHHL rabbits.
Br J Pharmacol 1999; 126: 961-968         < Abstract or Full paper >

426) Matsumura T, Kugiyama K, Sugiyama S, Ota Y, Doi H, Ogata N, Oka H, Yasue H
Suppression of atherosclerotic development in Watanabe heritable hyperlipidemic rabbits treated with an oral antiallergic drug, tranilast.
Circulation 1999; 99(7): 919-924         < Abstract or Full paper >

427) Shindo J, Ishibashi T, Yokoyama K, Ohwada T, Shiomi M, Maruyama Y
Granulocyte-macrophage colony-stimulating factor prevents the progression of atherosclerosis via changes in the cellular and extracellular composition of atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbits.
Circulation 1999; 99: 2150-2156         < Abstract or Full paper >

428) Stocker R
Dietary and pharmacological antioxidants in atherosclerosis.
Curr Opin Lipidol 1999; 10(6): 589-597         < Abstract or Full paper >

429) Pakkanen TM, Laitinen M, Hippelainen M, Kallionpaa H, Lehtolainen P, Leppanen P, Luoma JS, Tarvainen R, Alhava E, Yla-Herttuala S
Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver resection and thymidine kinase ganciclovir treatment.
Gene Therapy 1999; 6(1): 34-41         < Abstract or Full paper >

430) Napoli C, Cicala C, D'Armiento P, Roviezzo F, Somma P, de-Nigris F, Zulian P, Bucci M, Aleotti L, Casini A, Franconi F, Cirino G
Beneficial effects of ACE-inhibition with zofenopril on plaque formation and low-density lipoprotein oxidation in Watanabe heritable hyperlipidemic rabbits.
Gen Pharmacol 1999; 33(6): 467-477         < Abstract or Full paper >

431) Parise F, Simone L, Croce MA, Ghisellini M, Battini R, Borghi S, Tiozzo R, Ferrari S, Calandra S, Ferrari S
Construction and in vitro functional evaluation of a low-density lipoprotein receptor/transferrin fusion protein as a therapeutic tool for familial hypercholesterolemia.
Hum gene Ther 1999; 10(7): 1219-1228         < Abstract or Full paper >

432) Wakabayashi Y
Effect of red wine consumption on low-density lipoprotein oxidation and atherosclerosis in aorta and coronary artery in Watanabe heritable hyperlipidemic rabbits.
J Agrical Food Chem 1999; 47(11): 4724-4730         < Abstract or Full paper >

433) Mori M, Itabe H, Takatoku K, Shima K, Inoue J, Nishiura M, Takahashi H, Ohtake H, Sato R, Higashi Y, Imanaka T, Ikegami S, Takano T
Presence of phospholipid-neutral lipid complex structures in atherosclerotic lesions as detected by a novel monoclonal antibody.
J Biol Chem 1999; 274(35): 24828-24837         < Abstract or Full paper >

434) Yamaguchi Y, Kagota S, Kunitomi M, Haginaka J
High-performance liquid chromatographic assay of hydroperoxide levels in oxidatively modified lipoproteins.
J Chromatography B 1999; 731(2): 223-229         < Abstract or Full paper >

435) Witting P, Pettersson K, Ostlund-Lindqvist AM, Westerlund C, Wagberg M, Stocker R
Dissociation of atherosclerosis from aortic accumulation of lipid hydro(per)oxides in Watanabe heritable hyperlipidemic rabbits.
J Clin Invest 1999; 104(2): 213-220         < Abstract or Full paper >

436) Clunn GF, Wijetunge S, Hughes AD
Effect of hypercholesterolemia on voltage-operated calcium channel currents in rabbit arterial smooth muscle cells.
J Hum Hypertens 1999; 13(12): 849-853         < Abstract or Full paper >

437) Brousseau ME, Hoeg JM
Transgenic rabbits as models for atherosclerosis research.
J Lipid Res 1999; 40(3): 365-375         < Abstract or Full paper >

438) Tsimikas S, Palinski W, Halpern SE, Yeung DW, Curtiss LK, Witztum JL
Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo.
J Nutr Cardiol 1999; 6(1 Pt 1): 41-53         < Abstract or Full paper >

439) Allott CP, Barry CD, Bramley J, John NW, Mellor PM, Thomson DS, Reilly CF
Noninvasive 3-D ultrasound of atherosclerotic plaques in the Watanabe rabbit.
Ultrasound Med Biol 1999; 25(6): 905-914         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2000)

440) Metzler B, Hu YH, Dietrich H, Xu QB
Increased expression and activation of stress-activated protein kinase/c-jun NH2-terminal protein kinase in atherosclerotic lesional coincide with p53.
Am J Pathol 2000; 156: 1875-1886         < Abstract or Full paper >

441) Orfanos SE, Parkerson HB, Chen XL, Fisher EL, Glynos C, Papapetropoulos A, Gerrity RG, Catravas JD
Reduced lung endothelial angiotensin-converting enzyme activity in Watanabe heritable hyperlipidemic rabbits in vivo.
Am J Physiol Lung Cell Mol Physiol 2000; 278: L1280-L1288         < Abstract or Full paper >

442) Brousseau ME, Kauffman RD, Herderick EE, Demosky SJ, Evans W, Marcovina S, Santamarina-Fojo S, Brewer HB, Hoeg JM
LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptor in transgenic rabbits.
Arterioscler Thromb Vasc Biol 2000; 20(2): 450-458         < Abstract or Full paper >

443) Chen MY, Kakutani M, Minami M, Kataoka H, Kume N, Narumiya S, Kita T, Masaki T, Sawamura T
Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 2000; 20(4): 1107-1115         < Abstract or Full paper >

444) Tsutsumi K, Inoue Y, Murase T
Effects of NO-1886, a lipoprotein lipase promoting agent, on homozygous and heterozygous Watanabe heritable hyperlipidemic rabbits.
Arzneim Forsh/Drug Res 2000; 50: 118-121         < Abstract or Full paper >

445) Suzuki H, Yamazaki H, Aoki T, Kojima J, Tamaki T, Sato F, Kitahara M, Saito Y
Lipid-lowering and antiatherosclerotic effect of NK-104, in Watanabe heritable hyperlipidemic rabbits.
Arzneim Forsh/Drug Res 2000; 50: 995-1003         < Abstract or Full paper >

446) Sloop GD, Fallon KB, Lipscomb G, Takei H, Zieske A
The distribution of oxidatively-modified lysine in the human vasculature.
Atherosclerosis 2000; 148(2): 255-263         < Abstract or Full paper >

447) Worthley SG, Helft G, Fuster V, Zaman AG, Fayad ZA, Fallon JTT, Badimon JJ
Serial in vivo MRI documents arterial remodeling in experimental atherosclerosis.
Circulation 2000; 101(6): 586-589         < Abstract or Full paper >

448) de Nigris F, Youssef T, Ciafre S, Franconi F, Anania V, Condorelli GL, Palinski W, Napoli C
Evidence for oxidative activation of c-Myc-dependent nuclear signaling in human coronary smooth muscle cells and in early lesions of Watanabe heritable hyperlipidemic rabbits: Protective effects of vitamin E.
Circulation 2000; 102(17): 2111-2117         < Abstract or Full paper >

449) Amerongen GPV, Vermeer MA, Negre-Aminou P, Lankelma J, Emeis JJ, van Hinsbergh VWM
Simvastatin improves disturbed endothelial barrier function.
Circulation 2000; 102(23): 2803-2809         < Abstract or Full paper >

450) Oelze M, Mollnau H, Hoffmann N, Warnholtz A, Bodenschatz M, Smolenski A, Walter U, Skatchkov M, Meinertz T, Munzel T
Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction.
Circ Res 2000; 87(11): 999-1005         < Abstract or Full paper >

451) Suzumura K, KasaharaE, Ohnishi Y, Chien KC, Inoue M
Fluvastatin normalizes the decreased turnovers of glutathione and ascorbic acid in Watanabe heritable hyperlipidemic rabbits.
Clin Exp Pharmacol P 2000; 27: 709-714         < Abstract or Full paper >

452) Yamaguchi Y, Kagota S, Haginaka J, Kunitomo M
Evidence of modified LDL in the plasma of hypercholesterolemic WHHL rabbits injected with aqueous extracts of cigarette smoke.
Environ Toxicol Phamacol 2000; 8: 255-260         < Abstract or Full paper >

453) Shimada K, Yoshida K, Tadokoro H, Ueda M, Shiomi M, Kitsukawa S, Takami A, Komatsu R, Suzuki K, Tanada S, Masuda Y
Adenosine-induced coronary flow reserve in Watanabe heritable hyperlipidemic rabbits.
Jpn Circ J 2000; 64: 971-976         < Abstract or Full paper >

454) Ayajiki K, Ozaki M, Shiomi M, Okamura T, Toda N
Comparison of endothelium-dependent relaxation in carotid arteries from Japanese white and Watanabe heritable hyperlipidemic rabbits.
J Cardiovasc Pharmacol 2000; 36: 622-630         < Abstract or Full paper >

455) Fan J, Challah M, Shimoyamada H, Shiomi M, Marcovina S, Watanabe T
Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein(a).
J Lipid Res 2000; 41: 1004-1012         < Abstract or Full paper >

456) Suzumura K, Kasahara E, Wang Y, Chien KC, Inoue M
Decreased turnovers of glutathione and ascorbic acid in Watanabe heritable hyperlipidemic rabbits.
J Nutr Sci Vitaminol 2000; 46: 205-209         < Abstract or Full paper >

457) Pauletto P, Puato M, Faggin E, Sartore S
Low-dose cerivastatin inhibits spontaneous atherogenesis in heterozygous Watanabe heritable hyperlipidemic rabbits.
J Vasc Res 2000; 37: 189-194         < Abstract or Full paper >

458) Shiomi M, Ito T, Fujioka T, Tsujita Y
Age-associated decrease in plasma cholesterol and changes in cholesterol metabolism in homozygous Watanabe heritable hyperlipidemic rabbits.
Metabolism 2000; 49: 552-556         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2001)

459) Aliev G, Smith MA, Turmaine M, Neal ML, Zimina TV, Friedland RP, Perry G, LaManna JC, Burnstock G
Atherosclerotic lesions are associated with increased immunoreactivity for inducible nitric oxide synthase and endothelin-1 in thoracic aortic intimal cells of hyperlipidemic Watanabe rabbits.
Exp Mol Pathol 2001; 71: 40-54         < Abstract or Full paper >

460) Aikawa M, Rabkin E, Sugiyama S, Voglic SJ, Fukumoto Y, Furukawa Y, Shiomi M, Schoen FJ, Libby P
An HMG-CoA reductase inhibitor, Cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro.
Circulation 2001; 103 (1): 276-283         < Abstract or Full paper >

461) Ruehm SG, Corot C, Vogt P, Kolb S, Debatin JF
Magnetic resonance imaging of atherosclerotic plaque with ultrasmall superparamagnetic particles of iron oxide in hyperlipidemic rabbits.
Circulation 2001; 103 (1): 415-422         < Abstract or Full paper >

462) Fukumoto Y, Libby P, Rabkin E, Hill CC, Enomoto M, Hirouchi Y, Shiomi M, Aikawa M
Statins alter smooth muscle cell accumulation and collagen content in established atheroma of Watanabe heritable hyperlipidemic rabbits.
Circulation 2001; 103 (2): 993-999         < Abstract or Full paper >

463) Djahansouzi S, Braesen JH, Koenig K, Beisiegel-U, Kontush A
The effect of pharmacological doses of different antioxidants on oxidation parameters and atherogenesis in hyperlipidaemic rabbits.
Atherosclerosis 2001; 154 (2): 387-398         < Abstract or Full paper >

464) Hiltunen TP, Gough PJ, Greaves DR, Gordon S, Yla-Herttuala S
Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor.
Atherosclerosis 2001; 154 (2): 415-419         < Abstract or Full paper >

465) Ishida T, Kawashima S, Hirata K, Sakoda T, Shimokawa Y, Miwa Y, Inoue N, Ueyama T, Shiomi M, Akita H, Yokoyama M
Serotonin-induced hypercontraction through 5-hydroxytryptamine 1B receptors in atherosclerotic rabbit coronary arteries.
Circulation 2001; 103 (9): 1289-1295         < Abstract or Full paper >

466) Ito T, Shiomi M
Cerebral atherosclerosis occurs spontaneously in homozygous WHHL rabbits.
Atherosclerosis 2001; 156 (1): 57-66         < Abstract or Full paper >

467) Shiomi M, Ito T, Hirouchi Y, Enomoto M
Fibromuscular cap composition is important for the stability of established atherosclerotic plaques in mature WHHL rabbits treated with statins.
Atherosclerosis 2001; 157 (1): 75-84         < Abstract or Full paper >

468) Kakutani M, Ueda M, Naruko T, Masaki T, Sawamura T
Accumulation of LOX-1 ligand in plasma and atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits: identification by a novel enzyme immunoassay.
Biochem Biophys Res Comm 2001; 288: 180-185         < Abstract or Full paper >

469) Zoldhelyi P, Chen ZQ, Shelat HS, McNatt JM, Willerson JT
Local gene transfer of tissue factor pathway inhibitor regulates intimal hyperplasia in atherosclerotic arteries.
Proc Natl Acad Sci USA 2001; 98 (7): 4078-4083         < Abstract or Full paper >

470) Koike H
New pharmacologic aspects of CS-866, the newest angiotensin II receptor antagonist.
Am J Cardiol 2001; 87 (suppl): 33c-36c         < Abstract or Full paper >

471) Clubb FJ, Cerby JL, Deferrari DA, Butler-Aucoin MM, Willerson JT, Buja LM
Development of atherosclerotic plaque with endothelial disruption in Watanabe heritable hyperlipidemic rabbit aortas.
Cardiovasc Pathol 2001; 10 (1): 1-11         < Abstract or Full paper >

472) Takahashi S, Ohsugi K, Yamamoto T, Shiomi M, Sakuragawa N
A novel approach to ex vivo gene therapy for familial hypercholesterolemia using human amniotic epithelial cells as transgene carrier.
Tohoku J Exp Med 2001; 193: 279-292         < Abstract or Full paper >

473) Yamaguchi Y, Matsuno S, Kagota S, Haginaka J, Kunitomo M
Oxidants in cigarette smoke extract modify low-density lipoprotein in the plasma and facilitate atherogenesis in the aorta of Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 2001; 156 (1): 109-117         < Abstract or Full paper >

474) de Roos B, Caslake MJ, Ardern HA, Benson GM, Suckling KE, Packard CJ
Insulin resistance in the St. Thomas' mixed hyperlipidaemic (SMHL) rabbit, a model for familial combined hyperlipidaemia.
Atherosclerosis 2001; 156: 249-254         < Abstract or Full paper >

475) Aikawa M, Libby P
Vascular inflammation and activation: new targets for lipid lowering.
Eur Heart J 2001: 3 (Supplement B): B3-B11         < Abstract or Full paper >

476) Mortensen A, Breinholt V, Dalsgaard T, Frandsen H, Lauridsen ST, Laigaard J, Ottesen B, Larsen JJ
17b-estradiol but not the phytoestrogen naringenin attenuates aortic cholesterol accumulation in WHHL rabbits.
J Lipid Res 2001; 42: 834-843         < Abstract or Full paper >

477) Kamimura T, Suzuki S, Miyahara K, Shiomi M
Arteriosclerosis in the influx and intravisceral arteries of the liver, kidney and lung of WHHL rabbits.
Exp Anim 2001; 50: 423-426         < Abstract or Full paper >

478) Zhang B, Shiomi M, Tanaka H, Mei J, Fan P, Tsujita Y, Horikoshi H, Saku K
Effects of high-dose Troglitazone on insulin sensitivity and b-cell function in Watanabe heritable hyperlipidemic rabbits.
Eur J Drug Metab Ph 2001; 26(3): 185-192         < Abstract or Full paper >

479) Shiomi M, Ito T
MTP inhibitor decreases plasma cholesterol levels in LDL receptor-deficient WHHL rabbits by lowering the VLDL secretion.
Eur J Pharmacol 2001; 431: 127-131         < Abstract or Full paper >

480) Ishikawa K, Sugawara D, Goto J, Watanabe Y, Kawamura K, Shiomi M, Itabe H, Maruyama Y
Heme oxygenase-1 inhibits atherogenesis in Watanabe heritable hyperlipidemic rabbits.
Circulation 2001; 104 : 1831-1836         < Abstract or Full paper >

481) Wagberg M, Jansson AH, Westerlund C, Ostlund-Lindqvist AM, Sarnstrand B, Bergstrand H, Pettersson K
N,N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcholine, inhibits atherosclerosis in WHHL rabbits: Evidence for immunomodulatory agents as a new approach to prevent atherosclerosis.
J Pharmacol Exp Ther 2001; 299: 76-82         < Abstract or Full paper >

482) Hiyoshi H, Yanagimachi M, Ito M, Saeki T, Uoshida I, Okada T, Ikuta H, Shinmyo D, Tanaka K, Kurusu N, Tanaka H
Squalene synthase inhibitors reduce plasma triglyceride through a low-density lipoprotein in receptor-independent mechanism.
Eur J Pharmacol 2001; 431: 345-352         < Abstract or Full paper >

483) Mori M, Itabe H, Higashi Y, Fujimoto Y, Shiomi M, Yoshizumi M, Ouchi Y, Takano T
Foam cell formation containing lipid droplets enriched with free cholesterol by hyperlipidemic serum.
J Lipid Res 2001; 42: 1771-1781         < Abstract or Full paper >

484) Malle E, Wag G, Thiery J, Sattler W, Grone HJ
Hypochloride-modified (lipo)proteins are present in rabbit lesions in response to dietary cholesterol.
Biochem Biophys Res Commun 2001; 289: 894-9000         < Abstract or Full paper >

485) Fan J, Sun H, Unoki H, Shiomi M, Watanabe T
Enhanced atherosclerosis in Lp(a) WHHL transgenic rabbits.
Ann N Y Acad Sci 2001; 947: 362-365         < Abstract or Full paper >

486) Shiomi M, Ito T, Hirouchi Y, Enomoto M
Stability of atheromatous plaque affected by lesional composition: study of WHHL rabbits treated with statins.
Ann N Y Acad Sci 2001; 947: 419-423         < Abstract or Full paper >

487) Ishikawa K, Maruyama Y
Heme oxygenase as an intrinsic defense system in vascular wall: implication against atherogenesis.
J Atheroscler Thromb 2001; 8(3): 63-70         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2002)

489) McCabe PM, Gonzales JA, Zaias J, Szeto A, Kumar M, Herron AJ, Schneiderman N
Social environment influence the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.
Circulation 2002; 105: 354-359         < Abstract or Full paper >

489) Xu G, Pan Lx Lx, Erickson SK, Forman BM, Shneider BL, Ananthanarayanan M, Li X, Shefer S, Balasubramanian N, Ma L, Asaoka H, Lear SR, Nguyen LB, Dussault I, Suchy FJ, Tint GS, Salen G
Removal of the bile acid pool upregulates cholesterol-7a-hydroxylase by deactivating FXR in rabbits.
J Lipid Res 2002; 43: 45-50         < Abstract or Full paper >

490) Yamaguchi Y, Matsumoto S, Kagota S, Haginaka J, Kunitomo M
Fluvastatin reduces modification of low-density lipoprotein in hyperlipidemic rabbit loaded with oxidative stress.
Eur J Pharmacol 2002; 436: 97-105         < Abstract or Full paper >

491) Meding J, Dinkelborg LM, Grieshaber MK, Semmler W
Targeting of endothelin receptors for molecular imaging of atherosclerosis in rabbits.
J Nucl Med 2002; 43: 400-405         < Abstract or Full paper >

492) Suwa T, Hogg JC, Quinlan KB, Ohgami A, Vincent R, van Eeden SF
Particulate air pollution induces progression of atherosclerosis.
J Am Coll Cardiol 2002; 39: 935-942         < Abstract or Full paper >

493) Yoshida N, Murase H, Kunieda T, Toyokuni S, Tanaka T, Terao J, Naito Y, Tanigawa T, Yoshikawa T
Inhibitory effect of a novel water-soluble vitamin E derivative on atherosclerosis in rabbits.
Atherosclerosis 2002; 162: 111-117         < Abstract or Full paper >

494) Dalsgaard T, Larsen CR, Mortensen A, Larsen JJ, Ottesen B
New animal model for the study of postmenopausal coronary and cerebral artery function: the Watanabe heritable hyperlipidemic rabbit fed on a diet avoiding phytoestrogens.
Climacteric 2002; 5(2): 178-189         < Abstract or Full paper >

495) Sun H, Usui S, Shiomi M, Watanabe T, Fan J
A rapid PCR method of genotyping LDL receptor mutations in WHHL rabbits.
J Atheroscler Thromb 2002, 9(3): 145-148         < Abstract or Full paper >

496) Murakami S, Kondo Y, Kitajima H, Nagate T
Taurine suppresses development of atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits.
Atherosclerosis 2002; 163: 79-87         < Abstract or Full paper >

497) Schmitz SA, Taupitz M, Wagner S, Coupland SE, Gust R, Nikolova A, Wolf KJ
Iron-oxide-enhanced magnetic resonance imaging of atherosclerotic plaques: postmortem analysis of accuracy, inter-observer agreement, and pitfalls.
Invest Radiol 2002; 37(7): 405-411         < Abstract or Full paper >

498) Brasen JH, Koenig K, Bach H, Kontush A, Heinle H, Witting PK, Yla-Herttuala S, Stocker R, Beisiegel U
Comparison of the effects of a-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits.
Atherosclerosis 2002; 163: 249-259         < Abstract or Full paper >

499) Naghavi M, John R, Naguib S, Siadaty MS, Grasu R, Kurian KC, van Winkle WB, Soller B, Litovsky S, Madjid M, Willerson JT, Casscells W
pH heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque.
Atherosclerosis 2002; 164: 27-35         < Abstract or Full paper >

500) Sun H, Unoki H, Wang X, Liang J, Ichikawa T, Arai Y, Shiomi M, Marcovina SM, Watanabe T, Fan J
Lipoprotein(a) enhances advanced atherosclerosis in WHHL transgenic rabbits expressing human apolipoprotein(a).
J Biol Chem 2002; 277: 47486-47492         < Abstract or Full paper >

501) Warnholtz A, Mollnau H, Heitzer T, Kontush A, Moller-Bertram T, Lavall D, Giaid A, Beisiegel U, Marklund SL, Walter U, Meinertz T, Munzel T
Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits.
J Am Coll Cardiol. 2002 40:1356-1363         < Abstract or Full paper >

502) Yamada S, Ito T, Adachi J, Ueno Y, Shiomi M
Decreased arterial responses in WHHL rabbits, an animal model of spontaneous hypercholesterolemia and atherosclerosis.
Exp Anim 2002; 51: 493-499         < Abstract or Full paper >

503) Rikitake Y, Hirata K, Yamashita T, Iwai K, Kobayashi S, Itoh H, Ozaki M, Ejiri J, Shiomi M, Inoue N, Kawashima S, Yokoyama M
Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.
Arterioscler Thromb Vasc Biol. 2002; 22 (12): 2049-53         < Abstract or Full paper >

504) Ishi I, Satoh H, Kawachi H, Jingami H, Matsuoka N, Ohmori S, Bujo H, Yamamoto T, Saito Y, Kitada M
Intimal smooth muscle cells up-regulated b-very low density lipoprotein-mediated cholesterol accumulation by enhancing b-very loe density lipoprotein uptake and decreasing cholesterol efflux.
Biochim Biophys Acta 2002; 1585: 30-38         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2003)

505)Brasen JH, Hakkinen T, Malle E, Beisiegel U, Yla-Herttuala S.
Patterns of oxidized epitopes, but not NF-kB expression, change during atherogenesis in WHHL rabbits.
Atherosclerosis. 2003 Jan; 166 (1): 13-21         < Abstract or Full paper >

506) Van Royen N, Hoefer I , Buschmann I , Kostin S , Voskuil M , Bode CH , Schaper W , Piek JJ
Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits.
Cardiovasc Res 2003 Jan; 57(1): 178-185         < Abstract or Full paper >

507) Worthley SG, Helft G, Fuster V, Fayad ZA, Shinnar M, Minkoff LA, Schechter C, Fallon JT, Badimon JJ
A novel nonobstructive intravascular MRI coil: in vivo imaging of experimental atherosclerosis.
Arterioscler Thromb Vasc Biol 2003 Feb; 23 (2): 346-350         < Abstract or Full paper >

508) Eto Y, Shimokawa H, Tanaka E, Morishige K, Fuchigami M, Ishiwata Y, Matsushima K, Takeshita A
Long-term treatment with propagermanium suppresses atherosclerosis in WHHL rabbits.
J Cardiovasc Pharmacol 2003 Feb; 41 (2): 171-177         < Abstract or Full paper >

509) Tanaka E, Shimokawa H, Kamiuneten H, Eto Y, Matsumoto Y, Morishige K, Koike G, Yoshinaga M, Egashira K, Tokunaga O, Shiomi M, Takeshita A
Disparity of MCP-1 mRNA and protein expressions between the carotid artery and the aorta in WHHL rabbits: one aspect involved in the regional difference in atherosclerosis.
Arterioscler Thromb Vasc Biol 2003 Feb; 23 (2): 244-250         < Abstract or Full paper >

510) Amano Y, Nishimoto T, Tozawa R, Ishikawa E, Imura Y, Sugiyama Y
Lipid-lowering effects of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia.
Eur J Pharmacol 2003 Apr; 466 (1-2): 155-161         < Abstract or Full paper >

511) Mollnau H, Schulz E, Daiber A, Baldus S, Oelze M, Auguat M, Wendt M, Walter U, Geiger C, Agrawal R, Kleschyov AL, Meinertz T, Munzel T
Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells.
Arterioscler Thromb Vasc Biol 2003 April; 23 (4): 615-621         < Abstract or Full paper >

512) Nielsen IL, Dragsted LO, Rav-Haren G, Freese R, Rasmussen SE
Absorption and excretion of black currant anthocyanins in humans and Watanabe heritable hyperlipidemic rabbits.
J Agric Food Chem 2003 Apr; 51 (9): 2813-2820         < Abstract or Full paper >

513) Shichiri M, Tanaka A, Hirata Y
Intravenous gene therapy for familial hypercholesterolemia using ligand-facilitated transfer of a liposome:LDL receptor gene complex.
Gene Ther 2003 May; 10 (9): 827-831         < Abstract or Full paper >

514) Suzuki H, Kobayashi H, Sato F, Yonemitsu Y, Nakashima Y, Sueishi K
Plaque-stabilizing effect of pitavastatin in Watanabe heritable hyperlipidemic (WHHL) rabbits.
J Atheroscler Thromb 2003 10 (2): 109-116         < Abstract or Full paper >

515) Shyu K, Chang H, Isner JM
Synergistic effect of angiopoietin-1 and vascular endothelial growth factor on neoangiogenesis in hypercholesterolemic rabbit model with acute hind limb ischemia.
Life Sci 2003; 73: 563-579         < Abstract or Full paper >

516) Shiomi M, Ito T, Yamada S, Kawashima S, Fan J
Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit).
Arterioscler Thromb Vasc Biol. 2003; 23 (7): 1239-1244         < Abstract or Full paper >

517) Tamura K, Kato Y, Ishikawa A, Kato Y, Himori M, Yoshida M, Takashima Y, Suzuki T, Kawabe Y, Cynshi O, Kodama T, Niki E, Shimizu M
Design and synthesis of 4,6-Di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherosclerotic antioxidants.
J Med Chem 2003; Jul; 46 (14): 3083-3093         < Abstract or Full paper >

518) Shiomi M, Fan J, Kawashima S
Relation of vulnerable plaque to development of myocardial infarction/ acute coronary syndromes - Lessons from an animal model of spontaneous myocardial infarction.
Commentary to the International Atherosclerosis Society, IAS Website. September 5, 2003         < Abstract or Full paper >

519) Barkhausen J, Ebert W, Heyer C, Debatin JF, Weinmann HJ
Detection of atherosclerotic plaque with gadofluorine-enhanced magnetic resonance imaging.
Circulation 2003; 108 (5): 605 - 609         < Abstract or Full paper >

520) Proctor SD, Mamo CL
Intimal retention of cholesterol derived from apolipoprotein B100- and apolipoprotein B48-containing lipoproteins in carotid arteries of Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 2003; 23 (9): 1595 - 1600         < Abstract or Full paper >

521) Pettersson K, Bergstrand H
The antiatherosclerotic effect of DiNAC: experimental findings supporting immunomodulation as a new treatment for atherosclerosis related diseases.
Cardiovasc Drug Rev 2003; 21 (2): 119-132         < Abstract or Full paper >

522) Dalsgaard T, Mortensen A, Larsen CR, Larsen JJ, Ottesen B
Long-term estradiol treatment improves VIP-mediated vasodilation in atherosclerotic proximal coronary arteries.
Regul Pept 2003; 116 (1-3): 155-162         < Abstract or Full paper >

523) Ishimoto Y, Yamada K, Yamamoto S, Ono T, Notoya M, Hanasaki K
Group V and X secretory phospholipase A(2)s-induced modification of high-density lipoprotein linked to the reduction of its antiatherogenic functions.
Biochim Biophys Acta 2003; 1642 (3): 129-138         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2004)

524) Daiber A, August M, Baldus S, Wendt M, Oelze M, Syndow K, Kleschyov AL, Munzel T
Measurement of NAD(P)H oxidase-derived superoxide with the luminal analogue L-012.
Free Radic Biol Med. 2004 Jan; 36(1): 101-111         < Abstract or Full paper >

525) Perings SM, Grubert N, Kleinbongard P, Reinecke P, Schulz R, Hermsen D, Willers R, Kelm M
Chronic treatment with fluvastatin improves smooth muscle dilatory function in genetically determined hyperlipoproteinemia.
J Cardiovasc Pharmacol. 2004 Feb; 43 (2): 183-190         < Abstract or Full paper >

526) Shishido T, Tasaki K, Takeishi Y, Takasaki S, Miyamoto T, Itoh M, Takahashi H, Kubota I, Ito T, Katano Y, Wakabayashi I, Tomoike H
Chronic hypertriglyceridemia in young Watanabe heritable hyperlipidemic rabbits impairs endothelial and medial smooth muscle function.
Life Sci. 2004 Feb; 74 (12): 1487-1501         < Abstract or Full paper >

527) Wajima T, Makita S, Oshima K
Effects of HR780, a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in Watanabe heritable hyperlipidemic rabbits and cholesterol-fed rabbits.
Pharmacology. 2004 Mar; 70 (3): 123-129         < Abstract or Full paper >

528) Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Liu G, Sun H, Watanabe T, Yamada N, Fan J
Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity.
J Biol Chem. 2004 Feb; 279 (9): 7521-7529         < Abstract or Full paper >

529) Yamaguchi Y, Matsuno S, Kagota S, Haginaka J, Kunitomo M
Peroxynitrite-mediated oxidative modification of low-density lipoprotein by aqueous extracts of cigarette smoke and the preventive effect of fluvastatin.
Atherosclerosis. 2004 Feb; 172 (2): 259-265         < Abstract or Full paper >

530) Kankkonen HM, Turunen MP, Hiltunen MO, Lehtolainen P, Koponen J, Leppanen P, Turunen AM, Yla-Herttuala S
Feline immunodeficiency virus and retrovirus-mediated adventitial ex vivo gene transfer to rabbit carotid artery using autologous vascular smooth muscle cells.
J Mol Cell Cardiol. 2004 Mar; 36 (3): 333-341         < Abstract or Full paper >

531) Yamada S, Ito T, Tamura T, Shiomi M
Age-related changes in serum/plasma biochemical parameters of WHHLMI rabbits.
Exp Anim. 2004 Apr; 53 (2): 159-163         < Abstract or Full paper >

532) Ohmori K, Yamada H, Yasuda A, Yamamoto A, Matsuura N, Kiniwa M
Effects of a novel antihyperlipidemic agent, S-2E, on the blood lipid abnormalities in homozygous WHHL rabbits.
Metabolism. 2004 May ;53(5): 680-685         < Abstract or Full paper >

533) Kankkonen HM, Vahakangas E, Marr RA, Pakkanen T, Laurema A, Leppanen P, Jalkanen J, Verma IM, Yla-Herttuala S
Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy.
Mol Ther. 2004 Apr; 9(4): 548-556         < Abstract or Full paper >

534) Jacobsson LS, Yuan XM, Zieden B, Olsson AG
Effects of a-tocopherol and astaxanthin on LDL oxidation and atherosclerosis in WHHL rabbits.
Atherosclerosis. 2004 Apr; 173(2): 231-237         < Abstract or Full paper >

535) Goto Y, Hogg JC, Shih CH, Ishii H, Vincent R, Van Eeden SF
Exposure to ambient particles accelerates monocyte release from the bone marrow in atherosclerotic rabbits.
Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1): L79-L85         < Abstract or Full paper >

536) Szeto A, Gonzales JA, Spitzer SB, Levine JE, Zaias J, Saab PG, Schneiderman N, McCabe PM
Circulating levels of glucocorticoid hormones in WHHL and NZW rabbits: circadian cycle and response to repeated social encounter.
Psychoneuroendocrinology 2004 Aug; 29(7): 861-866         < Abstract or Full paper >

537) Ogawa M, Ishino S, Mukai T, Asano D, Teramoto N, Watabe H, Kudomi N, Shiomi M, Magata Y, Iida H, Saji H
18F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study.
J Nucl Med. 2004 Jul; 45 (7): 1245-1250         < Abstract or Full paper >

538) Ito T, Yamada S, Shiomi M
Progression of coronary atherosclerosis relates to the onset of myocardial infarction in an animal model of spontaneous myocardial infarction (WHHLMI rabbits).
Exp Anim. 2004 Jul; 53 (4): 339-346         < Abstract or Full paper >

539) Shiomi M, Ito T, Yamada S, Kawashima S, Fan J
Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit).
J Atheroscler Thromb 2004 Sep; 11 (4): 184-189         < Abstract or Full paper >

540) Li W, Hellsten A, Jacobsson LS, Blomqvist HM, Olsson AG, Yuan XM
Alpha-tocopherol and astaxanthin decrease macrophage infiltration, apoptosis and vulnerability in atheroma of hyperlipidaemic rabbits.
J Mol Cell Cardiol 2004 Nov; 37 (5): 969-978         < Abstract or Full paper >

541) Allegri G, Ragazzi E, Costa CV, Caparrotta L, Biasiolo M, Comai S, Bertazzo A
Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits.
Clin Chim Acta 2004 Dec; 350 (1-2): 41-49         < Abstract or Full paper >

542) Shiomi M, Ito T, Hasegawa M, Yoshida K, Gould KL
Novel insights into coronary lumen preservation during progression of coronary atherosclerosis in coronary atherosclerosis-prone rabbits.
Coronary Artery Disease 2004 Nov; 15(7): 419-426         < Abstract or Full paper >

543) Li W, Hellsten A, Nyhalah JD, Yuan XM
Enhanced expression of natural resistance-associated macrophage protein 1 in atherosclerotic lesions may be associated with oxidized lipid-induced apoptosis.
Ann N Y Acad Sci 2004 Dec; 1030:202-207         < Abstract or Full paper >

544) Aliev G, Castellani RJ, Petersen RB, Burnstock G, Perry G, Smith MA
Pathobiology of familial hypercholesterolemic atherosclerosis.
J Submicrosc Cytol Pathol 2004; 36 (3-4): 225-240         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2005)

545) Tanaka T, Fukubaga Y, Itoh H, Doi K, Yamashita J, Chun TH, Inoue M, Masatsugu K, Saito T, Sawada N, Sakaguchi S, Arai H, Nakao K
Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration.
Eur J Pharmacol 2005 Jan; 508 (1-3): 255-265         < Abstract or Full paper >

546) Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Sun H, Watanabe T, Liu G, Fan J
Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase.
Cardiovasc Res 2005 Feb; 65(2): 524-534         < Abstract or Full paper >

547) Shiomi M, Yamada S, Ito T
Atheroma stabilizing effects of simvastatin due to depression of macrophages or lipid accumulation in the atheromatous plaques of coronary atherosclerosis-prone WHHL rabbits.
Atherosclerosis 2005 Feb; 178(2): 287-294         < Abstract or Full paper >

548) Shiomi M, Ito T
Anti-atherosclerotic effects of statins, Lessons from animal model of spontaneous atherosclerosis.
Commentary to the International Atherosclerosis Society IAS Website. March 23, 2005         < Abstract or Full paper >

549) Finne NIL, Elbol RS, Mortensen A, Ravn-Haren G, Ping MH, Knuthsen P, Fischer HB, McPhail D, Freese R, Breinholt V, Frandsen H, Dragsted LO
Anthocyanins increase low-density lipoprotein and plasma cholesterol and do not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits.
Mol Nutr Food Res 2005 Mar; 49 (4): 301-308         < Abstract or Full paper >

550) Gonzales JA, Szeto A, Mendez AJ, Zaias J, Paredes J, Caperton CV, Llabre MM, Levine JE, Goldberg RB, Schneiderman N, McCabe PM
Effects of behavioral interventions on insulin sensitivity and atherosclerosis in Watanabe heritable hyperlipidemic rabbit.
Psychosom Med 2005 Mar-Apr; 67 (2): 172-178         < Abstract or Full paper >

551) Ohno T, Ogawa K, Yano S, Fukushima M, Suzuki N, Asao T
Synthesis and structure-activity relationship of 4-substituted benzoic acids and their inhibitory effect on the biosynthesis of fatty acids and sterols.
Arch Pharm (Weiheim) 2005 Apr; 338 (4): 147-158         < Abstract or Full paper >

552) Liu Q, Chen ZQ, Bobustuc GC, McNatt JM, Segall H, Pan S, Willerson JT, Zoldhelyi P
Local gene transduction of cyclooxygenase-1 increases blood flow in injured atherosclerotic rabbit arteries.
Circulation 2005 Apr; 111 (14): 1833-1840         < Abstract or Full paper >

553) Gupta H, White CR, Handattu S, Garber DW, Datta G, Chaddha M, Dai L, Gianturco SH, Bradley WA, Anantharamaiah GM
Apolipoprotein E mimetic peptide dramatically lowers plasma cholesterol and restores endothelial function in Watanabe heritable hyperlipidemic rabbits.
Circulation 2005 Jun; 111 (23): 3112-3118         < Abstract or Full paper >

554) de Roos B, Caslake MJ, Milliner K, Benson GM, Suckling KE, Packard CJ
Characterization of the lipoprotein structure in the St. Thomas' mixed hyperlipidaemic (SMHL) rabbit.
Atherosclerosis 2005 Jul; 181 (1): 63-68         < Abstract or Full paper >

555) Tasaki K, Wakabayashi I, Shishido T, Takasaki S, Takeishi Y, Kubota I, Ito T, Katano Y, Kubota I
Diminution of angiotensin II-induced contraction of the abdominal aorta isolated from Watanabe heritable hyperlipidemic rabbits.
J Smooth Muscle Res 2005; 41 (2): 87-97         < Abstract or Full paper >

556) Kato M, Sada T, Mizuno M, Kitayama K, Inaba T, Koike H
Effect of combination treatment with an angiotensin II receptor antagonist and an HMG-CoA reductase inhibitor on atherosclerosis in genetically hyperlipidemic rabbits.
J Caridovasc Pharmacol 2005; 46 (4): 556-562         < Abstract or Full paper >

557) Sun H, Koike T, Ichikawa T, Hatakeyama K, Shiomi M, Zhang B, Kitajima S, Morimoto M, Watanabe T, Asada Y, Chen YE, Fan J
C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance.
Am J Pathol. 2005 Oct;167(4):1139-1148         < Abstract or Full paper >

558) Ito T, Yamada S, Tamura T, Shiomi M
Discrimination of recent ischemic myocardial changes in WHHLMI rabbits from the findings of postmortem degeneration.
Exp Anim. 2005 Oct; 54(5): 413-419         < Abstract or Full paper >

559) Rajamannan NM, Subramaniam M, Caira F, Stock SR, Spelsberg TC
Atorvastatin Inhibits Hypercholesterolemia-Induced Calcification in the Aortic Valves via the Lrp5 Receptor Pathway.
Circulation 2005; 112 (suppl I): I-229-I-234         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2006)

560) Nakano A, Kinoshita M, Okuda R, Yasuda T, Abe M, Shiomi M
Pathogenesis of tedious xanthoma: histopathological study of the extremities of Watanabe heritable hyperlipidemic rabbits.
J Orthop Sci. 2006 Jan; 11(1): 75-80         < Abstract or Full paper >

561) Hofnagel O, Luechtenborg B, Eschert H, Weissen-Plenz G, Severs NJ, Robenek H
Pravastatin inhibits expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in Watanabe heritable hyperlipidemic rabbits: a new pleiotropic effect of statins.
Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):604-610         < Abstract or Full paper >

562) Hasegawa H, Takano H, Ohtsuka M, Ueda K, Niitsuma Y, Qin Y, Tadokoro H, Shiomi M, Komuro I
G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbits.
Biochem Biophys Res Commun. 2006 May 26;344(1):370-376         < Abstract or Full paper >

563) Kouchi M, Ueda Y, Horie H, Tanaka K
Ocular lesions in Watanabe heritable hyperlipidemic rabbits.
Vet Ophthalmol. 2006 May-Jun; 9(3): 145-148         < Abstract or Full paper >

564) Wang YX, Kuribayashi H, Wagberg M, Holmes AP, Tessier JJ, Waterton JC
Gradient echo MRI characterization of development of atherosclerosis in the abdominal aorta in Watanabe heritable hyperlipidemic rabbits.
CardioVasc Intervent Radiol. 2006 Jul-Aug; 29 (4): 605-612         < Abstract or Full paper >

565) Kitayama K, Koga T, Maeda N, Inaba T, Fujioka T
Pactimibe stabilizes atherosclerotic plaque through macrophage acyl-CoA:cholesterol acyltransferase inhibition in WHHL rabbits.
Eur J Pharmacol. 2006 Jun 6; 539(1-2): 81-88         < Abstract or Full paper >

566) Herborn CU, Vogt FM, Lauenstein TC, Dirsch O, Corot C, Tobert P, Ruehm SG
Magnetic resonance imaging of experimental atherosclerotic plaque: Comparison of two ultrasmall superparamagnetic particles of iron oxide.
J Magn Reson Imagining. 2006 Aug; 24(2): 386-393         < Abstract or Full paper >

567) Pedersen SH, Nielsen LB, Mortensen A, Sheykhzade M, Nilas L, Ottesen B
Medroxyprogesterone acetate attenuates long-term effects of 17 b-estradiol in coronary arteries from hyperlipidemic rabbits.
Steroids. 2006 September; 71(9):834-842         < Abstract or Full paper >

568) Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumaki J, Laakso M, Herzig KH, Yla-Herttuala S
VEGF-A, VEGF-D, VEGF-F receptor-2, NF-kB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits.
FASEB J. 2006 Aug 25; 20: E1550-E1559         < Abstract or Full paper >

569) Paredes J, Szeto A, Levine JE, Zaias J, Gonzales JA, Mendez AJ, Llabre MM, Schneiderman N, McCabe PM
Social experience influences hypothalamic oxytocin in the WHHL rabbit.
Psychoneuroendocrinology 2006 Oct; 31 (9): 1062-1075         < Abstract or Full paper >

570) Oka K, Yasuhara M, Suzumura K, Tanaka K, Sawamura T
Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
J Cardiovasc Pharmacol. 2006 Oct;48(4):177-183         < Abstract or Full paper >

571) Ogawa M, Magata Y, Kato T, Hatano K, Ishino S, Mukai T, Shiomi M, Ito K, Saji H
Application of 18F-FDG PET for monitoring the therapeutic effect of antiinflammatory drugs on stabilization of vulnerable atherosclerotic plaques.
J Nucl Med. 2006 Nov;47(11):1845-1850         < Abstract or Full paper >

572) Priest AN, Ittrich H, Jahntz CL, Kooijman H, Weber C, Adam G
Investigation of atherosclerotic plaques with MRI at 3T using ultrasmall superparamagnetic particles of iron oxide.
Magn Reson Imaging. 2006 Dec;24(10):1287-1293         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2007)

573) Lund CO, Mortensen A, Nilas L, Breinholt VM, Larsen JL, Ottesen B
Estrogen and phytoestrogens: Effect on eNOS expression and in vitro vasodilation in cerebral arteries in ovariectomized Watanabe heritable hyperlipidemic rabbits.
Eur J Obstet Gynecol Reprod Biol. 2007 Jan; 12; 130(1) 84-92         < Abstract or Full paper >

574) Frederiksen H, Rasmussen SE, Schroder M, Bysted A, Jakobsen J, Frandsen H, Ravn-Haren G, Mortensen A
Dietary supplementation with an extract of lycopene-rich tomatoes does not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits.
Br J Nutr 2007 Jan; 97 (1) 6-1         < Abstract or Full paper >

575) Pettersson KS, Eliasson UB, Abrahamsson T, Wagberg M, Carrier M, Kengatharan KM
N,N-diacetyl-L-cystin improves endothelial function in atherosclerotic Watanabe heritable hyperlipidemic rabbits.
Basic Clin Pharmacol Toxicol. 2007 Jan; 100 (1): 36-42         < Abstract or Full paper >

576) Ishino S, Kuge Y, Takai N, Tamaki N, Strauss HW, Blankenberg FG, Shiomi M, Saji H
(99m)Tc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits.
Eur J Nucl Med Mol Imaging 2007 Jun; 34(6): 889-899         < Abstract or Full paper >

577) Broisat A, Riu LM, Ardisson V, Boturyn D, Dumy P, Fagret D, Ghezzi C
Molecular imaging of vascular cell adhesion molecule-1 expression in experimental atherosclerotic plaques with radiolabelled B2702-p.
Eur J Nucl Med Mol Imaging. 2007 Jan 12; 34:830-840         < Abstract or Full paper >

578) Ishino S, Mukai T, Kume N, Asano D, Ogawa M, Kuge Y, Minami M, Kita T, Shiomi M, Saji H
Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability-analysis in hypercholesterolemic rabbits.
Atherosclerosis. 2007(Nov); 195(1): 48-56         < Abstract or Full paper >

579) Wetterholm R, Caidahl K, Volkmann R, Brandt-Eliasson U, Fritsche-Danielson R, Gan LM
Imaging of atherosclerosis in WHHL rabbits using high-resolution ultrasound.
Ultrasound Med Biol. 2007 May; 33(5): 720-726         < Abstract or Full paper >

580) Meding J, Urich M, Licha K, Reinhardt M, Misselwitz B, Fayad ZA, Weinmann HJ
Magnetic resonance imaging of atherosclerosis by targeting extracellular matrix deposition with Gadofluorine M.
Contrast Media Mol Imaging 2007 May; 2 (3): 120-129         < Abstract or Full paper >

581) Frederiksen H, Mortensen A, Schroder M, Frandsen H, Bysted A, Knuthsen P, Rasmussen SE
Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Mol Nutr Food Res. 2007 May; 51 (5): 564-571         < Abstract or Full paper >

582) Tamura T, Ito T, Yamane K, Yamada S, Shiomi M
Relation of cranial abnormal growth to torticollis in WHHLMI rabbits.
J Exper Anim Technol 2007; 42 (1): 1-8 (in Japanese)           < Full paper > 

583) Kuge Y, Takai N, Ishino S, Temma T, Shiomi M, Saji H
Distribution profiles of membrane Type-1 matrix metalloproteinase (MT1-MMP), matrix metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) in rabbit atherosclerosis: comparison with plaque instability analysis.
Biol Pharm Bull 2007 Sep; 39(9):1634-1640         < Abstract or Full paper >

584) Steen H, Lima JA, Chatterjee S, Kolmakova A, Gao F, Rodriguez ER, Stuber M
High-resolution three-dimensional aortic magnetic resonance angiography and quantitative vessel wall characterization of different atherosclerotic stages in a rabbit model.
Invest Radiol. 2007 Sep;42(9):614-621         < Abstract or Full paper >

585) Iwata A, Miura S, Imaizumi B, Saku K
Measurement of atherosclerotic plaque volume in hyperlipidemic rabbit aorta by intravascular ultrasound.
J Cardiol 2007 Oct; 50(4): 229-234         < Abstract or Full paper >

586) Brasen JH, Leppanen O, Onkala M, Heikura T, Levin M, Ahrens F, Rupanen J, Pietsch H, Nergqvist D, Levonen AL, Basu S, Zeller T, Kloppel G, Laukkanen MO, Yla-herttuala S
Extracellular superoxide dismutase accelerates endothelial recovery and inhibits in-stent restenosis in stented atherosclerotic Watanabe heritable hyperlipidemic rabbit aorta.
J Am Coll Cardiol 2007 Dec; 50(23):2249-2253         < Abstract or Full paper >

587) Kitajima S, Jin Y, Koike T, Yu Y, Liu E. Shiomi M, Marcovina SM, Morimoto M, Watanabe T, Fan J
Lp(a) enhances coronary atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 2007; 193(2): 269-276         < Abstract or Full paper >

588) Worthley SG, Helft G, Corti R, Worthley MI, Chew DP, Fayad ZA, Zaman AG, Fallon JT, Fuster V, Badimon JJ
Statin therapy alone and in combination with an acyl-CoA:cholesterol O-acyltransferase inhibitor on experimental atherosclerosis.
Pathophysiol Haemaost Thromb 2007/2008; 36(1):9-17         < Abstract or Full paper >

589) Smith BR, Heverhagen J, Knopp M, Schmalbrock P, Shapiro J, Shiomi M, Moldovan NI, Ferrari M, Lee SC
Localization to atherosclerotic plaque and biodistribution of biochemically derivatized superparamagnetic iron oxide nanoparticles (SPIONs) contrast particles for magnetic resonance imaging (MRI).
Biomed Microdevices 2007; 9: 719?727.         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2008)

590) Yatera K, Hsieh J, Hogg JC, Tranfield E, Suzuki H, Shih CH, Nehzad AR, Vincent R, van Eden SF
Particulate matter air pollution exposeure promotes the recruitment of monocytes into atherosclerotic plaques.
Am J Physiol Heart Circ Physiol 2008 Feb; 294(2): H944-953         < Abstract or Full paper >

591) Pedersen SH, Nielsen LB, Mortensen A, Nilas L, Ottesen B
Progressions oppose the effects of estradiol on the endothelin-1 receptor type B in coronary arteries from ovariectomized hyperlipidemic rabbits.
Menopause 2008 May-Jul; 15(3): 503-510         < Abstract or Full paper >

592) Imanishi T, Ikejima H, Tsujioka H, Kuroi A, Kobayashi K, Muragaki Y, Mochizuki S, Goto M, Yoshida K, Akasaka T
Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability.
Hypertension 2008 Mar;51(3): 734-741         < Abstract or Full paper >

593) Nation DA, Gonzales JA, Mendez AJ, Zaias J, Szeto A, Brooks LG, Paredes J, D'Angola A, Schneiderman N, McCabe PM
The Effect of social environment on markers of vascular oxidative stress and inflammation in the Watanabe heritable hyperlipidemic rabbit.
Psychosom Med. 2008 Apr; 70(3): 269-275         < Abstract or Full paper >

594) Imanishi T, Kuroi A, Ikejima H, Kobayashi K, Muragaki Y, Mochizuki S, Goto M, Yoshida K, Akasaka T
Effects of angiotensin converting enzyme inhibitor and angiotensin II receptor antagonist combination on nitric oxide bioavailability and atherosclerotic change in Watanabe heritable hyperlipidemic rabbits.
Hypertens Res 2008 Mar; 31(3): 575-584         < Abstract or Full paper >

595) Ikejima H, Imanishi T, Tsujioka H, Kuroi A, Kobayashi K, Shiomi M, Muragaki Y, Mochizuki S, Goto M, Yoshida K, Akasaka T
Effects of telmisartan, a unique angiotensin receptor blocker with selective peroxisome proliferator-activated receptor-gamma-modulating activity, on nitric oxide bioavailability and atherosclerotic change.
J Hypertens 2008 May; 26(5):964-972         < Abstract or Full paper >

596) Shiomi M, Yamada S, Matsukawa A, Itabe H, Ito T
Invasion of atheromatous plaques into tunica media causes coronary outward remodeling in WHHLMI rabbits.
Atherosclerosis 2008; 198:287-293         < Abstract or Full paper >

597) Shiomi M, Yamada S, Amano Y, Nishimoto T, Ito T
Lapaquistat acetate, a squalene synthesis inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolemic rabbits into fibrous lesions.
Br J Pharmacol 2008; 154: 949-957         < Abstract or Full paper >

598) Ohtani H, Shingu T, ChayamaK, Hayashi K
Different role of macrophages and vascular smooth muscle cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic (WHHL) rabbit between aorta and coronary artery.
Hiroshima J Med Sci 2008 June; 57(2): 53-60         < Abstract or Full paper >

599) Imanishi T, Ikejima H, Tsujioka A, Kuroi A, Kobayashi K, Shiomi M, Muragaki Y, Mochizuki S, Goto M, Yoshida K, Akasaka T
Combined effects of an 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and angiotensin II receptor antagonist on nitric oxide bioavailability and atherosclerotic change in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits.
Hypertens Res 2008 June; 31 (6): 1199-1208         < Abstract or Full paper >

600) Ozegowski JH, Presselt N, Hartl A, Bocker T, Sanger J, Schmidt A, Willing K, Muller PJ
Anti-atherosclerotic effect of microbial hyaluronate lyase from group B streptococci.
Pharmazie 2008 Aug; 63(8): 601-605         < Abstract or Full paper >

601) Kuge Y, Kume N, Ishino S, Takai N, Ogawa Y, Mukai T, Minami M, Shiomi M, Saji H
Prominent lectin-like oxidized low density lipoprotein (LDL) receptor-1 (LOX-1) expression in atherosclerotic lesions is associated with tissue factor expression and apoptosis in hypercholesterolemic rabbits.
Biol Pharm Bull 2008 Aug; 31(8):1475-1482         < Abstract or Full paper >

602) Imanishi T, Tsujioka H, Ikejima H, Kuroi A, Takarada S, Kitabata H, Tanimoto T, Muragaki Y, Mochizuki S, Goto M, Yoshida K, Akasaka T
Renin inhibitor allskiren improve impaired nitric oxide bioavailability and protects against atherosclerotic changes.
Hypertension 2008 Sep; 52(3): 563-572         < Abstract or Full paper >

603) Ishino S, Mukai T, Kuge Y, Kume N, Ogawa M, Takai N, Kamihashi J, Shiomi M, Minami M, Kita T, Saji H
Targeting of lectin like oxidized low-density lipoprotein recptor-1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque.
J Nucl Med 2008 Oct; 49 (10): 1677-1685         < Abstract or Full paper >

604) Shiomi M, Fan J
Unstable coronary plaques and cardiac events in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits: questions and quandaries.
Curr Opin Lipidol 2008 Oct; 19 (6): 631-636         < Abstract or Full paper >

605) Sakr SW, Potter-Perigo S, Kinsella MG, Johnson PY, Braun KR, Goueffic Y, Rosenfeld ME, Wight TN
Hyaluronan accumulation is elevated in cultures of low density lipoprotein receptor-deficient cells and is altered by manipulation of cell cholesterol content.
J Biol Chem 2008 Dec; 283(52): 36195-36204         < Abstract or Full paper >

606) Oh J, Feldman MD, Kim J, Sanghi P. Do D, Mancusi JJ, Kemp N, Cilingiroglu M, Milner TE
Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography.
J Biomed Opt 2008 Sep; 13(5): 054006-1 - 054006-8         < Abstract or Full paper >

607) Yu Y, Koike T, Kitajima S, Liu E, Morimoto M, Shiomi M, Hatakeyama K, Asada Y, Wang KY, Sasaguri Y, Watanabe T, Fan J
Temporal and quantitative analysis of expression of metalloproteinases (MMPs) and their endogenous inhibitors in atherosclerotic lesions.
Histol Histopathol 2008 Dec; 23(12): 1503-1516         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2009)

608) Shiomi M, Ito T
The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: A tribute to the late Dr. Yoshio Watanabe.
Atherosclerosis 2009 Nov; 207 (1): 1-7         < Abstract or Full paper >

609) Shiomi M
Rabbit as a Model for the Study of Human Diseases.
In Houdebine LM, Fan J eds. Rabbit Biotechnology: Rabbit genomics, transgenesis, cloning and models . Springer Science + Buisiness Media.(New York, USA), 49-64 (2009)         < Abstract or Full paper >

610) Schroder M, Fricke C, Pilegaard K, Poulsen M, Wester I, Lutjohann D, Mortensen A
Effect of rapeseed oil-derived plant sterol and stanol esters on atherosclerosis parameters in cholesterol-challenged heterozygous Watanabe Heritable Hyperlipidemic rabbits.
Br J Nutr 2009 Sep 22: 1-12         < Abstract or Full paper >

611) Zhang C, Jin Y, Liu T, Liu F, Ito T
Hypertriglyceridemia in Watanabe heritable hyperlipidemic rabbits was associated with increased production and reduced catabolism of very-low-density lipoproteins.
Pathobiology 2009 Nov; 76 (6): 315-321         < Abstract or Full paper >

612) Ohkawara H, Ishibashi T, Shiomi M, Sugimoto K, Uekita H, Kamioka M, Takuwa Y, Teramoto T, Maruyama Y, Takeishi Y
RhoA and Rac1 changes in the stherosclerotic lesions of WHHLMI rabbits.
J Atheroscler Thromb 2009 Dec; 16 (6): 846-856         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2010)

613) Heroux J, Gharib AM, Danthi NS, Cecchini S, Ohayon J, Pettigrew RI
High-affinity avb3 integrin targeted optical probe as a new imaging biomarker for early atherosclerosis: initial studies in Watanabe rabbits.
Mol Imaging Biol 2010; 12(1): 2-8         < Abstract or Full paper >

614) Ying Z, Kherada N, Farrar B, Kampfrath T, Chung Y, Simonetti O, Deiuliis J, Desikan R, Khan B, Villamena F, Sun Q, Parthasarathy S, Rajagopalan S
Lipoic acid effects on established atherosclerosis.
Life Sci. 2010; 86: 95-102         < Abstract or Full paper >

615) Cui X, Kushiyama A, Yoneda M, Nakatsu Y, Guo Y, Zhang J, Ono H, Kanna M, Sakoda H, Ono H, Kikuchi T, Fujishiro M, Shiomi M, Kamata H, Kurihara H, Kikuchi M, Kawazu S, Nishimura F, Asano T
Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy.
Diabetes Res Clin Pract 2010 Jan; 87(1): 57-63         < Abstract or Full paper >

616) Yoshida M, Masunaga K, Nagata T, Satoji Y, Shiomi M
The effects of chronic hyperlipidemia on bladder function in myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits.
Neurorol Urodyn 2010 Sep;29 (7):1350-1354         < Abstract or Full paper >

617) Ko AC, Ridsdale A, Smith MS, Mostaco-Guidolin LB, Hewko MD, Pegoraro AF, Kohienberg EK, Schattka B, Shiomi M, Stolow A, Sowa MG
Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits.
J Biomed Opt 2010 Mar-Apr; 15(2):020501-020503         < Abstract or Full paper >

618) Roy H, Bhardwaj S, Babu M, Lahteenvuo JE, Yla-Hertuala S
VEGF-D NC mediated angiogenesis in skeletal muscles of diabetic WHHL rabbits.
Eur J Clin Invest 2010 May; 40(5): 422-432         < Abstract or Full paper >

619) Kuge Y, Takai N, Ogawa Y, Temma T, Zhao Y, Nishigori K, Ishino S, Kamihashi J, Kiyono Y, Shiomi M, Saji H
Imaging with radiolabelled anti-membrane type-1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques.
Eur J Nucl Med Mol Imaging 2010 Jul; 37(11):2093-2104         < Abstract or Full paper >

620) Walton BL, Leja M, Vickers KC, Estevez-Femandez M, Sanguino A, Wang E, Clubb FJ Jr, Morrisett J, Lopez-Beresterin G
Delivery of negatively charged liposomes into the atheromas of Watanabe heritable hyperlipidemic rabbits.
Vasc Med 2010 Aug; 15(4): 307-313         < Abstract or Full paper >

621) Tranfield EM, van Eeden SF, Yatera K, Hogg JC, Walker DC
Ultrastructual changes in atherosclerotic plaques following the instillation of airborne particulate matter into the lungs of rabbits.
Can J Cardiol 2010 Jul; 26(7): e258-269         < Abstract or Full paper >

622) Nitta-Seko A, Nitta N, Shiomi M, Sonoda A, Ota S, Tsuchiya K, Takahashi M, Fujimiya M, Murata K
Utility of contrast-enhanced ultrasonography for qualitative imaging of atherosclerosis in Watanabe heritable hyperlipidemic rabbits: initial experimental study.
Jpn J Radiol 2010 Nov; 28(9): 656-662         < Abstract or Full paper >

623) Temma T, Ogawa Y, Kuge Y, Ishino S, Takai N, Nishigori K, Shiomi M, Ono M, Saji H
Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model.
J Nucl Med 2010; 51: 1979-1986         < Abstract or Full paper >

624) Popescu DP, Flueraru C, Mao Y, Chang S, Sowa MG
Signal attenuation and box-counting fractal analysis of optical coherence tomography images of arterial tissue.
Biomed Opt Express. 2010 Jul 26;1(1):268-277         < Abstract or Full paper >

625) Hazama H, Ishi K, Awazu K
Less-invasive laser therapy and diagnosis using a tabletop mid-infrared tunable laser.
Journal of Innovative Optical Health Science. 2010; 3(4): 285-292         < Abstract or Full paper >

626) Mostaco-Guidolin LB, Sowa MG, Ridsdale A, Pegoraro AF, Smith MS, Hewko MD, Kohlenberg EK, Schattka B, Shiomi M, Stolow A, Ko AC
Differentiating atherosclerotic plaque burden in arterial tissues using femtosecond CARS-based multimodal nonlinear optical imaging.
Biomed Opt Express. 2010 Jul 14;1(1):59-73         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2011)

627) Okura H, Saga A, Fumimoto Y, Soeda M, MoriyamaM, Moriyama H, Nagai K, Lee CM, Yamashita S, Ichinose A, Hayakawa T, Matsuyama A
Transplantation of human adipose tissue-derived multiline age progenitor cells reduces serum cholesterol in hyperlipidemic Watanabe rabbits.
Tissue Eng Part C Methods 2011 Jan; 17(2): 145-154         < Abstract or Full paper >

628) Kamioka M, Ishibashi T, Ohkawara H, Nagai R, Sugimoto K, Uekita H, Matsui T, Yamagishi S, Ando K, Sakamoto T, Sakamoto N, Takuwa Y, Wada I, Shiomi M, Maruyama Y, Takeishi Y
Involvement of membrane type 1-matrix metalloproteinase (MT1-MMP) in RAGE activation signaling pathways.
J Cell Physiol. 2011 Jun;226(6):1554-1563         < Abstract or Full paper >

629) Ooga T, Sato H, Nagashima A, Sasaki K, Tomita M, Soga T, Ohashi Y
Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia.
Mol Biosyst. 2011 Apr;7(4):1217-1223         < Abstract or Full paper >

630) Kobayashi T, Ito T, Shiomi M
Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseases.
J Biomed Biotechnol. 2011;2011:406473: 1-10         < Abstract or Full paper >

631) Iwata A, Miura SI, Zhang B, Imaizumi S, Uehara Y, Shiomi M, Saku K
Antiatherogenic effects of newly developed apolipoprotein A-I mimetic peptide/phospholipid complexes against aortic plaque burden in Watanabe-heritable hyperlipidemic rabbits.
Atherosclerosis. 2011; 218(2): 300-307         < Abstract or Full paper >

632) Takahashi S, Ito T, Zenimaru Y, Suzuki J, Miyamori I, Takahashi M, Takahashi M, Ishida T, Ishida T, Hirata K, Yamamoto TT, Iwasaki T, Hattori H, Shiomi M
Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression.
Biochem Biophys Res Commun. 2011 Apr 22;407(4):656-662         < Abstract or Full paper >

633) Saga A, Okura H, Soeda M, Tani J, Fumimoto Y, Komoda H, Moriyama M, Moriyama H, Yamashita S, Ichinose A, Daimon T, Hayakawa T, Matsuyama A
HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multiline age progenitor cells in hyperlipidemic homozygous Watanabe rabbits.
Biochem Biophys Res Commun. 2011 Aug 19;412(1):50-54         < Abstract or Full paper >

634) Ying Z, Kherada N, Kampfrath T, Mihai G, Simonetti O, Desikan R, Selvendiran K, Sun Q, Ziouzenkova O, Parthasarathy S, Rajagopalan S
A modified sesamol derivative inhibits progression of atherosclerosis.
Arterioscler Thromb Vasc Biol. 2011; 31: 536-542         < Abstract or Full paper >

635) Mostaco-Guidolin LB, C-T Ko A, Popescu DP, Smith MSD, Kohlenberg EK, Shiomi M, Major A, Sowa MG
Evaluation of texture parameters for the quantitative description of multimodal nonlinear optical images from atherosclerotic rabbit arteries.
Phys. Med. Biol. 56 (2011) 5319?5334         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2012)

636) Aboshady I, Cody DD, Johnson EM, Gahremanpour A, Vela D, Khalil KG, Dupont HL, Willerson JT, Buja LM, Gladish GW
Flat-panel versus 64-channel computed tomography for in vivo quantitative characterization of aortic atherosclerotic plaques.
Int J Cardiol. 2012; 156: 295-302         < Abstract or Full paper >

637) Lupia E, Zheng F, Grosjean F, Tack I, Doublier S, Elliot SJ, Vlassara H, Striker GE
Pentosan polysulfate inhibits atherosclerosis in Watanabe heritable hyperlipidemic rabbits: differential modulation of metalloproteinase-2 and -9.
Lab Invest. 2012 Feb; 92 (2):236-245         < Abstract or Full paper >

638) Zhang J, Yu Y, Nakamura K, Koike T, Waqar AB, Zhang X, Liu E, Nishijima K, Kitajima S, Shiomi M, Qi Z, Yu J, Graham MJ, Crooke RM, Ishida T, Hirata K, Hurt-Camejo E, Chen YE, Fan J
Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits.
J Atheroscler Thromb. 2012;19(3):213-226         < Abstract or Full paper >

639) Shiomi M, Kobayashi T, Kuniyoshi N, Yamada S, Ito T
Myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits with mesenteric fat accumulation are a novel animal model for metabolic syndrome.
Pathobiology, 2012;79(6):329-338         < Abstract or Full paper >

640) Tsuchiya K, Nitta N, Sonoda A, Nitta-Seko A, Ohta S,Takahashi M, Murata K, Mukaisho K, Shiomi M, Tabata Y, Nohara S
Evaluation of atherosclerotic lesions using dextran- and mannan-dextran-coated USPIO: MRI analysis and pathological findings.
International Journal of Nanomedicine 2012; 7:2271-2280         < Abstract or Full paper >

641) Kobayashi K, Ito T, Yamada S, Kuniyoshi N, Shiomi M
Electrocardiograms corresponding to the development of myocardial infarction in anesthetized WHHLMI rabbits (Oryctolagus cuniculus), an animal model for familial hypercholesterolemia.
Comp Med 2012; 62 (5):409-418         < Abstract or Full paper >

642) Wang B, Karpiouk A, Yeager D, Amirian J, Litovsky S, Smalling R, Emelianov S
In vivo intravascular ultrasound-guided photoacoustic imaging of lipid in plaques using an animal model of stherosclerosis.
Ultrasound Med Biol. 2012; 38(12): 2098-2103         < Abstract or Full paper >

643) Shiomi M, Koike T, Ishida T
Genetically Modified Animal Models for Lipoprotein Research.
In Frank S, Kostner G eds. Lipoproteins - Role in Health and Diseases. InTechopen.com.(University Campus STeP Ri, Rijeka, Croatia), 2012, Chapter 22, pp 533-560         < Abstract or Full paper >

644) Eisenbrey JR, Sridharan A, deMuinck ED, Doyley MM, Forsberg F
Parametric subharmonic imaging using a commercial intravascular ultrasound scanner, An in vivo feasibility study.
J Ultrasound Med 2012; 31(3): 361-371         < Abstract or Full paper >

645) Yoshida M, Kudoh J, Masunaga K, Nagata T, Shiomi M
Effects of chronic hyperlipidemia on lower urinary tract function - Bladder Dysfunction in myocardial infarction-prone Watanabe heritable hyperlipidemic Rabbits.
Lower Urinary Tract Symptomms 2012; 4: 21-26         < Abstract or Full paper >

646) Goulinet-Mainot S, Tranchart H, Groyer-Picard MT,Lainas P, Diop PS, Holopherne D, Gonin P,Benihoud K, Ba N, Gauthier O, Franco D, Guettier C,Pariente D, Weber A, Dagher I, Nguyen TH
Improved Hepatocyte Engraftment After Portal Vein Occlusion in LDL Receptor-Deficient WHHL Rabbits and Lentiviral-Mediated Phenotypic Correction In Vitro
Cell Medicine 2012; 4: 85-98         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2013)

647) Nishigori K, Temma T, Yoda K, Onoe S, Kondo N, Shiomi M, Ono M, Saji H
Radioiodinated peptide probe for selective detection of oxidized low density lipoprotein in atherosclerotic plaques.
Nucl Med Biol. 2013 Jan;40(1):97-103         < Abstract or Full paper >

648) Sridharan A, Eisenbrey JR, Machado P, Demuinck ED, Doyley MM, Forsberg F
Delineation of atherosclerotic plaque using subharmonic imaging filtering techniques and a commercial intravascular ultrasound system.
Ultrason Imaging. 2013 Jan;35(1):30-44         < Abstract or Full paper >

649) Szeto A, Rossetti MA, Mendez AJ, Noller CM, Herderick EE, Gonzales JA, Schneiderman N, McCabe PM
Oxytocin administration attenuates atherosclerosis and inflammation in Watanabe Heritable Hyperlipidemic rabbits.
Psychoneuroendocrinology. 2013 May; 385(5): 685-693.         < Abstract or Full paper >

650) Kawachi E, Uehara Y, Hasegawa K, Yahiro E, Ando S, Wada Y, Yano T, Nishikawa H, Shiomi M, Miura S, Watanabe Y, Saku K
Novel Molecular Imaging of Atherosclerosis With Gallium-68-Labeled Apolipoprotein A-I Mimetic Peptide and Positron Emission Tomography.
Circ J 2013 May 24; 77(6) 1482-1489.         < Abstract or Full paper >

651) Hasimura K, Ishii K, Akikusa N, Edamura T, Yoshida H, Awazu K
Selective ablation of WHHLMI rabbit atherosclerotic plaque by quantum cascade laser in the 5.7 mm wave length range for less-invasive laser angioplasty.
Proc. SPIE 8803, Medical Laser Applications and Laser-Tissue Interactions VI, 880301 (June 24, 2013)         < Abstract or Full paper >

652) Ueba H, Shiomi M, Brines M, Yamin M, Kobayashi T, Ako J, Momomura SI, Cerami A, Kawakami M
Suppression of coronary atherosclerosis by helix B surface peptide, a nonerythropoietic, tissue-protective compound derived from erythropoietin.
Mol Med. 2013 May 1. 19: 195-202.         < Abstract or Full paper >

653) Mostaco-Guidolin LB, Ko AC, Wang F, Xiang B, Hewko M, Tian G, Major A, Shiomi M, Sowa MG
Collagen morphology and texture analysis: from statistics to classification.
Sci Rep. 2013 Jul 12;3:2190         < Abstract or Full paper >

654) Shiomi M, Koike T, Ito T
Contribution of the WHHL rabbit, an animal model of familial hypercholesterolemia, to elucidation of the anti-atherosclerotic effects of statins.
Atherosclerosis 2013 Nov; 213(1): 39-47.         < Abstract or Full paper >

655) Tsuchiya K, Nitta N, Sonoda A, Otani H, Takahashi M, Murata K, Shiomi M, Tabata Y, Nohara S
Atherosclerotic imaging using 4 types of superparamagnetic iron oxides: New possibilities for mannan-coated particles.
Eur J Radiol. 2013 Nov; 82(11): 1919-1925         < Abstract or Full paper >

656) Shiomi M, Ishida T, Kobayashi T, Nitta N, Sonoda A, Yamada S, Koike T, Kuniyoshi N, Murata K, Hirata KI, Ito T, Libby P
Vasospasm of Atherosclerotic Coronary Arteries Precipitates Acute Ischemic Myocardial Damage in Myocardial Infarction-Prone Strain of the Watanabe Heritable Hyperlipidemic Rabbits.
Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11): 2518-2523         < Abstract or Full paper >

Bibliography of WHHL rabbits


(2014)

657) Ishino S, Ogawa M, Mori I, Nishimura S, Ikeda S, Sugita T, Oikawa T, Horiguchi T, Magata Y
18F-FDG PET and intravascular ultrasonography (IVUS) images compared with histology of atherosclerotic plaques: 18F-FDG accumulates in foamy macrophages.
Eur J Nucl Med Mol Imaging (2014) 41:624-633           < Abstract or Full paper > 

658) Ogawa M, Umeda IO, Kosugi M, Kawai A, Hamaya Y, Takashima M, Yin H, Kudoh T, Seno M, Magata Y
Development of 111In-Labeled Liposomes for Vulnerable Atherosclerotic Plaque Imaging.
J Nucl Med. 2014;55:115-120.           < Abstract or Full paper > 

659) Li S, Liang J, Niimi M, Waqar AB, Kang D, Koike T, Wang Y, Shiomi M, Fan J
Probucol Suppresses Macrophage Infiltration and MMP Expression in Atherosclerotic Plaques of WHHL Rabbits.
J Atheroscler Thromb 2014           < Abstract or Full paper > 

660) Yu Q, Kiu Z, Waqar AB, Ning B, Yang X, Shiomi M, Graham MJ, Crooke RM, Liu E, Dong S, Fan J.
Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL rabbits.
Mediators of Infarlammation 2014; 2014: 979132           < Abstract or Full paper > 

661) Mostaco-Guidolin LB, Kohlenberg EK, Smith M, Hewko M, Major A, Sowa MG, Ko ACT.
Quantitative Nonlinear Optical Assessment of Atherosclerosis Progression in Rabbits.
Anal Chem 2014; 86: 6346-6354           < Abstract or Full paper > 

662) Iwaki S, Hokamura K, Ogawa M, Takehara Y, Muramatsu Y, Yamane T, Hirabayashi K, Morimoto Y, Hagisawa K, Nakahara K, Mineno T, Terai T, Komatsu T, Ueno T, Tamura K, Adachi Y, Hirata Y, Arita M, Arai H, Umemura K, Nagano T, Hanaoka K.
A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques.
Org Biomol Chem. 2014 Oct 15;12(43):8611-8           < Abstract or Full paper > 

663) Fang C, Ning B, Waqar AB, Niimi M, Li S, Satoh K, Shiomi M, Ye T, Dong S, Fan J
Bisphenol A Exposure Enhances Atherosclerosis in WHHL Rabbits.
PLOS One 2014; 9: e110977           < Abstract or Full paper > 

664) Kee P, Bagalkot V, Johnson E, Danila D.
Noninvasive detection of macrophages in atheroma using a radiocontrast-loaded phosphatidylserine-containing liposomal contrast agent for computed tomography.
Mol Imaging Biol. 2015 Jun;17(3):328-36           < Abstract or Full paper > 

Bibliography of WHHL rabbits


(2015)

665) Fan J, Kitajima S, Watanabe T, Xu J, Zhang J, Liu E, Chen YE.
Rabbit models for the study of human atherosclerosis: From pathophysiological mechanisms to translational medicine.
Pharmacol Ther. 2015 Feb; 146: 104-119.           < Abstract or Full paper > 

666) Zhao Y, Fukao K, Zhao S, Watanabe A, Hamada T, Yamasaki K, Shimizu Y, Kubo N, Ukon N, Nakano T, Tamaki N, Kuge Y.
Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by 18F-Fluorodeoxyglucose Positron Emission Tomography.
Mol Imaging. 2015 Mar 1;14(0):1-8.           < Abstract or Full paper > 

667) Fang C, Ning B, Waqar AB, Niimi M, Li S, Satoh K, Shiomi M, Ye T, Dong S, Fan J.
Bisphenol A exposure induces metabolic disorders and enhances atherosclerosis in hyperlipidemic rabbits.
J Appl Toxicol. 16 APR 2015 | DOI: 10.1002/jat.3154           < Abstract or Full paper > 

668) Kim B, Yang J, Lee YH, Kim MH, Heo D, Lee E, Suh JS, Haam S, Huh YM.
Compensatory UTE/T2W Imaging of Inflammatory Vascular Wall in Hyperlipidemic Rabbits.
PLoS One. 2015 May 15;10(5):e0124572.           < Abstract or Full paper > 

669) Brinkmann SJ, Worner EA, Buijs N, Richir M, Cynober L, van Leeuwen PA, Couderc R.
The Arginine/ADMA Ratio Is Related to the Prevention of Atherosclerotic Plaques in Hypercholesterolemic Rabbits When Giving a Combined Therapy with Atorvastatine and Arginine.
Int J Mol Sci. 2015 May 29;16(6):12230-42.           < Abstract or Full paper > 

670) Zhang G, Chen Y, BilalWaqar A, Han L, Jia M, Xu C, Yu Q.
Quantitative analysis of rabbit coronary atherosclerosis. Practical techniques utilizing open-source software.
Anal Quant Cytopathol Histpathol. 2015 Apr;37(2):115-22.           < Abstract or Full paper > 

671) Kaneko C, Nitta N, Tsuchiya K, Watanabe S, Nitta-Seko A, Ohta S, Otani H, Sonoda A, Murata K, Shiomi M.
MRI study of atherosclerotic plaque progression using ultrasmall superparamagnetic iron oxide in Watanabe heritable hyperlipidemic rabbits.
Br J Radiol. 2015 Jul 8:20150167           < Abstract or Full paper > 

672) Takeda H, Koike T, Izumi Y, Yamada T, Yoshida M, Shiomi M, Fukusaki E, Bamba T.
Lipidomic analysis of plasma lipoprotein fractions in myocardial infarction-prone rabbits.
J Biosci Bioeng. 2015 Jul 7. pii: S1389-1723(15)00093-6           < Abstract or Full paper > 

673) Ning B, Wang X, Yu Y, Waqar AB, Yu Q, Koike T, Shiomi M, Liu E, Wang Y, Fan J.
High-fructose and high-fat diet-induced insulin resistance enhances atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Nutr Metab (Lond). 2015 Aug 12;12:30.           < Abstract or Full paper > 

674) Hashimura K, Ishii K, Awazu K.
Selective removal of atherosclerotic plaque with a quantum cascade laser in the 6.7micro-m wavelength range.
Jap J Appl Physics. 2015; 54:112701-1-112701-6.           < Abstract or Full paper > 

Bibliography of WHHL rabbits


(2016)

675) Hashimura K, Ishii K, Awazu K.
Selective ablation of atherosclerotic lesions with less thermal damage by controlling the pulse structure of a quantum cascade laser in the 5.7micro-m wavelength range.
Opt Rev. 2016;23: 299-306.           < Abstract or Full paper > 

676) Haruta H, Hiro T, Mitsumata M, Takayama T, Sudo M, Li Y, Takahashi R, Taniguchi Y, Shiomi M, Hirayama A.
Stabilization of atherosclerotic plaque by pitavastatin in Watanabe heritable hyperlipidemic rabbits: A serial tissue-characterizing intravascular ultrasound study.
J Cardiol. 2015 Jul 17. pii: S0914-5087(15)00142-2.           < Abstract or Full paper > 

677) Li S, Wang YN, Niimi M, Ning B, Chen Y, Kang D, Waqar AB, Wang Z, Yu Q, Liu E, Zhang J, Shiomi M, Chen YE, Fan J.
Angiotensin II Destabilizes Coronary Plaques in Watanabe Heritable Hyperlipidemic Rabbits.
Arterioscler Thromb Vasc Biol. 2016 May;36(5):810-6.           < Abstract or Full paper > 

678) Chihara H, Oishi N, Ishii A, Munemitsu T, Arai D, Ikeda H, Miyamoto S.
In vivo detection of atherosclerotic plaque using non-contact and label-free near-infrared hyperspectral imaging.
Atherosclerosis. 2016 Jul;250:106-13.           < Abstract or Full paper > 

679) Wang Z, Zhang J, Li H, Li J, Niimi M, Ding G, Chen H, Xu J, Zhang H, Xu Z, Dai Y, Gui T, Li S, Liu Z, Wu S, Cao M, Zhou L, Lu X, Wang J, Yang J, Fu Y, Yang D, Song J, Zhu T, Li S, Ning B, Wang Z, Koike T, Shiomi M, Liu E, Chen L, Fan J, Chen YE, Li Y.
Hyperlipidemia-associated gene variations and expression patterns revealed by whole-genome and transcriptome sequencing of rabbit models.
Sci Rep. 2016 Jun 1;6:26942.           < Abstract or Full paper > 

680) Tissier F, Mallem Y, Goanvec C, Didier R, Aubry T, Bourgeois N, Desfontis JC, Dubreuil M, Le Grand Y, Mansourati J, Pichavant-Rafini K, Plee-Gautier E, Roquefort P, Theron M, Gilard M.
A non-hypocholesterolemic atorvastatin treatment improves vessel elasticity by acting on elastin composition in WHHL rabbits.
Atherosclerosis. 2016 May 26;251:70-77.           < Abstract or Full paper 4> 

681) Koike T, Tamura S, Yu Y, Kuniyoshi N, Shiomi M.
High susceptibility of atherosclerotic coronary arteries to the onset of vasospasm and angina pectoris-like symptoms due to coronary spasm in WHHLMI rabbits.
Exp Anim. 2016 Nov 1; 65(4): 419-426 .           < Abstract or Full paper > 

682) Iwaki T, Mizuma H, Hokamura K, Onoe H, Umemura K.
[18F]FDG Uptake in the Aortic Wall Smooth Muscle of Atherosclerotic Plaques in the Simian Atherosclerosis Model.
Biomed Res Int. 2016;2016:8609274. doi: 10.1155/2016/8609274          < Abstract or Full paper > 

683) Noller CM, Boulina M, McNanara G, Szeto A, McCabe PM, Mendez AJ.
A Practical Approach to Quantitative Processing and Analysis of Small Biological Structures by Fluorescent Imaging.
Journal of Biomolecular Techniques 2016; 27:90?97

  < Abstract or Full paper > 

Bibliography of WHHL rabbits


(2017)

684) Noller CM, Mendez AJ, Szeto A, Boulina M, Llabre MM, Zaias J, Schneiderman N, McCabe PM.
Structural Remodeling of Sympathetic Innervation in Atherosclerotic Blood Vessels: Role of Atherosclerotic Disease Progression and Chronic Social Stress. in WHHLMI rabbits.
Psychosom Med. 2017 Jan;79(1):59-70.          < Abstract or Full paper > 

685) Yamada S, Koike T, Nakagawa T, Kuniyoshi N, Ying Y, Itabe H, Yamashita A, Asada Y, Shiomi M.
Morphological features of coronary plaques in WHHLMI rabbits (Oryctolagus cuniculus), an animal model for familial hypercholesterolemia.
Exp Anim. 2017; 66 (2): 145-157          < Abstract or Full paper > 

686) Sasaki T, Kobayashi K, Kita S, Kojima K, Hirano H, Shen L, Takenaka F, Kumon H, Matsuura E.
In vivo distribution of single chain variable fragment (scFv) against atherothrombotic oxidized LDL/2-glycoprotein I complexes into atherosclerotic plaques of WHHL rabbits: Implication for clinical PET imaging.
Autoimmun Rev. 2017 Feb;16(2):159-167          < Abstract or Full paper > 

687) Takahashi S.
Triglyceride Rich Lipoprotein -LPL-VLDL Receptor and Lp(a)-VLDL Receptor Pathways for Macrophage Foam Cell Formation
J Atheroscler Thromb. 2017 Jun;24(6):552-559.          < Abstract or Full paper > 

688) Takeda H, Izumi Y, Tomita A, Koike T, Shiomi M, Fukusaki E, Matsuda F, Bamba T.
Lipoprotein profiling methodology based on determination of apolipoprotein concentration.
Bioanalysis. 2017 Jan;9(1):9-19.          < Abstract or Full paper > 

689) Sudo M, Li Y, Hiro T, Takayama T, Mitsumata M, Shiomi M, Sugitani M, Matsumoto T, Hao H, Hirayama A.
Inhibition of plaque progression and promotion of plaque stability by glucagon-like peptide-1 receptor agonist: Serial in vivo findings from iMap-IVUS in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis. 2017 Oct;265:283-291.          < Abstract or Full paper > 


Bibliography of WHHL rabbits


(2018)

690)Tamura S, Koike Y, Takeda H, Koike T, Izumi Y, Nagasaka R, Tsunoda T, Tori M, Ogawa K, Bamba T, Shiomi M.
Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits).
Eur J Pharmacol. 2018 Feb 1;822:147-153.           < Abstract or Full paper > 

691)Li J, Yao Q, Feng F, He S, Lin P, Yang L, Yang C, Li H, Li Y.
Systematic identification of rabbit LncRNAs reveals functional roles in atherosclerosis.
Biochim Biophys Acta. 2018 Jan 6. pii: S0925-4439(18)30001-2. [Epub ahead of print]          < Abstract or Full paper > 

692)Nagasaka R, Koike T, Tsukada N, Tamura S, Shiomi M.
The Coronary Artery Running Pattern is One of the Causes of Individual Differences in the Progression of Coronary Atherosclerosis in WHHLMI Rabbits, an Animal Model for Coronary Atherosclerosis.
J Atheroscler Thromb. 2017 Nov 1. [Epub ahead of print]          < Abstract or Full paper > 


Bibliography of WHHL rabbits