Bibliography of WHHL rabbits


1991 - 2000


Papers before 1991


(1991)

176) Havel RJ, Shames DM
Kinetic studies of the origin of apolipoprotein (Apo) B-100 in low density lipoproteins of normal and Watanabe heritable hyperlipidemic (WHHL) rabbits.
Adv Exp Med Biol 1991; 285: 245-255

177) Gross PL, Rand ML, Barrow DV, Packman MA
Platelet function in Watanabe heritable hyperlipidemic rabbits: Decreased sensitivity to thromboxane A2.
Arterioscler Thromb 1991; 11: 610-616

178) O'Brien K, Nagano Y, Gown A, Kita T, Chait A
Probucol treatment affects the cellular composition but not anti-oxidized low density lipoprotein immunoreactivity of plaques from Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb 1991; 11: 751-759

179) Stewart-Lee AL, Burnstock G
Changes in vasoconstrictor and vasodilator responses of the basilar artery during maturation in the Watanabe heritable hyperlipidemic rabbit differ from those in the New Zealand white rabbit.
Arterioscler Thromb 1991; 11: 1147-1155

180) Mao SJT, Yates MT, Parker RA, Chi EM, Jackson RL
Attenuation of atherosclerosis in a modified strain of hypercholesterolemic Watanabe rabbits with use of a probucol analogue (MDL29, 311) that does not lower serum cholesterol.
Arterioscler Thromb 1991; 11: 1266-1275

181) Demacker PNM, Staels B, Stalenhoef AFH, Auwerx J
Increased removal of b-very low density lipoproteins after ethinyl estradiol is associated with increased mRNA levels for hepatic lipase, lipoprotein lipase, and the low density lipoprotein receptor in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb 1991; 11: 1652-1659

182) Chinellato A, Banchineri N, Pandoifo L, Ragazzi E, Froldi G, Norido F, Caparrotta L, Fassina G
Aortic response to relaxing agents in Watanabe heritable hyperlipidemic (WHHL) rabbits of different age.
Atherosclerosis 1991; 89: 223-230

183) Oguchi A, Ikeda U, Miyashita H, Ohara T, Tsuruya Y, Natsume T, Yaginuma T, Shimada K
Vascular smooth muscle cells from genetically hyperlipidemic rabbit (WHHL rabbit) exhibit decreased growth response.
Atherosclerosis 1991; 90: 101-108

184) Zhang B, Saku K, Hirata K, Liu R, Tateishi K, Yamamoto K, Arakawa K
Insulin resistance observed in WHHL rabbits.
Atherosclerosis 1991; 91: 277-278

185) Bowler A, Redgrave TG, Mamo JCL
Chylomicron-remnant clearance in homozygote and heterozygote Watanabe-heritable-hyperlipidemic rabbit is defective.
Biochem J 1991; 276: 381-386

186) Mol MJT, Stalenhoef FH, Demacker PNM, Laar AV
Alteration in the metabolism of very-low-and low-density lipoproteins after partial ileal-bypass surgery in the Watanabe heritable hyperlipidemic rabbit.
Biochem J 1991; 278: 651-657

187) Mamo JCL, Boelwe A, Elsegood CL, Redgrave TG
Defective plasma clearance of chylomicron-like lipid emulsions in Watanabe heritable hyperlipidemic rabbits.
Biochim Biophys Acta. 1991; 1081: 241-245

188) Mokuno H, Yamada N, Shimano H, Ishibashi S, Mori N, Takahashi K, Oka T, Yoon TH, Takaku F
The enhanced cellular uptake of very-low-density lipoprotein enriched in apolipoprotein E.
Biochim Biophys Acta 1991; 1082: 63-70

189) Carlson TL, Kottke A
Effect of coconut oil on plasma apoA-1 levels in WHHL and NZW rabbits.
Biochim Biophys Acta 1991; 1083: 221-229

190) Stoudemire JB, Garnick MB
Effects of recombinant human macrophage colony- stimulating factor on plasma cholesterol levels.
Blood 1991; 77: 750-755

191) Daugherty A, Zweifel BS, Schonfeld G
The effects of probucol on the progression of atherosclerosis in mature Watanabe heritable hyperlipidemic rabbits.
Br J Pharmacol 1991; 103: 1013-1018

192) Stewart-Lee AL, Aberdeen J, Burnstock G
Sympathetic neurotransmission in the Watanabe heritable hyperlipidemic rabbit mesentery artery.
Cardiovasc Res 1991; 25: 1035-1041

193) Demer LL
Effect of calcification on in vivo mechanical response of rabbit arteries to balloon dilation.
Circulation 1991; 83: 2083-2093

194) Tagawa H, Tomoike H, Nakamura M
Putative mechanisms of the impairment of endothelium-dependent relaxation of the aorta with atheromatous plaque in heritable hyperlipidemic rabbits.
Circ Res 1991; 68: 330-337

195) Fukuo Y, Nagashima M, Saitoh A, Kobayashi Y, Terashi A, Nakama K, Kameyama K, Asano G
Effect of simvastatin on serum lipids and atherosclerosis in WHHL rabbits.
Clin Ther 1991; 13: 417-424

196) Daugherty A, Rateri DL
Heterogeneity of very low density lipoproteins: Factors influencing the ability of specific subfractions to modulate cholesterol metabolism in macrophages in vitro.
Coron Artery Dis 1991; 2: 775-787

197) Finckh B, Niendorf A, Rath M, Beisiegel U
Antiatherosclerotic effect of probucol in WHHL rabbits: are there plasma parameters to evaluate this effect ?
Eur J Clin Pharmacol 1991; 40: S77-S80

198) Hara A, Taketomi T
Characterization and changes of glycosphingolipids in the aorta of the Watanabe heritable hyperlipidemic rabbit.
J Biochem 1991; 109: 904-908

199) Daugherty A, Rateri DL
Failure of the intracellular itinerary of b-very low density lipoproteins to augment cholesterol esterification in macrophages from Watanabe heritable hyperlipidemic rabbits.
J Biol Chem 1991; 266: 17269-17275

200) Donnelly TM, Kelsey SF, Levine DM, Parker TS
Control of variance in experimental studies of hyperlipidemia using the WHHL rabbit.
J Lipid Res 1991; 32: 1089-1098

201) Mao STJ, Yates MT, Rechtin AE, Jackson RL, Sickle WAV
Antioxidant activity of probucol and its analogues in hypercholesterolemic Watanabe rabbits.
J Med Chem 1991; 34: 299-302

202) Moerlein SM, Daugherty A, Sobel BE, Welch MJ
Metabolic imaging with gallium-68-and indium-111- labeled low-density lipoprotein.
J Nucl Med 1991; 32: 300-307

203) Kim SS, Kutsumi Y, Nakai T, Miyabo S
In vivo characterization of two types of LDL apheresis module and effect of repetitive LDL apheresis on plasma cholesterol levels and aortic atherosclerosis in heterozygous WHHL rabbits.
Jpn Circ J 1991; 55: 68-80

204) Khachadurian AK, Shimamura T, Rozovski SJ, Ananthakrisnan R, Armenian B, Coly E, Alhinai A, Martucci C, Schneider SH, Amorosa JF
Pravastatin decreases serum lipids and vascular cholesterol deposition in Watanabe heritable hyperlipidemic (WHHL) rabbits.
Jpn Heart J 1991; 32: 675-685

205) Carison TL, Kottke BA
ApoA-1 secretion by rabbit intestinal mucosa cell cultures.
Lipids 1991; 26: 684-688

206) Tanganelli P, Bianciardi G, Barbagli L, Centi L, Resi L, Salvi M, Weber G
Some aspects of the evolution with age of arterial lesions in Watanabe heritable hyperlipidemic rabbits: Morphological and morphometrical observations of aortic thoracic lesions.
Nutr Metab Cardiovasc Dis 1991; 1: 31-36

207) Cybulsky MI, Gimbrone MA
Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis.
Science 1991; 251: 788-791

208) Chowdhury JR, Grossman M, Gupta S, Chowdhury NR, Baker JR, Wilson JM
Long-term improvement of hypercholesterolemia after ex vivo gene therapy LDLR-deficient rabbits.
Science 1991; 254: 1802-1805

209) Dichek D, Bratthauer GL, Beg ZH, Anderson KD, Newman KD, Zwiebel JA, Hoeg JM, Anderson WF
Retroviral vector-mediated in vivo expression of low-density-lipoprotein receptors in the Watanabe heritable hyperlipidemic rabbit.
Somat Cell Mol Genet 1991; 17: 287-301

210) Bianciardi G, Tanganelli P, Palummo N, Zatta A, Prosdocimi M, Weber G
Platelet function abnormalities in 6-12 month-old Watanabe heritable hyperlipidemic (WHHL) rabbits.
Thromb Res 1991; 64: 109-115

Bibliography of WHHL rabbits



(1992)

211) Takano T
Accumulation of cholesteryl ester in atherosclerotic lesions.
Acta Pathol Jpn 1992; 42: 625-631

212) Rosenfeld ME, Yla-Herttuala S, Lipton BA, Ord VA, Witztum JL, Steinberg D
Macrophage colony-stimulating factor mRNA and protein in atherosclerotic lesions of rabbits and humans.
Am J Pathol 1992; 140: 291-300

213) Atkinson JB, Swift LL, Virmani R
Animal model of human disease: Watanabe heritable hyperlipidemic rabbits.
Am J Pathol 1992; 140: 749-753

214) Hirata K, Akita H, Yokoyama M, Watanabe Y
Impaired vasodilatory response to arterial natriuretic peptide during atherosclerosis progression.
Arterioscler Thromb 1992; 12: 99-105

215) Rand ML ,Gross PL, Barrow DV, Packhan MA
Acute in vitro effects of ethanol on responses of platelets from cholesterol-fed and Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb 1992; 12: 437-445

216) Rosenfeld ME, Carew TE, Hodenberg EV, Pittman RC, Ross R, Steinberg D
Autoradiographic analysis of the distribution of 125I-tyramine-cellobiose-LDL in atherosclerotic lesions of the WHHL rabbit.
Arterioscler Thromb 1992; 12: 985-995

217) Chinellato A, Ragazzi E, Pandolfo L, Froldi G, Bevilacqua C, Prosdocimi M, Caparrota L, Fassina G
Protective role of heparin on in vitro functional aortic response in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1992; 92: 17-24

218) Nagano Y, Nakamura T, Matsuzawa Y, Cho M, Ueda Y, Kita T
Probucol and atherosclerosis in the Watanabe heritable hyperlipidemic rabbit: Long-term antiatherogenic effect and effects on established plaques.
Atherosclerosis 1992; 92: 131-140

219) Ikeda U, Ikeda M, Seino Y, Takahashi M, Kano S, Shimada K
Interleukin 6 gene transcripts are expressed in atherosclerotic lesions of genetically hyperlipidemic rabbits.
Atherosclerosis 1992; 92: 213-218

220) Roux SP, Kuhn H, Lengsfeld H, Morand OH
Effects of chronic aortic coarctation on atherosclerosis and arterial lipid accumulation in the Watanabe heritable hyperlipidemic (WHHL) rabbit.
Atherosclerosis 1992; 93; 123-132

221) Cirillo R, Aliev G, Italiano G, Prosdocimi M
Functional responses of hindlimb circulation in aged normal and WHHL rabbits.
Atherosclerosis 1992; 93: 133-144

222) Tsunemitsu M, Ishikawa Y, Taniguchi T, Fukuzaki H, Yokoyama M
Association of N-glycosylation of apolipoprotein B-100 with plasma cholesterol levels in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1992: 93: 229-235

223) Inoue I, Inaba T, Motoyoshi K, Harada K, Shimano H, Kawamura M, Gotoda T, Oka T, Shiomi M, Watanabe Y, Tsukada T, Yazaki Y, Takaku F, Yamada N
Macrophage colony stimulating factor prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1992; 93; 245-254
   < Abstract or Full paper >

224) Williams RJ, Motteram JM, Sharp CH, Gallagher PJ
Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits.
Atherosclerosis 1992; 94: 153-159

225) Shiomi M, Ito T, Shiraishi M, Watanabe Y
Inheritability of atherosclerosis and the role of lipoproteins as risk factors in the development of atherosclerosis in WHHL rabbits: Risk factors related to coronary atherosclerosis are different from those related to aortic atherosclerosis.
Atherosclerosis 1992; 96: 43-52
   < Abstract or Full paper >

226) Demacker PNM, Heijst PJ, Stalenhoef AFH
A study of the chylomicron metabolism in WHHL rabbits after fat loading.
Biochem J 1992; 285: 641-646

227) Cohn W, Goss-Sampson MA, Grun H, Muller DPR
Plasma clearance and net uptake of a-tocopherol and low density lipoprotein by tissues in WHHL and control rabbits.
Biochem J 1992; 287: 247-254

228) Mezdour H, Nomura S, Yamamura T, Yamamoto A
Concentration and distribution of apolipoproteins A-1 and E in normolipidemic, WHHL and diet-induced hyperlipidemic rabbit sera.
Biochim Biophys Acta 1992; 1127: 116-123

229) Okutomi T, Nishizawa T, Inagawa H, Takano T, Morikawa A, Soma G, Mizuno D
Homeostasis as regulated by activated macrophage. VII. Suppression of serum cholesterol level by LPSw (a lipopolysaccharide from wheat flour) in WHHL (Watanabe heritable hyperlipidemic) rabbit.
Chem Pharm Bull 1992; 40: 1268-1270

230) Nakamura M, Abe S
Small coronary artery sclerosis of the intermittent hypercholesterolemic rabbit differs from that of the hereditary hypercholesterolemic rabbit.
Circulation 1992; Suppl1: 371 (abstract)

231) Ambrosioni E, Bacchelli S, Esposti D, Borghi C
ACE-inhibitors and atherosclerosis.
Eur J Epidemiol 1992; 8: 129-133

232) Stewart- Lee AL, Aberdeen J, Burnstock G
The effect of atherosclerosis on neuromodulation of sympathetic neurotransmission by neuropeptide Y and calcitonin gene-related peptide in the rabbit mesenteric artery.
Eur J Pharmacol 1992; 216: 167-174

233) Ebbe s, Dalal K, Forte T, Tablin F
Microcytic thrombocytosis, small megakaryocytes, platelet lipids and hyperreactivity to collagen, lymphocytopenia, eosinophilia, and low blood volume in genetically hyperlipidemic rabbits.
Exp Hematol 1992; 20: 486-493

234) Nickerson CJ, Haudenschild CC, Chobanian AV
Effects of hypertension and hyperlipidemia on the myocardium and coronary vasculature of the WHHL rabbit.
Exp Mol Pathol 1992; 56: 173-185

235) Chobanian AV, Haudenschild CC, Nickerson C, Hope S
Trandolapril inhibits atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.
Hypertension 1992; 20: 473-477

236) Kuroda M, Matsumoto A, Itakura H, Watanabe Y, Ito T, Shiomi M, Fukushige J, Nara F, Fukami M, Tsujita Y
Effects of pravastatin sodium alone and in combination with cholestyramine on hepatic, intestinal and adrenal low density lipoprotein receptors in homozygous Watanabe heritable hyperlipidemic rabbits.
Japan J Phamacol 1992; 59: 65-70
   < Abstract or Full paper >

237) Lawrence JB, Prevosti LG, Kramer WS, Smith PD, Bonner RF, Lu DV, Leon MB
Pulsed laser and thermal ablation of atherosclerotic plaque: morphometrically defined surface thrombogenecity in studies using an annular perfusion chamber.
J Am Coll Cardiol. 1992; 19: 1091-1100

238) Wilson J, Grossman M, Wu CH, Chowdhury NR, Wu GY Chowdhury JRC
Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits.
J Biol Chem 1992; 267: 963-967

239) Brizzolara AL, Tomlinson A, Aberdeen J, Gourdie RG, Burnstock G
Sex and age as factors influencing the vascular reactivity in Watanabe heritable hyperlipidemic (WHHL) rabbits: a pharmacological and morphological study of the hepatic artery.
J Cardiovasc Pharmacol 1992; 19: 86-95

240) Nomura H, Maichesky PS, Goldcamp JB, Yamashita M, Werynski A, Nose Y
Selective removal of cholesterol by plasmapheresis and the progression of atherosclerosis.
J Clin Apheresis 1992; 7: 194-200

241) Amorosa LF, Rozovski SJ, Ananthakrishnan A, Coly E, Alhinai A, Martucci C, Scheider SH, Shimamura T, Khachadurian AK
Effects of pravastatin on cholesterol metabolism in Watanabe heritable hyperlipidemic rabbits.
Jpn Heart J 1992; 33: 451-463

242) Yamada N, Inoue I, Kawamura M, Harada K, Watanabe Y, Shimano H, Gotoda T, Shimada M, Kohzaki K, Tsukada T, Shiomi M, Yatanabe Y, Yazaki Y
Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
J Clin Invest. 1992; 89: 706-711
   < Abstract or Full paper >

243) Delessandri KM, Wedemeyer W, Tsukamoto H
Watanabe hyperlipidemic rabbit as a model of aortic degeneration of the medial lamella elastin unit.
J Invest Surg 1992; 5: 19-23

244) Irie T, Fukunaga K, Garwood MK, Carpenter TO, Pitha J, Pitha J
Hydroxypropylcyclodextrins in parental use. II: Effects on transport and disposition of lipids in rabbit and humans.
J Pharm Sci 1992; 81: 524-528

245) Katsuda S, Hosomi H, Shiomi M, Watanabe Y
Effects of atherosclerosis on mean and daily variation of arterial pressure in conscious WHHL rabbits.
J Vet Med Sci 1992; 54: 669-673
   < Abstract or Full paper >

246) Katsuda S, Hosomi H, Shiomi M, Watanabe Y
Impaired baroreflex control of arterial pressure in WHHL rabbits.
J Vet Med Sci 1992; 54: 983-987
   < Abstract or Full paper >

247) Mizuno D, Soma G
Oral or percutaneous administration of lipopolysaccharide of small molecular size may cure various intractable diseases: A new version of coley's toxin.
Mol Biother 1992; 4: 166-169

248) Libby P, Clinton SK
Cytokines as mediators of vascular pathology.
Nouv Rev Fr Hematol 1992; 34: 47-53

249) Chinellato A, Ragazzi E, Laureto PPD, Fassina G
Reduced L-arginine/lysine and L- arginine /aspartic acid rations in aorta from Watanabe heritable hyperlipidemic (WHHL) rabbit.
Pharmacol Res 1992; 25: 225-258

250) Ragazzi E, Chinellato A
Purinergic receptors, prostacyclin and atherosclerosis.
Pharmacol Res 1992; 26: 123-129

251) Yamada N, Ishibashi S, Shimano H, Inaba T, Gotoda T, Harada K, Shimada M, Shiomi M, Watanabe Y, Kawakami M, Yazaki Y, Takaku F
Role of monocyte colony-stimulating factor in form cell generation (43427).
Proc Soc Exp Biol Med 1992; 200: 240-244
   < Abstract or Full paper >

252) Tejera ML, Cienfuegos JA, Maganto P, Pardo F, Santamaria LL, Codesal J, Andres SD, Hernandez JL, Castillo-olivares JL
Reduction of cholesterol levels following liver cell grafting in hyperlipidemic (WHHL) rabbits.
Transplant Proc 1992; 24: 160-161

Bibliography of WHHL rabbits



(1993)

253) Caparrota l, Pandolfo L, Chinellato A, Ragazzi E, Froldi G, Aliev G, Fassina G
L-arginine does not improve endothelium-dependent relaxation in in vitro Watanabe rabbit thoracic aorta.
Amino Acids 1993; 5: 403-411

254) Giuriato L, Scatena M, Chiavegato A, Zanellato AMC, Guidolin D, Pauletto P, Sartore S
Localization and smooth muscle cell composition of atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb 1993; 13: 347-359

255) Aliev G, Mironov A, Cirillo R, Mironov A, Gorelova E, Prosdocimi M
Evidence for the presence of early vascular lesions in newborn Watanabe heritable hyperlipidemic (WHHL) rabbits.
Atherosclerosis 1993; 101: 17-24

256) Demacker PNM, Hijmans AGM, Kleinveld HA, Stalenhoef AFH
Indications for the presence of circulating peroxidized low density lipoproteins in WHHL rabbits treated with antioxidants.
Atherosclerosis 1993; 102: 69-77

257) Liu R, Saku K, Zhang B, Hirata K, Shiomi M, Arakawa K
In vivo kinetics of oxidatively modified HDL.
Biochem Med Metab Biol 1993; 49: 392-397
   < Abstract or Full paper >

258) Bell FP
Effect of the lipid-lowering drug lifibrol on lipid metabolism in rat macrophages and in atherosclerotic arteries from swine and WHHL rabbits, in vitro: Implications in atherogenesis.
Biochem Pharmacol 1993; 46: 1475-1480

259) Raper SE, Wilson JM
Cell transplantation in liver-directed gene therapy.
Cell Transplant 1993; 2: 381-400

260) Liu R, Saku K, Kostner GM, Hirata K, Zhang B, Shiomi M, Arakawa K
In vivo kinetics of lipoprotein(a) in homozygous Watanabe heritable hyperlipidemic rabbits.
Eur J Clin Invest 1993; 23: 561-565
   < Abstract or Full paper >

261) Hara A, Taketomi T
Sulphatide as a major glycosphingolipid in WHHL rabbit serum lipoproteins and its anticoagulant activity.
Indian J Biochem Biohys 1993; 30: 353-357

262) Wanibuchi H, Dingemans KP, Becker AE, Ueda M, Naruko T, Tanizawa S, Nakamura K
Is the Watanabe heritable hyperlipidemic rabbit a suitable experimental model for percutaneous transluminal coronary angioplasty in humans ?
J Am Coll Cardiol 1993; 21: 1490-1496

263) Hardoff R, Braegelmann F, Zanzonico P, Herrold EM, Lees RS, Lees AM, Dean RT, James JL, Borer JS
External imaging of atherosclerosis in rabbits using an 123I-labeled synthetic peptide fragment.
J Clin Pharmacol 1993; 33: 1039-1047

264) Esper E, Chan EK, Buchwald H
Natural history of atherosclerosis and hyperlipidemia in heterozygous WHHL (WHHL-Hh) rabbits: I. The effects of aging and gender on plasma lipids and lipoproteins.
J Lab Clin Med 1993; 121: 97-102

265) Esper E, Runge WJ, Gunther R, Buchwald H
Natural history of atherosclerosis and hyperlipidemia in heterozygous WHHL (WHHL-Hh) rabbits: II. Morphologic evaluation of spontaneously occurring aortic and coronary lesions.
J Lab Clin Med 1993; 121: 103-110

266) Demacker PNM, Dormans TPJ, Koenders EB, Corstens FHM
Evaluation of indium-111-polyclonal immunoglobulin G to quantitate atherosclerosis in Watanabe heritable hyperlipidemic rabbits with scintigraphy: Effect of age and treatment with antioxidants or ethinylestradiol.
J Nucl Med 1993; 34: 1316-1321

267) Ragazzi E, Chinellato A, Pandoolfo L, Froldi G, Caparrotta L, Prosdocimi M, Aliev G, Fassina G
Atherosclerosis-related remodeling of aortic relaxation to purines in the Watanabe heritable hyperlipidemic rabbit.
J Pharmacol Exp Ther 1993; 266: 1091-1096

268) Norido F, Zatta A, Fiorito C, Prosdocimi M, Weber G
Hematologic and biochemical profiles of selectively bred WHHL rabbits.
Lab Anim Sci 1993; 43: 319-323

269) Chinellato A, Ragazzi E, Pandolfo L, Froldi G, Preosdocimi M, Caparrotta L, Fassina G
Unimpaired adenosine 5'-triphosphate-induced relaxation in in vitro Watanabe heritable hyperlipidemic rabbit aorta.
Nutr Metab Cardiovasc Dis 1993; 3: 5-9

270) Corr L, Buratock G, Pool-Wilson P
Effects of age and hyperlipidemia on rabbit coronary responses to neuropeptide Y and the interaction with norepinephrine.
Peptides 1993; 14: 359-364

271) Amin D, Gustafson SK, Weinacht JM, Cornell SA, Neuenschwander K, Kosmider B, Scotese AC, Regan JR, Perrone MH
RG 12561 (dalvastatin): A novel synthetic inhibitor of HGM-CoA reductase and cholesterol-lowering agent.
Pharmacology 1993; 46: 13-22

272) Labeque R, Mullon CJP, Ferreira JPM, Lees RS, Langer R
Enzymatic modification of plasma low density lipoproteins in rabbits: a potential treatment for hypercholesterolemia.
Proc Natl Acad Sci USA 1993; 91: 3476-3780

Suppl 1993-1) Kroon AA, Stalenhoef AFH, Buikema H, Demacker PNM, de Wilde PCM, Leijten PA, van Gilst WH
The effect of cholesterol reduction on the endothelial function and progression of atherosclerosis in WHHL rabbits.
Atherosclerosis 1993; 103: 221-230

Bibliography of WHHL rabbits



(1994)

273) Hansen BF, Mortensen A, Hansen JF, Ibsen P, Frandsen H, Nordestgaard BG
Atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
APMIS 1994; 102: 177-190

274) Yla-Herttuala S, Palinski W, Butler SW, Picard S, Steinberg D, Witztum JL
Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL.
Arterioscler Thromb. 1994; 14: 32-40

275) Schaub RG, Bree MP, Hayes LL, Rudd MA, Rabbani L, Loscalzo J, Clinton SK
ecombinant human macrophage colony-stimulating factor reduces plasma cholesterol and carrageenan granuloma foam cell formation in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb. 1994; 14: 70-76

276) Fisher WR, Zeeh LA, Stacpoole PW
ApoB metabolism in familial hypercholesterolemia: inconsistencies with the LDL receptor paradigm.
Arterioscler Theromb. 1994; 14: 501-510

277) Shiomi M, Ito T, Tsukada T, Yata T Ueda M
Cell compositions of coronary and aortic atherosclerotic lesions in WHHL rabbits differ: an immunohistochemical study.
Arterioscler Thromb. 1994; 14: 931-937
   < Abstract or Full paper >

278) Kleinveld HA, Demacker PNM, Stalenhoef AFH
Comparative study on the effect of low-dose vitamin E and probucol on the susceptibility of LDL to oxidation and the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb. 1994; 14: 1386-1391

279) Ishibashi T, Yokoyama K, Shindo J, Hamazaki Y, Endo Y, Sato T, Takahashi S, Kawabayashi Y, Shiomi M, Yamamoto T, Maruyama Y
Potent cholesterol-lowering effect by human granulocyte-macrophage colony-stimulating factor in rabbits: possible implications of enhancement of macrophage function and an increase in mRNA for VLDL receptor.
Arterioscler Thromb. 1994; 14: 1534-1541
   < Abstract or Full paper >

280) Daugherty A, Rateri DL
Presence of LDL receptor-related protein/a2-Macroglobulin receptors in macrophages of atherosclerotic lesions form cholesterol-fed New Zealand and heterozygous Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb. 1994; 14: 2017-2024

281) Shiomi M, Shiraishi M, Yata T, Ito T
Effect of fluvastatin sodium on secretion of very low density lipoprotein and serum cholesterol levels: In vivo study using low density lipoprotein receptor deficient Watanabe heritable hyperlipidemic rabbits.
Arzneim Forsch/Drug Res 1994; 44: 1154-1156
   < Abstract or Full paper >

282) Tsubamoto Y, Tamada N, Watanabe Y, Inaba T, Shiomi M, Shimano H, Gotoda T, Harada K, Shimada M, Ohsuga J, Kawamura M, Yazaki Y
Dextran sulfate, a competitive inhibitor for scavenger receptor, prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1994; 106: 43-50
   < Abstract or Full paper >

283) Fujioka Y, Taniguchi T, Ishikawa Y, Shiomi M, Yokoyama M
Relation of N-glycosylation of apolipoprotein B-100 to cellular metabolism of low density lipoprotein.
Atherosclerosis 1994; 108: 91-102
   < Abstract or Full paper >

284) Ikeda U, Oguchi A, Okada K, Ishikawa S, Saito T, Ikeda M, Kano S, Takahashi M, Shiomi M, Shimada K
Involvement of LDL receptor in the proliferation of vascular smooth muscle cells.
Atherosclerosis 1994; 110: 87-94
   < Abstract or Full paper >

285) Kinter M, Robinson CS, Grimminger LC, Gillies PJ, Shimshick EJ, Ayers C
Whole blood and plasma concentrations of 4-hydroxy-2-nonenal in Watanabe heritable hyperlipidemic versus New Zealand white rabbits.
Biochem Biophys Res Commun 1994; 199: 671-675

286) Inoue S, Orimo A, Hosoi T, Ikegami A, Kozaki K, Ouchi Y, Nomura S, Muramatsu M, Orimo H
Demonstration of activin-A in arteriosclerotic lesions.
Biochem Biophys Res Comm 1994; 205: 441-448

287) Sohma Y, Suzuki T, Sasano H, Nahura H, Nose M, Yamamoto T
Increased mRNA for CD63 antigen in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
Cell Struct Funct 1994; 19: 219-225

288) Miwa Y, Hirata K, Matsuda Y, Suematsu M, Kawashima S, Yokoyama M
Augmented receptor-mediated Ca2+ mobilization causes supersensitivity of contractile response to serotonin in atherosclerotic arteries.
Circ Res 1994; 75: 1096-1102

289) Mamo JCL, Bowler A, Redgrave TG, Elsegood CL
Clearance of chylomicron-like lipid emulsions is increased in normal rabbits but not in heterozygous Watanabe heritable hyperlipidemic rabbits following treatment with cholestyramine or pravastatin.
Clin Exp Pharmacol Physiol 1994; 21: 687-694

290) Ito T, Tsukada T, Ueda M, Wanibuchi H, Shiomi M
Immunohistochemical and quantitative analysis of cellular and extra-cellular components of aortic atherosclerosis in WHHL rabbits.
J Atheroscler Thromb 1994; 1: 45-52
   < Abstract or Full paper >

291) Sohma Y, Suzuki T, Sasano H, Nagura H, Nose M, Yamamoto T
Expression of mRNA for matrix g-carboxyglutamic acid protein during progression of atherosclerosis in aortas of Watanabe heritable hyperlipidemic rabbits.
J Biochem 1994; 116: 747-751

292) Kozarsky KF, Mckinley DR, Austin LL, Raper SE, Perricaudet LDS, Wilson JM
In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses.
J Biol Chem 1994; 269: 13695-13702

293) Robins ED, Nelson LM, Hoeg JM
Aberrant hypothalamic-pituitary-ovarian axis in the Watanabe heritable hyperlipidemic rabbit.
J Lipid Res 1994; 35: 52-59

294) Chao F, Blanchette-Mackie EJ, Dickens BF, Gamble W, Kruth HS
Development of unesterified cholesterol-rich lipid particles in atherosclerotic lesions of WHHL and cholesterol-fed NZW rabbits.
J Lipid Res 1994; 35: 71-83

295) Breugnot C, Privat S, Guillonneau C, Regnier G, Bouzom F, Vilaine J, Lenaers A
S12340: A potent inhibitor of the oxidative modification of low-density lipoprotein in vitro and ex vivo in WHHL rabbits.
J Pharmacol Exp Ther 1994; 269: 515-520

296) Brizzolara AL, Stewart- Lee A, Burnstock G
Responses of rabbit basilar arteries to vasoconstrictor and vasodilator agents: the effects of atherosclerosis, age and sex.
J Vasc Res 1994; 31: 106-113

297) Calderon TM, Factor SM, Hatcher VB, Berliner JA, Berman JW
An endothelial cell adhesion protein for monocytes recognized by monoclonal antibody IF9.
Lab Invest 1994; 70: 836-849

298) Zhang B, Saku K, Hirata K, Liu R, Takeishi K, Shiomi M, Arakawa K
Quantitative characterization of insulin-glucose response in Watanabe heritable hyperlipidemic and cholesterol-fed rabbits and effect of cilazapril.
Metabolism 1994; 43: 360-366
   < Abstract or Full paper >

299) Shiomi M, Ito T
Pravastatin sodium, a competitive inhibitor of hepatic 3-hydoroxy-3-methylglutaryl coenzyme A reductase, decreases the cholesterol content of newly secreted very-low-density lipoprotein in Watanabe heritable hyperlipidemic rabbits.
Metabolism 1994; 43: 559-564
   < Abstract or Full paper >

Bibliography of WHHL rabbits



(1995)

300) Ishibashi T, Yokoyama K, Shindo J, Hamazaki Y, Endo Y, Sato T, Takahashi S, Kawarabayasi Y, Shiomi M, Yamamoto T, Maruyama Y
Human granulocyte-macrophage colony-stimulating factor lowers the levels of plasma cholesterol with an increase in mRNA for very low density lipoprotein receptor in rabbits.
Ann N Y Acad Sci 1995; 748: 630-633

301) Watanabe Y, Inaba T, Gotoda T, Harada K, Shimada M, Ohsuga J, Kawamura M, Yazaki Y, Yamada N
Role of macrophage colony-stimulating factor in the initial process of atherosclerosis.
Ann N Y Acad Sci 1995; 357-366

302) Villeneuve N, Janiak P, Brunel-Jacquemin C, Canovi C, Pillon A, Breugnot C, Vilaine DGJP
La deoxycorticosterone a dose non hypertensive accelere la progression de I'atherosclerose chez le lapin WHHL.
Arch Mal Coeur 1995; 88: 1197-201

303) Kleinveld HA, Hak-Lemmers HLM, Hectors MPC, Fouw NJ, Demacker PNM, Stalenhoef AFH
Vitamin E and fatty acid intervention does not attenuate the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1995; 15: 290-297

304) Dowell FJ, Hamilton CA, Lindop GBM, Reid JL
Development and progression of atherosclerosis in aorta form heterozygous and homozygous WHHL rabbits: effects of simvastatin treatment.
Arterioscler Thromb Vasc Biol 1995; 15: 1152-1160

305) Taguchi H, Faraci FM, Kitazono T, Heistad DD
Relaxation of the carotid artery to hypoxia is impaired in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1995; 15: 1641-1645

306) Shiomi M, Ito T, Tsukada T, Yata T, Watanabe Y, Tsujita Y, Fukami M, Fukushige J, Hosohawa T, Tamura A
Reduction of serum cholesterol levels alters lesional composition of atherosclerotic plaques: Effect of pravastatin sodium on atherosclerosis in mature WHHL rabbits.
Arterioscler Theromb Vasc Biol 1995; 15: 1938-1944
   < Abstract or Full paper >

307) Mezdour H, Tamamura T, Nomura S, Yamamoto A
Genetic but not diet-induced hypercholesterolemia causes low apolipoprotein A-IV level in rabbit sera.
Atherosclerosis 1995; 113: 171-178

308) Tanaka M, Otani H, Yokode M, Kita T
Regulation of apolipoprotein B secretion in hepatocytes from Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.
Atherosclerosis 1995; 114: 73-82

309) Giuriato L, Chiavegato A, Pauletto P, Sartore S
Correlation between the presence of an immature smooth muscle cell population in tunica media and the development of atherosclerotic lesion. A study on different-sized rabbit arteries from cholesterol-fed and Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1995; 116: 77-92

310) Kurokawa J, Hayashi K, Toyota Y, Shingu T, Shiomi M, Kajiyama G
High dose of fluvastatin sodium (Xu62-320), a new inhibitor of 3-hydroxy-3-merhylglutaryl coenzyme A reductase, lowers plasma cholesterol levels in homozygous Watanabe-heritable hyperlipidemic rabbits.
Biochim Biophys Acta 1995; 1259: 99-104
   < Abstract or Full paper >

311) Matsuo M, Ito F, Kondo A, Akita M, Tomoi M, Shimomura K
Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits: Evidence for a direct effect on the arterial wall.
Biochim Biophys Acta 1995; 1259: 254-260

312) Hiltunen T, Luoma J, Nikkari T, Yla-Herttuala S
Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions.
Circulation 1995; 92: 3297-3303

313) Sobey CG, Brooks RM, Heistad DD
Evidence that expression of inducible nitric oxide synthase in response to endotoxin is augmented in atherosclerotic rabbits.
Circ Res 1995; 77: 536-543

314) Lopez-Candales A, Scott MJ, Wickline SA
Cholesterol feeding modulates spatial expression of TGF-b1 and -b2 in aortas of Watanabe rabbits.
Cytokine 1995; 7: 554-561

315) Bihain BE, Delplanqe B, Khallou J, Chevreuil O, Troussard AA, Michel L, Mann CJ, Yen FT
Lipolysis-stimulated receptor: a newcomer on the lipoprotein research scene.
Diabete Metab 1995; 21: 121-126

316) Hata H, Kuga T, Takeshita A
Adherent leukocytes to the aortic wall promotes atherosclerosis in the Watanabe heritable hyperlipidemic rabbits.
Fukuoka Acta Med 1995; 86: 437-442

317) Chobanian AV, Hope S, Brecher P
Dissociation between the antiatherosclerotic effect of trandolapril and suppression of serum and aortic angiotensin-converting enzyme activity in the Watanabe heritable hyperlipidemic rabbit.
Hypertension 1995; 25: 1306-1310

318) Simonsen K, Horn T, Mortensen A, Hansen BF, Hansen JF
Liver fibrosis in heterozygous WHHL rabbits fed cholesterol and fats; a new animal model.
Int Hepatol Commun 1995; 3: 310-315

319) Kumabe T, Souma Y, Yamamoto T
Genes expressed in monocyte/macrophage cell differentiation and atherosclerotic plaques in WHHL rabbits.
J Atheroscler Thromb 1995; 1: S21

320) Sato R, Mori M, Imanaka T, Takano T
Accumulation of vitronectin in atherosclerotic lesions where lipids deposited.
J Atheroscler Thromb 1995; 1: S50-S54

321) Hussain MM, Innerarity TL, Brecht WJ, Mahley RW
Chylomicron metabolism in normal, cholesterol-fed, and Watanabe heritable hyperlipidemic rabbits: Saturation of the sequestration step of the remnant clearance pathway.
J Biol Chem 1995; 270: 8578-8587

322) Takahashi S, Suzuki J, Kohno M, Oida K, Tamai T, Miyabo S, Yamamoto T, Nakai T
Enhancement of the binding of triglyceride-rich lipoproteins to the very low density lipoprotein receptor by apolipoprotein E and lipoprotein lipase.
J Biol Chem 1995; 270: 15747-15754

323) Ragazzi E, Chinellato A, Pandolfo L, Froldi G, Caparrotta L, Aliev G, Prosdocimi M, Fassina G
Endothelial nucleotide-mediated aorta relaxation in aged Watanabe heritable hyperlipidemic rabbits.
J Cadiovasc Pharmacol 1995; 26: 119-126

324) Hansen BF, Mortensen A, Hansen JF, Frandsen H
Anipamil retards atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
J Cardiovasc Pharmacol 1995; 26: 485-489

325) Li J, Fang B, Eisensmith RC, Li XHC, Nasonkin I, Lin-Lee Y, Mims MP, Hughes A, Montgomery CD, Roberts JD, Parker TS, Levine DM, Woo SLC
In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene.
J Clin Invest 1995; 95: 768-773

326) Xu G, Salen G, Shefer S, Ness GC, Nguyen LB, Parker TS, Chen TS, Zhao Z, Donnelly TM, Tint GS
Unexpected inhibition of cholesterol 7a-hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits.
J Clin Invest 1995; 95: 1497-1504

327) Redgrave TG, Martins IJ, Mortimer B
Measurement of expired carbon dioxide to assess the metabolism of remnant lipoproteins.
J Lipid Res 1995; 36: 2670-3675

328) Chakrabarti M, Cheg K, Spicer KM, Kirsch WM, Fowler SD, Kelln W, Griende S, Cannarella SN, Willerson R, Spicer SS, Koch T
Biodistribution and radioimmunopharmacokinetics of 131I-AMA monoclonal antibody in atherosclerotic rabbits.
Nucl Med Biol 1995; 22: 693-697

329) Chinellato A, Ragazzi E
Receptor-mediated pathways of endothelium activity in experimental atherosclerosis.
Pharmacol Res 1995; 31: 163-168

330) Sohma Y, Sasano H, Shiga R, Saeki S, Suzuki T, Nagura H, Nose M, Yamamoto T
Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
Proc Natl Acad Sci USA 1995; 92: 4937-4941

331) Braesen JH, Beisigel U, Niendorf A
Probucol inhibits not only the progression of atherosclerotic disease, but causes a different composition of atherosclerotic lesions in WHHL-rabbits.
Virchows Arch 1995; 426: 179-188

Bibliography of WHHL rabbits



(1996)

332) Moazed TC, Kuo CC, Patton DL, Grayston JT, campbell LA
Experimental rabbit models of Chlamydia pneumoniae infection.
Am J Pathol 1996; 148: 667-676

333) Kanazawa K, Kawashima S, Mikami S, Miwa Y, Hirata K, Suematsu M, Hayashi Y, Itoh H, Yokoyama M
Endothelial constitutive nitric oxide synthase protein and mRNA increased in rabbit atherosclerotic aorta despite impaired endothelium-dependent vascular relaxation.
Am J Pathol 1996; 148: 1949-1956
   < Abstract or Full paper >

334) Nakazato K, Ishibashi T, Shindo J, Shiomi M, Maruyama Y
Expression of very low density lipoprotein receptor mRNA in rabbit atherosclerotic lesions.
Am J Pathol 1996; 149; 1831-1838
   < Abstract or Full paper >

335) O'leary VJ, Tilling L, Fleetwood G, Stone D, Darley-Usmar V
The resistance of low density lipoprotein to oxidation promoted by copper and its use as an index of antioxidant therapy.
Atherosclerosis 1996; 119: 169-179

336) Nakamura M, Abe S, Kinukawa N
Casual relationship between occlusive lesions of the coronary artery and myocardial fibrosis in atherosclerotic rabbits: Differences between cholesterol-fed and heritable hyperlipidemic rabbits.
Atherosclerosis 1996; 124: 37-47

337) Kogushi M, Tanaka H, Ohtsuka I, Yamada T, Kobayashi H, Saeki T, Takada M, Hiyoshi H, Yanagimachi M, Kimura T, Yoshitake S, Saito I
Anti-atherosclerotic effect of E5324, an inhibitor of acyl-CoA: cholesterol acyltransferase, in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1996; 124: 203-210

338) Lei X, Buja LM
Detection and localization of tumor necrosis factor-a in WHHL rabbit arteries.
Atherosclerosis 1996; 125: 81-89

339) Sharma HM, Lee JY, Kauffman EM, Hanna AN
In vivo effect of herbal mixture mak-4 on antioxidant capacity of brain microsomes.
Biochem Arch 1996; 12: 181-186

340) Mamo JCL, Elsegood CL, Gennat HC, Yu K
Degradation of chylomicron remnants by macrophages occurs via phagocytosis.
Biochemistry 1996; 35: 10210-10214

341) Proctor SD, Mamo JCL
Arterial fatty lesions have increased uptake of chylomicron remnants but not low-density lipoproteins.
Coron Artery Dis 1996; 7: 239-245

342) Xu G, Salen G, Shefer S, Ness GC, Nguyen LB, Tint S, Paker TS, Roberts J, Batta AK, Chen TS, Zhao Z, Kong X
Increasing hepatic cholesterol 7ahydroxylase reduces plasma cholesterol concentrations in normocholesterolemic and hypercholesterolemic rabbits.
Hepatology 1996; 24: 882-887

343) Kozarsky KF, Bonen DK, Giannoni F, Funahashi T, Wilson JM, Davidson NO
Hepatic expression of the catalytic subunit of the apolipoprotein B mRNA editing enzyme (apobec-1) ameliorates hypercholesterolemia in LDL receptor-deficient rabbits.
Hum Gene Ther 1996; 7: 943-957

344) Shen J, Herderick E, Cornhill JF, Zsigmond E, Kim H, Kuhn H, Guevara NV, Chan L
Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.
J Clin Invest 1996; 98: 2201-2208

345) Greeve J, Jona VK, Chowdhury NR, Horwitz MS, Chowdhury JR
Hepatic gene transfer of the catalytic subunit of the apolipoprotein B mRNA editing enzyme results in a reduction of plasma LDL levels in normal and Watanabe heritable hyperlipidemic rabbits.
J Lipid Res 1996; 37: 2001-2017

346) Mortensen A, Frandsen H
Reproductive performance and changes in blood lipids in breeding females and in growing Watanabe heritable hyperlipidemic and New Zealand white rabbits.
Lab Anim 1996; 30: 252-259

347) Lei X, Buja LM
Measurement by quantitative reverse transcription-polymerase chain reaction of the levels of tumor necrosis factor alpha mRNA in atherosclerotic arteries in Watanabe heritable hyperlipidemic rabbits.
Lab Invest 1996; 74: 135-145

348) Brown DR, Brousseau ME, Shamburek RD, Talley GD, Meyn S, Demosky SJ, Santamarina-Fojo S, Brewer HB, Hoeg JM
Adenoviral delivery of low-density lipoprotein receptors to hyperlipidemic rabbits: receptor expression modulates high-density lipoproteins.
Metabolism 1996; 45: 1447-1457

349) Matsuo M, Hashimoto M, Suzuki J, Iwanami K, Tomoi M, Shimomura K
Difference between normal and WHHL rabbits in susceptibility to the adrenal toxicity of an acyl-CoA: cholesterol acyltransferase inhibitor, FR145237.
Toxicol Appl Pharmacol 1996; 140: 387-392

350) Eguchi S, Rozga J, Lebow LT, Chen SC, Wang C, Rosenthal R, Fogli L, Hewitt WR, Middleton Y, Demetriou AA
Treatment of hypercholesterolemia in the Watanabe rabbit using allogeneic hepatocellular transplantation under a regeneration stimulus.
Transplantation 1996; 62: 588-593

351) Li X, Fox G, Erdman SE, Lipman NS
Intestinal plasmacytosis in rabbits: A histologic and ultrastructural study.
Vet Pathol 1996; 33: 721-724

Bibliography of WHHL rabbits



(1997)

352) Saku K, Zhang B, Ohta T, Arakawa K
Troglitazone lowers blood pressure and enhances insulin sensitivity in Watanabe heritable hyperlipidemic rabbits.
Am J Hypertens 1997; 10: 1027-1033

353) Yin Y, Lim K, Weinbaum S, Chien S, Rumschitzki DS
A model for the initiation and growth of extracellular lipid liposomes in arterial intima.
Am J Physiol 1997; 272: H1033-H1046

354) Nakamura M, Abe S
Arteriosclerotic lesions of the distal small coronary artery in cholesterol-fed rabbits differ from those in Watanabe heritable hyperlipidemic rabbits.
Ann N Y Acad Sci 1997; 811: 420-423

355) Nakamura M, Abe S
An experimental induction of acute myocardial infarction and arterial thrombosis in rabbits.
Ann N Y Acad Sci 1997; 811: 424-428

356) Sakai A, Kume N, Nishi E, Tanoue K, Miyasaka M, Kita T
P-selectin and vascular cell adhesion molecule-1 are focally expressed in aortas of hypercholesterolemic rabbits before intimal accumulation of macrophages and T lymphocytes.
Arterioscler Thromb Vasc Biol 1997; 17: 310-316

357) Fruebis J, Gonzalez V, Silvestre M, Palinsky W
Effect of probucol treatment on gene expression of VCAM-I, MCP-I, and M-CSF in the aortic wall of LDL receptor-deficient rabbits during early atherosclerosis.
Arterioscler Thromb Vasc Biol 1997; 17: 1289-1302

358) Hong MK, Vossoughi J, Mintz GS, Kauffman RD, Hoyt Jr RF, Cornhill JF, Herderick EE, Leon MB, Hoeg JM
Altered compliance and residual strain precede angiographically detectable early atherosclerosis in low-density lipoprotein receptor deficiency.
Arterioscler Thromb Vasc Biol 1997; 17: 2209-2217

359) Holvoet P, Collen D
b-VLDL hypercholesterolemia relative to LDL hypercholesterolemia is associated with higher levels of oxidized lipoproteins and a more rapid progression of coronary atherosclerosis in rabbits.
Arterioscler Thromb Vasc Biol 1997; 17: 2376-2382

360) Hoshida S, Yamashita N, Igarashi J, Aoki K, Kuzuya T, Hori M
Long-term probucol treatment reverses the severity of myocardial injury in Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 1997; 17: 2801-2807

361) Takagi M, Ueda M, Becker AE, Takeuchi K, Takeda T
The Watanabe heritable hyperlipidemic rabbit is a suitable experimental model to study differences in tissue response between intimal and medial injury after balloon angioplasty.
Arterioscler Thromb Vasc Biol 1997; 17: 3611-3619

362) Harsch M, Breaesen JH, Niendorf A
Effects of low-dose pravastatin sodium on plasma cholesterol levels and aortic atherosclerosis of heterozygous WHHL rabbits fed a low cholesterol (0.03%) enriched diet for one year.
Atherosclerosis 1997; 128: 139-147

363) Nakamura M, Abe S, Kinukawa M
Aortic medial necrosis with or without thrombosis in rabbits treated with Russell's viper venom and angiotensin II.
Atherosclerosis 1997; 128: 149-156

364) Nordestgaard BG, AgerholmLarsen B, Mortensen A, Hansen BF, Ibsen P, Kjeldsen K
Intermediate density lipoprotein cholesterol as the best lipoprotein predictor of atherosclerosis severity in the Watanabe heritable hyperlipidemic rabbit.
Atherosclerosis 1997; 132: 119-122

365) Lee Y, Lott JA, Kauffman EM, Sharma HM
Effect of the herbal mixture MAK-4 on organ function in WHHL rabbits.
Biochem Arch 1997; 13: 285-296

366) Yu KC, Mamo JCL
Binding and uptake of chylomicron remnants by cultured arterial smooth muscle cells from normal and Watanabe heritable hyperlipidemic rabbits.
Biochim Biophys Acta 1997; 1346: 212-220

367) Igarashi M, Takeda Y, Mori S, Ishibashi N, Komatsu E, Takahashi K, Fuse T, Yamamura M, Kubo K, Sugiyama Y, Saito Y
Suppression of neointimal thickening by a newly developed HMG-CoA reductase inhibitor, BAYw6228, and its inhibitory effect on vascular smooth muscle cell growth.
Br J Pharmacol 1997; 120: 1172-1178

368) Liu R, Saku K, Jimi S, Ohta T, Zhang B, Takebayashi S, Arakawa K
Mechanism of action of gemfibrozil on HDL metabolism and atherosclerosis in WHHL rabbits.
Cardiovasc Drug Therapy 1997; 11: 659-668

369) Steinberg D
Lewis A. Conner Memorial Lecture: Oxidative modification of LDL and atherogenesis.
Circulation 1997; 95: 1062-1071

370) VabBelle E, Rivard A, Chen DH, Silver M, Bunting S, Ferrara N, Symes JF, Bauters C, Isner JM
Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines.
Circulation 1997; 96: 2667-2674

371) Stangle K, Dschietzig T, Laule M, Alexiou K, Wernecke KD, Baumann G
Pulmonary big endothelin affects coronary tone and leads to enhanced, ETa-mediated coronary constriction in early endothelial dysfunction.
Circulation 1997; 96: 3192-3200

372) Saku K, Zhang B, Ohta T, Arakawa K
Effects of troglitazone on serum lipids, lipoproteins, and hyperinsulinemia in Watanabe heritable hyperlipidemic rabbits.
Curr Ther Res Clin Exper 1997; 58: 876-887

373) Catapano AL
Calcium antagonists and atherosclerosis: experimental evidence.
Eur Heart J 1997; 18: A80-A86

374) Watanabe Y, Inaba T, Shimano H, Gotoda T, Kawamura M, Shiomi M, Yazaki Y, Yamada N
Effect of macrophage colony stimulating factor on the advanced atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Horm Metab Res 1997; 29: 507-509
   < Abstract or Full paper >

375) Fruebis J, Bird DA, Pattison J, Palinski W
Extent of antioxidant protection of plasma LDL is not a predictor of the antiatherogenic effect of antioxidants.
J Lipid Res 1997; 38: 2455-2466

376) Striker GE, Lupia E, Elliot S, Zheng F, McQuinn C, Blagg C, Selim S, Vilar J, Striker LJ
Glomerulosclerosis, arteriosclerosis, and vascular graft stenosis: Treatment with oral heparinoids.
Kidney Int 1997; 52 (Suppl 63): S120-S123

377) Varret M, Rabes JP, Boileau C
Familial hypercholesterolemia 25 years after. 1. LDL receptor defects.
Med Sci 1997; 13: 1399-1408

378) Zhang B, Saku K, Arakawa K
Quantification of the effects of troglitazone on insulin sensitivity and b-cell function in Watanabe heritable hyperlipidemic rabbits: an animal model analysis.
Metabolism 1997; 46: 273-281

379) Donnelly LH, Bree MP, Hunter SE, Keith JC, Schaub RG
Immunoreactive macrophage colony-stimulating factor is increased in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits after recombinant human macrophage colony-stimulating factor therapy.
Mol Reprod Dev 1997; 46: 92-95

380) Gunsalus JR, Brady DA, Cohlter SM, Gray BM, Edge ASB
Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation.
Nature Medicine 1997; 3: 48-53

381) Allison BA, Crespo MT, Jain AK, Richter AM, Hsiang YN, Levy JG
Delivery of benzoporphyrin derivative, a photosensitizer, into atherosclerotic plaque of Watanabe heritable hyperlipidemic rabbits and balloon-injured New Zealand rabbits.
Photochem Photobiol 1997; 65: 877-883

382) Zimmermann GG, Quick HH, Hilfiker PR, von Sculthess K, Giovanoli P, Debatin JF
Intravascular MR imaging: The first in vivo experiences in an animal atherosclerosis model.
Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 1997; 167: 180-186

Bibliography of WHHL rabbits



(1998)

383) Nagata N, Nishizaki Y, Watanabe N, Tsuda M, Matsuzaki S
An enzyme immune assay for serum antiacetaldehyde adduct antibody using low-density lipoprotein adduct and its significance in alcoholic liver injury.
Alcohol Clin Exp Res 1998; 22: 150S-155S

384) Higaki J, Hara S, Takasu N, Tonda K, Miyata K, Shike T, Nagata K, Mizui T
Inhibition of Ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits.
Arterioscler Thromb Vasc Biol 1998; 18: 1304-1311

385) Ooboshi H, Toyoda K, Faraci FM, Lang MG, Heistad DD
Improvement of relaxation in an atherosclerotic artery by gene transfer of endothelial nitric oxide synthase.
Arterioscler Thromb Vasc Biol 1998; 18: 1752-1758

386) Miyazaki A, Koga T
Lipid lowering effects of pravastatin in common marmosets.
Arzneim Forsh/Drug Res 1998; 48: 154-160

387) Shiomi M, Ito T, Tsukada T, Shiraishi M, Yata T
Effect of fluvastatin sodium on the smooth muscle cells in atherosclerotic plaques: In vivo study using low-density lipoprotein receptor deficient Watanabe heritable hyperlipidemic (WHHL) rabbits.
Arzneim Forsh/Drug Res 1998; 48: 680-685
   < Abstract or Full paper >

388) Naka Y, Yoshino G, Hirano T, Murata Y, Maeda E, Kazumi T, Kasuga M
Triglyceride metabolism in heterozygote of Watanabe heritable hyperlipidemic rabbit.
Atherosclerosis 1998; 136: 325-332

389) Oshima R, Ikeda T, Watansbe K, Itakura H, Sugiyama N
Probucol treatment attenuates the aortic atherosclerosis in Watanabe heritable hyperlipidmic rabbits.
Atherosclerosis 1998; 137: 13-22

390) Yamaguchi Y, Kogata S, Kunitomo M, Haginaka J
Evidence of modified lipoprotein in the plasma of Watanabe heritable hyperlipidemic rabbits by anion-exchange high-performance liquid chromatographic assay.
Atherosclerosis 1998; 139: 323-331

391) Mortensen A, Hansen BF, Hansen JF, Frandsen H, Bartnikowska E, Andersen PS, Bertelsen LS
Comparison of the effects of fish oil and olive oil on blood lipids and aortic atherosclerosis in Watanabe heritable hyperlipidaemic rabbits.
Br J Nutr 1998; 80: 565-73

392) Haesch M, Gebhardt A, Reymann A, Lang G, Schliack M, Loser R, Braesen JH, Niendorf A
Effects of pravastatin on cholesterol metabolism of cholesterol-fed heterozygous WHHL rabbits.
Br J Pharmacol 1998; 124: 277-282

393) Sullivan ME, Dashwood MR, Thompson CS, Mikhailidis DP, Morgan RJ
Down-regulation of endothelin-B receptor sites in cavernosal tissue of hypercholesterolemic rabbits.
Br J Urology 1998; 81: 128-134

394) Hiltunen TP, Luoma JS, Nikkari T, YlaHerttuala S
Expression of LDL receptor, VLDL receptor, LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions: Marked induction of scavenger receptor and VLDL receptor expression during lesion development.
Circulation 1998; 97: 1079-1086

395) Miller FJ, Gutterman DD Jr, Rios CD, Heistad DD, Davidson BL
Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis.
Cir Res 1998; 82: 1298-1305

396) Kogata S, Yamaguchi Y, Shinozuka K, Kunitomi M
Mechanisms of impairment of endothelium-dependent relaxation to acetylcholine in Watanabe heritable hyperlipidemic rabbit aortas.
Clin Exper Pharmacol Physiol 1998; 25: 104-109

397) Dschietzig T, Laule M, Alexiou K, Schror K, Baumann G, Stangl K
Coronary constriction and consequent cardiodepression in pulmonary embolism are mediated by pulmonary big endothelin and enhanced in early endothelial dysfunction.
Crit Care Med 1998; 26: 510-517

398) Roth BD
ACAT inhibitors: evolution from cholesterol-absorption inhibitors to antiatherosclerotic agents.
Drug Discovery Today 1998; 3: 19-25

399) Hamilton CA, Howie CA, Jardine E, Reid JL
Endothelium dependent and independent relaxation of aortic rings from Watanabe heritable hyperlipidemic rabbits after exposure to a free radical generating system.
Free Rad Res 1998; 28: 251-257

400) Aliev G, Burnstock G
Watanabe rabbits with heritable hypercholesterolemia: a model of atherosclerosis.
Histol Histopathol 1998; 13: 797-817

401) Handy DE, Johns C, Bresnahan MR, Tavares A, Bursztyn M, Gavrasb H
Expression of a2-adrenergic receptors in normal and atherosclerotic rabbit aorta.
Hypertension 1998; 32: 311-317

402) Yokouchi T, Iwabuchi S, Tomiyama A, Samejima H, Takahashi K, Shiomi M
Morphological study of carotid artery of WHHL rabbit after balloon dilatation.
Interventional Neuroradiology 1998; 4: 183-186

403) Ikeno-A, Sumiya-T, Minato-H, Fujitani-B, Masuda-Y, Hosoki-K, Kurono-M, Yasuba-M
Effects of monatepil maleate, a new Ca2+ channel antagonist with alpha1-adrenoceptor antagonistic activity, on cholesterol absorption and catabolism in high cholesterol diet-fed rabbits.
Jpn J Pharmacol 1998; 78: 303-12

404) Alexiou K, Dschietzig T, Simsch O, Laule M, Hundertmark J, Baumann G, Stangl K
Arrhythmogenic effects induced by coronary conversion of pulmonary big endothelin to endothelin: Aggravation of this phenomenon in heritable hyperlipidemia.
J Am Coll Cardiol 1998; 32: 1773-1778

405) Kim DH, Inagaki Y, Suzuki H, Ioka RX, Yoshioka SZ, Magoori K, Kang MJ, Cho Y, Nakano AZ, Liu Q, Fujino T, Suzuki H, Sasano H, Yamamoto TT
A new low density lipoprotein receptor belated protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E.
J Biochem 1998; 124: 1072-1076

406) Yamaguchi Y, Kunitomo M, Haginaka J
Anion-exchange high-performance liquid chromatographic assay of plasma lipoproteins of rabbits, rats and mice.
J Chromatog B 1998; 716: 57-64

407) Brousseau M, Wang J, Demosky SJ Jr, Vaisman BL, Talley GD, Santamarina-Fojo S, Brewer HB jr, Hoeg JM
Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase.
J Lipid Res 1998; 39: 1558-1567

408) Aliev G, Ragazzi E, Cirillo R, Bevilacqua C, Mironov A, Prosdocimi M, Paro M
Cryodamage of the vessel wall accelerates the development of atherosclerotic lesions in arterial vessels of Watanabe heritable hyperlipidemic rabbits.
J Submicrosc Cytol Pathol 1998; 30: 417-423

409) Corjay MH, Kearney MA, Munzer DA, Diamond SM, Stoltenborg JK
Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human.
Lab Invest 1998; 78: 847-858

410) Aliev G, Bodin P, Burnstock G
Free radical generators cause changes in endothelial and inducible nitric oxide synthases and endothelin-1: Immunoreactivity in endothelial cells from hyperlipidemic rabbits.
Mol Genet Metab 1998; 63: 191-197

411) Cynshi O, Kawabe Y, Suzuki T, Takashima Y, Kaise H, Nakamura M, Ohba Y, Kato Y, Tamura K, Hayasaka A, Higashida A, Sakaguchi H, Takeya M, Takahashi K, Inoue K, Noguchi N, Niki E, Kodama T
Antiatherogenic effects of the antioxidant BO-653 in three different animal models.
Proc Natl Acad Sci USA 1998; 95: 10123-10128

412) Wetterau JR, Gregg RE, Harrity TW, Arbeeny C, Cap M, Connolly F, Chu CH, George RJ, Gordon DA, Jamil H, Jolibois JG, Kunselman LK, Lan AJ, Maccagnan TJ, Ricci B, Yan M, Young D, Chen Y, Fryszman OM, Logan JVH, Musial CL, Poss MA, Robel JA, Simpkins LM, Slusasrchyk WA, Sulsky R, Taunk P, Magnin DR, Tino JA, Lawrence RM, Dickson JK Jr, Viller SA
An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.
Science 1998; 282: 751-754

413) Lund DD, Faraci FM, Ooboshi H, Davidson BL, Heistad DD
Adenovirus-mediated gene transfer is augmented in basilar and carotid arteries of heritable hyperlipidemic rabbits.
Stroke 1998; 29: 120-125

414) Brasen JH, Harsch M, Miendorf A
Survival and cardiovascular pathology of heterozygous Watanabe heritable hyperlipidemic rabbits treated with pravastatin and probucol on a low cholesterol (0.03%)-enriched diet.
Virchows Arch 1998; 432: 557-562

Bibliography of WHHL rabbits



(1999)

415) Hope S, Brecher P, Chobanian AV
Comparison of the effects of AT(1) receptor blockade and angiotensin converting enzyme inhibition on atherosclerosis.
Am J Hypertens 1999; 12: 28-34

416) Hakkinen T, Luoma JS, Hiltunen MO, Macphee CH, Milliner KJ, Patel L, Rice SQ, Tew DG, Karkola K, Yla-Herttunla S
Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase, is expressed by macrophages in human and rabbit atherosclerotic lesions.
Arterioscler Thromb Vasc Biol 1999; 19: 2909-2917

417) Lauridsen ST, Mortensen A
Probucol selectively increases oxidation of atherogenic lipoproteins in cholesterol-fed mice and in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1999; 142: 169-178

418) Shiomi M, Ito T, Tsukada T, Tsujita Y, Horikoshi H
Combination treatment with troglitazone, an insulin action enhancer, and pravastatin, an inhibitor of HMG-CoA reductase, shows synergistic effect on atherosclerosis of WHHL rabbits.
Atherosclerosis 1999; 142: 345-353
   < Abstract or Full paper >

419) Pang ZJ, Zhou M, Chen Y, Wan J
Macrophage colony-stimulating factor reduces tetra-butyl hydroperoxide induced oxidative injury to monocytes/macrophages.
Atherosclerosis 1999; 147: 33-40

420) Laury-Kleintop LD, Gleason M, Tulenko TN
Expression of the heterogeneous nuclear ribonucleoprotein complex K protein and the prolyl-4-hydroxylase alpha-subunit in atherosclerotic arterial smooth muscle cells.
Biochem Biophys Res Comm 1999; 260: 382-389

421) Shiomi M, Ito T
Effects of cerivastatin sodium, a new inhibitor of HMG-CoA reductase, on plasma lipid levels, progression of atherosclerosis, and the lesional composition in the plaques of WHHL rabbits.
Br J Pharmacol 1999; 126: 961-968
   < Abstract or Full paper >

422) Matsumura T, Kugiyama K, Sugiyama S, Ota Y, Doi H, Ogata N, Oka H, Yasue H
Suppression of atherosclerotic development in Watanabe heritable hyperlipidemic rabbits treated with an oral antiallergic drug, tranilast.
Circulation 1999; 99: 919-924

423) Shindo J, Ishibashi T, Yokoyama K, Ohwada T, Shiomi M, Maruyama Y
Granulocyte-macrophage colony-stimulating factor prevents the progression of atherosclerosis via changes in the cellular and extracellular composition of atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbits.
Circulation 1999; 99: 2150-2156
   < Abstract or Full paper >

424) Stocker R
Dietary and pharmacological antioxidants in atherosclerosis.
Curr Opin Lipidol 1999; 10: 589-597

425) Pakkanen TM, Laitinen M, Hippelainen M, Kallionpaa H, Lehtolainen P, Leppanen P, Luoma JS, Tarvainen R, Alhava E, Yla-Herttuala S
Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver resection and thymidine kinase ganciclovir treatment.
Gene Therapy 1999; 6: 34-41

426) Napoli C, Cicala C, D'Armiento P, Roviezzo F, Somma P, de-Nigris F, Zulian P, Bucci M, Aleotti L, Casini A, Franconi F, Cirino G
Beneficial effects of ACE-inhibition with zofenopril on plaque formation and low-density lipoprotein oxidation in Watanabe heritable hyperlipidemic rabbits.
Gen Pharmacol 1999; 33: 467-477

427) Parise F, Simone L, Croce MA, Ghisellini M, Battini R, Borghi S, Tiozzo R, Ferrari S, Calandra S, Ferrari S
Construction and in vitro functional evaluation of a low-density lipoprotein receptor/transferrin fusion protein as a therapeutic tool for familial hypercholesterolemia.
Human gene Therapy 1999; 10: 1219-1228

428) Wakabayashi Y
Effect of red wine consumption on low-density lipoprotein oxidation and atherosclerosis in aorta and coronary artery in Watanabe heritable hyperlipidemic rabbits.
J Agrical Food Chem 1999; 47: 4724-4730

429) Mori M, Itabe H, Takatoku K, Shima K, Inoue J, Nishiura M, Takahashi H, Ohtake H, Sato R, Higashi Y, Imanaka T, Ikegami S, Takano T
Presence of phospholipid-neutral lipid complex structures in atherosclerotic lesions as detected by a novel monoclonal antibody.
J Biol Chem 1999; 274: 24828-24837

430) Yamaguchi Y, Kogata S, Kunitomi M, Haginaka J
High-performance liquid chromatographic assay of hydroperoxide levels in oxidatively modifies lipoproteins.
J Chromatography 1999; 731: 223-229

431) Witting P, Pettersson K, Ostlund-Lindqvist AM, Westerlund C, Wagberg M, Stocker R
Dissociation of atherosclerosis from aortic accumulation of lipid hydro(pero)xides in Watanabe heritable hyperlipidemic rabbits.
J Clin Invest 1999; 104: 213-220

432) Clunn GF, Wijetunge S, Hughes AD
Effect of hypercholesterolemia on voltage-operated calcium channel currents in rabbit arterial smooth muscle cells.
J Hum Hypertens 1999; 13: 849-853

433) Brousseau ME, Hoeg JM
Transgenic rabbits as models for atherosclerosis research.
J Lipid Res 1999; 40: 365-375

434) Tsimikas S, Palinski W, Halpern SE, Yeung DW, Curtiss LK, Witztum JL
Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo.
J Nutr Cardiol 1999; 6: 41-53

435)

436) Allott CP, Barry CD, Bramley J, John NW, Mellor PM, Thomson DS, Reilly CF
Noninvasive 3-D ultrasound of atherosclerotic plaques in the Watanabe rabbit.
Ultrasound Med Biol 1999; 25: 905-914

Bibliography of WHHL rabbits





(2000)

437) Metzler B, Hu YH, Dietrich H, Xu QB
Increased expression and activation of stress-activated protein kinase/c-jun NH2-terminal protein kinase in atherosclerotic lesional coincide with p53.
Am J Pathol 2000; 156: 1875-1886

438) Orfanos SE, Parkerson HB, Chen XL, Fisher EL, Glynos C, Papapetropoulos A, Gerrity RG, Catravas JD
Reduced lung endothelial angiotensin-converting enzyme activity in Watanabe heritable hyperlipidemic rabbits in vivo.
Am J Physiol Lung Cell Mol Physiol 2000; 278: L1280-L1288

439) Brousseau ME, Kauffman RD, Herderick EE, Demosky SJ, Evans W, Marcovina S, Santamarina-Fojo S, Brewer HB, Hoeg JM
LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptor in transgenic rabbits.
Arterioscler Thromb Vasc Biol 2000; 20: 450-458

440) Chen MY, Kakutani M, Minami M, Kataoka H, Kume N, Narumiya S, Kita T, Masaki T, Sawamura T
Increased expression of lectinlike oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 2000; 20: 1107-1115

441) Tsutsumi K, Inoue Y, Murase T
Effects of NO-1886, a lipoprotein lipase promoting agent, on homozygous and heterozygous Watanabe heritable hyperlipidemic rabbits.
Arzneim Forsh/Drug Res 2000; 50: 118-121

442) Suzuki H, Yamazaki H, Aoki T, Kojima J, Tamaki T, Sato F, Kitahara M, Saito Y
Lipid-lowering and antiatherosclerotic effect of NK-104, in Watanabe heritable hyperlipidemic rabbits.
Arzneim Forsh/Drug Res 2000; 50: 995-1003

443) Sloop GD, Fallon KB, Lipscomb G, Takei H, Zieske A
The distribution of oxidatively-modified lysine in the human vasculature.
Atherosclerosis 2000; 148: 255-263

444) Worthley SG, Helft G, Fuster V, Zaman AG, Fayad ZA, Fallon JTT, Badimon JJ
Serial in vivo MRI documents arterial remodeling in experimental atherosclerosis.
Circulation 2000; 101: 586-589

445) de Nigris F, Youssef T, Ciafre S, Franconi F, Anania V, Condorelli GL, Palinski W, Napoli C
Evidence for oxidative activation of c-Myc-dependent nuclear signaling in human coronary smooth muscle cells and in early lesions of Watanabe heritable hyperlipidemic rabbits: Protective effects of vitamin E.
Circulation 2000; 102: 2111-2117

446) Amerongen GPV, Vermeer MA, Negre-Aminou P, Lankelma J, Emeis JJ, van Hinsbergh VWM
Simvastatin improves disturbed endothelial barrier function.
Circulation 2000; 102: 2803-2809

447) Oelze M, Mollnau H, Hoffmann N, Warnholtz A, Bodenschatz M, Smolenski A, Walter U, Skatchkov M, Meinertz T, Munzel T
Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction.
Circ Res 2000; 87: 999-1005

448) Suzumura K, KasaharaE, Ohnishi Y, Chien KC, Inoue M
Fluvastatin normalizes the decreased turnovers of glutathione and ascorbic acid in Watanabe heritable hyperlipidemic rabbits.
Clin Exp Pharmacol P 2000; 27: 709-714

449) Yamaguchi Y, Kagota S, Haginaka J, Kunitomo M
Evidence of modified LDL in the plasma of hypercholesterolemic WHHL rabbits injected with aqueous extracts of cigarette smoke.
Environ Toxicol Phamacol 2000; 8: 255-260

450) Shimada K, Yoshida K, Tadokoro H, Ueda M, Shiomi M, Kitsukawa S, Takami A, Komatsu R, Suzuki K, Tanada S, Masuda Y
Adenosine-induced coronary flow reserve in Watanabe heritable hyperlipidemic rabbits.
Jpn Circ J 2000; 64: 971-976
   < Abstract or Full paper >

451) Ayajiki K, Ozaki M, Shiomi M, Okamura T, Toda N
Comparison of endothelium-dependent relaxation in carotid arteries from Japanese white and Watanabe heritable hyperlipidemic rabbits.
J Cardiovasc Pharmacol 2000; 36: 622-630
   < Abstract or Full paper >

452) Fan J, Challah M, Shimoyamada H, Shiomi M, Marcovina S, Watanabe T
Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein(a).
J Lipid Res 2000; 41: 1004-1012
   < Abstract or Full paper >

453) Suzumura K, Kasahara E, Wang Y, Chien KC, Inoue M
Decreased turnovers of glutathione and ascorbic acid in Watanabe heritable hyperlipidemic rabbits.
J Nutr Sci Vitaminol 2000; 46: 205-209

454) Pauletto P, Puato M, Faggin E, Sartore S
Low-dose cerivastatin inhibits spontaneous atherosclerosis in heterozygous Watanabe heritable hyperlipidemic rabbits.
J Vasc Res 2000; 37: 189-194

455) Shiomi M, Ito T, Fujioka T, Tsujita Y
Age-associated decrease in plasma cholesterol and changes in cholesterol metabolism in homozygous Watanabe heritable hyperlipidemic rabbits.
Metabolism 2000; 49: 552-556
   < Abstract or Full paper >




(2001)



Bibliography of WHHL rabbits