Bibliography of WHHL rabbits


1975 - 1990


(1975)

1) Kondo T, Watanabe Y
A heritable hyperlipidemic rabbit.
Exp Anim 1975; 24: 89-94

Bibliography of WHHL rabbits


(1980)

2) Watanabe Y
Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit).
Atherosclerosis 1980; 36: 261-268

3) Tanzawa K, Shimada Y, Kuroda M, Tsujita Y, Arai M, Watanabe Y
WHHL-rabbit: A low density lipoprotein receptor-deficient animal model for familial hypercholesterolemia.
FEBS Lett 1980; 118: 81-84

Bibliography of WHHL rabbits


(1981)

4) Kawai K, Maruno H, Watanabe Y, Hirohata K
Fat necrosis of osteocytes as a casusative factor in idiopathic osteonecrosis in heritable hyperlipidemic rabbits.
Clin Orthop 1981; 118: 557-564

5) Watanabe Y, Ito T, Saeki M, Kuroda M, Tanzawa K, Mochizuki M, Tsujita Y, Arai M
Hypolipidemic effects of CS-500 (ML-236B) in WHHL-rabbit, a heritable animal model for hyperlipidemia.
Atherosclerosis 1981; 38: 27-31

6) Shimada Y, Tanzawa K, Kuroda M, Tsujita Y, Arai M, Watanabe Y
Biochemical characterization of skin fibroblasts derived from WHHL-rabbit, a notable animal for familial hypercholesterolemia.
Eur J Biochem 1981; 118: 557-564

7) Kita T, Brown MS, Watanabe Y, Goldstein JL
Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia.
Proc Natl Acad Sci USA 1981; 78: 2268-2272

8) Attie AD, Pittman RC, Watanabe Y, Steinberg D
Low density lipoprotein receptor deficiency in cultured hepatocytes of the WHHL rabbit.
J Biol Chem 1981; 256: 9789-9792

Bibliography of WHHL rabbits


(1982)

9) Havel RJ, Kita T, Kotite L, Kane JP, Hamilton RL, Goldstein JL, Brown MS
Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit.
Arteriosclerosis 1982; 2: 467-474

10) Tsukitani M, Okamoto R, Suehiro A, Hatani M, Fujino M, Imai N, Takano S, Watanabe Y, Fukuzaki H
LDL receptor activity of cultured arterial smooth muscle cells from genetically hyperlipidemic rabbits (WHHL-rabbit).
 Kobe J Med Sci 1982; 28: 171-179

11) Bilheimer DW, Watanabe Y, Kita T
Impaired receptor-mediated catabolism of low density lipoprotein in the WHHL rabbit, an animal model of familial hypercholesterolemia.
Proc Natl Acad Sci USA 1982; 79: 3305-3309

12) Kita T, Goldstein JL, Brown MS, Watanabe Y, Hornick CA, Havel RJ
Hepatic uptake of chylomicron remnants in WHHL rabbits: A mechanism genetically distinct from the low density lipoprotein receptor.
Proc Natl Acad Sci USA 1982; 79: 3623-3627

13) Kita T, Brown MS, Bilheimer DW, Goldstein JL
Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.
Proc Natl Acad Sci USA 1982; 79: 5693-5697

14) Pittman RC, Carew TE, Attie AD, Witztum JL, Watanabe Y, Steinberg D
Receptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits.
J Biol Chem 1982; 257: 7994-8000

Bibliography of WHHL rabbits


(1983)

15) Niekerk JLMV, Demacker PNM, Hendriks T, Boer HHMD
A comparative study on serum lipids and atherosclerotic plaque formation in diet-induced and familial hypercholesterolemia in rabbits, and the effect of partial ileal bypass.
Artery 1983; 12: 263-276

16) Buja LM, Kita T, Goldstein JL, Watanabe Y, Brown MS
Cellular pathology of progressive atherosclerosis in the WHHL rabbit, an animal model of familial hypercholesterolemia
Arteriosclerosis 1983; 3: 87-101

17) Okamoto R, Hatani M, Tsukitani M, Suehoro A, Fujino M, Imai N, Takano S, Watanabe Y, Fukuzaki H
The effect of oxygen on the development of atherosclerosis in WHHL rabbits.
Atherosclerosis 1983; 47: 47-53

18) Niekerk JLMV, Demacker PNM, Hendriks T, Boer HHMD
Partial ileal bypass inhibits atherosclerosis in WHHL rabbits.
Atherosclerosis 1983; 48: 243-252

19) Yokoyama M, Akita H, Mizutani T, Fukuzaki H, Watanabe Y
Hyperreactivity of coronary arterial smooth muscles in response to ergonovine from rabbits with hereditary hyperlipidemia.
Circ Res 1983; 53: 63-71

20) Steinbrecher P, Witztum JL, Kesaniemi YA, Elam RL
Comparison of glucosylated low density lipoprotein with methylated or cyclohexanedione-treated low density lipoprotein in the measurement of receptor-independent low density lipoprotein catabolism.
J Clin Invest 1983; 71: 960-964

21) Dietschy JM, Kita T, Suckling KE, Goldstein JL, Brown MS
Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors.
J Lipid Res 1983; 24: 469-480

22) Goldstein JL, Kita T, Brown MS
Defective lipoprotein receptors and atherosclerosis: Lessons from an animal counterpart of familial hypercholesterolemia.
N Engl J Med 1983; 309: 288-296

23) Schneider WJ, Brown MS, Goldstein JL
Kinetic defects in the processing of the low density lipoprotein receptor in fibroblasts from WHHL rabbits and a family with familial hypercholesterolemia.
Mol Biol Med 1983; 1: 353-367

24) Hornick CA, Kita T, Hamilton RL, Kane JP, Havel RJ
Secretion of lipoproteins from the liver of normal and Watanabe heritable hyperlipidemic rabbits.
Proc Natl Acad Sci USA 1983: 80: 6096-6100

25) Kolata G
Cholesterol-heart disease link illuminated.
Science 1983; 221: 1164-1166

Bibliography of WHHL rabbits


(1984)

26) Baker DP, Lenten BJV, Fogelman AM, Edwards PA, Kean C, Berliner JA
LDL, scavenger, and b-VLDL receptors on aortic endothelial cells.
Arteriosclerosis 1984; 4: 248-255

27) Yokoyama S, Hayashi R, Kikkawa T, Tani N, Takada S, Hatanaka K, Yamamoto A
Specific sorbent of apolipoprotein B-containing lipoproteins for plasmapheresis: characterization and experimental use in hypercholesterolemic rabbits.
Arteriosclerosis 1984; 4: 276-282

28) Niekerk JLMV, Hendriks T, Boer HHMD, Laar AV
Does nifedipine suppress atherogenesis in WHHL rabbits?
Atherosclerosis 1984; 53: 91-98

29) Niekerk JLMV, Hendriks T, Leuven JAG, Havekes L, Boer HHMD
The lipid-lowering effects of 3-hydroxy-3-methylglutaryl acid and bile acid drainage in WHHL rabbits.
Clin Sci 1984; 67: 439-444

30) Morii H, Nishizawa Y, Okui Y, Miki T, Inaba M, Kikkawa T, Yamamoto A, Watanabe Y
Effect of calcitonin on lipid metabolism in experimental animals.
Endocrine Control of Bone and Calcium Metabolism 1984; 365-368

31) Niekerk JLMV, Hendriks T, Boer HHMD
Bile acid drainage by partial small bowel bypass or cholestyramine: Effects on serum cholesterol in Watanabe heritable hyperlipidemic rabbits.
Eur Surg Res 1984; 16: 282-287

32) Huettinger M, Schneider WJ, Ho YK, Goldstein JL, Brown MS
Use of monoclonal anti-receptor antibodies to probe the expression of the low density lipoprotein receptor in tissues of normal and Watanabe heritable hyperlipidemic rabbits.
J Clin Invest 1984; 74: 1017-1026

33) Wakasugi T, Mabuchi H, Sakai Y, Sakai T, Yoshimura A, Watanabe A, Koizumi J, Miyamoto S, Takeda R, Watanabe Y
ApoVLDL of the Watanabe heritable hyperlipidemic rabbit and the cholesterol-fed rabbit.
J Lipid Res 1984; 25: 246-253

34) Naruszewicz M, Carew TE, Pittman RC, Witztum JL, Steinberg D
A novel mechanism by which probucol lowers low density lipoprotein levels demonstrated in the LDL receptor-deficient rabbit.
J Lipid Res 1984; 25: 1206-1213

35) Stalenhoef AFH, Niekerk JLMV, Demacker PNM, Laar AV
Partial ileal bypass reduces the production rate of low density lipoproteins in Watanabe heritable hyperlipidemic rabbits.
J Lipid Res 1984; 25: 1350-1357

36) Huettinger M, Corbett JM, Schneider WJ, Willerson JT, Brown MS, Goldstein JL
Imaging of hepatic low density lipoprotein receptors by radionuclide scintiscanning in vivo.
Proc Natl Acad Sci USA 1984; 81: 7599-7603

Bibliography of WHHL rabbits


(1985)

37) Watanabe Y, Ito T, Shiomi M
The effect of selective breeding on the development of coronary atherosclerosis in WHHL rabbits, an animal model for familial hypercholesterolemia.
Atherosclerosis 1985; 56: 71-79
   < Abstract or Full paper >

38) Tilton GD, Buja LM, Bilheimer DW, Apprill P, Ashton J, Mcnatt J, Kita T, Willerson JT
Failure of a slow channel calcium antagonist, verapamil, to retard atherosclerosis in the Watanabe heritable hyperlipidemic rabbit, an animal model of familial hypercholesterolemia.
J Am Coll Cardiol 1985; 6: 141-144

39) Phelan JP, Lenten BJV, Fogelman AM, Kean C, Haberland ME, Edwards PA
Notes on the breeding of the WHHL rabbit, an animal model of familial hypercholesterolemia.
J Lipid Res 1985; 26: 776-778

40) Hoeg JM, Loriaux L, Gregg RE, Green WR, Brewer GH
Impaired adrenal reserve in the Watanabe heritable hyperlipidemic Rabbit: Implications for LDL-receptor function in steroidogenesis.
Metabolism 1985; 34: 194-197

Bibliography of WHHL rabbits


(1986)


41) Takano T, Amanuma K, Kimura J, Kanaseki T, Ohkuma S
Involvement of macrophages in accumulation and elimination of cholesterol ester in atherosclerotic aorta.
Acta Histochem Ccytochem 1986; 19: 135-143

42) Son YC, Zilversmit DB
Increased lipid transfer activities in hyperlipidemic rabbit plasma.
Arteriosclerosis 1986; 6: 345-351

43) Tsukada T, Rosenfeld M, Ross R, Gown AM
Immunocytochemical analysis of cellular components in atherosclerotic lesions: Use of monoclonal antibodies with the Watanabe and fat-fed rabbit.
Arteriosclerosis 1986; 6: 601-613

44) Richards T, Horlock H, Gallagher P
Atherosclerosis in modified WHHL rabbits.
Animal Technology 1986; 37: 1-6

45) Mowri H, Chinen k Ohkuma S, Takano T
Peroxidized lipid isolated by HPLC from atherosclerotic aorta.
Biochem Int 1986; 12: 437-352

46) Tsujita Y, Kuroda M, Shimada Y, Tanzawa K, Arai M, Kaneko I, Tanaka M, Masuda H, Tarumi C, Watanabe Y, Fujii S
CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: Tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species.
Biochim Biophys Acta 1986; 877: 50-60

47) Hosomi H, Katsuda S, Watanabe Y
Effect of atherosclerosis on the responsiveness of the rapidly acting arterial pressure control system in WHHL rabbits.
Cardiovasc Res 1986; 20: 195-200

48) Wade DP, Knight BL, Soutar K
Binding of low-density lipoprotein and chylomicron remnants to the hepatic low-density lipoprotein receptor of dogs, rats and rabbits demonstrated by ligand blotting: Failure to detect a distinct chylomicron-remnant- binding protein by ligand blotting.
Eur J Biochem 1986; 159: 334-340

49) Kita T, Yokode M, Watanabe Y, Narumiya S, Kawai
Stimulation of cholesteryl ester synthesis in mouse peritoneal macrophages by cholesterol-rich very low density lipoproteins from the Watanabe heritable hyperlipidemic rabbit, an animal model of familial hypercholesterolemia.
J Clin Invest 1986; 77: 1460-1465

50) Navab M, Hough GP, Berline JA, Frank JA, Fogelman AM, Haberland ME, Edwards PA
Rabbit beta-migrating very low density lipoprotein increases endothelial macromolecular transport without altering electrical resistans.
J Clin Invest 1986; 78: 389-397

51) Ecsedi GG, Virag S
Accumulation of cholesterol ester in cultured smooth muscle cells of congenital hypercholesterolemic (WHHL) rabbits treated with normal and WHHL rabbit plasma LDL.
Methods Find Exp Clin Pharmacol 1986; 8(9): 535-542

52) Ma PTS, Gil G, Sudhof TC, Billheimer DW, Goldstein JL, Brown MS
Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits.
Proc Natl Acad Sci USA 1986; 83: 8370-8374

53) Yamamoto T, Bishop RW, Brown MS, Goldstein JL, Russell DW
Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit.
Science 1986; 232: 1230-1237

54) Kutsumi Y, Fujiwara R, Tamai T, Takai H, Nakai T, Miyabo S
Long-tern repetitive plasmapheresis in hypercholesterolemic rabbits.
ASIO Trans 1986; 32: 163-167

55) Kimura J, Nakagami K, Amanuma K, Ohkuma S, Yoshida Y, Takano T
Monoclonal antibodies recognizing lipid-laden cells and extracellular regions with lipid-deposits in atherosclerotic aorta.
Virchows Arch A 1986; 410: 159-164

56) Amanuma K, Kanaseki T, Ikeuchi Y, Ohkuma S, Takano T
Studies on fine structure and location of lipids in quick-freeze replicas of atherosclerotic aorta of WHHL rabbits.
Virchows Arch A 1986; 410: 231-238

Bibliography of WHHL rabbits


(1987)

57) Hatanaka K, Ito T, Shiomi M, Yamamoto A, Watanabe Y
Ischemic heart disease in the WHHL rabbit: A model for myocardial injury in genetically hyperlipidemic animals.
Am Heart J 1987; 113: 280-288
   < Abstract or Full paper >

58) Kovanen PT
Regulation of plasma cholesterol by hepatic low-density lipoprotein receptors.
Am Heart J 1987; 113: 464-469

59) Rosenfeld ME, Tsukada T, Gown AM, Ross R
Fatty streak initiation in Watanabe heritable hyperlipidemic and comparably hypercholesterolemic fat-fed rabbits.
Arteriosclerosis 1987; 7: 9-23

60) Rosenfeld ME, Tsukada T, Chait A, Bierman EL, Gown AM, Ross R
Fatty streak expansion and maturation in Watanabe heritable hyperlipidemic and comparably hypercholesterolemic fat-fed rabbits.
Arteriosclerosis 1987; 7: 24-34

61) Kano M, Koizumi J, Jadhav A, Thompson GR
Plasma exchange and low density lipoprotein apheresis in Watanabe heritable hyperlipidemic rabbits.
Arteriosclerosis 1987; 7: 256-261

62) Watanabe N, Ishikawa Y, Okamoto R, Watanabe Y, Fukuzaki H
Nifedipine suppressed atherosclerosis in cholesterol-fed rabbits but not in Watanabe heritable hyperlipidemic rabbits.
Artery 1987; 14(5): 283-294

63) Niekerk JLMV, Hendriks T, Boer HHMD
Effect of partial ileal bypass on the progression of atherosclerosis lesions in WHHL rabbits.
Atherosclerosis 1987; 63: 225-230

64) Ishikawa Y Watanabe N, Okamoto R, Watanabe Y, Fukuzaki H
Nifedipine-suppressed atherosclerosis in cholesterol-fed rabbits but not in Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1987; 64: 79-80

65) Shiomi M, Ito T, Watanabe Y
Increase in hepatic low-density lipoprotein receptor activity during pregnancy in Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia.
Biochim Biophys Acta 1987; 917: 92-100
   < Abstract or Full paper >

66) Subbiah MTR, Yunker RL, Rymaszewski Z, Kottke BA, Bale LK
Cholestyramine treatment in early life of low-density lipoprotein receptor deficient Watanabe rabbits: Decreased aortic cholesteryl ester accumulation and atherosclerosis in adult life.
Biochim Biophys Acta 1987; 920: 251-258

67) Bell FP, Raymond TL, Patnode CL
The influence of diet and carnitine supplementation on plasma carnitine, cholesterol and triglyceride in WHHL (Watanabe-heritable hyperlipidemic), Netherlands dwarf and New Zealand rabbits (oryctolagus cuniculus).
Comp Biochem Physiol. 1987; 87B: 587-591

68) Raymond TL, Reynilds SA, Swanson JA, Patnode CA, Bell FP
The effect of oral 1-carnitine on lipoprotein composition in the Watanabe heritable hyperlipidemic rabbit (oryctolagus cuniculus).
Comp Biochem Physiol 1987; 88A: 503-506

69) Hara A, Taketomi T
Occurrence of sulfatide as a major glycosphingolipid in WHHL rabbit serum lipoproteins.
J Biochem 1987; 102: 83-92

70) Tsukitani M, Okamoto R, Ishikawa Y, Mukodani J, Watanabe N, Suehiro A, Hatani M, Fujino M, Takano S, Watanabe Y, Fukuzaki H
Effect of hypoxia on lipid accumulation in cultured fibroblasts from normal rabbit and Watanabe heritable hyperlipidemic rabbit.
J Clin Biochem Nutr 1987; 2: 279-286

71) Yamada N, Shames DM, Havel RJ
Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma.
J Clin Invest 1987; 80: 507-515

72) Ikeda M, Kodama H, Nohara N
Process of foam cell formation in diet-induced hypercholesterolemic rabbit and the Watanabe heritable hyperlipidemic rabbit.
J Dermatol 1987; 14: 305-312

73) Spady DK, Huettinger M, Bilheimer DW, Dietschy JM
Role of receptor-independent low density lipoprotein transport in the maintenance of tissue cholesterol balance in the normal and WHHL rabbit.
J Lipid Res 1987; 28: 32-41

74) Shiomi M, Ito T, Watanabe Y
Effects of hyperlipidemia on the nursing ability of WHHL rabbits.
Lab Anim Sci 1987; 84-88
   < Abstract or Full paper >

75) Kita T, Nagano Y, Yokode M, Ishii K, Kume N, Ooshima A, Yoshida H, Kawai C
Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.
Proc Natl Acad Sci USA 1987; 84: 5928-5931

76) Hofmann SL, Russell DW, Goldstein JL, Brown MS
mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits.
Proc Natl Acad Sci USA 1987; 84: 6312-6316

77) Carew TE, Schwenke DC, Steinberg D
Antiatherogenic effect of probucol unrelated to its hypercholesterolemic effect: Evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbits.
Proc Natl Acad Sci USA 1987; 84: 7725-7729

Bibliography of WHHL rabbits


(1988)

78) Steinberg D, Parthasarathy S, Carew TE
In vivo inhibition of form cell development by probucol in Watanabe rabbits.
Am J Cardiol 1988; 62: 6B-12B

79) Kita T, Nagano Y, Yokode M, Ishii K, Kume N, Narumiya S, Kawai C
Prevention of atherosclerotic progression in Watanabe rabbits by probucol.
Am J Cardiol 1988; 62: 13B-19B

80) Clozel JP, Lengsfeld H, Kuhn H, Baumgartner HR
Decreased coronary vascular reserve in Watanabe heritable hyperlipidemic rabbits.
Arteriosclerosis 1988; 8: 310-320

81) Rosenfeld ME, Chait A, Bierman EL, King W, Goodwin P, Walden CE, Ross R
Lipid composition of aorta Watanabe heritable hyperlipidemic and comparably hypercholesterolemic fad-fed rabbits: Plasma lipid composition determines aortic lipid composition of hypercholesterolemic rabbits.
Arteriosclerosis 1988; 8: 338-347

82) Daugherty A, Zweifel BS, Sobel BE, Schonfeld G
Isolation of low density lipoprotein from atherosclerotic vascular tissue of Watanabe heritable hyperlipidemic rabbits.
Arteriosclerosis 1988; 8: 768-777

83) Rall CJN, Hong JM, Gregg RE, Law SW, Monge JC, ME, Meng MS, Zech LA, Brewer HB
Enhanced apolipoprotein E production with normal hepatic mRNA levels in the Watanabe heritable hyperlipidemic rabbit.
Arteriosclerosis 1988; 8: 804-809

84) Olsson G, Ostlund-lindquist AM, Bondjers G, Wiklund O, Olofsson SO
Quantification of plasma lipids and apolipoproteins in British Halflop rabbits: A comparison between normocholesterolemic rabbits, hypercholesterolemic rabbits (modified WHHL rabbits) and rabbits fed an atherogenic diet.
Atherosclerosis 1988; 70: 81-94

85) Gallagher PJ, Nanjee MN, Richards T, Roche ER, Miller NE
Biochemical and pathological features of a modified strain of Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 1988; 71: 173-183

86) Watanabe Y, Ito T, Shiomi M, Tsujita Y, Kuroda M, Arai M, Fukami M, Tamura A
Preventive effect of pravastatin sodium, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on coronary atherosclerosis and xanthoma in WHHL rabbits.
Biochim Biophys Acta 1988; 960: 294-302
   < Abstract or Full paper >

87) Ishii K, Kita T, Kume N, Nagano Y, Kawai
Uptake of acetylated LDL by peritoneal macrophages obtained from normal and Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia.
Biochim Biophys Acta 1988; 962: 387-389

88) Mowri H, Ohkuma S, Takano T
Monoclonal DLR1a/104G antibody recognizing peroxidized lipoproteins in atherosclerotic lesions.
Biochim Biophys Acta 1988; 963: 208-214

89) Hasegawa M, Watanabe Y
Rheological properties of the thoracic aorta in normal and WHHL rabbits.
Biorheology 1988; 25: 147-156

90) Morita H, Nishida Y, Motochigawa H, Watanabe Y, Hosomi H
Depressed baroreflex control of renal nerve activity in conscious WHHL rabbits.
Cardiovasc Res 1988; 22: 679-685

91) Uchida T, Tsuchiya R, Harada N, Tsunoda T, Yamaguchi T, Eto T, Furukawa M
Ischemic Changes in the pancreas of Watanabe heritable hyperlipidemic (WHHL) rabbits.
Int J Pancreatol 1988; 3: 261-272

92) Wu D, Fujiwara H, Tanaka M, Onodera T, Matsuda M, Ishida M, Kawamura A, Takemura G, Fujiwara T, Nagano Y, Ishii K, Kita T, Kawai C, Hamashima Y
Distribution and progression of coronary arterial and aortic lesions in the conventional Watanabe heritable hyperlipidemic rabbit.
Jpn Circ J 1988; 52: 327-340

93) Yokoyama S
Treatment of hypercholesterolemia by chemical adsorption of lipoproteins.
J Clin Apheresis 1988; 4: 66-71

94) Nishizawa Y, Okui Y, Inaba M, Okuno S, Yukioka K, Miki T, Watanabe Y, Morii H
Calcium/ calmodulin-mediated action of calcitonin on lipid metabolism in rats.
J Clin Invest 1988; 82: 1165-1172

95) Yamada N, Shames DM, Takahashi K, Havel RJ
Metabolism of apolipoprotein B-100 in large very low density lipoproteins of blood plasma.
J Clin Invest 1988; 82: 2106-2113

96) Williams KJ, Vallabhajosula S, Rahman IU, Donnelly TM, Parker T, Weinrauch M, Goldsmith SJ
Low density lipoprotein receptor-independent hepatic uptake of a synthetic, cholesterol-scavenging lipoprotein: Implications for the treatment of receptor-deficient atherosclerosis.
Proc Natl Acad Sci USA 1988; 85: 242-246

97) Wilson JM, Johnston DE, Jefferson DM, Mulligan RC
Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit.
Proc Natl Acad Sci USA 1988; 85: 4421-4425

98) Miyanohara A, Sharkey MF, Witztum,JL, Steinberg D, Friendmann T
Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vivo.
Proc Natl. Acad Sci USA 1988; 85: 6538-6542

99) Haberland ME, Fong D, Cheng L
Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits.
Science 1988; 241: 215-218

100) Garibaldi BA, Goad MEP
Lipid keratopathy in the Watanabe (WHHL) rabbit.
Vet Pathol 1988; 25: 173-174

101) Pfister SL, Schmitz JM, Willerson JT, Cambell WB
Characterization of arachidonic acid metabolism in Watanabe heritable hyperlipidemic (WHHL) and New Zealand white (NZW) rabbit aortas.
 Prostaglandins 1988; 36: 515-532

Bibliography of WHHL rabbits


(1989)

102) Nakagami K, Shimazaki O, Sato R, Komine Y, Ohkuma S, Takano T
Monoclonal antibody EMR1a/212D recognizing site of deposition of extracellular lipid in atherosclerosis: purification and characterization of the antigen.
 Am J Pathol 1989; 135: 93-100

103) Boyd HC, Gown AM, Wolfbaur G, Chait A
Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit.
 Am J Pathol 1989; 135: 815-825

104) Cohn W, Kuhn H
The role of the low density lipoprotein receptor for a-tocopherol delivery to tissues.
 Ann N Y Acad Sci 1989; 570: 61-71

105) Rich S, Miller JM, Charous S, Davis HR, Shanks P, Glagov S, Lands WEM
Development of atherosclerosis in genetically hyperlipidemic rabbits during chronic fish-oil ingestion.
 Arteriosclerosis 1989; 9: 189-194

106) Wines PA, Schmitz JM, Pfister SL, Clubb FJ, Buja LM, Wilson JT, Campbell WB
Augmented vasoconstrictor responses to serotonin precede development of atherosclerosis in aorta of WHHL rabbit.
 Arteriosclerosis 1989; 9: 195-202

107) Nagano Y, Kita T, Yokode M, Ishii K, Kume N, Otani H, Arai H, Kawai C
Probucol does not affect lipoprotein metabolism in macrophages of Watanabe heritable hyperlipidemic rabbits.
 Arteriosclerosis 1989; 9: 453-461

108) Wernette-Hammond ME, Garcia Z, Arnold KS, Innerarity TL
b-very low density lipoprotein uptake in cultured fibroblasts and smooth muscle cells from Watanabe heritable hyperlipidemic rabbits.
 Arteriosclerosis 1989; 9: 501-510

109) Clubb FJ, Schmitz JM, Butler MM, Buja LM, Willerson JT, Campbell WB
Effect of dietary omega-3 fatty acid on serum lipids, platelet function, and atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
 Arteriosclerosis 1989; 9: 529-537

110) Havel RJ, Yamada N, Shames DM
Watanabe heritable hyperlipidemic rabbit: animal model for familial hypercholesterolemia.
 Arteriosclerosis Suppl I 1989; 9: I-33 -I-38

111) Simon TC, Makheja AN, Bailey JM
Formation of 15-hydroxyeicosatetraenoic acid (15-HETE) as the predominant eicosanoid in aortas from Watanabe heritable hyperlipidemic and cholesterol-fed rabbits.
 Atherosclerosis 1989; 75: 31-38

112) Makheja AN, Bloom S, Muesing R, Simon T, Bailey JM
Anti-inflammatory drugs in experimental atherosclerosis 7. Spontaneous atherosclerosis in WHHL rabbits and inhibition by cortisone acetate.
 Atherosclerosis 1989; 76: 155-161

113) Atkinson JB, Hoover RL, Berry KK, Swift LL
Cholesterol-fed heterozygous Watanabe heritable hyperlipidemic rabbits: A new model for atherosclerosis.
 Atherosclerosis 1989; 78: 123-136

114) Saku K, Yamamoto K, Sakai T, Yanagida T, Hidaka K, Sasaki J, Arakawa K
Kinetics of HDL-apoA-1 in the WHHL rabbit, an animal model of familial hypercholesterolemia.
 Atherosclerosis 1989; 79: 225-230

115) Ragazzi E, Chinellato A, Biasi MD, Pandolfo L, Proadocimi M, Norido F, Caparrotta L, Fassina G
Endothelium-dependent relaxation, cholesterol content and high energy metabolite balance in Watanabe hyperlipidemic rabbit aorta.
 Atherosclerosis 1989; 80: 125-134

116) Mol MJTM, Stalenhoef FH, Demacker PNM, Laar AV
Low-density lipoprotein catabolism in WHHL rabbits after partial ileal bypass surgery.
 Biochim Biophys Acta 1989; 1003: 167-174

117) Allain P, Krari N, Chaleil D, Balanant Y, Bled F, Girault M
The distribution of elements in the tissues of Watanabe heritable hyperlipidemic rabbits.
 Biol Trace Elem Res 1989; 19: 153-160

118) Tsujita Y, Watanabe Y
Pravastatin sodium: A novel cholesterol-lowering agent that inhibits HMG-CoA reductase.
 Cardiovasc Drug Rev 1989; 7: 110-126

119) Kume N, Kita T, Mikami A, Yokode M, Ishii K, Nagano Y, Kawai C
Induction of mRNA for low-density lipoprotein receptor in heterozygous Watanabe heritable hyperlipidemic rabbits treated with CS-514 (Pravastatin) and cholestyramine.
 Circulation 1989; 79: 1084-1090

120) Shiomi M, Ito T, Watanabe Y, Tsujita Y, Kuroda M, Arai M, Fukami M, Fukushige J
Suppressive effect of the combination treatment with pravastatin sodium and cholestyramine on the progression of atherosclerosis and xanthoma in mature WHHL rabbits.
 Clin Ter Cardiovasc 1989; 8: 281-283

121) Pfister S, Rosolowsky M, Schmitz JM, Clubb FJ, Campbell WB
Eicosapentaenoic acid alters reactivity and platelet adhesion in Watanabe heritable hyperlipidemic rabbits.
 Eur J Pharmacol 1989; 161: 85-89

122) Chobanian AV, Lichtenstein AH, Nilakhe V, Haudenschild CC, Drago R, Nickerson C
Influence of hypertension on aortic atherosclerosis in the Watanabe rabbit
 Hypertension 1989; 14: 203-209

123) Taketomi T, Hara A, Uemura K, Kyogashima N
Effect of long-tern treatment on hyperlipidemia and progression of atherosclerosis in WHHL rabbits.
 Japan J Exp Med 1989; 59: 221-231

124) Kono K, Iwata Y, Tajima T, Kuzuya F
Effect of AJ814 on lipid metabolism and atherosclerotic lesions in cholesterol-fed rabbits, Triton- injected rabbits and WHHL rabbit.
 J Jpn Atheroscler Soc 1989; 17: 97-99

125) Hofmann SL, Brown MS, Lee E, Pathak RK, Anderson RGW, Goldstein JL
Purification of a sarcoplasmic reticulum protein that bonds Ca2+ and plasma lipoproteins.
 J Biol Chem 1989; 264: 8260-8270

126) Mahley RW, Weisgraber KH, Hussein MM, Greenman B, Fisher M, Vogel T, Goreck M
Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits.
 J Clin Invest 1989; 83: 2125-2130

127) Dalessandri KM, Lantz BMT, Tsukamoto H, Link DP, Brock J
Superior mesenteric artery vasoactivity in hyperlipidemic Watanabe rabbits versus normal lipidemic New Zealand controls.
 J Invest Surg 1989; 2: 471-477

128) Ishii K, Kita T, Yokode M, Kume N, Nagano Y, Otani H, Yamamura T, Murayama S, Morimoto Y, Teranishi Y, Kawai C
Characterization of very low density lipoprotein from Watanabe heritable hyperlipidemic rabbits.
 J Lipid Res 1989; 30: 1-7

129) Frank JS, Fogelman AM
Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching.
 J Lipid Res 1989; 30: 967-978

130) Lichtenstein AH, Drago R, Nickerson C, Prescott MF, Lee SQ, Chobanian AV
Effect of propranolol on atherogenesis in the Watanabe heritable hyperlipidemic rabbit.
 J Vas Med Biol 1989; 1: 248-254

131) Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JM
Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenecity.
 N Engl J Med 1989; 320: 915-924

132) Mori Y
A study on coagulability in Watanabe heritable hyperlipidemic rabbits and patients with familial hypercholesterolemia.
 Mie Med J 1989; 36: 83-97

133) Udon C, Barnard D, Smoth T
Serum cholinesterase isoenzymes and the WHHL rabbit: the relationship between the activity of cholinesterase not bound to low-density-lipoprotein and lipoprotein titer.
 Mol Cell Biochem 1989; 90: 121-125

134) Pandolfo L, Chinellato A, Zambonin M, Biasi MD, Ragazzi E, Caparrotta L
Influence of the age on energy metabolism and purines turnover in Watanabe hyperlipidemic (WHHL) rabbit aorta.
 Pharmacol Res 1989; 21: 115-116

135) Yamada N, Shimano H, Mokuno H, Ishibashi S, Gotohda T, Kawakami M, Watanabe Y, Akanuma Y, Murase T, Takaku F
Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits.
 Proc Natl Acad Sci USA 1989; 86: 665-669

136) Palinski W, Rosenfeld ME, Yla-herttuala S, Gurtner GC, Socher SS, Bulter SW, Partharathy S, Carew TE, Steinberg D, Witztum JL
Low density lipoprotein undergoes oxidative modification in vivo.
 Proc Natl Acad Sci USA 1989; 86: 1372-1376

137) Mathe D, Baudet MF, Boisnier C, Jacotot B
Le lapin WHHL et l'therosclerose experimentale: caracteristiques et utilisation.
 Sci Tech Anim Lab 1989; 14: 65-71

138) Mori Y, Wada H, Nagano Y, Deguchi K, Kita T, Shirakawa S
Hypercoagulable state in the Watanabe heritable hyperlipidemic rabbit, an animal model for the progression of atherosclerosis: effect of probucol on coagulation
Thromb Haemostas 1989; 61: 140-143

139) Lawrence JB, Prevosti LG, Kramer WS, Lu DY, Leon MB
Platelet adherence and thrombus formation with flowing human blood on atherosclerotic plaque: reduced thrombogenecity of Watanabe-heritable hyperlipidemic rabbit aortic subendothelium.
 Thromb Res 1989; 54: 99-114

140) Simon TC, Makheja AN, Bailey JM
The induced lipoxygenase in atherosclerotic aorta converts linoleic acid to the platelet chemorepellant factor 13-HODE.
 Thromb Res 1989; 55: 171-178

141) Komiyama Y, Masuda M, Murakami T, Nishikado H, Egawa H, Nishimura T, Morii S, Murata K
Accumulation of 125I-factor XI in atheroma of rabbit with hereditary hyperlipidemia (WHHL-rabbit).
 Thromb Res 1989; 56: 49-58

Bibliography of WHHL rabbits


(1990)

142) Workman JR, Schmidt SP, Donovan DL, Clarke R
The effect of heparin upon atherogenesis in the Watanabe heritable hyperlipidemic rabbit.
 Ann Vasc Surg 1990; 4: 344-350

143) Rosenfeld ME, Palinski W, Yla-Herttuala S, Bulter S, Witztum JL
Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.
 Arteriosclerosis 1990; 10: 336-349

144) Tsunemitsu M, Ishikawa Y, Taniguchi T, Fukuzaki H
Heterogeneity of n-linked sugar chains of apolipoprotein B-100 in Watanabe heritable hyperlipidemic and fasting rabbits.
 Arteriosclerosis 1990; 10: 386-393

145) Lichtenstein AH, Chobanian AV
Effect of fish oil on atherogenesis in Watanabe heritable hyperlipidemic rabbit.
 Arteriosclerosis 1990; 10: 597-606

146) Rosenfeld ME, Ross R
Macrophage and smooth muscle cell proliferation in atherosclerotic lesions of WHHL and comparably hypercholesterolemic fat-fed rabbits.
 Arteriosclerosis 1990; 10: 680-687

147) Saku K, Fujino M, Yamamoto K, Ying H, Tashiro N, Harada R, Okabe M, Arakawa K
Cardiac function of WHHL rabbit, an animal model of familial hypercholesterolemia.
 Artery 1990; 17: 271-280

148) Beaumont JL, Vivier P
Circulating IgA-Lp complexes in Watanabe heritable hyperlipidemic and cholesterol fed NZW rabbit.
 Atherosclerosis 1990; 82: 227-235

149) Shiomi M, Ito T, Watanabe Y, Tsujita Y, Kuroda M, Arai M, Fukami M, Fukushige J, Tamura A
Suppression of established atherosclerosis and xanthomas in mature WHHL rabbits by keeping their serum cholesterol levels extremely low: Effect of pravastatin sodium in combination with cholestyramine.
 Atherosclerosis 1990; 83: 69-80
   < Abstract or Full paper >

150) Saku K, Harada R, Yamamoto K, Ying H, Ozaki I, Arakawa K
Apolipoprotein AI mRNA levels in WHHL rabbits.
 Atherosclerosis 1990; 84: 73-74

151) Atkinson JB, Swift LL
Nifedipine reduces atherogenesis in cholesterol-fed heterozygous WHHL rabbits.
 Atherosclerosis 1990; 84: 195-201

152) Armstrong ML, Heistad DD
Animal model of atherosclerosis.
 Atherosclerosis 1990; 85: 15-23

153) Beaumont J, Assadollahi F
Retinyl palmitate labeled intestinally derived lipoproteins accumulate in the circulation of WHHL rabbits.
 Atherosclerosis 1990; 85: 103-111

154) Denacker NM, Mol MJT, Stalenhoef FH
Increased hepatic lipase activity and increased direct removal of very-low-density lipoprotein remnants in Watanabe heritable hyperlipidemic (WHHL) rabbits treated with ethinyl oestradiol.
 Biochem J 1990; 272: 647-651

155) Kolodgie FD, Virmani R, Rice HE, Mergner WJ
Vascular reactivity during the progression of atherosclerotic plaque: a study in Watanabe heritable hyperlipidemic rabbits.
 Circ Res 1990; 66: 1112-1126

156) Chobanian AV
The effect of ACE inhibitors and other antihypertensive drugs on cardiovascular risk factors and atherogenesis.
 Clin Cardiol 1990; 13: VII-43-48

157) St John LC, Bell FP
Arterial fatty acid-binding protein activity associated with dietarily-induced and spontaneously occurring atherosclerosis in the rabbit (oryctolagug cuniculus).
 Comp Biochem Physiol 1990; 97B: 123-127

158) Buja LM, Clubb FJ, Bilheimer DW, Willerson JT
Pathobiology of human familial hypercholesterolemia and a related animal model, the Watanabe heritable hyperlipidemic rabbit.
 Eur Heart J 1990; 11: 41-52

159) Kita T, Ishii K, Yokode M, Kume N, Nagano Y, Arai H, Kawai C
The role of oxidized low density lipoprotein in the pathogenesis of atherosclerosis.
 Eur Heart J 1990; 11: 122-127

160) Mokuno H, Ishibashi S, Shimano H, Gotohda T, Takaku F, Yamada N
Effect of exogenous apo E on the cellular binding of lipoproteins.
 Gerontology 1990; 36: 42-48

161) Chobanian AV, Haudenschild CC, Nickerson C, Drago R
Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit.
 Hypertension 1990; 15: 327-331

162) Chobanian AV
1989 Corcoran lecture: Adaptive and maladaptive responses of the arterial wall to hypertension.
 Hypertension 1990; 15: 666-674

163) Shimamura T, Amorosa LF, Wilson AC, Lelkes L, Khachadurian AK
Atherosclerosis and glomerulosclerosis in WHHL rabbits and obese Zucker rats.
 Japan J Exp Med 1990; 60: 105-109

164) Hara A, Taketomi T
Characterization and change of phospholipids in the aorta of Watanabe heritable hyperlipidemic rabbit.
 Japan J Exp Med 1990; 60: 311-318

165) Shimano H, Yamada N, Ishibashi S, Harada K, Matsumoto A, Mori N, Inaba T, Motoyoshi K, Itakura H, Takaku F Human monocyte colony-stimulating factor enhances the clearance of lipoproteins containing apolipoprotein B-100 via both low density lipoprotein receptor-dependent and-independent pathways in rabbits.
 J Biol Chem 1990; 265: 12869-12875

166) Sato R, Komine Y, Imanaka T, Takano T
Monoclonal antibody EMR1a/212D recognizing site of deposition of extracellular lipid in atherosclerosis: isolation and characterization of a cDNA clone for the antigen.
 J Biol Chem 1990; 265: 21232-21236

167) Herz J, Kowal RC, Ho YK, Brown MS, Goldstein JL
Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver.
 J Biol Chem 1990; 265: 21355-21362

168) Tsujita Y
A potent HMG-CoA reductase inhibitor, pravastatin sodium-tissue-selective inhibition of cholesterogenesis and preventive effect on atherosclerosis in WHHL rabbits.
 J Drug Dev 1990; 3: 155-159

169) Dalessandri KM, Bogren H, Lantz BMT, Tsukamoto H, Bjorkerud S, Brock J
Aortic compliance in hypercholesterolemic Watanabe rabbits compared to normal New Zealand controls.
 J Invest Surg 1990; 3: 245-251

170) Shames DM, Yamada N, Havel RJ
Metabolism of apoB-100 in lipoproteins separated by density gradient ultracentrifugation in normal and Watanabe heritable hyperlipidemic rabbits.
 J Lipid Res 1990; 31: 753-762

171) Sharkey MF, Miyanohara A, Elam RL, Friedmann T, Witztum JL
Post-transcriptional regulation of retroviral vector-transduced low density lipoprotein receptor activity.
 J Lipid Res 1990; 31: 2167-2178

172) Nolte CJM, Tercyak AM, Wu HM, Small DM
Chemical and physicochemical comparison of advanced atherosclerotic lesions of similar size and cholesterol content in cholesterol-fed New Zealand white and Watanabe heritable hyperlipidemic rabbits.
 Lab Invest 1990; 62: 213-222

173) Wilson JM, Chowdhury NR, Grossman M, Wajsman R, Epstein A, Mulligan RC, Chowdhury JR
Temporary amelioration of hyperlipidemia in low density lipoprotein receptor-deficient rabbits transplanted with genetically modified hepatocytes.
 Proc Natl Acad Sci USA 1990; 87: 8437-8441

174) Wiederkehr JC, Kondos GT, Pollak R
Hepatocyte transplantation for the low-density lipoprotein receptor-deficient state: a study in Watanabe rabbit.
 Transplantation 1990; 50: 466-476

175) Dichek DA, Bratthauer GL, Beg ZH, Newman KD, Anderson KD, Zwiebel JA, Hoeg JM, Anderson EF
A genetic therapy for familial hypercholesterolemia.
 Trans Assoc Am Physicians 1990; 103: 73-79



(1991)



Bibliography of WHHL rabbits