456) Aliev G, Smith MA, Turmaine M, Neal ML, Zimina TV, Friedland RP, Perry G, LaManna JC, Burnstock G
Atherosclerotic lesions are associated with increased immunoreactivity for inducuble nitric oxide synthase and endothelin-1 in thoracic aortic intimal cells of hyperlipidemic Watanabe rabbits.
Exp Mol Pathol 2001; 71: 40-54
   < Abstract or Full paper >

457) Aikawa M, Rabkin E, Sugiyama S, Voglic SJ, Fukumoto Y, Furukawa Y, Shiomi M, Schoen FJ, Libby P
An HMG-CoA reductase inhibitor, Cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro.
Circulation 2001; 103 (1): 276-283
   < Abstract or Full paper >

458) Ruehm SG, Corot C, Vogt P, Kolb S, Debatin JF
Magnetic resonance imaging of atherosclerotic plaque with ultrasmall superparamagnetic particles of iron oxide in hyperlipidemic rabbits.
Circulation 2001; 103 (1): 415-422
   < Abstract or Full paper >

459) Fukumoto Y, Libby P, Rabkin E, Hill CC, Enomoto M, Hirouchi Y, Shiomi M, Aikawa M
Statins alter smooth muscle cell accumulation and collagen content in established atheroma of Watanabe heritable hyperlipidemic rabbits.
Circulation 2001; 103 (2): 993-999
   < Abstract or Full paper >

460) Djahansouzi S, Braesen JH, Koenig K, Beisiegel-U, Kontush A
The effect of pharmacological doses of different antioxidants on oxidation parameters and atherogenesis in hyperlipidaemic rabbits.
Atherosclerosis 2001; 154 (2): 387-398
   < Abstract or Full paper >

461) Hiltunen TP, Gough PJ, Greaves DR, Gordon S, Yla-Herttuala S
Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominat negative form of the macrophage scavenger receptor.
Atherosclerosis 2001; 154 (2): 415-419
   < Abstract or Full paper >

462) Ishida T, Kawashima S, Hirata K, Sakoda T, Shimokawa Y, Miwa Y, Inoue N, Ueyama T, Shiomi M, Akita H, Yokoyama M
Serotonin-induced hypercontraction through 5-hydroxytryptamine 1B receptors in atherosclerotic rabbit coronary arteries.
Circulation 2001; 103 (9): 1289-1295
   < Abstract or Full paper >

463) Ito T, Shiomi M
Cerebral atherosclerosis occurs spontaneously in homozygous WHHL rabbits.
Atherosclerosis 2001; 156 (1): 57-66
   < Abstract or Full paper >

464) Shiomi M, Ito T, Hirouchi Y, Enomoto M
Fibromuscular cap composition is important for the stability of established atherosclerotic plaques in mature WHHL rabbits treated with statins.
Atherosclerosis 2001; 157 (1): 75-84
   < Abstract or Full paper >

465) Kakutani M, Ueda M, Naruko T, Masaki T, Sawamura T
Accumulation of LOX-1 ligand in plasma and atherosclerotic lesions of Watanabe heribable hyperlipidemic rabbits: identification by a novel enzyme immunoassay.
Biochem Biophys Res Comm 2001; 288: 180-185
   < Abstract or Full paper >

466) Zoldhelyi P, Chen ZQ, Shelat HS, McNatt JM, Willerson JT
Local gene transfer of tissue factor pathway inhibitor regulates intimal hyperplasia in atherosclerotic arteries.
Proc Natl Acad Sci USA 2001; 98 (7): 4078-4083
   < Abstract or Full paper >

467) Koike H
New pharmacologic aspects of CS-866, the newest angiotensin II receptor antagonist.
Am J Cardiol 2001; 87 (suppl): 33c-36c
   < Abstract or Full paper >

468) Clubb FJ, Cerby JL, Deferrari DA, Butler-Aucoin MM, Willerson JT, Buja LM
Development of atherosclerotic plaque with endothelial disruption in Watanabe heritable hyperlipidemic rabbit aortas.
Cardiovasc Pathol 2001; 10 (1): 1-11
   < Abstract or Full paper >

469) Takahashi S, Ohsugi K, Yamamoto T, Shiomi M, Sakuragawa N
A novel approach to ex vivo gene therapy for familial hypercholesterolemia using human amniotic epithelial cells as transgene carrier.
Tohoku J Exp Med 2001; 193: 279-292
   < Abstract or Full paper >

470) Yamaguchi Y, Matsuno S, Kagota S, Haginaka J, Kunitomo M
Oxidants in cigarette smoke extract modify low-density lipoprotein in the plasma and facilitate atherogenesis in the aorta of Watanabe heritable hyperlipidemic rabbits.
Atherosclerosis 2001; 156 (1): 109-117
   < Abstract or Full paper >

471) de Roos B, Caslake MJ, Ardern HA, Benson GM, Suckling KE, Packard CJ
Insulin resistance in the St. Thomas' mixed hyperlipidaemic (SMHL) rabbit, a model for familial combined hyperlipidaemia.
Atherosclerosis 2001; 156: 249-254
   < Abstract or Full paper >

472) Aikawa M, Libby P
Vascular inflamation and activation: new targets for lipid lowering.
Eur Heart J 2001: 3 (Supplement B): B3-B11

473) Mortensen A, Breinholt V, Dalsgaard T, Frandsen H, Lauridsen ST, Laigaard J, Ottesen B, Larsen JJ
17b -estradiol but not the phytoestrogen naringenin attenuates aortic cholesterol accumulation in WHHL rabbits.
J Lipid Res 2001; 42: 834-843
   < Abstract or Full paper >

474) Kamimura T, Suzuki S, Miyahara K, Shiomi M
Arteriosclerosis in the influx and intravisceral arteries of the liver, kidney and lung of WHHL rabbits.
Exp Anim 2001; 50: 423-426
   < Abstract or Full paper >

475) Zhang B, Shiomi M, Tanaka H, Mei J, Fan P, Tsujita Y, Horikoshi H, Saku K
Effects of high-dose Troglitazone on insulin sensitivity and b-cell function in Watanabe heritable hyperlipidemic rabbits.
Eur J Drug Metab Ph 2001; 26: 185-192
   < Abstract or Full paper >

476) Shiomi M, Ito T
MTP inhibitor decreases plasma cholesterol levels in LDL receptor-deficient WHHL rabbits by lowering the VLDL secretion.
Eur J Pharmacol 2001; 431: 127-131
   < Abstract or Full paper >

477) Ishikawa K, Sugawara D, Goto J, Watanabe Y, Kawamura K, Shiomi M, Itabe H, Maruyama Y
Heme oxygenase-1 inhibits atherogenesis in Watanabe heritable hyperlipidemic rabbits.
Circulation 2001; 104 : 1831-1836
   < Abstract or Full paper >

478) Wagberg M, Jansson AH, Westerlund C, Ostlund-Lindqvist AM, Sarnstrand B, Bergstrand H, Pettersson K
N,N '-diaceytl-L-cystine (DiNAC), the disulphide dimer of N-acetylcholine, inhibits atherosclerosis in WHHL rabbits: Evidence for immunomodulatory agents as a new approach to prevent atherosclerosis.
J Pharmacol Exp Ther 2001; 299: 76-82
   < Abstract or Full paper >

479) Hiyoshi H, Yanagimachi M, Ito M, Saeki T, Uoshida I, Okada T, Ikuta H, Shinmyo D, Tanaka K, Kurusu N, Tanaka H
Squalene synthase inhibitors reduce plasma triglyceride through a low-density lipoprotein in receptor-independent mechanism.
Eur J Pharmacol 2001; 431: 345-352
   < Abstract or Full paper >

480) Mori M, Itabe H, Higashi Y, Fujimoto Y, Shiomi M, Yoshizumi M, Ouchi Y, Takano T
Foam cell formation containing lipid droplets enriched with free cholesterol by hyperlipidemic serum.
J Lipid Res 2001; 42: 1771-1781
   < Abstract or Full paper >

481) Malle E, Wag G, Thiery J, Sattler W, Grone HJ
Hypochloride-modified (lipo)proteins are present in rabbit lesions in response to dietary cholesterol.
Biochem Biophys Res Commun 2001; 289: 894-9000
   < Abstract or Full paper >

482) Fan J, Sun H, Unoki H, Shiomi M, Watanabe T
Enhanced atherosclerosis in Lp(a) WHHL transgenic rabbiys.
Ann N Y Acad Sci 2001; 947: 362-365
   < Abstract or Full paper >

483) Shiomi M, Ito T, Hirouchi Y, Enomoto M
Stability of atheromatous plaque affected by lesional composition: study of WHHL rabbits treated with statins.
Ann N Y Acad Sci 2001; 947: 419-423
   < Abstract or Full paper >

484) Ishikawa K, Maruyama Y
Heme oxygenase as an intrinsic defense system in vascular wall: implication against atherogenesis.
J Atheroscler Thromb 2001; 8: 63-70
   < Abstract or Full paper >

485) McCabe PM, Gonzales JA, Zaias J, Szeto A, Kumar M, Herron AJ, Schneiderman N
Social environment influence the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.
Circulation 2002; 105: 354-359
   < Abstract or Full paper >

486) Xu G, Pan Lx Lx, Erickson SK, Forman BM, Shneider BL, Ananthanarayanan M, Li X, Shefer S, Balasubramanian N, Ma L, Asaoka H, Lear SR, Nguyen LB, Dussault I, Suchy FJ, Tint GS, Salen G
Removal of the bile acid pool upregulates cholesterol-7alpha-hydroxylase by deactivating FXR in rabbits.
J Lipid Res 2002; 43: 45-50
   < Abstract or Full paper (access to DOI) >

487) Yamaguchi Y, Matsumoto S, Kagota S, Haginaka J, Kunitomo M
Fluvastatin reduces modification of low-density lipoprotein in hyperlipidemic rabbit loaded with oxidative stress.
Eur J Pharmacol 2002; 436: 97-105
   < Abstract or Full paper >

488) Hardoff R, Zanzonico P, Braegelmann F, Herrold EM, Lees RS, Lees AM, Dean RT, Lister-James J, Borer JS
Localization of (99m)TC-Labeled apoB synthetic peptide in arterial lesions of an experimental model of spontaneous atherosclerosis.
Am J Ther 1995 2: 88-99
   < Abstract or Full paper >

489) Meding J, Dinkelborg LM, Grieshaber MK, Semmler W
Targeting of endothelin receptors for molecular imaging of atherosclerosis in rabbits.
J Nucl Med 2002; 43: 400-405
   < Abstract or Full paper >

490) Suwa T, Hogg JC, Quinlan KB, Ohgami A, Vincent R, van Eeden SF
Particulate air pollution induces progression of atherosclerosis.
J Am Coll Cardiol 2002; 39: 935-942
   < Abstract or Full paper >

491) Yoshida N, Murase H, Kunieda T, Toyokuni S, Tanaka T, Terao J, Naito Y, Tanigawa T, Yoshikawa T
Inhibitory efect of a novel watere-soluble vitamin E derivative on atherosclerosis in rabbits.
Atherosclerosis 2002; 162: 111-117
   < Abstract or Full paper >

492) Dalsgaard T, Larsen CR, Mortensen A, Larsen JJ, Ottesen B
New animal model for the study of postmenopausal coronary and cerebral artery fumction: the Watanabe heritable hyperlipidemic rabbit fed on a diet avoiding phytoestrogens.
Climacteric 2002; 5: 178-189
   < Abstract or Full paper >

493) Sun H, Usui S, Shiomi M, Watanabe T, Fan J
A rapid PCR method of genotyping LDL receptor mutations in WHHL rabbits.
J Atheroscler Thromb 2002, 9: 145-148
   < Abstract or Full paper >

494) Murakami S, Kondo Y, Kitajima H, Nagate T
Taurine suppresses development of atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits.
Atherosclerosis 2002; 163: 79-87
   < Abstract or Full paper >

495) Schmitz SA, Taupitz M, Wagner S, Coupland SE, Gust R, Nikolova A, Wolf KJ
Iron-oxide-enhanced magnetic resonance imaging of atherosclerotic plaques: postmortem analysis of accuracy, inter-observer agreement, and pitfalls.
Invest Radiol 2002; 37: 405-411
   < Abstract or Full paper >

496) Brasen JH, Koenig K, Bach H, Kontush A, Heinle H, Witting PK, Yla-Herttuala S, Stocker R, Beisiegel U
Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits.
Atherosclerosis 2002; 163: 249-259
   < Abstract or Full paper >

497) Naghavi M, John R, Naguib S, Siadaty MS, Grasu R, Kurian KC, van Winkle WB, Soller B, Litovsky S, Madjid M, Willerson JT, Casscells W
pH heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque.
Atherosclerosis 2002; 164: 27-35
   < Abstract or Full paper >

498) Sun H, Unoki H, Wang X, Liang J, Ichikawa T, Arai Y, Shiomi M, Marcovina SM, Watanabe T, Fan J
Lipoprotein(a) enhances advanced atherosclerosis in WHHL transgenic rabbits expressing human apolipoprotein(a).
J Biol Chem 2002; 277: 47486-47492
   < Abstract or Full paper >

499) Warnholtz A, Mollnau H, Heitzer T, Kontush A, Moller-Bertram T, Lavall D, Giaid A, Beisiegel U, Marklund SL, Walter U, Meinertz T, Munzel T
Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits.
J Am Coll Cardiol. 2002 40:1356-1363
   < Abstract or Full paper >

500) Yamada S, Ito T, Adachi J, Ueno Y, Shiomi M
Decreased arterial responses in WHHL rabbits, an animal model of spontaneous hypercholesterolemia and atherosclerosis.
Exp Anim 2002; 51: 493-499
   < Abstract or Full paper >

501) Rikitake Y, Hirata K, Yamashita T, Iwai K, Kobayashi S, Itoh H, Ozaki M, Ejiri J, Shiomi M, Inoue N, Kawashima S, Yokoyama M
Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.
Arterioscler Thromb Vasc Biol. 2002; 22 (12): 2049-53
   < Abstract or Full paper >

502) Ishi I, Satoh H, Kawachi H, Jingami H, Matsuoka N, Ohmori S, Bujo H, Yamamoto T, Saito Y, Kitada M.
Intimal smooth muscle cells up-regulated b-very low density lipoprotein-mediated cholesterol accumulation by enhancing b-very loe density lipoprotein uptake and decreasing cholesterol efflux.
Biochim Biophys Acta 2002; 1585: 30-38
   < Abstract or Full paper >

503) Brasen JH, Hakkinen T, Malle E, Beisiegel U, Yla-Herttuala S.
Patterns of oxidized epitopes, but not NF-kappaB expression, change during atherogenesis in WHHL rabbits.
Atherosclerosis. 2003 Jan; 166 (1): 13-21
   < Abstract or Full paper >

504) Van Royen N, Hoefer I , Buschmann I , Kostin S , Voskuil M , Bode Ch , Schaper W , Piek JJ
Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits.
Cardiovascular Research 2003 Jan; 57(1): 178-185
   < Abstract or Full paper >

505) Worthley SG, Helft G, Fuster V, Fayad ZA, Shinnar M, Minkoff LA< Schechter C, Fallon JT, Badimon JJ
A novel nonobstructive intravascular MRI coil: in vivo imaging of experimental atherosclerosis.
Arterioscler Thromb Vasc Biol 2003 Feb; 23 (2): 346-350
   < Abstract or Full paper >

506) Eto Y, Shimokawa H, Tanaka E, Morishige K, Fuchigami M, Ishiwata Y, Matsushima K, Takeshita A
Long-term treatment with propagermanium suppresses atherosclerosis in WHHL rabbits.
J Cardiovasc Pharmacol 2003 Feb; 41 (2): 171-177
   < Abstract or Full paper >

507) Tanaka E, Shimokawa H, Kamiuneten H, Eto Y, Matsumoto Y, Morishige K, Koike G, Yoshinaga M, Egashira K, Tokunaga O, Shiomi M, Takeshita A
Disparity of MCP-1 mRNA and protein expressions between the carotid artery and the aorta in WHHL rabbits: one aspect involved in the regional difference in atherosclerosis.
Arterioscler Thromb Vasc Biol 2003 Feb; 23 (2): 244-250
   < Abstract or Full paper >

508) Amano Y, Nishimoto T, Tozawa R, Ishikawa E, Imura Y, Sugiyama Y
Lipid-lowering effescts of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia.
Eur J Pharmacol 2003 Apr; 466 (1-2): 155-161
   < Abstract or Full paper >

509) Mollnau H, Schulz E, Daiber A, Baldus S, Oelze M, Auguat M, Wendt M, Walter U, Geiger C, Agrawal R, Kleschyov AL, Meinertz T, Munzel T
Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflamatory cells.
Arterioscler Thromb Vasc Biol 2003 April; 23 (4): 615-621
   < Abstract or Full paper >

510) Nielsen IL, Dragsted LO, Rav-Haren G, Freese R, Rasmussen SE
Absorption and excretion of black currant anthocyanins in humans and Watanabe heritable hyperlipidemic rabbits.
J Agric Food Chem 2003 Apr; 51 (9): 2813-2820
   < Abstract or Full paper >

511) Shichiri M, Tanaka A, Hirata Y
Intravenous gene therapy for familial hypercholesterolemia using ligand-facilitated transfer of a liposome:LDL receptor gene complex.
Gene Ther 2003 May; 10 (9): 827-831
   < Abstract or Full paper >

512) Suzuki H, Kobayashi H, Sato F, Yonemitsu Y, Nakashima Y, Sueishi K
Plaque-stabilizing effect of pitavastatin in Watanabe heritable hyperlipidemic (WHHL) rabbits
J Atheroscler Thromb 2003 10 (2): 109-116
   < Abstract or Full paper >

513) Shyu K, Chang H, Isner JM
Synergistic effect of angiopoietin-1 and vascular endothelial growth factor on neoangiogenesis in hypercholesterolemic rabbit model with acute hindlimb ischemia
Life Sci 2003; 73: 563-579
   < Abstract or Full paper >

514) Shiomi M, Ito T, Yamada S, Kawashima S, Fan J
Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit).
Arterioscler Thromb Vasc Biol. 2003; 23 (7): 1239-1244
   < Abstract or Full paper >

515) Tamura K, Kato Y, Ishikawa A, Kato Y, Himori M, Yoshida M, Takashima Y, Suzuki T, Kawabe Y, Cynshi O, Kodama T, Niki E, Shimizu M
Design and synthesis of 4,6-Di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel seriea of antiatherosclerotic antioxidants.
J Med Chem 2003; Jul; 46 (14): 3083-3093
   < Abstract or Full paper >

516) Shiomi M, Fan J, Kawashima S
Relation of vulnerable plaque to development of myocardial infarction/ acute coronary syndromes - Lessons from an animal model of spontaneous myocardial infarction.
Commentary to the International Atherosclerosis Society, IAS Website (http://www.athero.org/comm-index.asp) September 5, 2003
   < Abstract or Full paper >

517) Barkhausen J, Ebert W, Heyer C, Debatin JF, Weinmann HJ
Detection of atherosclerotic plaque with gadofluorine-enhanced magnetic resonance imaging.
Circulation 2003; 108 (5): 605 - 609
   < Abstract or Full paper >

518) Proctor SD, Mamo CL
Intimal retention of cholesterol derived from apolipoprotein B100- and apolipoprotein B48-containing lipoproteins in carotid arteries of Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol 2003; 23 (9): 1595 - 1600
   < Abstract or Full paper >

519) Pettersson K, Bergstrand H
The antiatherosclerotic effect of DiNAC: experimental findings supporting immunomodulation as a new treatment for atherosclerosis related diseases.
Cardiovasc Drug Rev 2003; 21 (2): 119-132
   < Abstract or Full paper >

520) Dalsgaard T, Mortensen A, Larsen CR, Larsen JJ, Ottesen B
Long-term estradiol treatment improves VIP-mediated vasodilation in atherosclerotic proximal coronary arteries.
Regul Pept 2003; 116 (1-3): 155-162
   < Abstract or Full paper >

521) Ishimoto Y, Yamada K, Yamamoto S, Ono T, Notoya M, Hanasaki K
Group V and X secretory phospholipase A(2)s-induced modification of high-density lipoprotein linked to the reduction of its antiatherogenic functions.
Biochim Biophys Acta 2003; 1642 (3): 129-138
   < Abstract or Full paper >

522) Daiber A, August M, Baldus S, Wendt M, Oelze M, Syndow K, Kleschyov AL, Munzel T
Measurement of NAD(P)H oxidase-derived superoxide with the luminol analogue L-012.
Free Radic Biol Med. 2004 Jan; 36(1): 101-111
   < Abstract or Full paper >

523) Perings SM, Grubert N, Kleinbongard P, Reinecke P, Schulz R, Hermsen D, Willers R, Kelm M
Chronic Treatment with Fluvastatin Improves Smooth Muscle Dilatory Function in Genetically Determined Hyperlipoproteinemia.
J Cardiovasc Pharmacol. 2004 Feb; 43 (2): 183-190
   < Abstract or Full paper >

524) Shishido T, Tasaki K, Takeishi Y, Takasaki S, Miyamoto T, Itoh M, Takahashi H, Kubota I, Ito T, Katano Y, Wakabayashi I, Tomoike H
Chronic hypertriglyceridemia in young Watanabe heritable hyperlipidemic rabbits impairs endothelial and medial smooth muscle function.
Life Sci. 2004 Feb; 74 (12): 1487-1501
   < Abstract or Full paper >

525) Wajima T, Makita S, Oshima K
Effects of HR780, a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in Watanabe heritable hyperlipidemic rabbits and cholesterol-fed rabbits.
Pharmacology. 2004 Mar; 70 (3): 123-129
   < Abstract or Full paper >

526) Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Liu G, Sun H, Watanabe T, Yamada N, Fan J
Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity.
J Biol Chem. 2004 Feb; 279 (9): 7521-7529
   < Abstract or Full paper >

527) Yamaguchi Y, Matsuno S, Kogata S, Haginaka J, Kunitomo M
Peroxynitrite-mediated oxidative modification of low-density lipoprotein by aqueous extracts of cigarette smoke and the preventive effect of fluvastatin.
Atheroscelrosis. 2004 Feb; 172 (2): 259-265
   < Abstract or Full paper >

528) Kankkonen HM, Turunen MP, Hiltunen MO, Lehtolainen P, Koponen J, Leppanen P, Turunen AM, Yla-Herttuala S
Feline immunodeficiency virus and retrovirus-mediated adventitial ex vivo gene transfer to rabbit carotid artery using autologous vascular smooth muscle cells.
J Mol Cell Cardiol. 2004 Mar; 36 (3): 333-341
   < Abstract or Full paper >

529) Yamada S, Ito T, Tamura T, Shiomi M
Age-related changes in serum/plasma biochemical parameters of WHHLMI rabbits.
Exp Anim. 2004 Apr; 53 (2): 159-163
   < Abstract or Full paper >

530) Ohmori K, Yamada H, Yasuda A, Yamamoto A, Matsuura N, Kiniwa M
Effects of a novel antihyperlipidemic agent, S-2E, on the blood lipid abnormalities in homozygous WHHL rabbits.
Metabolism. 2004 May ;53(5): 680-685
   < Abstract or Full paper >

531) Kankkonen HM, Vahakangas E, Marr RA, Pakkanen T, Laurema A, Leppanen P, Jalkanen J, Verma IM, Yla-Herttuala S.
Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy.
Mol Ther. 2004 Apr; 9(4): 548-556
   < Abstract or Full paper >

532) Jacobsson LS, Yuan XM, Zieden B, Olsson AG.
Effects of alpha-tocopherol and astaxanthin on LDL oxidation and atherosclerosis in WHHL rabbits.
Atherosclerosis. 2004 Apr; 173(2): 231-237.
   < Abstract or Full paper >

533) Goto Y, Hogg JC, Shih CH, Ishii H, Vincent R, Van Eeden SF
Exposure to ambient particles accelerates monocyte release from the bone marrow in atherosclerotic rabbits.
Am J Physiol Lung Cell Mol Physiol. Jul; 287(1): L79-L85
   < Abstract or Full paper >

534) Szeto A, Gonzales JA, Spitzer SB, Levine JE, Zaias J, Saab PG, Schneiderman N, McCabe PM
Circulating levels of glucocorticoid hormones in WHHL and NZW rabbits: circadian cycle and response to repeated social encounter.
Psychoneuroendocrinology. 2004 Aug; 29(7): 861-866
   < Abstract or Full paper >

535) Ogawa M, Ishino S, Mukai T, Asano D, Teramoto N, Watabe H, Kudomi N, Shiomi M, Magata Y, Iida H, Saji H
¹⁸F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study.
J Nucl Med. 2004 Jul; 45 (7): 1245-1250
   < Abstract or Full paper >

536) Ito T, Yamada S, Shiomi M
Progression of coronary atherosclerosis relates to the onset of myocardial infarction in an animal model of spontaneous myocardial infarction (WHHLMI rabbits).
Exp Anim. 2004 Jul; 53 (4): 339-346
   < Abstract or Full paper >

537) Shiomi M, Ito T, Yamada S, Kawashima S, Fan J
Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit)
J Atheroscler Thromb 2004 Sep; 11 (4): 184-189
   < Abstract or Full paper >

538) Li W, Hellsten A, Jacobsson LS, Blomqvist HM, Olsson AG, Yuan XM
Alpha-tocopherol and astaxanthin decrease macrophage infiltration, apoptosis and vulnerability in atheroma of hyperlipidaemic rabbits.
J Mol Cell Cardiol 2004 Nov; 37 (5): 969-978
   < Abstract or Full paper >

539) Allegri G, Ragazzi E, Costa CV, Caparrotta L, Biasiolo M, Comai S, Bertazzo A
Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits.
Clin Chim Acta 2004 Dec; 350 (1-2): 41-19
   < Abstract or Full paper >

540) Shiomi M, Ito T, Hasegawa M, Yoshida K, Gould KL
Novel insights into coronary lumen preservation during progression of coronary atherosclerosis in coronary atherosclerosis-prone rabbits.
Coronary Artery Disease 2004 Nov; 15(7): 419-426
   < Abstract or Full paper >

541) Li W, Hellsten A, Nyhalah JD, Yuan XM
Enhanced expression of natural resistance-associated macropahge protein 1 in atherosclerotic lesions may be associated with oxidized lipid-induced apoptosis.
Ann N Y Acad Sci 2004 Dec; 1030:202-207
   < Abstract or Full paper >

542) Aliev G, Castellani RJ, Petersen RB, Burnstock G, Perry G, Smith MA
Pathobiology of familial hypercholesterolemic atherosclerosis.
J Submicrosc Cytol Pathol 2004; 36 (3-4): 225-240.
   < Abstract or Full paper >

543) Tanaka T, Fukubaga Y, Itoh H, Doi K, Yamashita J, Chun TH, Inoue M, Masatsugu K, Saito T, Sawada N, Sakaguchi S, Arai H, Nakao K
Therapeutic potential of thioazolidine diones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration.
Eur J Pharmacol 2005 Jan; 508 (1-3): 255-265
   < Abstract or Full paper >

544) Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Sun H, Watanabe T, Liu G, Fan J
Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase.
Cardiovasc Res 2005 Feb; 65(2): 524-534
   < Abstract or Full paper >

545) Shiomi M, Yamada S, Ito T
Atheroma stabilizing effects of simvastatin due to depression of macrophages or lipid accumulation in the atheromatous plaques of coronary atherosclerosis-prone WHHL rabbits.
Atherosclerosis 2005 Feb; 178(2): 287-294
   < Abstract or Full paper >

546) Shiomi M, Ito T
Anti-atherosclerotic effects of statins, Lessons from animal model of spontaneous atherosclerosis
Commentary to the International Atherosclerosis Society IAS Website (http://www.athero.org/comm-index1.asp#1) March 23, 2005
   < Abstract or Full paper >

547) Finne NIL, Elbol RS, Mortensen A, Ravn-Haren G, Ping MH, Knuthsen P, Fischer HB, McPhail D, Freese R, Breinholt V, Frandsen H, Dragsted LO
Anthocyanins increase low-density lipoprotein and plasma cholesterol and do not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits.
Mol Nutr Food Res 2005 Mar; 49 (4): 301-308
   < Abstract or Full paper >

548) Gonzales JA, Szeto A, Mendez AJ, Zaias J, Paredes J, Caperton CV, Llabre MM, Levine JE, Goldberg RB, Schneiderman N, McCabe PM
Effects of behavioral interventions on insulin sensitivity and atherosclerosis in Watanabe heritable hyperlipidemic rabbit.
Psychosom Med 2005 Mar-Apr; 67 (2): 172-178
   < Abstract or Full paper >

549) Ohno T, Ogawa K, Yano S, Fukushima M, Suzuki N, Asao T
Synthesis and structure-activity relationship of 4-substituted benzoic acids and their inhibitory effect on the biosynthesis of fatty acids and sterols.
Arch Pharm (Weiheim) 2005 Apr; 338 (4): 147-158
   < Abstract or Full paper >

550) Liu Q, Chen ZQ, Bobustuc GC, McNatt JM, Segall H, Pan S, Willerson JT, Zoldhelyi P
Local gene transduction of cyclooxygenase-1 increases blood flow in injured atherosclerotic rabbit arteries.
Circulation 2005 Apr; 111 (14): 1833-1840
   < Abstract or Full paper >

551) Gupta H, White CR, Handattu S, Garber DW, Datta G, Chaddha M, Dai L, Gianturco SH, Bradley WA, Anantharamaiah GM
Apolipoprotein E mimetic peptide dramatically loweres plasma cholesterol and restores endothelial function in Watanabe heritable hyperlipidemic rabbits.
Circulation 2005 Jun; 111 (23): 3112-3118
   < Abstract or Full paper >

552) de Roos B, Caslake MJ, Milliner K, Benson GM, Suckling KE, Packard CJ
Characterisation of the lipoprotein structure in the St. Thomas' mixed hyperlipidaemic (SMHL) rabbit.
Atherosclerosis 2005 Jul; 181 (1): 63-68
   < Abstract or Full paper >

553) Tasaki K, Wakabayashi I, Shishido T, Takasaki S, Takeishi Y, Kubota I, Ito T, Katano Y, Kubota I
Diminution of angiotensin II-induced contraction of the abdominal aorta isolated from Watanabe heritable hyperlipidemic rabbits.
J Smooth Muscle Res 2005; 41 (2): 87-97
   < Abstract or Full paper >

554) Kato M, Sada T, Mizuno M, Kitayama K, Inaba T, Koike H
Effect of Combination treatment with an angiotensin II receptor antagonist and an HMG-CoA reductase inhibitor on atherosclerosis in genetically hyperlipidemic rabbits.
J Caridovasc Pharmacol 2005; 46 (4): 556-562
   < Abstract or Full paper >

555) Sun H, Koike T, Ichikawa T, Hatakeyama K, Shiomi M, Zhang B, Kitajima S, Morimoto M, Watanabe T, Asada Y, Chen YE, Fan J.
C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance.
Am J Pathol. 2005 Oct;167(4):1139-48.
   < Abstract or Full paper >

556) Ito T, Yamada S, Tamura T, Shiomi M.
Discrimation of recent ischemic myocardial changes in WHHLMI rabbits from the findings of postmortem degeneration.
Exp Anim. 2005 Oct; 54(5): 413-419.
   < Abstract or Full paper >

557) Nakano A, Kinoshita M, Okuda R, Yasuda T, Abe M, Shiomi M
Pathogenesis of tendinous xanthoma: histopathological study of the extremities of Watanabe heritable hyperlipidemic rabbits.
J Orthop Sci. 2006 Jan; 11(1): 75-80.
   < Abstract or Full paper >

558) Hofnagel O, Luechtenborg B, Eschert H, Weissen-Plenz G, Severs NJ, Robenek H
Pravastatin inhibits expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in Watanabe heritable hyperlipidemic rabbits: a new pleiotropic effect of statins.
Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):604-610.
   < Abstract or Full paper >   < Abstract or Full paper-2 >

559) Hasegawa H, Takano H, Ohtsuka M, Ueda K, Niitsuma Y, Qin Y, Tadokoro H, Shiomi M, Komuro I.
G-CSF prevents the progression of atherosclerosis and neointimal formation in rabbits.
Biochem Biophys Res Commun. 2006 May 26;344(1):370-376.
   < Abstract or Full paper >

560) Kouchi M, Ueda Y, Horie H, Tanaka K.
Ocular lesions in Watanabe heritable hyperlipidemic rabbits.
Vet Ophthalmol. 2006 May-Jun; 9(3): 145-148.
   < Abstract or Full paper >

561) Wang YX, Kuribayashi H, Wagberg M, Holmes AP, Tessier JJ, Waterton JC.
Gradient Echo MRI Characterization of Development of Atherosclerosis in the Abdominal Aorta in Watanabe Heritable Hyperlipidemic Rabbits.
CardioVasc Intervent Radiol. 2006 Jul-Aug; 29 (4): 605-612.
   < Abstract or Full paper >

562) Kitayama K, Koga T, Maeda N, Inaba T, Fujioka T.
Pactimibe stabilizes atherosclerotic plaque through macrophage acyl-CoA:cholesterol acyltransferase inhibition in WHHL rabbits.
Eur J Pharmacol. 2006 Jun 6; 539(1-2): 81-88.
   < Abstract or Full paper >

563) Herborn CU, Vogt FM, Lauenstein TC, Dirsch O, Corot C, Tobert P, Ruehm SG.
Magnetic resonance imaging of experimental atherosclerotic plaque: Comparison of two ultrasmall superparamagnetic particles of iron oxide.
J Magn Reson Imagining. 2006 Aug; 24(2): 386-393.
   < Abstract or Full paper >

564) Pedersen SH, Nielsen LB, Mortensen A, Sheykhzade M, Nilas L, Ottesen B.
Medroxyprogesterone acetate attenuates long-term effects of 17 beta-estradiol in coronary arteries from hyperlipidemic rabbits.
Steroids. 2006 September; 71(9):834-842.
   < Abstract or Full paper >

565) Lund CO, Mortensen A, Nilas L, Breinholt VM, Larsen JL, Ottesen B.
Estrogen and phytosterogens: Effect on eNOS expression and in vitro vasodilation in cerebral arteries in ovariectomized Watanabe heritable hyperlipidemic rabbits.
Eur J Obstet Gynecol Reprod Biol. 2007 Jan; 12; 130(1) 84-92
   < Abstract or Full paper >

566) Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumaki J, Laakso M, Herzig KH, Yla-Herttuala S.
VEGF-A, VEGF-D, VEGF-F receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits.
FASEB J. 2006 Aug 25; 20: E1550-E1559.
   < Abstract or Full paper >

567) Paredes J, Szeto A, Levine JE, Zaias J, Gonzales JA, Mendez AJ, Llabre MM, Schneiderman N, McCabe PM.
Social experience influences hypothalamic oxtocin in the WHHL rabbit.
Psychoneuroendocrinology 2006 Oct; 31 (9): 1062-1075.
   < Abstract or Full paper >

568) Kitajima S, Jin Y, Koike T, Yu Y, Liu E. Shiomi M, Marcovina SM, Morimoto M, Watanabe T, Fan J.
Lp(a) enhances coronary atherosclerosis in trangenic Watanabe heritable hyperlipidemic rabbits
Atherosclerosis 2007; 193: 269-276.
   < Abstract or Full paper >

569) Oka K, Yasuhara M, Suzumura K, Tanaka K, Sawamura T.
Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
J Cardiovasc Pharmacol. 2006 Oct;48(4):177-183.
   < Abstract or Full paper > < Abstract or Full paper >

570) Ogawa M, Magata Y, Kato T, Hatano K, Ishino S, Mukai T, Shiomi M, Ito K, Saji H.
Application of 18F-FDG PET for Monitoring the Therapeutic Effect of Antiinflammatory Drugs on Stabilization of Vulnerable Atherosclerotic Plaques.
J Nucl Med. 2006 Nov;47(11):1845-1850.
   < Abstract or Full paper >

571) Priest AN, Ittrich H, Jahntz CL, Kooijman H, Weber C, Adam G.
Investigation of atherosclerotic plaques with MRI at 3T using ultrasmall superparamagnetic particles of iron oxide.
Magn Reson Imaging. 2006 Dec;24(10):1287-93.
   < Abstract or Full paper >

572) Frederiksen H, Rasmussen SE, Schroder M, Bysted A, Jakobsen J, Frandsen H, Ravn-Haren G, Mortensen A.
Dietary supplementation with an extract of lycopene-rich tomatoes does not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits.
Br J Nuctr 2007 Jan; 97 (1) 6-10.
   < Abstract or Full paper >

573) Pettersson KS, Eliasson UB, Abrahamsson T, Wagberg M, Carrier M, Kengatharan KM.
N,N-diacetyl-L-cystin improves endothelial function in atherosclerotic Watanabe heritable hyoerlipidemic rabbits.
Basic Clin Pharmacol Yoxicol. 2007 Jan; 100 (1): 36-42.
   < Abstract or Full paper >

574) Ishino S, Kuge Y, Takai N, Tamaki N, Strauss HW, Blankenberg FG, Shiomi M, Saji H.
(99m)Tc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits.
Eur J Nucl Med Mol Imaging 2007 Jun; 34(6): 889-899.
   < Abstract or Full paper >

575) Broisat A, Riu LM, Ardisson V, Boturyn D, Dumy P, Fagret D, Ghezzi C.
Molecular imaging of vascular cell adhesion molecule-1 expression in experimental atherosclerotic plaques with radiolabelled B2702-p.
Eur J Necl Med Mol Imaging. 2007 Jan 12; 34:830-40.
   < Abstract or Full paper >

576) Ishino S, Mukai T, Kume N, Asano D, Ogawa M, Kuge Y, Minami M, Kita T, Shiomi M, Saji H.
Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability-analysis in hypercholesterolemic rabbits.
Atherosclerosis. 2007(Nov); 195(1): 48-56
   < Abstract or Full paper >

577) Wetterholm R, Caidahl K, Volkmann R, Brandt-Eliasson U, Fritsche-Danielson R, Gan LM.
Imaging of atherosclerosis in WHHL rabbits using high-resolution ultrasound.
Ultrasound Med Biol. 2007 May; 33(5): 720-6.
   < Abstract or Full paper >

578) Meding J, Urich M, Licha K, Reinhardt M, Misselwitz B, Fayad ZA, Weinmann HJ
Magnetic resonance imaging of atherosclerosis by targeting extracellular matrix deposition with Gadofluorine M.
Contrast Media Mol Imaging 2007 May; 2 (3): 120-129
   < Abstract or Full paper >

579) Frederiksen H, Mortensen A, Schrøder M, Frandsen H, Bysted A, Knuthsen P, Rasmussen SE.
Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Mol Nutr Food Res. 2007 May; 51 (5): 564-571
   < Abstract or Full paper >

580) Tamura T, Ito T, Yamane K, Yamada S, Shiomi M.
Relation of cranial abnormal growth to torticollis in WHHLMI rabbits.
J Exper Anim Technol 2007; 42 (1): 1-8 (in Japanese)

581) Kuge Y, Takai N, Ishino S, Temma T, Shiomi M, Saji H.
Distribution profiles of membrane Type-1 matrix metalloproteinase (MT1-MMP), matorix metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) in rabbit atheroscelrosis: comparison with plaque instability analysis.
Biol Pharm Bull 2007 Sep; 39(9):1634-1640.
   < Abstract or Full paper >

582) Steen H, Lima JA, Chatterjee S, Kolmakova A, Gao F, Rodriguez ER, Stuber M.
High-resolution three-dimensional aortic magnetic resonance angiography and quantitative vessel wall characterization of different atherosclerotic stages in a rabbit model.
Invest Radiol. 2007 Sep;42(9):614-621.
   < Abstract or Full paper >

583) Meding J, Urich M, Licha K, Misselwitz B, Fayad ZA, Weinmann HJ.
Magnetic resonance imaging of atherosclerosis by targeting extracellular matrix deposition with Gadofluorine M.
Contrast Media Mol Imaging 2007 May; 2(3): 120-129.
   < Abstract or Full paper >

584) Steen H, Lima JA, Chatterjee S, Kolmakova A, Gao F, Rodrigues ER, Stuber M.
High-resolution three-dimensional aortic magnetic resonance angiography and quantitative vessel wall characterization of different atherosclerotic stages in a rabbit model.
Invest Radiol 2007 Sep; 42(9):614-621.
   < Abstract or Full paper >

585) Iwata A, Miura S, Imaizumi B, Saku K.
Measurement of atherosclerotic plaque volume in hyperlipidemic rabbit aorta by intravascular ultrasound.
J Cardiol 2007 Oct; 50(4): 229-234.
   < Abstract or Full paper >

586) Brasen JH, Leppanen O, Onkala M, Heikura T, Levin M, Ahrens F, Rupanen J, Pietsch H, Nergqvist D, Levonen AL, Basu S, Zeller T, Kloppel G, Laukkanen MO, Yla-herttuala S.
Extracellular superoxide dismutase accelerates endothelial recovery and inhibits in-stent restenosis in stented atherosclerotic Watanabe heritable hyperlipidemic rabbit aorta.
J Am Coll Cardiol 2007 Dec; 50(23):2249-2253.
   < Abstract or Full paper >

587) Yatera K, Hsieh J, Hogg JC, Tranfield E, Suzuki H, Shih CH, Nehzad AR, Vincent R, van Eden SF.
Particulate matter air pollution exposeure promotes the recruitment of monocytes into atherosclerotic plaques.
Am J Physiol Heart Circ Physiol 2008 Feb; 294(2): H944-53.
   < Abstract or Full paper >

588) Pedersen SH, Nielsen LB, Mortensen A, Nilas L, Ottesen B.
Progrestins oppose the effects of estradiol on the endothelin-1 receptor type B in coronary arteries from ovariectomized hyperlipidemic rabbits.
Menopause 2008 May-Jul; 15(3): 503-10.
   < Abstract or Full paper >

589) Imanishi T, Ikejima H, Tsujioka H, Kuroi A, Kobayashi K, Muragaki Y, Mochizuki S, Goto M, Yoshida K, Akasaka T.
Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability.
Hypertension 2008 Mar;51(3): 734-41.
   < Abstract or Full paper >

590) Nation DA, Gonzales JA, Mendez AJ, Zaias J, Szeto A, Brooks LG, Paredes J, D'Angola A, Schneiderman N, McCabe PM.
The Effect of social environment on markers of vascular oxidative stress and inflammation in the Watanabe heritable hyperlipidemic rabbit.
Psychosom Med. 2008 Apr; 70(3): 269-75.
   < Abstract or Full paper >

591) Worthley SG, Helft G, Corti R, Worthley MI, Chew DP, Fayad ZA, Zaman AG, Fallon JT, Fuster V, Badimon JJ.
Statin therapy alone and in combination with an acyl-CoA:cholesterol O-acyltransferase inhibitor on experimental atheroscelrosis.
Pathophysiol Haemaost Thromb 2007/2008; 36(1):9-17.
   < Abstract or Full paper >

592) Imanishi T, Kuroi A, Ikejima H, Kobayashi K, Muragaki Y, Mochizuki S, Goto M, Yoshida K, Akasaka T.
Effects of angiotensin converting enzyme inhibitor and angiotensin II receptor antagonist combination on nitric oxide bioavailability and atherosclerotic change in Watanabe heritable hyperlipoidemic rabbits.
Hypertens Res 2008 Mar; 31(3): 575-584.
   < Abstract or Full paper >

593) Ikejima H, Imanishi T, Tsujioka H, Kuroi A, Kobayashi K, Shiomi M, Muragaki Y, Mochizuki S, Goto M, Yoshida K, Akasaka T.
Effects of telmisartan, a unique anigiotensin receptor blocker with selective peroxisome proliferator-activated receptor-gamma-modulating activity, on nitric oxide bioavailability and atherosclerotic change.
J Hypertens 2008 May; 26(5):964-972.
   < Abstract or Full paper >

594) Shiomi M, Yamada S, Matsukawa A, Itabe H, Ito t.
Invasion of atheromatous plaques into tunica media causes coronary outward remodeling in WHHLMI rabbits.
Atherosclerosis 2008; 198:287-293.
   < Abstract or Full paper >

595) Shiomi M, Yamada S, Amano Y, Nishimoto T, Ito T.
Lapaquistat acetate, a squalene synthesis inhibitor, changes machrophage/lipid-rich coronary plaques of hypercholesterolemic rabbits into fibrous lesions.
Br J Pharmacol 2008; 154: 949-957.
   < Abstract or Full paper >

596) Ohtani H, Shingu T, ChayamaK, Hayashi K.
Different role of macrophages and vascular smooth muscle cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic (WHHL) rabbit between aorta and coronary artery.
Hiroshima J Med Sci 2008 June; 57(2): 53-60.
   < Abstract or Full paper >

597) Imanishi T, Ikejima H, Tsujioka A, Kuroi A, Kobayashi K, Shiomi M, Muragaki Y, Mochizuki S, Goto M, Yoshida K, Akasaka T.
Combined effects of an 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor and angiotensin II receptor antagonist on nitric oxide bioavailability and atherosclerotic change in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits.
Hypertens Res 2008 June; 31 (6): 1199-1208.
   < Abstract or Full paper >

598) Ozegowski JH, Presselt N, Hartl A, Bocker T, Sanger J, Schmidt A, Willing K, Muller PJ.
Anti-atherosclerotic effect of microbial hyaluronate lyase from group B streptococci.
Pharmazie 2008 Aug; 63(8): 601-5.
   < Abstract or Full paper >

599) Kuge Y, Kume N, Ishino S, Takai N, Ogawa Y, Mukai T, Minami M, Shiomi M, Saji H.
Prominent lectin-like oxidized low density lipoprotein (LDL) receptor-1 (LOX-1) expression in atherosclerotic lesions is associated with tissue factor expression and apoptosis in hypercholesterolemic rabbits.
Biol Pharm Bull 2008 Aug; 31(8):1475-82.
   < Abstract or Full paper >

600) Imanishi T, Tsujioka H, Ikejima H, Kuroi A, Takarada S, Kitabata H, Tanimoto T, Muragaki Y, Mochizuki S, Goto M, Yoshida K, Akasaka T.
Renin inhibitor allskiren improve impaired nitric oxide bioavailability and protects against atherosclerotic changes.
Hypertension 2008 Sep; 52(3): 563-72.
   < Abstract or Full paper >

601) Ishino S, Mukai T, Kuge Y, Kume N, Ogawa M, Takai N, Kamihashi J, Shiomi M, Minami M, Kita T, Saji H.
Targeting of lectin like oxidized low-density lipoprotein recptor-1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque.
J Nucl Med 2008 Oct; 49 (10): 1677-85.
   < Abstract or Full paper >

602) Shiomi M, Fun J.
Unstable coronary plaques and cardiac events in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits: questions and quandaries.
Curr Opin Lipidol 2008 Oct; 19 (6): 631-6.
   < Abstract or Full paper >

603) Sakr SW, Potter-Perigo S, Kinsella MG, Johnson PY, Braun KR, Goueffic Y, Rosenfeld ME, Wight TN.
Hyaluronan accumulation is elevated in cultures of low density lipoprotein receptor-deficient cells and is altered by manipulation of cell cholesterol content.
J Biol Chem 2008 Dec; 283(52): 36195-204.
   < Abstract or Full paper >

604) Oh J, Feldman MD, Kim J, Sanghi P. Do D, Mancusi JJ, Kemp N, Cilingiroglu M, Milner TE.
Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography.
J Biomed Opt 2008 Sep; 13(5): 054006.
   < Abstract or Full paper >

605) Yu Y, Koike T, Kitajima S, Liu E, Morimoto M, Shiomi M, Hatakeyama K, Asada Y, Wang KY, Sasaguri Y, Watanabe T, Fan J.
Temporal and quantitative analysis of expression of metalloproteinases (MMPs) and their endogenous inhibitors in atherosclerotic lesions.
Histol Histopathol 2008 Dec; 23(12): 1503-1516.
   < Abstract or Full paper >

606) Shiomi M, Ito T.
The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: A tribute to the late Dr. Yoshio Watanabe.
Atherosclerosis 2009 Nov; 2007 (1): 1-7.
   < Abstract or Full paper >

607) Shiomi M.
Rabbit as a Model for the Study of Human Diseases.
In Houdebine LM, Fan J eds. Rabbit Biotechnology: Rabbit genomics, transgenesis, cloning and models . Springer Science + Buisiness Media.(New York, USA), 49-64 (2009).
   < Abstract or Full paper >

608) Schroder M, Fricke C, Pilegaard K, Poulsen M, Wester I, Lutjohann D, Mortensen A.
Effect of rapeseed oil-derived plant sterol and stanol esters on atherosclerosis parameters in cholesterol-challenged heterozygous Watanabe Heritable Hyperlipidemic rabbits.
Br J Nutr 2009 Sep 22: 1-12
   < Abstract or Full paper >

609) Heroux J, Gharib AM, Danthi NS, Cecchini S, Ohayon J, Pettigrew RI.
High-affinity alphavbeta3 integrin targeted oprical probe as a new imaging biomarker for early atherosclerosis: initail studies in Watanabe rabbits.
Mol Imaging Biol 2009 Nov 7[Equb ahead of print]
   < Abstract or Full paper >

610) Cui X, Kushiyama A, Yoneda M, Nakatsu Y, Guo Y, Zhang J, Ono H, Kanna M, Sakoda H, Ono H, Kikuchi T, Fujishiro M, Shiomi M, Kamata H, Kurihara H, Kikuchi M, Kawazu S, Nishimura F, Asano T.
Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy.
Diabetes Res Clin Pract 2009 Nov 23[Equb ahead of print]
   < Abstract or Full paper >

611) Ying Z, Kherada N, Farrar B, Kampfrath T, Chung Y, Simonetti O, Deiuliis J, Desikan R, Khan B, Villamena F, Sun Q, Parthasarathy S, Rajagopalan S.
Lipoic acid effects on established atherosclerosis.
Life Sci. 2009 Nov 26.[Equb ahead of print]
   < Abstract or Full paper >

612) Zhang C, Jin Y, Liu T, Liu F, Ito T.
Hypertriglyceridemia in Watanabe heritable hyperlipidemic rabbits was associated with increased production and reduced catabolism of very-low-density lipoproteins.
Pathobiology 2009 Nov; 76 (6): 315-21.[Equb ahead of print]
   < Abstract or Full paper >

613) Ohkawara H, Ishibashi T, Shiomi M, Sugimoto K, Uekita H, Kamioka M, Takuwa Y, Teramoto4 T, Maruyama Y, Takeishi Y.
RhoA and Rac1 Changes in the Atherosclerotic Lesions of WHHLMI Rabbits.
J Atheroscler Thromb 2009 Dec; 16 (6): 846-56.
   < Abstract or Full paper >