代表的な業績

2017

Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B4 pathway by high-density lipoprotein in macrophages.
Tsuda S, Shinohara M, Oshita T, Nagao M, Tanaka N, Mori T, Hara T, Irino Y, Toh R, Ishida T, Hirata KI.
Sci Rep. 2017 Oct 11;7(1):12989. doi: 10.1038/s41598-017-13154-0. PMID: 29021582

 

High-density lipoprotein protects cardiomyocytes from oxidative stress via the PI3K/mTOR signaling pathway.
Nagao M, Toh R, Irino Y, Nakajima H, Oshita T, Tsuda S, Hara T, Shinohara M, Ishida T, Hirata KI.
FEBS Open Bio. 2017 Aug 14;7(9):1402-1409. doi: 10.1002/2211-5463.12279. eCollection 2017 Sep. PMID: 28904868

 

Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.
Hara T, Monguchi T, Iwamoto N, Akashi M, Mori K, Oshita T, Okano M, Toh R, Irino Y, Shinohara M, Yamashita Y, Shioi G, Furuse M, Ishida T, Hirata KI.
Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1667-1673. doi: 10.1161/ATVBAHA.117.309721. Epub 2017 Jul 13. PMID: 28705794

 

Eicosapentaenoic Acid-Enriched High-Density Lipoproteins Exhibit Anti-Atherogenic Properties.
Tanaka N, Irino Y, Shinohara M, Tsuda S, Mori T, Nagao M, Oshita T, Mori K, Hara T, Toh R, Ishida T, Hirata KI.
Circ J 2017 in press. PMID: 28652532

 

Association between Serum Elaidic acid Concentration and Insulin Resistance in Two Japanese Cohorts with Different Lifestyles.
Itcho K, Yoshii Y, Ohno H, Oki K, Shinohara M, Irino Y, Toh R, Ishida T, Hirata KI, Yoneda M.
J Atheroscler Thromb. 2017 in press. PMID: 28484112

 

Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia.
Imahori T, Hosoda K, Nakai T, Yamamoto Y, Irino Y, Shinohara M, Sato N, Sasayama T, Tanaka K, Nagashima H, Kohta M, Kohmura E.
Neuroscience. 2017 May 4;349:1-16. PMID: 28257891

 

Excessive intake of trans fatty acid accelerates atherosclerosis through promoting inflammation and oxidative stress in a mouse model of hyperlipidemia.
Monguchi T, Hara T, Hasokawa M, Nakajima H, Mori K, Toh R, Irino Y, Ishida T, Hirata KI, Shinohara M.
J Cardiol. 2017 in press. PMID: 28254384

 

NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis.
Lee S, Nakahira K, Dalli J, Siempos II, Norris PC, Colas RA, Moon JS, Shinohara M, Hisata S, Howrylak JA, Suh GY, Ryter SW, Serhan CN, Choi AM.
Am J Respir Crit Care Med. 2017 in press. PMID: 28245134

 

2016

2-Aminobutyric acid modulates glutathione homeostasis in the myocardium.
Irino Y, Toh R, Nagao M, Mori T, Honjo T, Shinohara M, Tsuda S, Nakajima H, Satomi-Kobayashi S, Shinke T, Tanaka H, Ishida T, Miyata O, Hirata KI.
Sci Rep. 2016 Nov 9;6:36749. PMID: 27827456

 

G-CSF-induced sympathetic tone provokes fever and primes anti-mobilizing functions of neutrophils via PGE2.
Kawano Y, Fukui C, Shinohara M, Wakahashi K, Ishii S, Suzuki T, Sato M, Asada N, Kawano H, Minagawa K, Sada A, Furuyashiki T, Uematsu S, Akira S, Uede T, Narumiya S, Matsui T, Katayama Y.
Blood 2016 in publication. PMID: 27827823

 

Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids.
Park JH, Kotani T, Konno T, Setiawan J, Kitamura Y, Imada S, Usui Y, Hatano N, Shinohara M, Saito Y, Murata Y, Matozaki T.
PLoS One. 2016 May 27;11(5):e0156334. PMID: 27232601

 

Novel Endogenous Proresolving Molecules: Essential Fatty Acid-Derived and Gaseous Mediators in the Resolution of Inflammation.
Shinohara M, Serhan CN.
J Atheroscler Thromb.2016 Jun 1;23(6):655-64. PMID: 27052783

 

Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.
Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.
J Biol Chem.2016 Mar 4;291(10):4913-27. PMID: 26728457

 

2015

Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes.
Yokoi N, Beppu M, Yoshida E, Hoshikawa R, Hidaka S, Matsubara T, Shinohara M, Irino Y, Hatano N, Seino S.
Metabolomics.2015;11(5):1277-1286. PMID: 26366137

 

Metabolomic profiling in inner ear fluid by gas chromatography/mass spectrometry in guinea pig cochlea.
Fujita T, Yamashita D, Irino Y, Kitamoto J, Fukuda Y, Inokuchi G, Hasegawa S, Otsuki N, Yoshida M, Nibu K.
Neurosci Lett.2015 Oct 8;606:188-93. PMID: 26343935

 

Metabolomics analysis of saliva from patients with primary Sjögren's syndrome.
Kageyama G, Saegusa J, Irino Y, Tanaka S, Tsuda K, Takahashi S, Sendo S, Morinobu A.
Clin Exp Immunol.2015 Nov;182(2):149-53. PMID: 26201380

 

Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan.
Mori K, Ishida T, Yasuda T, Hasokawa M, Monguchi T, Sasaki M, Kondo K, Nakajima H, Shinohara M, Shinke T, Irino Y, Toh R, Nishimura K, Hirata KI.
Circ J.2015;79(9):2017-25. PMID: 26166015

 

Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment.
Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E.
J Clin Invest.2015 in press PMID: 25798620

 

Proresolving Lipid Mediator Profiles in Baboon Pneumonia are Regulated by Inhaled Carbon Monoxide.
Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, Chiang N, Welty-Wolf KE, Choi AM, Piantadosi CA, Serhan CN.
Am J Respir Cell Mol Biol.2015 Sep;53(3):314-25. PMID: 25568926

 

2014

Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion.
Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H, Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, Shibasaki T, Inagaki N, Bamba T, Mizoguchi A, Fukusaki E, Rorsman P, Seino S.
Cell Rep. 2014 Oct 23;9(2):661-73. PMID: 25373904

 

Cell-Cell Interactions and Bronchoconstrictor Eicosanoid Reduction With Inhaled Carbon Monoxide and Resolvin D1.
Shinohara M, Kibi M, Riley IR, Chiang N, Dalli J, Kraft BD, Piantadosi CA, Choi AM, Serhan CN.
Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L746-57 PMID: 25217660

 

Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nanoproresolving Medicines.
Arnardottir HH, Dalli J, Colas RA, Shinohara M, Serhan CN.
J Immunol 2014 Oct 15;193(8):4235-44 PMID: 25217168

 

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue.
Colas RA, Shinohara M, Dalli J, Chiang N, Serhan CN.
Am J Physiol Cell Physiol. 2014 Jul 1;307(1):C39-54. PMID: 24696140

 

2013

Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits.
Chiang N, Shinohara M, Dalli J, Mirakaj V, Kibi M, Choi AM, Serhan CN.
J Immunol. 2013 Jun 15;190(12):6378-88. PMID: 23650615

 

2012

Role of Phosphatidylinositol 3,4,5-trisphosphate (PIP3) 5-phosphatase, skeletal muscle and kidney enriched inositol polyphosphate phosphatase (SKIP) in myoblast differentiation.
Ijuin T, Takenawa T.
J Biol Chem. 2012 Jul 19. PMID: 22815484

 

Regulation of Insulin Signaling by the Phosphatidylinositol 3,4,5-Triphosphate Phosphatase SKIP through the Scaffolding Function of Pak1.
Ijuin T, Takenawa T.
Mol Cell Biol.
2012 Sep;32(17):3570-84. PMID: 22751929

 

Quantification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes.
Irino Y, Tokuda E, Hasegawa J, Itoh T, Takenawa T.
J Lipid Res. 2012 Apr;53(4):810-9. PMID: 22308508

 

Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
Ijuin T, Takenawa T.
J Biol Chem
. 2012 Mar 2;287(10):6991-9. Epub 2012 Jan 15. PMID: 22247557

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2011

SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain.
Hasegawa J, Tokuda E, Tenno T, Tsujita K, Sawai H, Hiroaki H, Takenawa T, Itoh T.
J Cell Biol. 2011 May 30;193(5):901-16.PMID: 21624956

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2010

WASP and WAVE family proteins: friends or foes in cancer invasion?
Kurisu S, Takenawa T.
Cancer Sci. 2010 Oct;101(10):2093-104. Review. PMID: 20707804

 

Phosphoinositide-binding interface proteins involved in shaping cell membranes.
Takenawa T.
Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(5):509-23. Review. PMID: 20467216

 

Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides.
Tsujita K, Itoh T, Kondo A, Oyama M, Kozuka-Hata H, Irino Y, Hasegawa J, Takenawa T.
J Biol Chem. 2010 Feb 26;285(9):6781-9. Epub 2009 Dec 22. PMID: 20032464

 

2009

The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration.
Itoh T, Hasegawa J, Tsujita K, Kanaho Y, Takenawa T.
Sci Signal. 2009 Sep 8;2(87):ra52. PMID: 19738202

 

The WASP and WAVE family proteins.
Kurisu S, Takenawa T.
Genome Biol. 2009;10(6):226. Epub 2009 Jun 15. Review. PMID: 19589182

 

Mechanisms of membrane deformation by lipid-binding domains.
Itoh T, Takenawa T.
Prog Lipid Res. 2009 Sep;48(5):298-305. Epub 2009 May 27. Review. PMID: 19481110

 

PtdIns(3,4)P2 instigates focal adhesions to generate podosomes.
Oikawa T, Takenawa T.
Cell Adh Migr. 2009 Apr-Jun;3(2):195-7. Epub 2009 Apr 29. Review. PMID: 19262173

 

Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates.
Yamazaki D, Kurisu S, Takenawa T.
Oncogene. 2009 Apr 2;28(13):1570-83. Epub 2009 Feb 23. PMID: 19234490

2008

Sequential signals toward podosome formation in NIH-src cells.
Oikawa T, Itoh T, Takenawa T.
J Cell Biol. 2008 Jul 14;182(1):157-69. Epub 2008 Jul 7. PMID: 18606851

 

Increased insulin action in SKIP heterozygous knockout mice.
Ijuin T, Yu YE, Mizutani K, Pao A, Tateya S, Tamori Y, Bradley A, Takenawa T.
Mol Cell Biol. 2008 Sep;28(17):5184-95. Epub 2008 Jun 23. PMID: 18573875

2007

Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.
Tokuda E, Fujita N, Oh-hara T, Sato S, Kurata A, Katayama R, Itoh T, Takenawa T, Miyazono K, Tsuruo T.
Cancer Res. 2007 Oct 15;67(20):9666-76. PMID: 17942896

 

The WASP-WAVE protein network: connecting the membrane to the cytoskeleton.
Takenawa T, Suetsugu S.
Nat Rev Mol Cell Biol. 2007 Jan;8(1):37-48. Review. PMID: 17183359

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