Takeshi Azuma:

1. Ohnishi, N., Yuasa, H., Tanaka, S., Sawa, H., Miura, M., Matsui, A., Higashi, H., Musashi, M., Iwabuchi, K., 　　Suzuki, M., Yamada, G., Azuma, T., and Hatakeyama, M. Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mice. Proc. Natl. Acad. Sci. U.S.A. 105:1003-1008, 2008.
2. Saadat, I., Higashi, H., Obuse, C., Umeda, M., Murata-Kamiya, N., Saito, Y., Lu, H., Ohnishi, N., Azuma, T., Suzuki, A., Ohno, S., and Hatakeyama, M. Helicobacter pylori CagA targets PAR-1/MARK kinase to disrupt epithelial cell polarity. Nature 447:330-333, 2007.
3. Matsumoto, Y., Marusawa, H., Kinoshita, K., Endo, Y., Kou, T., Morisawa, T., Azuma, T., Okazaki, I., Honjo, T., and Chiba, T. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat. Med. 13:470-176, 2007.
4. Higashi, H., Tsutsumi, R., Muto, S., Sugiyama, T., Azuma, T., Asaka, M., and Hatakeyama, M. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295:683-686, 2002.
5. Asahi, M., Azuma, T., Ito, S., Ito, Y., Suto, H., Nagai, Y., Tsubokawa, M., Tohyama, Y., Maeda, S., Omata, M., Suzuki, T., and Sasakawa, C. Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J. Exp. Med. 191:593-602, 2000.

Masato Kasuga:

1. Hosooka, T., Noguchi, T., Kotani, K., Nakamura, T., Sakaue, H., Inoue, H., Ogawa, W., Tobimatsu, K., Takazawa, K., Sakai, M., Matsuki, Y., Hiramatsu, R., Yasuda, T., Lazar, MA., Yamanashi, Y., and Kasuga, M. Dok1 mediates high-fat diet?induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation. Nat Med. 14:188-193, 2008
2. Uchida, T., Nakamura, T., Hashimoto, N., Matsuda, T., Kotani, K., Sakaue, H., Hayashi, Y., Nakayama, K.I., White, M.F., and Kasuga, M. Deletion of Cdkn1b gene ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat. Med. 11:175-182, 2005
3. Inoue, H., Ogawa, W., Ozaki, M., Haga, S., Matsumoto, M., Furukawa, K., Hashimoto, N., Kido, Y., Mori, T., Sakaue, H., Teshigawara, K., Jin, S., Iguchi, H., Hiramatsu, R., Leroith, D., Takeda, K., Akira, S, and Kasuga, M. Role of STAT-3 in regulation of hepatic gluconeogenic genes and of carbohydrate metabolism in vivo. Nat. Med. 10:168-174, 2004
4. Odawara, M., Kadowaki, T., Yamamoto, R., Shibasaki, Y., Tobe, K., Accili, D., Bevins, C., Mikami, Y., Matsuura, N., Akanuma, Y., Takaku, F., Taylor, S.I., and Kasuga, M. Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor. Science 245: 66-68, 1989
5. Kasuga, M., Karlsson, F.A., and Kahn, C.R. Insulin stimulates the phosphorylation of the 95K subunits of its own receptor. Science 215: 185-187, 1982

Susumu Seino:

1. Shibasaki, T., Takahashi, H., Miki, T., Sunaga, Y., Matsumura, K., Yamanaka, M., Zhang, C.L., Tamamoto, A., Satoh, T., Miyazaki, J., and Seino, S. Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc. Natl. Acad. Sci. U.S.A. 104:19333-19338, 2007
2. Minami, K., Okuno, M., Miyawaki, K., Okumachi, A., Ishizaki, K, Oyama, K., Kawaguchi, M., Ishizuka, N., Iwanaga, T., and Seino, S. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatinc acinar cells. Proc. Natl. Acad. Sci. U.S.A. 102:15116-15121, 2005
3. Miki, T., Liss, B., Minami, K., Shiuchi, T., Saraya, A., Kashima, Y., Horiuchi, M., Ashcroft, F., Minokoshi, Y., Roeper, J., and Seino, S. ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat. Neurosci. 4:507-512, 2001
4. Ozaki, N., Shibasaki, T., Kashima, Y., Miki, T., Takahashi, K., Ueno, H., Sunaga, Y., Yano, H., Iwanaga, T., Matuura, Y., Takai, Y., and Seino, S. cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat. Cell Biol. 2:805-811, 2000
5. Inagaki, N., Gonoi, T., Clement IV, J.P., Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S., and Bryan, J. Reconstitution of IKATP: An inward rectifier subunit plus the sulfonylurea receptor. Science 270:1166-1170, 1995

Hak Hotta:

1. Inubushi, S., Nagano-Fujii, M., Kitayama, K., Tanaka, M., An, C., Yokozaki, H., Yamamura, H., Nuriya, H. ,Kohara, K., Sada, K., and Hotta, H. Hepat itis C Virus NS5A protein interacts with and negatively regulates the non-receptor protein-tyrosine kinase Syk. J. Gen. Virol. (in press)
2. Nishise Y, Saito T, Sugahara K, Ito J, Saito K, Togashi H, Nagano-Fujii M, Hotta H, and Kawata S. Risk of hepatocellular carcinoma and secondary structure of hepatitis C virus (HCV) NS3 protein amino-terminus among patients infected with HCV subtype 1b. J. Infect. Dis. 196:1006-1009, 2007
3. Nomura-Takigawa, Y., Nagano-Fujii, M., Deng, L., Kitazawa, S., Ishido, S., Sada, K., and Hotta, H. Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis. J. Gen. Virol. 87:1935-1945, 2006
4. Deng, L., Nagano-Fujii, M., Tanaka, M., Nomura-Takigawa, Y., Ikeda, M., Kato, N., Sada, K., and Hotta, H. NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner. J. Gen. Virol. 87:1703-1713, 2006
5. Hidajat, R., Nagano-Fujii, M., Deng, L., Tanaka, M., Takigawa, Y., Kitazawa, S., and Hotta, H. Hepatitis C virus NS3 protein interacts with ELKS-δ and ELKS-α, members of a novel protein family involved in intracellular transport and secretory pathways. J. Gen. Virol. 86:2197-2208, 2005


Chikako Nishigori

1. Oniki, S., Nagai, H., Horikawa, T., Furukawa, J., Belladonna, M.L., Yoshimoto, T., Hara, I., and Nishigori, C. Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma. Cancer Res. 66:6395-6404, 2006.
2. Kunisada, M., Sakumi, K., Tominaga, Y., Budiyanto, A., Ueda, M., Ichihashi, M., Nakabeppu, Y., and Nishigori, C. 8-oxoguanine formation induced by chronic ultraviolet B exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis. Cancer Res. 65:6006-6010, 2005.
3. Nishigori, C., Yarosh, D.B., Ullrich, S, E., Vink, A. A. Bucana, C. D., Roza, L., and Kripke, M.L. Evidence that DNA damage triggers IL-10 cytokine production in UV-irradiated keratinocytes. Proc. Natl. Acad. Sci. U.S.A. 93:10354-10359, 1996
4. Nishigori, C., Wang, S., Miyakoshi, J., Sato, M., Tsukada, T., Yagi, T., Imamura, S., and Takebe, H. Mutations in ras genes in cells cultured from mouse skin tumors induced by ultraviolet irradiation. Proc. Natl. Acad. Sci. U.S.A. 91:7189-7193, 1994
5. Nishigori ,C., Zghal, M., Yagi, T., Imamura, S., Kamoun, M.R., and Takebe, H. High prevalence of a point mutation in exon 6 of XPAC gene in xeroderma pigmentosum group A patients in Tunisia. Am. J. Hum. Genet. 53:1001-1006, 1993

Yasuhiro Minami

1. Nishita, M., Yoo, S-K., Nomachi, A., Kani, S., Sougawa, N., Ohta, Y., Takada, S., Kikuchi, A., and Minami, Y. Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration. J. Cell. Biol. 175:555-562, 2006.
2. Fujimoto, H., Onishi, N., Kato, N., Takekawa, M., Xu, X. Z., Kosugi, A., Kondo, T., Oishi, I., Yoda, A., Imamura, M., and Minami, Y. Regulation of the anti-oncogenic Chk2 kinase by the oncogenic Wip1 phosphatase. Cell Death. Differ. 13:1170-1180, 2006.
3. Nomi, M., Oishi, I., Kani, S., Suzuki, H., Matsuda, T., Yoda, A., Kitamura, M., Itoh, K., Takeuchi, S., Takeda, K., Akira, S., Ikeya, M., Takada, S., and Minami, Y. Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2 deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Mol. Cell. Biol. 21:8329-8335, 2001.
4. Minami, Y., Nakagawa, Y., Kawahara, A., Miyazaki, T., Sada, K., Yamamura, H., and Taniguchi, T. Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor; Possible link with the c-myc induction pathway. Immunity 2:89-100, 1995.
5. Minami, Y., Kono, T., Miyazaki, T., and Taniguchi, T. The IL-2 receptor complex: Its structure, function, and target genes. Annu. Rev. Immunol. 11:245-267, 1993.

Tomoo Itoh

1. Banff Working Group, Demetris, A.J., Adeyi, O., Bellamy, C.O., Clouston, A., Charlotte, F., Czaja, A., Daskal, I., El-Monayeri, M.S., Fontes, P., Fung,J., Gridelli, B., Guido, M., Haga, H., Hart, J., Honsova, E., Hubscher, S., Itoh, T. et.al . Liver biopsy interpretation for causes of late liver allograft dysfunction. Hepatology 44:489-501, 2006
2. Sakai, Y., Atsumi, T., Itoh, T., and Koike, T. Uveitis, pancarditis, haemophagocytosis, and abdominal masses. Lancet 361 (9360):834, 2003
3. Itoh, T., Orba, Y., Takei, H., Ishida, Y., Saitoh, M., Nakamura, H., Meguro, T., Horita, S., Fujita, M., and Nagashima, K. Immunohistochemical detection of hepatocellular carcinoma in the setting of ongoing necrosis after radiofrequency ablation. Mod. Pathol. 15:110-115, 2002
4. Itoh, T., Chikai, K., Ota, S., Nakagawa, T., Takiyama, A., Mouri, G., Shinohara, N., Yamashita, T., Suzuki, S., Koyanagi, T., and Nagashima, K. Chromophobe renal cell carcinoma with osteosarcoma-like differentiation. Am. J. Surg. Pathol. 26:1358-1362, 2002
5. Itoh, T., Shimizu, M., Kitami, K., Kamata, K., Mitsumori, K., Fujita, M., Ohnishi, A., and Nagashima, K. Primary extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type in the CNS. Neuropathology 21:174-180,2001

Masafumi Matsuo

1. Takeshima, Y., Yagi, M., Wada, H., Ishibashi, K., Nishiyama, A., Kakumoto, M., Sakaeda, T., Saura, R., Okumura, K., and Matsuo, M. Intravenous infusion of an antisense oligonucleotide results in exon skipping in muscle dystrophin mRNA of Duchenne muscular dystrophy. Pediatr. Res. 59:690-694, 2006
2. Takeshima, Y., Nishio, H., Sakamoto, H., Nakamura, H., and Matsuo, M.. Modulation of in vitro splicing of the upstream intron by modifying an intra-exon sequence which is deleted from the dystrophin gene in dystrophin Kobe. J. Clin. Invest. 95:515-520, 1995
3. Narita, N., Nishio, H., Kitoh, Y., Ishikawa, Y., Ishikawa, Y., Minami, R., Nakamura, H., and Matsuo, M. Insertion of a 5' truncated L1 element into the 3' end of exon 44 of the dystrophin gene resulted in skipping of the exon during splicing in a case of Duchenne muscular dystrophy. J. Clin. Invest. 91:1862-1867, 1993
4. Matsuo, M., Masumura, T., Nishio, H., Nakajima, T., Kitoh, Y., Takumi, T., Koga, J., and Nakamura, H. Exon skipping during splicing of dystrophin mRNA precursor due to an intraexon deletion in the dystrophin gene of Duchenne muscular dystrophy Kobe. J. Clin. Invest. 87:2127-2131, 1991
5. Matsuo, M., Masumura, T., Nakajima, T., Kitoh, Y., Takumi, T., Nishio, H., Koga, J., and Nakamura, H. A very small frame-shifting deletion within exon 19 of the Duchenne muscular dystrophy gene. Biochem. Biophys. Res. Commun. 170:963-967, 1990
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
Hironobu Minami

1. Minami, H., Sai, K., Saeki, M., Saito, Y., Ozawa, S., Suzuki, K., Kaniwa, N., Sawada, J., Hamaguchi, T., Yamamoto, N., Shirao, K., Yamada, Y., Ohmatsu, H., Kubota, K., Yoshida, T., Ohtsu, A., and Saijo, N. Irinotecan pharmacokinetics/ pharmacodynamics and UGT1A genetic polymorphisms in Japanese: Roles of UGT1A1*6 and *28. Pharmacogenet. Genomics 17:497-504, 2007
2. Minami, H., Ohe, Y., Niho, S., Goto, K., Ohmatsu, H., Kubota, K., Kakinuma, R., Nishiwaki, Y., Nokihara, H., Sekine, I., Saijo, N., Hanada, K., and Ogata, H. Comparison of pharmacokinetics and pharmacodynamics of docetaxel and cisplatin in elderly and non-elderly patients, why is toxicity increased in elderly patients? J. Clin. Oncol. 22:2901-2908, 2004
3. Minami, H., Sasaki, Y., Saijo, N., Ohtsu, T., Fujii, H., Igarashi, T., and Itoh, K. Indirect response model for the time course of leukopenia with anticancer drugs. Clin. Pharmacol. Ther. 64:511-521, 1998
4. Minami, H., Ando, Y., Sakai, S., and Shimokata, K. Clinical and pharmacological analysis of a hyper-fractionated daily oral etoposide. J. Clin. Oncol. 13:191-199, 1995
5. Minami, H., Shimokata, K., Saka, H., Saito, H., Ando, Y., Senda, K., Nomura, F., and Sakai, S. Phase I clinical and pharmacokinetic study of 14-day infusion of etoposide in patients with lung cancer. J. Clin. Oncol. 11:1602-1608, 1993

Toshio Imai:

1. Mizutani, N., Sakurai, T., Shibata, T., Uchida, K., Fujita, J., Kawashima, R., Kawamura, Y.I., Toyama-Sorimachi, N., Imai, T., and Dohi, T. Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. J. Immunol. 179:7478-7487, 2007
2. Nanki, T., Urasaki, Y., Imai, T., Nishimura, M., Muramoto, K., Kubota, T., and Miyasaka, N. Inhibition of fractalkine ameliorates murine collagen-induced arthritis. J. Immunol., 173:7010-7016, 2004
3. Umehara, H., Bloom, H., Okazaki, T., Domae, N., and Imai, T. Fractalkine and vascular injury. Trends Immunol. 22:602-607, 2001
4. Imai, T., Nagira, M., Takagi, S., Kakizaki, M., Nishimura, M., Wang, J., Gray, P. W., Matsushima K., and Yoshie, O. Selective recruitment of CCR4-bearing Th2 cells toward antigen- presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int. Immunol. 11:81-88, 1999
5. Imai, T., Hieshima, K., Haskell, C., Baba, M., Nagira, M., Nishimura, M., Kakizaki, M., Takagi, S., Nomiyama, H., Schall, T. J., and Yoshie, O. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91:521-530, 1997

c) List their significant prizes/awards and scientific honors (Giving member’s name and year received.)

・Shionogi-Lilly Award from the Japan Diabetes Society (Masato Kasuga, 1987)
・Research-Encouragement Award from Japan Endocrine Society (Masato Kasuga, 1987)
・The Asia & Oceania Medal: The Society for Endocrinology, UK (Susumu Seino, 1997)
・Plenary Lecture: American Diabetes Association (Susumu Seino, 2002)
・The Naito Foundation Research Prize (Susumu Seino, 2005)
・The 1st Japanese Society for Photomedicine and Photobiology Award (Chikako Nishigori, 1988
・Hyogo Prefecture Award for Science (Masafumi Matsuo, 2006)
・Incitement Award, the Japanese Cancer Association (Hironobu Minami, 2001)
・Tamiya Memorial Award (Hironobu Minami, 2004)