Publications

2017

  1. Glutamate production from ammonia via glutamate dehydrogenase 2 activity supports cancer cell proliferation under glutamine depletion.

    Takeuchi Y, Nakayama Y, Fukusaki E, Irino Y.
    Biochem Biophys Res Commun.2017 Nov 14. pii: S0006-291X(17)32266-0. doi: 10.1016/j.bbrc.2017.11.088. PMID: 29146184

  2. The impact of serum trans fatty acids concentration on plaque vulnerability in patients with coronary artery disease: Assessment via optical coherence tomography.

    Nagasawa Y, Shinke T, Toh R, Ishida T, Otake H, Takaya T, Sugiyama D, Toba T, Kuroda M, Takahashi H, Terashita D, Tahara N, Shinkura Y, Uzu K, Kashiwagi D, Kuroda K, Nagano Y, Yamamoto H, Yanaka K, Tsukiyama Y, Hirata KI.
    Atherosclerosis.2017 Oct;265:312-317. doi: 10.1016/j.atherosclerosis.2017.06.922. PMID: 28697847

  3. Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B4 pathway by high-density lipoprotein in macrophages.

    Tsuda S, Shinohara M, Oshita T, Nagao M, Tanaka N, Mori T, Hara T, Irino Y, Toh R, Ishida T, Hirata KI.
    Sci Rep.2017 Oct 11;7(1):12989. PMID: 29021582

  4. High-density lipoprotein protects cardiomyocytes from oxidative stress via the PI3K/mTOR signaling pathway.

    Nagao M, Toh R, Irino Y, Nakajima H, Oshita T, Tsuda S, Hara T, Shinohara M, Ishida T, Hirata KI.
    FEBS Open Bio.2017 Aug 14;7(9):1402-1409. PMID: 28904868

  5. Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.

    Hara T, Monguchi T, Iwamoto N, Akashi M, Mori K, Oshita T, Okano M, Toh R, Irino Y, Shinohara M, Yamashita Y, Shioi G, Furuse M, Ishida T, Hirata KI.
    Arterioscler Thromb Vasc Biol.2017 Sep;37(9):1667-1673. PMID: 28705794

  6. Eicosapentaenoic Acid-Enriched High-Density Lipoproteins Exhibit Anti-Atherogenic Properties.

    Tanaka N, Irino Y, Shinohara M, Tsuda S, Mori T, Nagao M, Oshita T, Mori K, Hara T, Toh R, Ishida T, Hirata KI.
    Circ J.2017 Jun 23. doi: 10.1253/circj.CJ-17-0294. PMID: 28652532

    　
  7. Cholesterol Uptake Capacity: A New Measure of HDL Functionality for Coronary Risk Assessment.

    Amane Harada, Ryuji Toh, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Takuya Kubo, Yasuhiro Irino, Kenta Mori, Nobuaki Tanaka, Kunihiro Nishimura, Tatsuro Ishida, Ken-ichi Hirata
    The Journal of Applied Laboratory Medicine: An AACC Publication.2017

  8. Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis.

    Takahashi S, Saegusa J, Sendo S, Okano T, Akashi K, Irino Y, Morinobu A.
    Arthritis Res Ther. 2017 Apr 11;19(1):76. PMID: 28399896

  9. Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia.

    Imahori T, Hosoda K, Nakai T, Yamamoto Y, Irino Y, Shinohara M, Sato N, Sasayama T, Tanaka K, Nagashima H, Kohta M, Kohmura E.
    Neuroscience. 2017 May 4;349:1-16. PMID: 28257891

  10. Excessive intake of trans fatty acid accelerates atherosclerosis through promoting inflammation and oxidative stress in a mouse model of hyperlipidemia.

    Monguchi T, Hara T, Hasokawa M, Nakajima H, Mori K, Toh R, Irino Y, Ishida T, Hirata KI, Shinohara M.
    J Cardiol. 2017 Feb 18. pii: S0914-5087(17)30015-1. PMID: 28254384

2016

  1. 2-Aminobutyric acid modulates glutathione homeostasis in the myocardium.

    Irino Y, Toh R, Nagao M, Mori T, Honjo T, Shinohara M, Tsuda S, Nakajima H, Satomi-Kobayashi S, Shinke T, Tanaka H, Ishida T, Miyata O, Hirata KI.
    Sci Rep. 2016 Nov 9;6:36749. PMID: 27827456 

    本研究成果が神戸大学と神戸新聞に紹介されました。

  2. β-Hydroxybutyrate elevation as a compensatory response against oxidative stress in cardiomyocytes.

    Nagao M, Toh R, Irino Y, Mori T, Nakajima H, Hara T, Honjo T, Satomi-Kobayashi S, Shinke T, Tanaka H, Ishida T, Hirata K.
    Biochem Biophys Res Commun. 2016 Jul 8;475(4):322-8. PMID: 27216458

  3. Comparison of telmisartan/amlodipine and telmisartan/hydrochlorothiazide in the treatment of Japanese patients with uncontrolled hypertension: the TAT-Kobe study.

    Kondo K, Toh R, Ishida T, Mori K, Yasuda T, Hirata K.
    Blood Press Monit. 2016 Jun;21(3):171-7. PMID: 26719915 

  4. Enhanced Impact of Cholesterol Absorption Marker on New Atherosclerotic Lesion Progression After Coronary Intervention During Statin Therapy.

    Mori K, Ishida T, Tsuda S, Oshita T, Shinohara M, Hara T, Irino Y, Toh R, Hirata KI.
    J Atheroscler Thromb. 2016 Aug 4. PMID: 27487947 

  5. Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma.

    Nagashima H, Tanaka K, Sasayama T, Irino Y, Sato N, Takeuchi Y, Kyotani K, Mukasa A, Mizukawa K, Sakata J, Yamamoto Y, Hosoda K, Itoh T, Sasaki R, Kohmura E.
    Neuro Oncol. 2016 Nov;18(11):1559-1568. PMID: 27154922 

  6. Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.

    Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.
    J Biol Chem. 2016 Mar 4;291(10):4913-27. PMID: 26728457 

2015

  1. Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment.

    Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E.
    J Clin Invest. 2015 Apr;125(4):1591-602. PMID: 25798620 

  2. Metabolomics analysis of saliva from patients with primary Sjögren's syndrome.

    Kageyama G, Saegusa J, Irino Y, Tanaka S, Tsuda K, Takahashi S, Sendo S, Morinobu A.
    Clin Exp Immunol. 2015 Nov;182(2):149-53. PMID: 26201380 

  3. Metabolomic profiling in inner ear fluid by gas chromatography/mass spectrometry in guinea pig cochlea.

    Fujita T, Yamashita D, Irino Y, Kitamoto J, Fukuda Y, Inokuchi G, Hasegawa S, Otsuki N, Yoshida M, Nibu K.
    Neurosci Lett. 2015 Oct 8;606:188-93. PMID: 26343935 

  4. Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes.

    Yokoi N, Beppu M, Yoshida E, Hoshikawa R, Hidaka S, Matsubara T, Shinohara M, Irino Y, Hatano N, Seino S.
    Metabolomics. 2015;11(5):1277-1286. PMID: 26366137 

  5. Trans-fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via Toll-like receptors.

    Kondo K, Ishida T, Yasuda T, Nakajima H, Mori K, Tanaka N, Mori T, Monguchi T, Shinohara M, Irino Y, Toh R, Rikitake Y, Kiyomizu K, Tomiyama Y, Yamamoto J, Hirata K.
    Mol Nutr Food Res. 2015 Apr;59(4):729-40. PMID: 25546502 

  6. Segmental aortic stiffening contributes to experimental abdominal aortic aneurysm development.

    Raaz U, Zöllner AM, Schellinger IN, Toh R, Nakagami F, Brandt M, Emrich FC, Kayama Y, Eken S, Adam M, Maegdefessel L, Hertel T, Deng A, Jagger A, Buerke M, Dalman RL, Spin JM, Kuhl E, Tsao PS.
    Circulation. 2015 May 19;131(20):1783-95. PMID: 25904646 

  7. Comparison of cardiovascular mortality in the Great East Japan and the Great Hanshin-Awaji Earthquakes　- a large-scale data analysis of death certificates.

    Takegami M, Miyamoto Y, Yasuda S, Nakai M, Nishimura K, Ogawa H, Hirata K, Toh R, Morino Y, Nakamura M, Takeishi Y, Shimokawa H, Naito H.
    Circ J. 2015;79(5):1000-8. PMID: 25912562 

  8. Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan.

    Mori K, Ishida T, Yasuda T, Hasokawa M, Monguchi T, Sasaki M, Kondo K, Nakajima H, Shinohara M, Shinke T, Irino Y, Toh R, Nishimura K, Hirata K.
    Circ J. 2015;79(9):2017-25. PMID: 26166015 

  9. Transcription Factor Runx2 Promotes Aortic Fibrosis and Stiffness in Type 2 Diabetes Mellitus.

    Raaz U, Schellinger IN, Chernogubova E, Warnecke C, Kayama Y, Penov K, Hennigs JK, Salomons F, Eken S, Emrich FC, Zheng WH, Adam M, Jagger A, Nakagami F, Toh R, Toyama K, Deng A, Buerke M, Maegdefessel L, Hasenfuß G, Spin JM, Tsao PS.
    Circ Res. 2015 Aug 28;117(6):513-24. PMID: 26208651 

2014

  1. miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.

    Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nakagami F, Heymann HM, Chernogubova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS.
    Nat Commun. 2014 Oct 31;5:5214. PMID: 25358394 

  2. Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia.

    Tanaka N, Ishida T, Nagao M, Mori T, Monguchi T, Sasaki M, Mori K, Kondo K, Nakajima H, Honjo T, Irino Y, Toh R, Shinohara M, Hirata K.
    Atherosclerosis. 2014 Dec;237(2):577-83. PMID: 25463091 

  3.  Serum myeloperoxidase/paraoxonase 1 ratio as potential indicator of dysfunctional high-density lipoprotein and risk stratification in coronary artery disease.

    Haraguchi Y, Toh R, Hasokawa M, Nakajima H, Honjo T, Otsui K, Mori K, Miyamoto-Sasaki M, Shinohara M, Nishimura K, Ishida T, Hirata K.
    Atherosclerosis. 2014 Jun;234(2):288-94. PMID: 24704632 

  4. Plasma activity of endothelial lipase impacts high-density lipoprotein metabolism and coronary risk factors in humans.

    Sun L, Ishida T, Miyashita K, Kinoshita N, Mori K, Yasuda T, Toh R, Nakajima K, Imamura S, Hirata K.
    J Atheroscler Thromb. 2014;21(4):313-21. PMID: 24369272 

  5. Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer.

    Tokuda E, Itoh T, Hasegawa J, Ijuin T, Takeuchi Y, Irino Y, Fukumoto M, Takenawa T.
    Cancer Res. 2014 Jun 1;74(11):3054-66. PMID: 24706697 

  6. GC/MS-based metabolomics detects metabolic alterations in serum from SLE patients.

    Saegusa J, Irino Y, Yoshida M, Tanaka S, Kogata Y, Kageyama G, Tsuji G, Takenawa T, Kawano S, Kumagai S, Morinobu A.
    Clin Exp Rheumatol. 2014 Jan-Feb;32(1):148. Epub 2014 Jan 3. PMID:24387928 

2013

  1. Pitavastatin increases HDL particles functionally preserved with cholesterol efflux capacity and antioxidative actions in dyslipidemic patients.

    Miyamoto-Sasaki M, Yasuda T, Monguchi T, Nakajima H, Mori K, Toh R, Ishida T, Hirata K.
    J Atheroscler Thromb. 2013;20(9):708-16. PMID: 23739642 

  2. Endothelial lipase modulates pressure overload-induced heart failure through alternative pathway for fatty acid uptake.

    Nakajima H, Ishida T, Satomi-Kobayashi S, Mori K, Hara T, Sasaki N, Yasuda T, Toh R, Tanaka H, Kawai H, Hirata K.
    Hypertension. 2013 May;61(5):1002-7. PMID: 23460280 

  3. Fasting serum concentration of apolipoprotein B48 represents residual risks in patients with new-onset and chronic coronary artery disease.

    Mori K, Ishida T, Yasuda T, Monguchi T, Sasaki M, Kondo K, Hasokawa M, Nakajima H, Haraguchi Y, Sun L, Shinohara M, Toh R, Nishimura K, Hirata K.
    Clin Chim Acta. 2013 Jun 5;421:51-6. PMID: 23428589 

  4. Serum and tissue metabolomics of head and neck cancer.

    Yonezawa K, Nishiumi S, Kitamoto-Matsuda J, Fujita T, Morimoto K, Yamashita D, Saito M, Otsuki N, Irino Y, Shinohara M, Yoshida M, Nibu K.
    Cancer Genomics Proteomics. 2013 Sep-Oct;10(5):233-8. PMID: 24136976 

  5. GC/MS-based metabolomic analysis of cerebrospinal fluid (CSF) from glioma patients.

    Nakamizo S, Sasayama T, Shinohara M, Irino Y, Nishiumi S, Nishihara M, Tanaka H, Tanaka K, Mizukawa K, Itoh T, Taniguchi M, Hosoda K, Yoshida M, Kohmura E.
    J Neurooncol. 2013 May;113(1):65-74. PMID: 23456655