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神戸大学大学院科学技術イノベーション研究科 先端医療学分野 バイオロジクス探索研究室                                                                                                                                  

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〒650-0017 神戸市中央区楠町7-5-1 研究棟C 2階

研究業績Research publishing

2017

Kitagawa K, Shigemura K, Onuma KI, Nishida M, Fujiwara M, Kobayashi S, Yamasaki M, Nakamura T, Yamamichi F, Shirakawa T, Tokimatsu I, Fujisawa M. Improved bacterial identification directly from urine samples with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J Clin Lab Anal. 2017 Jul 24. doi: 10.1002/jcla.22301. [Epub ahead of print]

Saito H, Kitagawa K, Yoneda T, Fukui Y, Fujsawa M, Bautista D, Shirakawa T. Combination of p53-DC vaccine and rAd-p53 gene therapy induced CTLs cytotoxic against p53-deleted human prostate cancer cells in vitro.  Cancer Gene Ther. 2017 Jun 16. doi: 10.1038/cgt.2017.21. [Epub ahead of print]

Osawa K, Shigemura K, Nukata Y, Kitagawa K, Yamamichi F, Yoshida H, Shirakawa T, Arakawa S, Fujisawa M. penA, ponA, porB1, and mtrR Mutations and Molecular Epidemiological Typing of Neisseria gonorrhoeae with Decreased Susceptibility to Cephalosporins. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e01174-17. doi: 10.1128/AAC.01174-17. Print 2017 Aug.

Kitagawa K, Oda T, Saito H, Araki A, Gonoi R, Shigemura K, Hashii Y, Katayama T, Fujisawa M, Shirakawa T. Development of oral cancer vaccine using recombinant Bifidobacterium displaying Wilms' tumor 1 protein.  Cancer Immunol Immunother. 2017 Mar 15. doi: 10.1007/s00262-017-1984-0.

Kitagawa K, Omoto C, Oda T, Araki A, Saito H, Shigemura K, Katayama T, Hotta H, Shirakawa T. Oral Combination Vaccine, Comprising Bifidobacterium Displaying Hepatitis C Virus Nonstructural Protein 3 and Interferon-α, Induces Strong Cellular Immunity Specific to Nonstructural Protein 3 in Mice. Viral Immunol. 2017 Jan 23. doi: 10.1089/vim.2016.0111.

2016

Iijima Y, Oundo JO, Hibino T, Saidi SM, Hinenoya A, Osawa K, Shirakawa T, Osawa R, Yamasaki S. High Prevalence of Diarrheagenic Escherichia coli among Children with Diarrhea in Kenya.Jpn J Infect Dis. 2017 Jan 24;70(1):80-83. doi: 10.7883/yoken.JJID.2016.064.

Wasito EB, Shigemura K, Osawa K, Fardah A, Kanaida A, Raharjo D, Kuntaman K, Hadi U, Harijono S, Sudarmo SM, Nakamura T, Shibayama K, Fujisawa M, Shirakawa T. Antibiotic susceptibilities and genetic characterization of extended spectrum beta-lactamase producing Escherichia coli isolated from stools of pediatric diarrhea patients in Surabaya, Indonesia. Jpn J Infect Dis. 2016 Dec 22. doi: 10.7883/yoken.JJID.2016.234.

2015

Osawa K, Shigemura K, Shimizu R, Kato A, Kusuki M, Jikimoto T, Nakamura T, Yoshida H, Arakawa S, Fujisawa M, Shirakawa T. Molecular characteristics of extended-spectrum β-lactamase-producing Escherichia coli in a university teaching hospital. Microb Drug Resist. 2015 Apr;21(2):130-9. doi: 10.1089/mdr.2014.0083.

Shigemura K, Osawa K, Miura M, Tanaka K, Arakawa S, Shirakawa T, Fujisawa M. Azithromycin resistance and its mechanism in Neisseria gonorrhoeae strains in Hyogo, Japan. Antimicrob Agents Chemother. 2015 May;59(5):2695-9. doi: 10.1128/AAC.04320-14.

Shirakawa T. [Development of the novel oral vaccine against hepatitis C virus utilizing bifidobacteria]. Nihon Rinsho. 2015 Feb;73(2):239-42. Review. [Japanese]

Sudarmo SM, Shigemura K, Athiyyah AF, Osawa K, Wardana OP, Darma A, Ranuh R, Raharjo D, Arakawa S, Fujisawa M, Shirakawa T. Genotyping and clinical factors in pediatric diarrhea caused by rotaviruses: one-year surveillance in Surabaya, Indonesia. Gut Pathog. 2015 Feb 8;7:3. doi: 10.1186/s13099-015-0048-2.

Shigemura K, Osawa K, Kato A, Tokimatsu I, Arakawa S, Shirakawa T, Fujisawa M. Association of overexpression of efflux pump genes with antibiotic resistance in Pseudomonas aeruginosa strains clinically isolated from urinary tract infection patients. J Antibiot (Tokyo). 2015 Sep;68(9):568-72. doi: 10.1038/ja.2015.34.J Antibiot (Tokyo). 2015 Sep;68(9):568-72. doi: 10.1038/ja.2015.34.

Tada Y, Hiroshima K, Shimada H, Morishita N, Shirakawa T, Matsumoto K, Shingyoji M, Sekine I, Tatsumi K, Tagawa M. A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene. Springerplus. 2015 Jul 16;4:358. doi: 10.1186/s40064-015-1123-3.

Yamamichi F, Shigemura K, Behnsawy HM, Yamashita M, Shirakawa T, Fujisawa M. Beta-3 adrenergic receptors could be significant factors for overactive bladder-related symptoms. Int J Clin Exp Pathol. 2015 Sep 1;8(9):11863-70.

Osawa K, Shigemura K, Shirai H, Kato A, Okuya Y, Jikimoto T, Arakawa S, Fujisawa M, Shirakawa T. BACTERIAL IDENTIFICATION USING SSRA ENCODING TRANSFER-MESSENGER RNA. Southeast Asian J Trop Med Public Health. 2015 Jul;46(4):720-7.

2014

Osawa K, Shigemura K, Shimizu R, Kato A, Kusuki M, Jikimoto T, Nakamura T, Yoshida H, Arakawa S, Fujisawa M, Shirakawa T. Molecular Characteristics of Extended-Spectrum β-Lactamase-Producing Escherichia coli in a University Teaching Hospital. Microb Drug Resist. 2014 Oct 31. [Epub ahead of print]

Yamamichi F, Shigemura K, Behnsawy HM, Meligy FY, Huang WC, Li X, Yamanaka K, Hanioka K, Miyake H, Tanaka K, Kawabata M, Shirakawa T, Fujisawa M. Sonic hedgehog and androgen signaling in tumor and stromal compartments drives epithelial-mesenchymal transition in prostate cancer. Scand J Urol. 2014 Dec;48(6):523-32.

Saito H, Ando S, Morishita N, Lee KM, Dator D, Dy D, Shigemura K, Adhim Z,Nibu K, Fujisawa M, Shirakawa T. A combined lymphokine-activated killer (LAK) cell immunotherapy and adenovirus-p53 gene therapy for head and neck squamouscell carcinoma. Anticancer Res. 2014 Jul;34(7):3365-70.

Shimizu R, Osawa K, Shigemura K, Yoshida H, Fujiwara M, Iijima Y, Fujisawa M, Shirakawa T. Development of multiplex PCR for rapid identification of four Salmonella serovars most commonly isolated in Japan. Southeast Asian J Trop Med Public Health. 2014 May;45(3):654-61.

Osawa K, Shigemura K, Jikimoto T, Shirakawa T, Fujisawa M, Arakawa S. Comparison between phage-open-reading frame typing and automated repetitive-sequence-based PCR for typing MRSA isolates. J Antibiot (Tokyo). 2014  Aug;67(8):565-9. doi: 10.1038/ja.2014.41. Epub 2014 Apr 16.

Takei S, Omoto C, Kitagawa K, Morishita N, Katayama T, Shigemura K, Fujisawa M, Kawabata M, Hotta H, Shirakawa T. Oral administration of genetically modified  Bifidobacterium displaying HCV-NS3 multi-epitope fusion protein could induce an HCV-NS3-specific systemic immune response in mice. Vaccine. 2014 May 23;32(25):3066-74.

Osawa K, Shigemura K, Shimizu R, Kato A, Kimura M, Katayama Y, Okuya Y, Yutaka S, Nishimoto A, Kishi A, Fujiwara M, Yoshida H, Iijima Y, Fujisawa M, Shirakawa T. Antimicrobial resistance in Salmonella strains clinically isolated in Hyogo, Japan (2009-2012). Jpn J Infect Dis. 2014;67(1):54-7.

2013

Osawa K, Raharjo D, Wasito EB, Harijono S, Shigemura K, Osawa R, Sudarmo SM, Iijima Y, Shirakawa T. Frequency of diarrheagenic Escherichia coli among children in Surabaya, Indonesia. Jpn J Infect Dis. 2013;66(5):446-8.

Behnsawy HM, Shigemura K, Meligy FY, Yamamichi F, Yamashita M, Haung WC, Li X, Miyake H, Tanaka K, Kawabata M, Shirakawa T, Fujisawa M. Possible role of sonic hedgehog and epithelial-mesenchymal transition in renal cell cancer progression.  Korean J Urol. 2013 Aug;54(8):547-54.

Osawa K, Shigemura K, Iguchi A, Shirai H, Imayama T, Seto K, Raharjo D, Fujisawa M, Osawa R, Shirakawa T. Modulation of O-antigen chain length by the wzz gene in Escherichia coli O157 influences its sensitivities to serum complement. Microbiol Immunol. 2013 Sep;57(9):616-23.

Adhim Z, Otsuki N, Kitamoto J, Morishita N, Kawabata M, Shirakawa T, Nibu K. Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention against head and neck cancer-containing HPV16 cell lines. Acta Otolaryngol. 2013 Jul;133(7):761-71.

Shirakawa T, Haraguchi T, Shigemura K, Morishita S, Minayoshi K, Miyazaki J, Yamada Y, Miyake H, Tanaka K, Fujisawa M. Silodosin versus naftopidil in Japanese patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized multicenter study. Int J Urol. 2013 Sep;20(9):903-10.

2012

Adhim Z, Otsuki N, Kitamoto J, Morishita N, Kawabata M, Shirakawa T, Nibu KI. Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention against head and neck cancer-containing HPV16 cell lines. Acta Otolaryngol. 2013 May 3. [Epub ahead of print] PubMed PMID: 23638950.

Shirakawa T, Haraguchi T, Shigemura K, Morishita S, Minayoshi K, Miyazaki J, Yamada Y, Miyake H, Tanaka K, Fujisawa M. Silodosin versus naftopidil in Japanese patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: A randomized multicenter study. Int J Urol. 2012 Dec 17. doi: 10.1111/iju.12055. [Epub ahead of print] PubMed PMID: 23252453.

Shigemura K, Tanaka K, Yamamichi F, Shirakawa T, Miyake H, Fujisawa M. Does mutation in gyrA and/or parC or efflux pump expression play the main role in fluoroquinolone resistance in Escherichia coli urinary tract infections?: A statistical analysis study. Int J Antimicrob Agents. 2012 Dec;40(6):516-20. doi: 10.1016/j.ijantimicag.2012.07.019. Epub 2012 Oct 13. PubMed PMID: 23068598.

Matsuoka T, Shigemura K, Yamamichi F, Fujisawa M, Kawabata M, Shirakawa T. Detection of tumor markers in prostate cancer and comparison of sensitivity between real time and nested PCR. Kobe J Med Sci. 2012 Jun 27;58(2):E51-9. PubMed PMID: 22972169.

Yamamichi F, Matsuoka T, Shigemura K, Kawabata M, Shirakawa T, Fujisawa M. Potential establishment of lung metastatic xenograft model of androgen receptor-positive and androgen-independent prostate cancer (C4-2B). Urology. 2012 Oct;80(4):951.e1-7. doi: 10.1016/j.urology.2012.06.023. Epub 2012 Aug 22. PubMedPMID: 22920407.

Sonn CH, Choi JR, Kim TJ, Yu YB, Kim K, Shin SC, Park GH, Shirakawa T, Kim HS, Lee KM. Augmentation of natural cytotoxicity by chronic low-dose ionizing radiation in murine natural killer cells primed by IL-2. J Radiat Res. 2012 Nov 1;53(6):823-9. doi: 10.1093/jrr/rrs037. Epub 2012 Aug 21. PubMed PMID: 22915781; PubMed Central PMCID: PMC3483842.

Matsumoto M, Shigemura K, Shirakawa T, Nakano Y, Miyake H, Tanaka K, Kinoshita S, Arakawa S, Kawabata M, Fujisawa M. Mutations in the gyrA and parC genes and in vitro activities of fluoroquinolones in 114 clinical isolates of Pseudomonasaeruginosa derived from urinary tract infections and their rapid detection by denaturing high-performance liquid chromatography. Int J Antimicrob Agents. 2012  Nov;40(5):440-4. doi: 10.1016/j.ijantimicag.2012.06.021. Epub 2012 Aug 10. PubMed PMID: 22884856.

Meligy FY, Shigemura K, Behnsawy HM, Fujisawa M, Kawabata M, Shirakawa T. The  efficiency of in vitro isolation and myogenic differentiation of MSCs derived from adipose connective tissue, bone marrow, and skeletal muscle tissue. In Vitro Cell Dev Biol Anim. 2012 Apr;48(4):203-15. doi: 10.1007/s11626-012-9488-x. Epub 2012 Mar 7. PubMed PMID: 22396125.

2011

Adhim Z, Lin X, Huang W, Morishita N, Nakamura T, Yasui H, Otsuki N, Shigemura K, Fujisawa M, Nibu K, Shirakawa T. E10A, an adenovirus-carrying endostatin gene, dramatically increased the tumor drug concentration of metronomic chemotherapy with low-dose cisplatin in a xenograft mouse model for head and neck squamous-cell carcinoma. Cancer Gene Ther. 2012 Feb;19(2):144-52. doi: 10.1038/cgt.2011.79. Epub 2011 Nov 25. PubMed PMID: 22116375.

Iguchi K, Sakurai F, Tomita K, Katayama K, Yamaguchi T, Kawabata K, Tagawa M, Kawabata M, Shirakawa T, Mizuguchi H. Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells. Cancer Gene Ther. 2012 Feb;19(2):118-25. doi: 10.1038/cgt.2011.74. Epub 2011 Nov 11. PubMed PMID: 22076042.

Yasufuku T, Shigemura K, Shirakawa T, Matsumoto M, Nakano Y, Tanaka K, Arakawa S, Kawabata M, Fujisawa M. Mechanisms of and risk factors for fluoroquinolone resistance in clinical Enterococcus faecalis isolates from patients with urinary tract infections. J Clin Microbiol. 2011 Nov;49(11):3912-6. doi: 10.1128/JCM.05549-11. Epub 2011 Sep 14. PubMed PMID: 21918020; PubMed Central PMCID: PMC3209098.
Adhim Z, Matsuoka T, Bito T, Shigemura K, Lee KM, Kawabata M, Fujisawa M,Nibu K, Shirakawa T. In vitro and in vivo inhibitory effect of three Cox-2 inhibitors and epithelial-to-mesenchymal transition in human bladder cancer cell  lines. Br J Cancer. 2011 Jul 26;105(3):393-402. doi: 10.1038/bjc.2011.262. Epub 2011 Jul 12. PubMed PMID: 21750550; PubMed Central PMCID: PMC3172915.

Saito A, Morishita N, Mitsuoka C, Kitajima S, Hamada K, Lee KM, Kawabata M, Fujisawa M, Shirakawa T. Intravenous injection of irradiated tumor cell vaccine carrying oncolytic adenovirus suppressed the growth of multiple lung tumors in a  mouse squamous cell carcinoma model. J Gene Med. 2011 Jun;13(6):353-61. doi: 10.1002/jgm.1578. PubMed PMID: 21674738.

Nishibori T, de Vries GC, Rahardjo D, Wasito EB, De I, Kinoshita S, Hayashi Y, Hotta H, Kawabata M, Shirakawa T, Iijima Y, Osawa R. Phenotypic and genotypic  characterization of Vibrio cholerae clinically isolated in Surabaya, Indonesia. Jpn J Infect Dis. 2011;64(1):7-12. PubMed PMID: 21266749.

2010

Yasufuku T, Shigemura K, Shirakawa T, Matsumoto M, Nakano Y, Tanaka K, Arakawa S, Kinoshita S, Kawabata M, Fujisawa M. Correlation of overexpression of  efflux pump genes with antibiotic resistance in Escherichia coli Strains clinically isolated from urinary tract infection patients. J Clin Microbiol. 2011 Jan;49(1):189-94. doi: 10.1128/JCM.00827-10. Epub 2010 Nov 3. PubMed PMID: 21048014; PubMed Central PMCID: PMC3020419.

Yasufuku T, Shigemura K, Shirakawa T, Nakano Y, Tanaka K, Arakawa S, Kinoshita S, Nishimura K, Kawabata M, Fujisawa M. Risk factors and mechanisms of  fluoroquinolone resistance in 156 Escherichia coli strains clinically isolated from urinary tract infections. Scand J Infect Dis. 2011 Feb;43(2):83-8. doi: 10.3109/00365548.2010.526632. Epub 2010 Oct 14. PubMed PMID: 20942776.

Yamamoto S, Wada J, Katayama T, Jikimoto T, Nakamura M, Kinoshita S, Lee KM, Kawabata M, Shirakawa T. Genetically modified Bifidobacterium displaying Salmonella-antigen protects mice from lethal challenge of Salmonella Typhimurium  in a murine typhoid fever model. Vaccine. 2010 Sep 24;28(41):6684-91. doi: 10.1016/j.vaccine.2010.08.007. Epub 2010 Aug 13. PubMed PMID: 20709009.

Hatta M, Ratnawati, Tanaka M, Ito J, Shirakawa T, Kawabata M. NRAMP1/SLC11A1 gene polymorphisms and host susceptibility to Mycobacterium tuberculosis and M. leprae in South Sulawesi, Indonesia. Southeast Asian J Trop Med Public Health. 2010 Mar;41(2):386-94. PubMed PMID: 20578522.

Bito T, Sumita N, Masaki T, Shirakawa T, Ueda M, Yoshiki R, Tokura Y, Nishigori C. Ultraviolet light induces Stat3 activation in human keratinocytes and fibroblasts through reactive oxygen species and DNA damage. Exp Dermatol. 2010 Jul 1;19(7):654-60. doi: 10.1111/j.1600-0625.2010.01084.x. Epub 2010 Apr 20. PubMed PMID: 20456494.

2009

Yanagi D, de Vries GC, Rahardjo D, Alimsardjono L, Wasito EB, De I, Kinoshita S, Hayashi Y, Hotta H, Osawa R, Kawabata M, Shirakawa T. Emergence of fluoroquinolone-resistant strains of Salmonella enterica in Surabaya, Indonesia.  Diagn Microbiol Infect Dis. 2009 Aug;64(4):422-6. doi: 10.1016/j.diagmicrobio.2009.04.006. PubMed PMID: 19631095.

Terao S, Shirakawa T, Acharya B, Miyata M, Hinata N, Tanaka K, Takenaka A, Hara I, Naoe M, Fuji K, Okegawa T, Higashihara E, Kamidono S, Fujisawa M, Gotoh A. A pilot study of quality of life of patients with hormone-refractory prostate  cancer after gene therapy. Anticancer Res. 2009 May;29(5):1533-7. PubMed PMID: 19443362.

Shirakawa T. Clinical trial design for adenoviral gene therapy products. Drug News Perspect. 2009 Apr;22(3):140-5. doi: 10.1358/dnp.2009.22.3.1354090. Review.  PubMed PMID: 19440556.

Nakagawa T, Tanaka H, Shirakawa T, Gotoh A, Hayashi Y, Hamada K, Tsukuda M, Nibu K: Cyclooxygenase 2 promoter-based replication-selective adenoviral vector for hypopharyngeal cancer. Arch Otolaryngol Head Neck Surg 2009;135:282-286.

Gardner TA, Lee SJ, Lee SD, Li X, Shirakawa T, Kwon DD, Park RY, Ahn KY, Jung
 C:Differential expression of osteocalcin during the metastatic progression of prostate cancer. Oncol Rep 2009 Apr:21(4):903-8. PubMed PMID: 19287987.

2008

Shirakawa T, Fujisawa M, Gotoh A: Gene therapy in prostate cancer: past, present and future. Front Biosci 2008;13:2115-2119.

Shirakawa T: The Current Status of Adenovirus-based Cancer Gene Therapy. Mol Cells 2008;25:462-466.

Okamura N, Masuda T, Gotoh A, Shirakawa T, Terao S, Kaneko N, Suganuma K, Watanabe M, Matsubara T,Seto R, Matsumoto J, Kawakami M, Yamamori M, Nakamura T, Yagami T, Sakaeda T, Fujisawa M, Nishimura O,Okumura K: Quantitative proteomic analysis to discover potential diagnostic markers and therapeutic targets in human renal cell carcinoma. Proteomics 2008;8:3194-3203.

Okamoto A, Shirakawa T, Bito T, Shigemura K, Hamada K, Gotoh A, Fujisawa M, Kawabata M: Etodolac, a selective cyclooxygenase-2 inhibitor, induces upregulation of E-cadherin and has antitumor effect on human bladder cancer cells in vitro and in vivo. Urology 2008;71:156-160.

Ito J, Dung DT, Vuong MT, Tuyen do G, Vinh le D, Huong NT, Ngoc TB, Ngoc NT, Hien MT, Hao DD, Oanh LT,Lieu do T, Fujisawa M, Kawabata M, Shirakawa T: Impact and perspective on chronic kidney disease in an asian developing country: a large-scale survey in north Vietnam. Nephron Clin Pract 2008;109:c25-32.

2007

Takako Utsumi, Yoshihiko Yano, Bui Xuan Truong, Yasuhito Tanaka, Masashi Mizokami, Yasushi Seo, Masato Kasuga, Masato Kawabata and Yoshitake Hayashi: Molecular epidemiological study of hepatitis B virus infection in two different ethnic populations from the Solomon Islands. Journal of Medical Virology 79:229-235 (2007)

大橋眞、川端眞人:LEDマラリアプログラム?LEDライトボックスによる顕微鏡マラリア診断術向上と啓発活動プログラム? Journal of International Health. Vol.22 No.2 2007, 95-98

Terao S, Shirakawa T, Kubo S, Bishunu A, Lee SJ, Goda K, Tsukuda M, Hamada K, Tagawa M, Takenaka A,Fujisawa M, Gotoh A: Midkine promoter-based conditionally replicative adenovirus for targeting midkine-expressing human bladder cancer model. Urology 2007;70:1009-1013.

Shirakawa T, Terao S, Hinata N, Tanaka K, Takenaka A, Hara I, Sugimura K, Matsuo M, Hamada K, Fuji K, Okegawa T, Higashihara E, Gardner TA, Kao C, Chung LW, Kamidono S, Fujisawa M, Gotoh A: Long-term outcome of phase I/II clinical trial of Ad-OC-TK/VAL gene therapy for hormone-refractory metastatic prostate cancer. Hum Gene Ther 2007;18:1225-1232.

Hoshitani Y, Ishida H, Otsuki N, Shirakawa T, Gotoh A, Nibu K: Induction of immunological antitumor effects byadenovirus-mediated gene transfer of B7-1 in a murine squamous cell carcinoma cell line. Arch Otolaryngol Head Neck Surg 2007;133:270-275.

Hamada K, Desaki J, Nakagawa K, Zhang T, Shirakawa T, Gotoh A, Tagawa M: Carrier Cell-mediated Delivery of a Replication-competent Adenovirus for Cancer Gene Therapy. Mol Ther 2007;15:1121-1128.


2006

Yuichi Chigusa, Hidehiro Otake, Hiroshi Ohmae, Masashi Kirinoki, Eunice J. Ilagan, Nina G. Barzaga, Masato Kawabata, Masataka Hayashi and Hajime Matsuda: Determination of the period for establishment of a liver network echogenic pattern in Schistosomajaponicum infection. Parasitology International 55 33-37, 2006

Naoko Sakiyama, Hiroshi Ohmae, Bernard Bakote
e, Masato Kawabata, Kenji Hirayama, and Kazuyuki Tanabe: Limited allelic diversity of Plasmodiumfalciparum merozoite surface protein 1 gene from population in the Solomon Islands. Am J Trop Med Hyg. 74(1) 31-40,2006

Hashimoto K., Cordon-Rosales C., Trampe R and Kawabata M.: Impact of single and multiple residual spraying of Pyrethroid insecticides against Triatomadimidiate (Reduviiade; Triatominae), the principal vector of Chagas disease in Jutiapa, Guatemala Am J Trop Med Hyg 75(2) 226-230, 2006

Takata T, Shirakawa T, Kawasaki Y, Kinoshita S, Gotoh A, Kano Y, Kawabata M: Genetically engineered Bifidobacterium animalis expressing the Salmonella flagellin gene for the mucosal immunization in a mouse model. J Gene Med 2006;8:1341-1346.

Takata T, Shirakawa T, Ito J, Okamoto A, Massi MN, Kinoshita S, Hatta M, Kawabata M: SCCmec typing and detection of VISA-related genes in methicillin-resistant Staphylococcus aureus clinical strains from Kobe University Hospital, Japan.Southeast Asian J Trop Med Public Health 2006;37:1149-1155.

Shirakawa T, Acharya B, Kinoshita S, Kumagai S, Gotoh A, Kawabata M: Decreased susceptibility to fluoroquinolones and gyrA gene mutation in the Salmonella enterica serovar Typhi and Paratyphi A isolated in Katmandu, Nepal, in 2003. Diagn Microbiol Infect Dis 2006;54:299-303.

Shigemura K, Shirakawa T, Tanaka K, Arakawa S, Gotoh A, Fujisawa M: Rapid detection of the fluoroquinolone resistance-associated ParC mutation in Neisseria gonorrhoeae using TaqMan probes. Int J Urol 2006;13:277-281.

Okada H, Shirakawa T, Gotoh A, Kamiyama Y, Muto S, Ide H, Hamaguchi Y, Horie S: Enumeration of bacterial cell numbers and detection of significant bacteriuria by use of a new flow cytometry-based device. J Clin Microbiol 2006;44:3596-3599.

Miyata M, Shirakawa T, Acharya B, Terao S, Gotoh A: Effects of nafamostat mesilate on ADP-induced platelet aggregation and disaggregation in hemodialysis patients. Asaio J 2006;52:272-275.

Hinata N, Shirakawa T, Terao S, Goda K, Tanaka K, Yamada Y, Hara I, Kamidono S, Fujisawa M, Gotoh A: Progress report on phase I/II clinical trial of Ad-OC-TK plus VAL therapy for metastatic or locally recurrent prostate cancer: Initial experience at Kobe University. Int J Urol 2006;13:834-837.

Higuchi M, Kudo T, Suzuki S, Evans TT, Sasaki R, Wada Y, Shirakawa T, Sawyer JR, Gotoh A: Mitochondrial DNA determines androgen dependence in prostate cancer cell lines. Oncogene 2006;25:1437-1445.

Hamada K, Shirakawa T, Gotoh A, Roth JA, Follen M: Adenovirus-mediated transfer of human papillomavirus 16 E6/E7 antisense RNA and induction of apoptosis in cervical cancer. Gynecol Oncol 2006;103:820-830.

de Carvalho CM, Zuccherato LW, Fujisawa M, Shirakawa T, Ribeiro-Dos-Santos AK, Santos SE, Pena SD, Santos FR: Study of AZFc partial deletion gr/gr in fertile and infertile Japanese males. J Hum Genet 2006.

2005

Kenji Kimura, Shiba Kumar Rai, Sithat Insisiengmay, Masato Kawabata, Panagiotis, and Shoji Uga: Study on Cyclosporacayetanensis associated with diarrheal disease in Nepal and Lao RPD. Southeast Asian J Trop Med Public Health Vol 36 (6) 1371-1376, 2005

Takuya Oda, Masato Kawabata, and Shoji Uga: Detection of Giardiacytes in sewage and estimations of giardiasis prevalence among inhabitants in Hyogo Prefectue, Japan. Tropical Medicine and Health Vol.33 No.1:1-5, 2005

川端眞人:「ソロモン諸島国マライタ島のマラリア施設と住民の受診行動」 国際保健医療 Vol.20 No.1 13-17, 2005

Terao S, Yamada Y, Shirakawa T, Hara I, Kanomata N, Kamidono S: Granulocyte-colony stimulating factor producing urothelial carcinoma of renal pelvis. Int J Urol 2005;12:500-502.

Terao S, Shirakawa T, Goda K, Kamidono S, Fujisawa M, Gotoh A: Recombinant interleukin-2 enhanced the antitumor effect of ADV/RSV-HSV-tk/ACV therapy in a murine bladder cancer model. Anticancer Res 2005;25:2757-2760.

Tanaka H, Shirakawa T, Zhang Z, Hamada K, Gotoh A, Nibu K: A replication-selective adenoviral vector for head and neck cancers. Arch Otolaryngol Head Neck Surg 2005;131:630-634.

Shigemura K, Shirakawa T, Wada Y, Kamidono S, Fujisawa M, Gotoh A: Antitumor effects of etodolac, a selective cyclooxygenase-II inhibitor, against human prostate cancer cell lines in vitro and in vivo. Urology 2005;66:1239-1244.

Shigemura K, Shirakawa T, Okada H, Tanaka K, Kamidono S, Arakawa S, Gotoh A: Rapid detection and differentiation of Gram-negative and Gram-positive pathogenic bacteria in urine using TaqMan probe. Clin Exp Med 2005;4:196-201.

Shigemura K, Shirakawa T, Massi N, Tanaka K, Arakawa S, Gotoh A, Fujisawa M: Presence of a mutation in ponA1 of Neisseria gonorrhoeae in numerous clinical samples resistant to various beta-lactams and other, structurally unrelated, antimicrobials. J Infect Chemother 2005;11:226-230.

Sakaeda T, Okamura N, Gotoh A, Shirakawa T, Terao S, Morioka M, Tokui K, Tanaka H, Nakamura T, Yagi M, Nishimura Y, Yokoyama M, Okumura K:EGFR mRNA is upregulated, but somatic mutations of the gene are hardly found in renal cell carcinoma in Japanese patients. Pharm Res 2005;22:1757-1761.

Matsumoto Y, Morimoto I, Shibutani T, Mukubou M, Shirakawa T, Gotoh A, Kawabata M: Measles encephalitis in early pregnancy and after delivery. J Infect Chemother 2005;11:97-100.

Massi MN, Shirakawa T, Gotoh A, Hatta M, Kawabata M: Identification and sequencing of Salmonella enterica serotype typhi isolates obtained from patients with perforation and non-perforation typhoid fever. Southeast Asian J Trop Med Public Health 2005;36:118-122.

Massi MN, Shirakawa T, Gotoh A, Bishnu A, Hatta M, Kawabata M: Quantitative detection of Salmonella enterica serovar Typhi from blood of suspected typhoid fever patients by real-time PCR. Int J Med Microbiol 2005;295:117-120.

Gotoh A, Shirakawa T, Wada Y, Hinata N, Terao S, Hara I, Arakawa S, Kamidono S, Okada H, Takenaka A, Fujisawa M: [Gene therapy]. Hinyokika Kiyo 2005;51:75-79.

Acharya B, Shirakawa T, Pungky A, Damanik P, Massi MN, Miyata M, Matsuo M, Gotoh A: Polymorphism of the interleukin-4, interleukin-13, and signal transducer and activator of transcription 6 genes in Indonesian children with minimal change nephrotic syndrome. Am J Nephrol 2005;25:30-35.

2004

Naoko Sakiyama, Toshiaki Matsuo, Toshihide Mitamura, Toshihiro Horii, Masatsugu Kimura, Masato Kawabata, Kazuyuki Tanabe: Relative frequencies of polymorphisms of variation in Block 2 repeats and 5 recombinant types of Plasmodiumfalciparummsp1 alleles. Parasitology International 53:59-67 2004

Masato Kawabata: Pacific Islands and Health Development. P68. Tropical Medicine and Health. Vol 32:68. No.01, March 2004

Kenji Kimura, Shiba Kumar Rai, Kaoru Takemasa, Yoshinobu Ishibashi, Masato Kawabata, Miodrag Belosevic and Shoji Uga: Comparison of three microscopic techniques for diagnosis of Cyclosparacayetanensis. FEMS Microbiology Letters 238 (2004) 264-266

Yamamori M, Sakaeda T, Nakamura T, Okamura N, Tamura T, Aoyama N, Kamigaki T, Ohno M, Shirakawa T, Gotoh A, Kuroda Y, Matsuo M, Kasuga M, Okumura K: Association of VEGF genotype with mRNA level in colorectal adenocarcinomas. Biochem Biophys Res Commun 2004;325:144-150.

Shirakawa T, Okada H, Acharya B, Zhang Z, Hinata N, Wada Y, Uji T, Kamidono S, Gotoh A: Messenger RNA levels and enzyme activities of 5 alpha-reductase types 1 and 2 in human benign prostatic hyperplasia (BPH) tissue. Prostate 2004;58:33-40.

Shirakawa T, Hamada K, Zhang Z, Okada H, Tagawa M, Kamidono S, Kawabata M, Gotoh A: A cox-2 promoter-based replication-selective adenoviral vector to target the cox-2-expressing human bladder cancer cells. Clin Cancer Res 2004;10:4342-4348.

Shirakawa T, Gotoh A, Zhang Z, Kao C, Chung LW, Gardner TA: Development of human chorionic gonadotropin subunit-beta promoter-based toxic gene therapy for testicular cancer. Urology 2004;63:613-618.

Shigemura K, Shirakawa T, Okada H, Tanaka K, Udaka T, Kamidono S, Arakawa S, Gotoh A: Rapid detection of gyrA and parC mutations in fluoroquinolone-resistant Neisseria gonorrhoeae by denaturing high-performance liquid chromatography. J Microbiol Methods 2004;59:415-421.

Shigemura K, Shirakawa T, Okada H, Hinata N, Acharya B, Kinoshita S, Kofuku T, Kawabata M, Kamidono S, Arakawa S, Gotoh A: Mutations in the gyrA and parC genes and in vitro activities of fluoroquinolones in 91 clinical isolates of Neisseria gonorrhoeae in Japan. Sex Transm Dis 2004;31:180-184.

Shigemura K, Okada H, Shirakawa T, Tanaka K, Arakawa S, Kinoshita S, Gotoh A, Kamidono S: Susceptibilities of Neisseria gonorrhoeae to fluoroquinolones and other antimicrobial agents in Hyogo and Osaka, Japan. Sex Transm Infect 2004;80:105-107.

Nakahara T, Sakaeda T, Nakamura T, Tamura T, Nishioka C, Aoyama N, Okamura N, Shirakawa T, Gotoh A, Kamigaki T, Ohno M, Kuroda Y, Matsuo M, Kasuga M, Okumura K: Chemosensitivity assessed by collagen gel droplet embedded culture drug sensitivity test, and MDR1, MRP1, and MRP2 mRNA expression in human colorectal adenocarcinomas. Pharm Res 2004;21:406-412.

Hinata N, Shirakawa T, Okada H, Shigemura K, Kamidono S, Gotoh A: Quantitative detection of Escherichia coli from urine of patients with bacteriuria by real-time PCR. Mol Diagn 2004;8:179-184.

Hinata N, Shirakawa T, Okada H, Achaya B, Kamidono S, Gotoh A: Quantitative analysis of the levels of expression of muscarinic receptor subtype RNA in the detrusor muscle of patients with overactive bladder. Mol Diagn 2004;8:17-22.

Gotoh A, Shirakawa T, Hinata N, Wada Y, Hara I, Fujisawa M, Kawabata G, Okada H, Arakawa S, Kamidono S: Long-term outcome of postoperative interferon-alpha adjuvant therapy for non-metastatic renal cell carcinoma. Int J Urol 2004;11:257-263.

Gotoh A, Sakaeda T, Kimura T, Shirakawa T, Wada Y, Wada A, Kimachi T, Takemoto Y, Iida A, Iwakawa S, Hirai M, Tomita H, Okamura N, Nakamura T, Okumura K: Antiproliferative activity of Rhinacanthus nasutus (L.) Kurz extracts and the active moiety, Rhinacanthin C. Biol Pharm Bull 2004;27:1070-1074.

Gotoh A, Goto K, Sengoku A, Shirakawa T, Akao Y, Fujisawa M, Okada H, Arakawa S, Kamidono S: Inhibition mechanism of Gosha-jinki-gan on the micturition reflex in rats. J Pharmacol Sci 2004;96:115-123.

Goda K, Fujisawa M, Shirakawa T, Dobashi M, Shiota G, Zhang ZJ, Gotoh A, Kamidono S: Adenoviral-mediated HGF expression inhibits germ cell apoptosis in rats with cryptorchidism. J Gene Med 2004;6:869-876.

2003

N. Taguchi, M. Kawabata, M. Maekawa, T. Maruo, Adityawaman, L. Dewata: Influence of socio-economic background and antenatal care programmes on maternal mortality in Surabaya, Indonesia. Tropical Medicine and International Health, 8(9):847-852, 2003 

Sakaue M, Fuke Y, Katsuyama T, Kawabata M, Taniguchi H. Austronesian-speaking people in Papua New Guinea have susceptibility to obesity and type 2 diabetes. Diabetes Care 26(3) 955-6, 2003

Yoshiro Nagao, Yoes Prijatna Dachulan, Soedarto, Sri Hidajati, Subagyo Yotopranoto, Kusmartisnawati, Sri Subekti, Bariah Ideham, Yoshio Tsuda, Masato Kawabata, Masahiro Takagi, and Sornchai Looareesuwan: Distribution of two species of Malaria, Plasmodium falciparum and Plasmodium vivax, on Lombok Island, Indonesia. Southeast Asian J Trop Med Public Health 34(3):495-500, 2003

日本の危機管理としての防疫体制 川端眞人 兵庫県医師会医学雑誌 46(2):1-6, 2003

Zhou A, Ueno H, Shimomura M, Tanaka R, Shirakawa T, Nakamura H, Matsuo M, Iijima K: Blockade of TGF-beta action ameliorates renal dysfunction and histologic progression in anti-GBM nephritis. Kidney Int 2003;64:92-101.

Zhang Z, Shirakawa T, Hinata N, Matsumoto A, Fujisawa M, Okada H, Kamidono S, Matsuo M, Gotoh A: Combination with CD/5-FC gene therapy enhances killing of human bladder-cancer cells by radiation. J Gene Med 2003;5:860-867.

Shirakawa T, Fujisawa M, Gotoh A, Okada H, Arakawa S, Kamidono S: Complete resection of synovial sarcoma of prostatic fascia. Urology 2003;61:644.

Okada H, Shirakawa T, Miyake H, Gotoh A, Fujisawa M, Arakawa S, Kamidono S: Establishment of a prostatic small-cell carcinoma cell line (SO-MI). Prostate 2003;56:231-238.

Nakumura T, Sakaeda T, Ohmoto N, Moriya Y, Komoto C, Shirakawa T, Gotoh A, Matsuo M, Okmura K: Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines. Pharm Res 2003;20:324-327.

Matsuo T, Shirakawa T, Singhasivanon P, Looareesuwan S, Kawabata M: Effects of mefloquine usage on genetic polymorphism of Plasmodium falciparum in Thai-Myanmarese border. Kobe J Med Sci 2003;49:143-151.

Massi MN, Shirakawa T, Gotoh A, Bishnu A, Hatta M, Kawabata M: Rapid diagnosis of typhoid fever by PCR assay using one pair of primers from flagellin gene of Salmonella typhi. J Infect Chemother 2003;9:233-237.

Hinata N, Shirakawa T, Zhang Z, Matsumoto A, Fujisawa M, Okada H, Kamidono S, Gotoh A: Radiation induces p53-dependent cell apoptosis in bladder cancer cells with wild-type- p53 but not in p53-mutated bladder cancer cells. Urol Res 2003;31:387-396.

Gotoh A, Shirakawa T, Wada Y, Fujisawa M, Okada H, Kamidono S, Hamada K: The growth inhibitory effect of p21 adenovirus on androgen-dependent and -independent human prostate cancer cells. BJU Int 2003;92:314-318.

Carvalho CM, Fujisawa M, Shirakawa T, Gotoh A, Kamidono S, Freitas Paulo T, Santos SE, Rocha J, Pena SD, Santos FR: Lack of association between Y chromosome haplogroups and male infertility in Japanese men. Am J Med Genet A 2003;116:152-158.

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神戸大学大学院
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