Involvement of Gβγ subunits of Gi protein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes.

Kajimoto, T., Mohamed, NNI., Badawy, SMM., Matovelo, SA., Hirase, M., Nakamura, S., Yoshida, D., Okada, T., Ijuin, T., Nakamura, SI.

J. Biol. Chem. 293, 245-253 (2018)


DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling.

Badawy, SMM., Okada, T., Kajimoto, T., Ijuin, T., Nakamura, SI.

Sci. Rep. 7:16552 . doi:10.1038/s41598-017-16457-4 (2017)


Extracellular α-synuclein induces sphingosine 1-phosphate receptor subtype 1 uncoupled from inhibitory G-protein leaving β-arrestin signal intact.

Zhang, L., Okada, T., Badawy, S., Hirai, C., Kajimoto, T., Nakamura, SI.

Sci. Rep. 7:44248 . doi:10.1038/srep44248 (2017)


Impairment of PDGF-induced chemotaxis by extracellular α-synuclein through selective inhibition of Rac1 activation.

Okada, T., Hirai, C., Badawy, S., Zhang, L., Kajimoto, T., Nakamura, SI.

Sci. Rep. 6:37810. doi: 10.1038/srep37810 (2016)


Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein.

Jesko, H., Okada, T., Strosznajder, RP., Nakamura, S.

Folia Neuropathol. 52(1), 70-78 (2014)


Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes.

Kajimoto, T., Okada, T., Miya, S., Zhang, L., Nakamura, SI.

Nat. Commun. 4:2712. doi:10.1038/ncomms3712 (2013)


Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus.

Kanno, T., Nishizaki, T., Proia, RL., Kajimoto, T., Jahangeer, S., Okada, T., Nakamura, SI.

Neuroscience 171, 973-980 (2010)


Sphingosine kinase 1 regulates mucin production via ERK phosphorylation.

Kono, Y., Nishiuma, T., Okada, T., Kobayashi, K., Funada, Y., Kotani, Y., Jahangeer, S., Nakamura, SI., Nishimura, Y.

Pulm Pharmacol Ther. 23, 36-42 (2010)


CtBP1/BARS is an activator of phospholipase D1 necessary for agonist-induced macropinocytosis.

Haga, Y., Miwa, N., Jahangeer, S., Okada, T., Nakamura, SI.

EMBO J. 28, 1197-1207 (2009)


Roles of extracellular and intracellular sphingosine 1-phosphate in cell migration.

Yu, H., Okada, T., Kobayashi, M., Abo-Elmatty, DM., Jahangeer, S., Nakamura, SI.

Genes Cells. 14, 597-605 (2009)


Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system.

Okada, T., Kajimoto, T., Jahangeer, S., Nakamura, SI.

Cell. Signal. 21, 7-13 (2009)


Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model.

Nishiuma, T., Nishimura, Y., Okada, T., Kuramoto, E., Kotani, Y., Jahangeer, S., Nakamura, SI.

Am. J. Physiol. Lung Cell Mol. Physiol. 294, L1085-L1093 (2008)


Requirement of phospholipase D for ilimaquinone-induced Golgi membrane fragmentation.

Sonoda, H., Okada, T., Jahangeer, S., Nakamura, SI.

J. Biol. Chem. 282, 34085-34092 (2007)


Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1.

Kono, Y., Nishiuma, T., Nishimura, Y., Kotani, Y., Okada, T., Nakamura, SI., Yokoyama, M.

Am. J. Respir. Cell. Mol. Biol. 37, 395-404 (2007)


Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2.

Ding, G., Sonoda, H., Yu, H., Kajimoto, T., Goparaju, SK., Jahangeer, S., Okada, T., Nakamura, SI.

J. Biol. Chem. 282, 27493-27502 (2007)


Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons.

Kajimoto, T., Okada, T., Yu, H., Goparaju, SK., Jahangeer, S., Nakamura, SI.

Mol. Cell. Biol. 27(9), 3429-3440 (2007)


Involvement of N-terminally extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis.

Okada, T., Ding, G., Sonoda, H., Kajimoto, T., Haga, Y., Khosrowbeygi, A., Gao, S., Miwa, N., Jahangeer, S., Nakamura, SI.

J Biol Chem. 280(43), 36318-36325 (2005)


Delta-catenin/neural plakophilin-related armadillo repeat protein interacts with and activates sphingosine kinase 1.

Fujita, T., Okada, T., Hayashi, S., Jahangeer, S., Miwa, N., Nakamura, SI.

Biochem J. 382, 717-723 (2004)


Down-regulation of Melanogenesis by Phospholipase D2 through Ubiquitin Proteasome-mediated Degradation of Tyrosinase.

Kageyama, A., Oka, M., Okada, T., Nakamura, SI., Ueyama, T., Saito, N., Hearing, VJ., Ichihashi, M., Nishigori, C.

J Biol Chem. 279(26), 27774-27780 (2004)


PKCdelta inhibits PKCalpha-mediated activation of phospholipase D1 in a manner independent of its protein kinase activity.

Oka, M., Okada, T., Nakamura, SI., Ohba, M., Kuroki, T., Kikkawa, U., Nagai, H., Ichihashi, M., Nishigori, C.

FEBS Lett. 554, 179-183 (2003)


Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis.

Igarashi, N., Okada, T., Hayashi, S., Fujita, T., Jahangeer, S., Nakamura, SI.

J Biol Chem. 278(47), 46832-46839 (2003)


Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein.

Hayashi S, Okada T, Igarashi N, Fujita T, Jahangeer S, Nakamura SI.

J Biol Chem. 277(36), 33319-33324 (2002)

Dual regulation of phospholipase D1 by protein kinase C alpha in vivo.

Oka, M., Hitomi, T., Okada, T., Nakamura, SI., Nagai, H., Ohba, M., Kuroki, T., Kikkawa, U., Ichihashi, M.

Biochem Biophys Res Commun. 294(5), 1109-1113 (2002)


Regulation of mammalian phospholipase D2: interaction with and stimulation by G(M2) activator.

Sarkar, S., Miwa, N., Kominami, H., Igarashi, N., Hayashi, S., Okada, T., Jahangeer, S., Nakamura, SI.

Biochem J. 359, 599-604 (2001)


Isolation and properties of novel phospholipase A from rat brain that hydrolyzes fatty acids at sn-1 and sn-2 positions.

Yoshida, H., Tsujishita, Y., Hullin, F., Yoshida, K., Nakamura, SI., Kikkawa, U. Asaoka, Y.

Annals Clinical Biochem. 35, 295-301 (1998)


Purification of a heat-stable activator for ADP-ribosylation factor-dependent phospholipase D.

Akisue, T., Jinnai, H., Hitomi, T., Miwa, N., Yoshida, K. Nakamura, SI.

FEBS Lett. 422, 108-112 (1998)


Requirement of GM2 ganglioside activator for phospholipase D activation.

Nakamura, SI., Akisue, T., Jinnai, H., Hitomi, T., Srkar, S., Miwa, N., Okada, T., Yoshida, K., Kuroda, S., Kikkawa, U., Nishizuka, Y.

Proc. Natl. Acad. Sci. USA 95, 12249-12253 (1998)


Characterization of tyrosine-phosphorylated delta isoform of protein kinase C isolated from chinese hamster ovary cells.

Kadotani, M., Nishiuma, T., Nanahoshi, M., Tsujishita, Y., Ogita, K., Nakamura, SI., Kikkawa, U., Asaoka, Y.

J. Biochem. 121, 1047-1053 (1997)


Phosphatidylcholine hydrolysis and protein kinase C activation for intracellular signaling network.

Nakamura, SI.

J. Lipid Mediat. Cell Signal. 14, 197-202 (1996)


Reconstitution of GTP-gamma-S-dependent phospholipase D activity with ARF, RhoA, and a soluble 36-kDa protein.

Shimooku, K., Akisue, T., Jinnai, H., Hitomi, T., Ogino, C., Yoshida, K., Nakamura, SI. Nishizuka, Y.

FEBS Lett. 387, 141-144 (1996)


Mammalian phospholipase D: Phosphatidylethanolamine as an essential component.

Nakamura, SI., Kiyohara, Y., Jinnai, H., Hitomi, T., Ogino, C., Yoshi, K., Nishizuka, Y.

Proc. Natl. Acad. Sci. USA 93, 4330-4304 (1996)


Mammalian phospholipase D. Activation by ammonium sulfate and nucleotides.

Nakamura, SI., Shimooku, K., Akisue, T., Jinnai, H., Hitomi, T., Kiyohara, Y., Ogino, C., Yoshida, K., Nishizuka, Y.

Proc. Natl. Acad. Sci. USA 92, 12319-12322 (1995)


The protein kinase C isoforms leading to MAP-kinase activation in CHO cells.

Yamaguchi, K., Ogita, K., Nakamura, SI., Nishizuka, Y.

Biochem. Biophys. Res. Commun. 210, 639-647 (1995)


Potential role of protein phosphorylation in GTP-gamma-S-dependent activation of phospholipase D.

Inoue, H., Shimooku, K., Akisue, T., Nakamura, SI.

Biochem. Biophys. Res. Commun. 210, 542-548 (1995)