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業績リスト 　※赤塗りの箇所は本プログラムに直接に関連した業績です。
春日雅人
(糖尿病・代謝・内分泌内科学)		 堀田　博
(微生物学)
岡村　均
(分子脳科学)		 塩澤俊一
(保健学科 検査技術科学分野)
清野　進
(細胞分子医学)		 佐藤孝哉
(分子生物学)
黒田嘉和
(食道胃腸外科学)		 北澤荘平
(病理学)
横野浩一
(老年内科学)		 深川雅史
(腎臓内科学)
久野高義
(分子薬理・薬理ゲノム学)		 寺師浩人
(形成外科学)
南　康博
(細胞生理学)		 宮脇郁子
(保健学科 成人看護学)
饗場　篤
(分子遺伝学)		 岡田太郎
(生化学)
千原和夫
(糖尿病・代謝・内分泌内科学)		 丹羽仁史
(理化学研究所 発生・再生科学
総合研究センター)
松尾雅文
(小児科学)		 中江　淳
(COE上級研究員)
横山光宏（平成18年度まで）
(循環呼吸器病態学)		 堀　裕一
(COE上級研究員)
根木　昭
(眼科学)
　
[春日]
1. Yasuo Okamoto, Wataru Ogawa, Akihiko Nishizawa, Hiroshi Inoue, Kiyoshi Teshigawara, Shinichi Kinoshita, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Hiroshi Sakaue, Tetsuo Noda, and Masato Kasuga. Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1. 2006 in press
2. Tamom Sakai, Hiroshi Sakaue, Takehiro Nakamura, Mitsuru Okada, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatu, Keiko Nakayama, Keiichi INakayama,and Masato Kasuga. Skp2 controls adipocyte proliferation during the development of obesity. J. Biol. Chem. 2006 in press
3. Hashimoto, N., Kido, Y., Uchida, T., Asahara, S., Shigeyama, Y., Matsuda, T., Takeda, A., Tsuchihashi, D.,Nishizawa, A., Ogawa, W., Fujimoto, Y., Okamura, H., Arden, KC., Herrera, PL., Noda, T and Kasuga, M. Ablation of PDK1 in pancreatic βcells induces diabetes as a result of loss of β-cell mass. Nature Genet. 38,589-593. 2006.
4. Kanda, H., Tateya, S., Tamori, Y., Kotani, K., Hiasa, K., Kitazawa, R., Kitazawa, S., Miyachi, H., Maeda, S., Egashira, K and Kasuga, M. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 116:1495-505. 2006.
5. Inoue, H., Ogawa, W., Asakawa, A., Okamoto, Y., Nishizawa, A., Matsumoto, M., Teshigawara, K., Matsuki, Y., Watanabe, E., Hiramatsu, R., Notohara, K., Katayose, K., Okamura, H., Kahn, CR., Noda, T., Takeda, K., Akira, S., Inui, A and Kasuga, M. Role of hepatic STAT3 in brain insulin action on hepatic glucose production. Cell Metab. 3:267-75. 2006.
6. Fukuyama K, Ohara T, Hirota Y, Maeda K, Kuno S, Zenibayashi M, Teranishi T, Kouyama K, Maeda E, Sakamoto N, and Kasuga M. Association of the -112A>C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes. Biochem Biophys Res Commun. 339:1212-6. 2006.
7. Mori T, Sakaue H, Iguchi H, Gomi H, Okada Y, Takashima Y, Nakamura K, Nakamura T, Yamauchi T, Kubota N, Kadowaki T, Matsuki Y, Ogawa W, Hiramatsu R, Kasuga M. Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem. 280:12867-12875, 2005.
8. Teshigawara K, Ogawa W, Mori T, Matsuki Y, Watanabe E, Hiramatsu R, Inoue H, Miyake K, Sakaue H, Kasuga M. Role of Kruppel-like factor 15 in PEPCK gene expression in the liver. Biochem Biophys Res Commun. 327:920-6. 2005.
9. Uchida T, Nakamura T, Hashimoto N, Matsuda T, Kotani K, Sakaue H, Hayashi Y, Nakayama KI, White MF, and Kasuga M. Deletion of Cdkn1b gene ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nature Med. 11:175-82. 2005.
10. Kanda H, Tamori Y, Shinoda H, Yoshikawa M, Sakaue M, Udagawa J, Otani H, Tashiro F, Miyazaki J, and Kasuga M. Adipocytes from Munc18c-null mice show increased sensitivity in insulin-stimulated GLUT4 externalization. J. Clin. Invest. 115:291-301. 2005.
11. Hashimoto N, Kido Y, Uchida T, Matsuda T, Suzuki K, Inoue H, Matsumoto M, Ogawa W, Maeda S, Fujihara H, Ueta Y, Uchiyama Y, Akimoto H, Ohno S, Noda T, and Kasuga M. PKC? regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells. J. Clin. Invest. 115:138-145. 2005.
12. Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, Teshigawara K, Jin S, Iguchi H, Hiramatsu R, Leroith D, Takeda K, Akira S and Kasuga M. Role of STAT-3 in regulation of hepatic gluconeogenic genes and of carbohydrate metabolism in vivo. Nature Med. 10:168-174. 2004.
13. Sakaue H, Ogawa W, Nakamura T, Mori T, Nakamura K, Kasuga M. Role of MAPK phosphatase-1 (MKP-1) in adipocyte differentiation. J Biol Chem. 279:39951-7. 2004.
14. Sakaue H, Nishizawa A, Ogawa W, Teshigawara K, Mori T, Takashima Y, Noda, T and Kasuga M. Requirement for 3-phosphoinositide-dependent kinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes. J. Biol. Chem. 278:38870-38874. 2003.
15. Matsumoto M, Ogawa W, Akimoto K, Inoue H, Miyake K, Furukawa K, Hayashi Y, Iguchi H, Matsuki Y, Hiramatsu R, Shimano H, Yamada N, Ohno S, Kasuga M and Noda T. Protein kinase Cλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J. Clin. Invest. 112:935-944. 2003.

トップへ
　
[岡村]
1. Ishida A, Mutoh T, Ueyama T, Bando H, Masubuchi S, Nakahara D, Tsujimoto G, Okamura H. Light activates the adrenal gland: Timing of gene expression and glucocorticoid release. Cell Metab, 2:297-307, 2005.
2. Okamura H: Integration mechanism of molecular rhythm in biological clock. Sleep Biol. Rhythms, 2, S40-S41, 2004.
3. Okamura H: Clock genes and cell clocks: Roles, actions and mysteries. J. Biol. Rhythms, 19, 388-399, 2004.
4. Yamamoto Y, Yagita Y, Okamura H: Role of cyclic mPer2 expression in mammalian cellular clock. Mol. Cell Biol., 25, 1912-1921, 2005.
5. Masubuchi S, Kataoka N, Sassone-Corsi P, Okamura H: Mouse Period1 (mPER1) acts as a circadian adapter to entrain the oscillator to environmental light/dark cycles by regulating mPER2 protein. J. Neurosci., 25, 4719-24, 2005.
6. Dong X, Yagita K, Zhang J, Okamura H: Expression of ubiquitin-related enzymes in the suprachiasmatic nucleus with special reference to ubiquitin carboxy-terminal hydrolase UchL1. Biomed. Res., 26:43-9, 2005.
7. Zhang J, Dong X, Fujimoto Y, Okamura H: Molecular Signals of Mammalian Circadian Clock. Kobe J. Med. Sci., in press.
8. 岡村　均：体内時計の分子機構に関する研究、日本医師会雑誌、131、45-51, 2004.
9. 岡村　均、上山友子：体内時計による内分泌・自律神経の生体リズムの制御、ブレインメディカル、16、149-155、2004．
10. 岡村　均、藤本義人、董　新：ユビキチンと体内時計、医学のあゆみ、211、142-146、2004．
11. 岡村 均、深田吉孝編：時計遺伝子の分子生物学、シュプリンガー・フェアラーク東京、B5版219頁、ISBN:4-431-71023-X、2004.
12. Nomura K, Takeuchi Y, Yamaguchi S, Okamura H, Fukunaga K: Involvement of calcium /calmodulin-dependent protein kinase II in the induction of mPer1. J Neurosci Res., 72: 384-92, 2003.
13. Mutoh T, Shibata S, Korf HW, Okamura H: Melatonin modulates the light-induced sympathoexcitation and vagal suppression with participation of the suprachiasmatic nucleus in mice. J. Physiol. (London), 547, 317-332, 2003.
14. Okamura H: Integration of mammalian circadian clock signals: from molecule to behavior. J. Endocrinol., 177: 3-6, 2003.
15. Okamura H: Integration of molecular rhythms in the mammalian circadian system. In Molecular Clocks and Light Signaling. Novartis Foundation Symposium 253, Edited by D.J. Chadwick and J.A. Goode, John Wiley & Sons Ltd., Chichester, pp161-170, 2003.
16. Kawamoto K, Nagano M, Kanda F, Chihara K, Shigeyoshi Y, Okamura H: Two types of VIP neuronal components in rat suprachiasmatic nucleus. J. Neurosci. Res. 74: 852-857, 2003.
17. Sujino M, Matsumoto K, Yamaguchi S, van der Horst G, Okamura H, Inouye SIT: Suprachiasmatic nucleus grafts restore circadian behavioral rhythms of genetically arrythmic mice. Current Biology, 13:664-668, 2003.
18. Terazono H, Mutoh T, Yamaguchi S, Kobayashi M, Akiyama M, Udo R, Ohdo S, Okamura H, Shibata S: Adrenergic regulation of clock gene expression in the mouse liver. Proc. Natl. Acad Sci. USA, 100: 6795-6800, 2003.
19. Nakahara D, Nakamura M, Iigo M, Okamura H: Bimodal circadian secretion of melatonin from the pineal gland in a living CBA mouse. Proc. Natl. Acad. Sci. USA, 100: 9584-9589, 2003.
20. Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H: Control mechanism of the circadian clock for timing of cell division. Science, 302: 255-259, 2003.
21. Yamaguchi S, Isejima H, Matsuo T, Okura R, Yagita K, Kobayashi M, Okamura H: Synchronization of cellular clocks in the suprachiasmatic nucleus. Science 302: 1408 -1412, 2003.

トップへ

　
[清野]
1. Okuno, M., Minami, K., Okumachi, A., Miyawaki, K., Yokoi, N., Toyokuni, S., Seino, S. Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes. Am. J. Physiol. Endocrinol. Metab. (in press) 2006
2. Yokoi, N., Kanamori, M., Horikawa, Y., Takeda, J., Sanke, T., Furuta, H., Nanjo, K, Mori, H., Kasuga, M., Hara, K., Kadowaki, T., Tanizawa, Y., Oka, Y., Iwami, Y., Ohgawara, H., Yamada, Y., Seino, Y., Yano, H., Cox, N.J., Seino, S. Association studies of variants in the genes involved in pancreatic β-cell function in type 2 diabetes in Japanese subjects. Diabetes 55: 2379-2386, 2006
3. Oyama, K., Minami, K., Ishizaki, K., Fuse, M., Miki, T., Seino, S. Spontaneous recovery from hyperglycemia by regeneration of pancreatic β-cells in Kir6.2G132S transgenic mice. Diabetes 55: 1930-1938, 2006
4. Kawaguchi, M., Minami, K., Nagashima, K., Seino S. Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion. J. Biol. Chem. 281: 13015-13020, 2006
5. Shibasaki, T. and Seino, S. Physical and functional interaction of Noc2/Rab3 in exocytosis. Methods Enzymol. 403: 408-419, 2005
6. Minami, K., Okuno, M., Miyawaki, K., Okumachi, A., Ishizaki, K, Oyama, K., Kawaguchi, M., Ishizuka, N., Iwanaga, T. and Seino, S. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatinc acinar cells. Proc Natl Acad Sci U.S.A. 102:15116-15121, 2005
7. Seino, S. and Shibasaki, T. PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiol. Rev. 85: 1303-1342, 2005
8. Kimura, K., Miki, T., Shibasaki, T., Zhang, Y., Ogawa, M., Saisho, H., Okuno, M., Seino, S. Functional analysis of the transcriptional repressor Otx3/Dmbx1. FEBS Lett. 579: 2926-2932, 2005
9. Sasaki, T., Shibasaki, T., Beguin, P., Nagashima, K., Miyazaki, M., Seino, S. Direct inhibition of the interaction between AID and BID of voltage-dependent Ca2+ channels by Gem. J Biol Chem. 11: 9308-9312, 2005
10. Miki, T., Minami, K., Shinozaki, H., Matsumura, K., Saraya, A., Ikeda, H., Yamada, Y., Holst, J.J., and Seino, S. Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on potentiation of insulin secretion. Diabetes 54:1056-1063, 2005
11. Minami, K., Miki, T., Kadowaki, T., and Seino, S. Roles of ATP-sensitive potassium channels as metabolic sensors: Studies of Kir6.x null mice.　Diabetes 53 Suppl.: 176-180, 2004
12. Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J, Ohara O, and Seino S. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. DNA Res. 11:315-323, 2004
13. Saraya A, Yokokura M, Gonoi T, and Seino S. Effects of fluoroquinolones on insulin secretion and beta-cell ATP-sensitive K+ channels. Eur. J. Pharmacol. 497:111-117, 2004
14. Manabe S, Nishimura N, Yamamoto Y, Kitamura H, Morimoto S, Imai M, Nagahiro S, Seino S, and Sasaki T. Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells. Biochem. Biophys. Res. Commun. 316:218-225, 2004
15. Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, and Seino S. Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. Proc. Natl. Acad. Sci. U S A. 101:8313-8318, 2004
16. Kosoy R, Yokoi N, Seino S, and Concannon P. Polymorphic variation in the CBLB gene in human type 1 diabetes. Genes Immun. 5:232-235, 2004
17. Shibasaki T, Sunaga Y, Fujimoto K, Kashima Y, and Seino S. Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent calcium channel in insulin granule exocytosis. J. Biol. Chem. 279:7956-7961, 2004
18. Seino S and Miki T. Gene targeting approach to clarification of ion channel function: studies of Kir6.x null mice. J. Physiol. 554:295-300, 2004
19. Remedi, M.S., Koster, J.C., Markova, K., Seino, S., Miki, T., Patton, B.L., McDaniel, M.L., Nichols, C.G. Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels. Diabetes 53: 3159-3167, 2004
20. Shibasaki, T., Sunaga, Y., Seino, S. Integration of ATP, cAMP, and Ca2+ signals in insulin granule exocytosis. Diabetes 53 Suppl 3: 59-62, 2004
21. Miki, T., Seino, S. Roles of KATP channels as metabolic sensors in acute metabolic changes. J. Mol. Cell. Cardiol. 38: 917-925, 2004
22. Gong B, Legault D, Miki T, Seino S, and Renaud JM. KATP channels depress force by reducing action potential amplitude in mouse EDL and soleus muscle. Am. J. Physiol. Cell Physiol. 285:C1464-1474. 2003
23. Minami K, Morita M, Saraya A, Yano H, Terauchi Y, Miki T, Kuriyama T, Kadowaki T, and Seino S. ATP-sensitive K+ channel -mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling.　Am. J. Physiol. Endocrinol. Metab. 285: 1289-1296, 2003
24. Yokoi, N., Namae, M., Fuse, M., Wang, H-Y., Hirata, T., Seino, S., Komeda, K. Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred　strain. Exp. Anim. 52:295-301, 2003

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[黒田]
1. 谷岡康喜、酒井哲也、黒田嘉和。温阻血障害膵からの膵島移植に対する二層法の効用。今日の移植 17:660-666, 2004
2. 酒井哲也、谷岡康喜、黒田嘉和。膵臓移植と膵島移植－糖尿病性細小血管症に対する効果－。日本臨床 in press
3. 酒井哲也、谷岡康喜、黒田嘉和。日本および欧米における膵島移植の現状と問題点。胆と膵 25:259-265, 2004
4. Tanioka Y, Sakai T, Kuroda Y, et al. Augmentation of tissue ATP level during pancreas digestion using pre-oxygenated perfluorocarbon results in high yield ? new strategy for islet isolation -. Transplantation Proc. 37:220-2, 2005
5. Yoshikawa T, Suzuki Y, Sakai T, Tanioka Y, Kuroda Y, et al. Objective and rapid assessment of pancreas graft viability using 31P-nuclear magnetic resonance spectroscopy combined with two-layer cold storage method. Transplantation 78: 78-82, 2004
6. Kakinoki K, Tanioka Y, Sakai T, Kuroda Y, et al. Superiority of the two-layer method prior to islet isolation confirmed by in vivo viability assessment. Transplantation in press
7. Ichii H, Kuroda Y, Ricordi C, et al. Rescue purification maximizes the use of human islet preparations for transplantation. Am J Transplant 5: 21-30, 2005
8. Tsujimura T, Kuroda Y, Lakey J, et al. Ameliorating small bowel injury using a cavitary two-layer preservation method with perfluorocarbon and a nutrient-rich solution. Am J Transplant 4: 1421-1428, 2004
9. Tsujimura T, Kuroda Y, Lakey JRT, et al. Influence of pancreas preservation on human islet isolation outcomes: impact of the two-layer method. Transplantation 78: 96-100, 2004
10. Kakinoki K, Fujino Y, Suzuki Y, Li S, Yoshikawa T, Tanioka Y, Ku Y, Kuroda Y. Protection against ischemia reperfusion injury by the cavitary two-layer method in canine small intestinal transplantation wih reduction of reactive oxygen species. Surgery 135: 642-648. 2004.
11. Tsujimura T, Kuroda Y, Churchill TA, Avila JG, Kin T, Shapiro AMJ, Lakey JRT. Short-term storage of the ischemically damaged human pancreas by the two-layer method prior to islet isolation. Cell Transplantation 13:67-73. 2004.
12. Sakai T, Kuroda Y. Islet transplantation from a living donor. Insulin Free Times. 2004, http://www.insulinfreetimes.org/04-spring/ japan.htm.
13. Matsuda T, Suzuki Y, Tanioka Y, Toyama H, Kakinoki K, Hiraoka K, Fujino Y, Kuroda Y. Pancreas preservation by the two-layer cold storage method before islet isolation protects isolated islets against apoptosis through the mitchondrial pathway. Surgery 134:437-445. 2003.

トップへ

　
[横野]
1. Danawati CW, Nagata M, Moriyama H, Hara K, Yasuda H, Nakayama M, Kotani R, Yamada K, Sakata M, Kurohara M, Wiyono P, Asdie H, Sakaue M, Taniguchi H, Yokono K.: A possible association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma2 gene with obesity in native Javanese in Indonesia. Diabetes Metab Res Rev. 21:465-469. 2005
2. R. Kotani, M. Nagata , A. Imagawa , H. Yasuda , J. Miyagawa, T. Hanafusa and K. Yokono1: T lymphocyte response against pancreatic beta cell antigens in fulminant Type 1 diabetes Diabetologia 47:1285-1291. 2004
3. Nagata M, Kotani R, Moriyama H, Yokono K, Bart O. Roep and Mark Peakman: Detection of Autoreactive T Cells in Type 1 Diabetes Using Coded Autoantigens and an Immunoglobulin-Free Cytokine ELISPOT Assay: Report from the Fourth Immunology of Diabetes Society T Cell Workshop Ann. N.Y. Acad. Sci. 1037: 10-15. 2004
4. Nagata M, Kotani R, Moriyama H, Yokono K, Reop BO, Peakman M： T-lymphocyte response against pancreatic beta cell antigens in fulminant type 1 diabetes Ann N Y Acad Sci. in press. 2004

トップへ

　　
[久野]
1. Makoto Miyatake, Takayoshi Kuno, Ayako Kita, Kosaku Katsura, Kaoru Takegawa, Satoshi Uno, Toshiya Nabata, and Reiko Sugiura. Valproic Acid Affects Membrane Trafficking And Cell Wall Integrity in Fission Yeast. Genetics, 2007 in press
2. Yan Ma, Takayoshi Kuno, Ayako Kita, Yuta Asayama and Reiko Sugiura. Rho2 is a Target of the Farnesyltransferase Cpp1 and Acts Upstream of Pmk1 MAP Kinase Signaling in Fission Yeast. Mol. Biol. Cell, 17(12):5028-5037,2006
3. Yan Ma, Takayoshi Kuno, Ayako Kita, Toshiya Nabata, Satoshi Uno and Reiko Sugiura. Genetic Evidence for Phospholipid-Mediated Regulation of the Rab GDP-Dissociation Inhibitor in Fission Yeast. Genetics, 174(3):1259-1271, 2006.
4. Lu Deng, Reiko Sugiura, Mai Takeuchi, Masahiro Suzuki, Hidemine Ebina, Tomonori Takami, Atsushi Koike, Shiori Iba, and Takayoshi Kuno. Real-Time Monitoring of Calcineurin Activity in Living Cells: Evidence for Two Distinct Ca2+-Dependent Pathways in Fission Yeast. Mol. Biol. Cell, Vol. 17, Issue 11, 4790-4800, 2006
5. Yi He, Reiko Sugiura, Yan Ma, Ayako Kita, Lu Deng, Kaoru Takegawa, Ken Matsuoka, Hisato Shuntoh, and Takayoshi Kuno. Genetic and Functional Interaction between Ryh1 and Ypt3: two Rab GTPases that Function in S. pombe Secretory Pathway. Genes. Cells, Mar;11(3):207-21,2006
6. Deng L, Sugiura R, Ohta K, Tada K, Suzuki M, Hirata M, Nakamura SI, Shuntoh H, and Kuno T. Phosphatidylinositol-4-phosphate-5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway. J. Biol. Chem. 280(30):27561-27568, 2005.
7. Sio SO, Suehiro T, Sugiura R, Takeuchi M, Mukai H, and Kuno T. The role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to FK506 sensitivity. J. Biol. Chem. 280(13):12231-8, 2005.
8. 酵母ゲノミクスを用いたdrug discovery　春藤久人，杉浦麗子，久野高義　日本薬理学雑誌, 2005 Apr; 125(4) 213-218
9. Kita A, Sugiura R, Shoji H, He Y, Deng L, Lu Y, Sio SO, Takegawa K, Sakaue M, Shuntoh H, and Kuno T. Loss of Apm1, the AP-1 Clathrin-Adaptor mu1 Subunit, Causes Distinct Phenotypes and Synthetic Lethality with Calcineurin Deletion in Fission Yeast. Mol Biol Cell. 15(6):2920-2931, 2004
10. Sugiura R, Kita A, and Kuno T. Upregulation of mRNA in MAPK Signaling: Transcriptional Activation or mRNA Stabilization? Cell Cycle. 3(3):286-288, 2004
11. Maeda T, Sugiura R, Kita A, Saito M, Deng L, He Y, Lu Y, Fujita Y, Takegawa K, Shuntoh H, Kuno T. Pmr1, a P-type ATPase, and Pdt1, an Nramp Homolog, Cooperatively Regulate Cell Morphogenesis in Fission Yeast: The Importance of Mn2+ Homeostasis.Genes Cells. 9(1):71-82, 2004
12. RNA結合タンパク質によるMAPキナーゼシグナルの新たな制御機構　杉浦麗子，春藤久人，久野高義　細胞工学, 2003; 22(11):1212-1213.

トップへ

　
[南]
1. Nishita, M., Yoo, S-K., Nomachi, A., Kani, S., Sougawa, N., Ohta, Y.,Takada, S., Kikuchi, A., and Minami, Y.: Filopodia formation mediated byreceptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration.J. Cell. Biol., in press (2006).
2. Shreeram, S., Demidov, O. N., Hee, W. K., Yamaguchi, H., Onishi, N., Kek,C., Timofeev, O. N., Dudgeon, C., Fornace, A. J., Anderson, C. W., Minami,Y., Appella, E., and Bulavin, D. V.: Wip1 phosphatase modulatesATM-dependent signaling pathways. Mol. Cell, 23: 757-764, 2006.
3. Yoda, A., Xu, X. Z., Fujimoto, H., Kato, N., Onishi, N., Oishi, I., and Minami, Y.: Intrinsic kinase activity and SQ/TQ cluster domain of Chk2kinase as well as N-terminal domain of Wip1 phosphatase are required forregulation of Chk2 by Wip1. J. Biol. Chem., 281: 24847-24862, 2006.
4. Fujimoto, H., Onishi, N., Kato, N., Takekawa, M., Xu, X. Z., Kosugi, A.,Kondo, T., Oishi, I., Yoda, A., Imamura, M., and Minami, Y.: Regulation of the anti-oncogenic Chk2 kinase by the oncogenic Wip1 phosphatase. CellDeath Differ., 13: 1170-1180, 2006.
5. Udagawa, J., Hashimoto, R., Suzuki, H., Hatta, T., Sotomaru, Y., Hioki, K.,Kagohashi, Y., Nomura, T., Minami, Y., and Otani, H.: The role of leptin in the development of the cerebral cortex in mouse embryos. Endocrinology,147: 647-658, 2005.
6. Higashi, T., Tsukada, J., Yoshida, Y., Mizobe, T., Mouri, F., Minami, Y.,Morimoto, H., and Tanaka, Y.: Constitutive tyrosine and serine phosphorylation of STAT4 in T-cells transformed with HTLV-1. Genes Cells,10: 1153-1162, 2005.
7. Oishi, I., Yoda, A., Kani, S., and Minami, Y.: Functional analysis of Rorand Wnt signaling. Genetically Engineered Mice Handbook, Taylor & Francis,CRC Press, USA, p. 295-302, 2005.
8. Sakakida, Y., Miyamoto, Y., Nagoshi, E., Akashi, M., Nakamura, T. J.,Mamine, T., Kasahara, M., Minami, Y., Yoneda, Y., and Takumi, T.: Importinamediates nuclear transport of a mammalian circadian clock component, mCRY2,together with mPER2 through a bipartite nuclear localization signal. J.Biol. Chem. 280: 13272-13278, 2005.
9. Sammar, M., Stricker, S., Schwabe, G., Seiber, C., Hartung, A., Hanke, M., Oishi, I., Pohl, J., Minami, Y., Sebald, W., Mundlos, S. and Knaus, P.: Modulation of GDF5/BRI-? signaling through interaction with the tyrosine kinase receptor Ror2. Genes Cells, 9:1227-38, 2004.
10. Kani, S., Oishi, I., Yamamoto, H., Suzuki, H., Yoda, A., Suzuki, H., Akira Nomachi, Kengo Iozumi, Michiru Nishita, Takumi, T., Kikuchi, A., and Minami, Y.: The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase I?: autophosphorylation of Ror2 is required for subsequent activation of tyrosine kinase activity of Ror. J. Biol. Chem., 279:50102-9, 2004.
11. Kato, N., Fujimoto, H., Yoda, A., Oishi, I., Matsumura, N., Kondo, T., Tsukada, J., Tanaka, Y., Imamura, M., and Minami, Y.: Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines. Cell Death Differ. Suppl 2:S153-61, 2004.
12. Oishi, I., Yoda, A., Kani, S., and Minami, Y.: Functional analysis of Ror and Wnt signaling. Genetically Engineered Mice. Iowa State University Press. IA, USA, in press, 2004.
13. Kondo, T., Kobayashi, M., Tanaka, J., Yokoyama, A., Suzuki, S., Kato, N., Onozawa, M., Chiba, K., Hashino, S., Imamura, M., Minami, Y., Minamino, N., and Asaka, M. Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex. J. Biol. Chem. 279: 27315-27319, 2004.
14. Schwabe, G. C., Trepczik, B., Suring, K., Brieske, N., Tucker, A., Sharpe, P. T., Minami, Y., and Mundlos, S.: The Ror2 knock out mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome. Dev. Dyn. 229: 400-410, 2004.
15. Suzuki, K., Bachiller, D., Chen, Y. P., Kamikawa, M., Ogi, H., Haraguchi, R., Ogino, Y., Minami, Y., Mishina, Y., Ahn, K., Crenshaw III, E. B., and Yamada, G.: Regulation of outgrowth and apoptosis for the terminal appendage, external genitalia, development by concerted functions of Bmp signaling. Development 130: 6209-6220, 2003.
16. 兪　史幹、大西　伸幸、加藤　菜穂子、依田　成玄、南　康博：DNA損傷応答関連遺伝子の異常と悪性腫瘍・自己免疫疾患との関連について：Jpn. J. Clin. Immunol.（臨床免疫学会誌）、29巻3号、136-147、2006
17. 依田　成玄、大西　伸幸、西田　満、南　康博：DNA損傷応答システムとその破綻による癌化：実験医学、24巻10号（増刊）、28-35、2006
18. 大西　伸幸、西田　満、依田　成玄、南　康博：細胞周期チェックポイントのオン・オフ機構：放射線生物研究、40巻2号、67-81、2005
19. 加藤　菜穂子、藤本　浩子、大西　伸幸、南　康博：細胞周期調節による癌の治療：分子標的療法の基礎と臨床、55-65、2005
20. 西田　満、依田　成玄、大西　伸幸、南　康博：DNA損傷応答におけるチェックポイントとDNA修復のクロストーク機構の解析：放射線生物研究、39巻3号、244-257、2004
21. 依田　成玄、可児　修一、南　康博：WntとRor2によるPCP経路の制御：細胞工学、23巻6号、642-646、2004

トップへ

　
[饗場]
1. Maejima T, Oka S, Hashimotodani Y, Ohno-Shosaku T, Aiba A, Wu D, Waku K, Sugiura T, and Kano M. Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum. J. Neurosci., 25(9), 6826-6835, 2005.
2. Kassai H, Aiba A, Nakao K, Nakamura K, Katsuki M, Xiong WH, Yau KW, Imai H, Shichida Y, Satomi Y, Takao T, Okano T, and Fukada Y. Farnesylation of retinal transducin underlies its translocation during light adaptation. Neuron, 47(4), 529-39, 2005.
3. Nakamura M, Sato K, Fukaya M, Araishi K, Aiba A, Kano M, Watanabe M. Signaling complex formation of phospholipase Cbeta 4 with metabotropic glutamate receptor type 1alpha and 1,4,5-tris-phosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur. J. Neurosci., 20 (11), 2929-2944, 2004.
4. Tomemori Y, Ichiba M. Kusumoto A, Mizuno E, Sato D, Muroya S, Nakamura M, Kawaguchi H, Yoshida H, Ueno S, Nakao K, Nakamura K, Aiba A, Katsuki M, Sano A. A gene-targeted mouse model for chorea-acanthocytosis. J. Neurochem., 92 (4), 759-766, 2005.
5. Kuwajima M, Hall RA, Aiba A, and Smith Y. Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the monkey subthalamic nucleus. J Comp Neurol. 474:589-602, 2004.

トップへ

　　
[千原]
1. Yutaka Takahashi, Keiji Iida, Kentaro Takahashi, Shiro Yoshioka, Hidenori, Fukuoka, Ryoko Takeno, Mari Imanaka, Hitoshi Nishizawa, Michiko Takahashi,Yasushi Seo, Yoshitake Hayashi, Takuma Kondoh, Yasuhiko Okimura, Hidesuke, Kaji, Riko Kitazawa, Sohei Kitazawa, and Kazuo Chihara. Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency. Gastroenterology 2006 in press
2. Imanaka M, Iida K, Takahashi K, Tsuji K, Nishizawa H, Fukuoka H, Takeno R, Takahashi Y, Okimura Y, Kaji H, Chihara K. The N131S Mutation in the von Hippel-Lindau Gene in a Japanese Family with Pheochromocytoma and Hemangioblastomas. Endocr J. 2006 Sep 26; [Epub ahead of print]
3. Takahashi K, Iida K, Okimura Y, Takahashi Y, Naito J, Nishikawa S, Kadowaki S, Iguchi G, Kaji H, Chihara K. A novel mutation in the von Hippel-Lindau tumor suppressor gene identified in a Japanese family with pheochromocytoma and hepatic hemangioma. Intern Med. 2006 45(5):265-9.
4. Takahashi Y, Dominici M, Swift J, Nagy C, Ihle JN. Trophoblast stem cells rescue placental defect in SOCS3-deficient mice.　J Biol Chem. 2006 281(17):11444-5
5. Yoshioka S, Takahashi Y, Okimura Y, Takahashi K, Iguchi G, Iida K, Kaji H, Chihara K. Gene expression profile in the heart of spontaneous dwarf rat: In vivo effects of growth hormone. Biochem Biophys Res Commun. 2006 341(1):88-93
6. Kaji H, Iu MF, Naito J, Sugimoto T, Chihara K, A case of primary hyperparathyroidism with marked changes in bone mineral density and geometry after parathyroidectomy.　J Bone Miner Metab. 2006;24(4):349-52.
7. Chihara K, Kato Y, Kohno H, Takano K, Tanaka T, Teramoto A, Shimatsu A.　 Efficacy and safety of growth hormone (GH) in the treatment of adult Japanese patients with GH deficiency: a randomised, placebo-controlled study. Growth Horm IGF Res. 2006　16(2):132-42.
8. Tobimatsu T, Kaji H, Sowa H, Naito J, Canaff L, Hendy GN, Sugimoto T, Chihara K, Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells. Endocrinology. 2006 147(5):2583-90. D
9. JunD Naito J, H Kaji, H Sowa, G N Hendy, T Sugimoto and K Chihara. Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor. J Biol Chem 280:4785-4791, 2005
10. Mei-Fway lu, Hiroshi Kaji, Hideaki Sowa, Junko Naito, Toshitsugu Sugimoto and Kazuo Chihara Dexamethasone suppresses Smad3 pathway in osteoblastic cells. Journal of Endocrinology 185:131-138,2005
11. Kazuo Chihara, Ekaterina Koledova, Akira Shimatsu,Yuzuru Kato, Hitoshi Kohno, Toshiaki Tanaka, Akira Teramoto, Peter C Bates and Andrea F Attanasio. An individualized GH dose regimen for long-term GH treatment in Japanese patients with adult GH deficiency. European Journal of Endocrinology153:57-65,2005
12. Okamura A, N Iwata, A Nagata, A Tamekane, M Shimoyama, H Gomyo, K yakushijin, N Urahama, M Hamaguchi, C Fukui, K Chihara, M Ito and T Matsui. Involvement of casein kinase Iε in cytokine-induced granulocytic differentiation. Blood 103:2997-3004, 2004
13. Shimatsu A, M Hayakawa, Y Shimazaki, T Tsushima, Y Kato, K Takano, K Chihara and M Irie. Metabolic effects of human growth hormone Isoform (20K-hGH) in adult with growth hormone deficiency. Clinical Pediatric Endocrinology 13(Suppl 21):1-7, 2004
14. Kanatani M, T Sugimoto, H Sowa, T Kobayashi, M Kanzawa and K Chihara. Thyroid Hormone stimulates osteoclast differentiation by a mechanism independent of RANKL-RANK interaction. J Cell Physiol 201:17-25, 2004
15. Chihara K, E Koledova, A Shimatsu, Y Kato, H Kohno, T Tanaka, A Teramoto, P C Bates and A F Attanasio. Adult GH deficiency in Japanese patients:effects of GH treatment in a randomized, placebo-controlled trial. Eur J Endocrinol 151:343-350, 2004
16. Iida K, M Hanafusa, I Maekawa, T Kudo, K Takahashi, S Yoshioka, M Kishimoto, G Iguchi, T Tsukamoto, Y Okimura, H Kaji and K Chihara. A novel splice site mutation of the thiazide-sensitive NaCl cotransporter gene in a Japanese patients with Gitelman syndrome. Clinical Nephrology 62:180-184, 2004
17. Takeno R, Okimura Y, Iguchi G, Kishimoto M, Kudo T, Takahashi K, Takahashi Y, Kaji H, Ohno M, Ikuta H, Kuroda Y, Obara T, Hosoda H, Kangawa K, Chihara K. Intravenous administration of ghrelin stimulates growth hormone secretion in vagotomized patients as well as normal subjects. Eur J Endocrinol. 151(4):447-450. 2004.
18. Yoshioka S, Okimura Y, Takahashi Y, Iida K, Kaji H, Matsuo M, Chihara K. Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC. Life Sci. 74(17):2097-109. 2004.
19. Schuendeln M, Piekorz R, Wichmann C, Lee Y, McKinnon P, Boyd K, Takahashi Y, Ihle JN. The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Mol Cell Biol 24 (14) :6403-6409. 2004.
20. Rosilio M, Blum WF, Edwards DJ, Shavrikova EP, Valle D, Lamberts SW, Erfurth EM, Webb SM, Ross RJ, Chihara K, Henrich G, Herschbach P, Attanasio AF. Long-term improvement of quality of life during growth hormone (GH) replacement therapy in adults with GH deficiency, as measured by questions on life satisfaction-hypopituitarism (QLS-H). J Clin Endocrinol Metab. 89(4):1684-93. 2004.
21. Sowa H, Kaji H, Hendy GN, Canaff L, Komori T, Sugimoto T, Chihara K. Menin is required for BMP-2-and TGF-beta-regulated osteoblastic differentiation through interaction with Smads and Runx2.　J Biol Chem. 279(39):40267-75. 2004.
22. Sowa H, Kaji H, Kitazawa R, Kitazawa S, Tsukamoto T, Yano S, Tsukada T, Canaff L, Hendy GN, Sugimoto T, Chihara K.　Menin inactivation leads to loss of transforming growth factor beta inhibition of parathyroid cell proliferation and parathyroid hormone secretion. Cancer Res. 64(6):2222-8. 2004.
23. Nomura R, Sugimoto T, Tsukamoto T, Yamauchi M, Sowa H, Chen Q, Yamaguchi T, Kobayashi A, Chihara K. Marked and sustained increase in bone mineral density after parathyroidectomy in patients with primary hyperparathyroidism; a six-year longitudinal study with or without parathyroidectomy in a Japanese population. Clin Endocrinol (Oxf). 60(3):335-42. 2004.
24. Yamauchi M, Sugimoto T, Chihara K. Determinants of vertebral fragility: the participation of cortical bone factors. J Bone Miner Metab Res. 22(2):79-85. 2004.
25. Hayakawa M, Shimazaki Y, Tsushima T, Kato Y, Takano K, Chihara K, ShimatsuA, Irie M. Metabolic effects of 20-kilodalton human growth hormone (20K-hGH) for adults with growth hormone deficiency: results of an exploratory uncontrolled multicenter clinical trial of 20K-hGH. J Clin Endocrinol Metab. 89(4):1562-71. 2004.
26. Kaji H, Chihara K. Direct causes of death in Japanese patients with hypopituitarism as analyzed from a nation-wide autopsy database. Eur J Endocrinol. 150(2):149-52. 2004.
27. Iida K, Okimura Y, Takahashi K, Inomata S, Iguchi G, Kaji H, Chihara K. A variety of phenotype with R161Q germline mutation of the von Hippel-Lindau tumor suppressor gene in Japanese kindred. Int J Mol Med. 13(3):401 -4. 2004.
28. Yoshioka S, Okimura Y, Takahashi Y, Iida K, Kaji H, Matsuo M, Chihara K. Up -regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC. Life Sci. 74(17):2097- 109. 2004.
29. Carpino N, Turner S, Mekala D, Takahashi Y, Zang H, Geiger T, Doherty P, Ihle JN. Regulation of ZAP-70 Activation and TCR Signaling by Two Related Proteins, Sts-1 and Sts-2. Immunity 20(1): 37-46. 2004.
30. Chen Q, Kaji H, Iu MF, Nomura R, Sowa H, Yamauchi M, Tsukamoto T, Sugimoto T, Chihara K. Effects of an excess and a deficiency of endogenous parathyroid hormone on volumetric bone mineral density and bone geometry determined by peripheral quantitative computed tomography in female subjects. J Clin Endocrinol Metab. 88 (10):4655-8. 2003.
31. Sowa H, Kaji H, Iu MF, Tsukamoto T, Sugimoto T, Chihara K. Parathyroid hormone-Smad3 axis exerts anti-apoptotic action and augments anabolic action of transforming growth factor beta in osteoblasts. J Biol Chem. 278(52): 52240-52. 2003.
32. Iida K, Takahashi Y, Kaji H, Yoshioka S, Murata M, Iguchi G, Okimura Y, Chihara K. Diverse regulation of full-length and truncated growth hormone receptor expression in 3T3-L1 adipocytes. Mol Cell Endocrinol. 210(1-2): 21-9. 2003.

トップへ

　
[松尾]
1. Suminaga R, Takeshima Y, Wada H, Yagi M, Matsuo M: C-terminal Truncated Dystrophin Identified in Skeletal Muscle of an Asymptomatic Boy with a Novel Nonsense Mutation of the Dystrophin Gene. Pediatr Res 2004, 56:739-743.
2. Takagi M, Yagi M, Ishibashi K, Takeshima Y, Surono A, Matsuo M, Koizumi M: Design of 2'-0-Me RNA/ENATM chimera oligonucleotides to induce exon skipping in dystrophin pre-mRNA. Nucleic Acids Symp Ser 2004, 48:297-298.
3. Nakayama Y, Nara N, Kawakita Y, Takeshima Y, Arakawa M, Katoh M, Morita S, Iwatsuki K, Tanaka K, Okamoto S et al: Cloning of cDNA Encoding a Regeneration-associated Muscle Protease Whose Expression is Attenuated in Cell Lines Derived from Duchenne Muscular Dystrophy Patients. Am J Path 2004, 164:1773-1782.
4. Yagi M, Takeshima Y, Surono A, Takagi M, Koizumi M, Matsuo M: Chimeric RNA and 2'-O, 4'-C-ethylene-bridged nucleic acids have stronger activity than phosphorothioate oligodeoxynucleotides in induction of exon-19 skipping in dystrophin mRNA. Oligonucleotides 2004, 14:33-40.
5. Surono A, Khanh T, Takeshima Y, Wada H, Yagi M, Takagi M, Koizumi M, Matsuo M: Chimeric RNA/ethylene bridged nucleic acids promote dystrophin expression in myocytes of Duchenne muscular dystrophy by inducing skipping of the nonsense-mutation-encoding exon. Hum Gene Ther 2004, 15:749-757.
6. Suminaga R, Takeshima Y, Wada H, Yagi M, Matsuo M. C-terminal Truncated Dystrophin Identified in Skeletal Muscle of an Asymptomatic Boy with a Novel Nonsense Mutation of the Dystrophin Gene. Pediatric Research. 56(5): 1-5, 2004.

トップへ

　
[横山]
1. Shimokawa Y, Hirata K, Ishida T, Kojima Y, Inoue N, Quertermous T, and Yokoyama M. Increased expression of endothelial lipase in rat model of hypertension. Cardiovasc Res, 66:594-600, 2005.
2. Saifur Rohman M, Emoto N, Nonaka H, Okura R, Nishimura M, Yagita K, van der Horst GT, Matsuo M, Okamura H, and Yokoyama M. Circadian clock genes directly regulate expression of the Na/H exchanger NHE3 in the kidney. Kidney Int. 67(4):1410-1419, 2005
3. Takaishi H, Taniguchi T, Fujioka Y, Ishikawa Y, Yokoyama M. Impact of increasing diabetes on coronary artery disease in the past decade. J Atheroscler Thromb.11(5):271-277, 2004
4. Kojima Y, Hirata K, Ishida T, Shimokawa Y, Inoue N, Kawashima S, Quertermous T, and Yokoyama M. Endothelial lipase modulates monocyte adhesion to the vessel wall; A potential role in inflammation. J Biol Chem. 279(52):54032-54038, 2004
5. Ishida T, Choi SY, Kundu RK, Spin J, Yamashita T, Hirata K, Kojima Y, Yokoyama M, Cooper AD, and Quertermous T. Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E deficient mice. J Biol Chem. 279(52):45085-45092, 2004
6. Seno T, Inoue N, Matsui K, Ejiri J, Hirata K, Kawashima S, and Yokoyama M. Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells. J Vasc Res. 41: 345-51, 2004
7. Shiraki R, Inoue N, Kawasaki S, Takei A, Kadotani M, Ohnishi Y, Ejiri J, Kobayashi S, Hirata K, Kawashima S, and Yokoyama M. Expression of Toll-like receptors on human platelets. Thromb Res. 113: 379-85, 2004.
8. Yokoyama M. Oxidant stress and atherosclerosis. Curr Opin Pharmacol. 9: 110-5, 2004.
9. Iwai K, Hirata K, Ishida T, Takeuchi S, Hirase T, Rikitake Y, Kojima Y, Inoue N, Kawashima S, and Yokoyama M. An anti-proliferative gene BTG1 regulates angiogenesis in vitro. Biochem Biophys Res Commun. 316: 628-635, 2004.
10. Kawashima S, and Yokoyama M. Dysfunction of endothelial nitric oxide synthase and atherosclerosis. Arterioscler Thromb Vasc Biol. 24: 998-1005, 2004.
11. Namiki M, Kawashima S, Yamashita T, Ozaki M, Sakoda T, Inoue N, Hirata K, Morishita R, Kaneda Y, Yokoyama M. Intramuscular gene transfer of interleukin-10 cDNA reduces atherosclerosis in apolipoprotein E-knockout mice. Atherosclerosis. 172: 21-29, 2004.
12. Domoto K, Taniguchi T, Takaishi H, Takahashi T, Fujioka Y, Takahashi A, Ishikawa Y, Yokoyama M. Chylomicron remnants induce monocyte chemoattractant protein-1 expression via p38 MAPK activation in vascular smooth muscle cells. Atherosclerosis. 171:193-200, 2003.

トップへ

　
[根木]
1. Nagai-Kusuhara A, Nakamura M, Mukuno H, Kanamori A, Negi A, Seigel GM. cAMP-responsive element binding protein mediates a cGMP/protein kinase G-dependent anti-apoptotic signal induced by nitric oxide in retinal neuro-glial progenitor cells. Exp Eye Res in press.
2. Tatsumi Y, Nakamura M, Fujioka M, Nakanishi Y, Kusuhara A, Maeda H, Negi A. Quantification of retinal nerve fiber thickness reduction associated with a relative afferent pupillary defect in aymmetric glaucoma. Br J Ophthalmology in press.
3. Nakamura M, Darhad U, Tatsumi Y, Fujioka M, Kusuhara A, Maeda H, Negi A. Agreement of rebound tonometer in measuring intraocular pressure with three types of applanation tonometers. Am J Ophthalmol 142: 332-334, 2006.
4. Nakanishi Y, Nakamura M, Tatsumi Y, Nagai-Kusuhara A, Negi A. Quantification of retinal nerve fiber thickness reduction associated with a relative afferent pupillary defect. Graefes Arch Clin Exp Ophthalmol in press.
5. Nakanishi Y, Nakamura M, Mukuno H, Kanamori A, Seigel GM, Negi A. Latanoprost rescues retinal neuro-glial cells from apoptosis by inhibiting caspase-3, which is mediated by p44/p42 mitogen-activated protein kinase. Exp Eye Res 83: 1108-1117, 2006.
6. Kusuhara S, Nakamura M, Nagai-Kusuhara A, Nakanishi Y, Kanamori A, Negi A. Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography. Eye 20: 882-887, 2006.
7. Reiter CE, Wu X, Sandirasegarane L, Nakamura M, Gilbert KA, Singh RS, Fort PE, Antonetti DA, Gardner TW. Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin. Diabetes 55: 1148-1156, 2006.
8. Nakamura M, Kanamori A, Negi A. Diabetes mellitus as a risk factor for glaucomatous optic neuropathy. Ophthalmologica 219 (1-2): 1-10, 2005.
9. Kanamori A, Nakamura M, Nakanishi Y, Yamada Y, Negi A. Long-term glial reactivity in rat retinas ipsilateral and contralateral to experimental glaucoma. Exp Eye Res 81: 48-56, 2005.
10. Tatsumi Y, Kanamori A, Kusuhara A, Nakanishi Y, Kusuhara S, Nakamura M. Retinal nerve fiber layer thickness in optic tract syndrome. Jpn J Ophthalmol 49: 294-296, 2005.
11. Kanamori A, Nagai-Kusuhara A, Escano MF, Maeda H, Nakamura M, Negi A. Comparison of confocal scanning laser ophthalmoscopy, scanning laser polarimetry and optical coherence tomography to discriminate ocular hypertension and glaucoma at an early stage. Graefes Arch Clin Exp Ophthalmol 26: 1-11, 2005.
12. Nakamura M, Kanamori A, Kushuhara S, Ishibashi K, Negi A. Alternate total ophthalmoplegia and optic neuropathy associated with ulcerative colitis. Eye 19: 235-237, 2005.
13. Nagai A, Kananmori A, Kusuhara S, Nakamura M, Negi A. Unilateral manifestation of Leber’s hereditary optic neuropathy after blunt ocular trauma. Jpn J Ophthalmol 49: 65-67, 2005.
14. 中村　誠. グリア細胞と脳疾患. 糖尿病網膜症. Clinical Neuroscience 23 (2): 216-218, 2005.
15. Kanamori A, Nakamura M, Nakanishi Y, Nagai A, Mukuno H, Yamada Y, Negi A. Akt is activated via insulin/IGF-1 receptor in rat retina with episcleral vein cauterization. Brain Res.1022 (1-2):195-204, 2004.
16. Mukuno H, Nakamura M, Kanamori A, Nagai A, Negi A, Seigel G. Unoprostone isopropyl rescues retinal progenitor cells from apoptosis in vitro. Curr Eye Res. 29(6):457-64, 2004.
17. Kanamori A, Nakamura M, Mukuno H, Negi A. Diabetes has an additive effect on neural apoptosis in rat retina with chronically elevated intraocular pressure. Curr Eye Res 28 (1): 47-54, 2004.
18. Kanamori A, Matsui N, Tatsumi Y, Nagai A, Nakanishi Y, Nakamura M, Negi A. Optical coherence tomography detects characteristic retinal nerve fiber layer thickness corresponding to band atrophy of the optic discs. Ophthalmology 111: 2278-2283, 2004.
19. Kanamori A, Nakamura M, Matsui N, Tomimori H, anase M, Seya R, Maeda H, Negi A. Goniosynechialysis with lens aspiration and posterior chamber intraocular lens implantation for glaucoma in spherophakia. J Cataract Refract Surg 30: 513-516, 2004.

トップへ

　
[堀田]
1. Nomura-Takigawa Y, Nagano-Fujii M, Deng L, Kitazawa S, Ishido S, Sada K, Hotta H. Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis. J Gen Virol 87:1935-1945, 2006.
2. Deng L, Nagano-Fujii M, Tanaka M, Nomura-Takigawa Y, Ikeda M, Kato N, Sada K, Hotta H. NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner. J Gen Virol 87:1703-1713, 2006.
3. Tanaka M, Nagano-Fujii M. Deng L, Ishido S, Sada K Hotta H. Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3. Biochem Biophys Res Commun 340:792-799, 2006.
4. Kim KI, Kim SR, Sasase N, Taniguchi M, Harada S, Kinoshita K, Kim SH, Akimoto Y, Shikata M, Kimura N, Izawa S, Ohtani A, Nakao K, Motojima M, Kinoshita M, Hirai M, Ohzu M, Hirooka T, Nabeshima S, Ishii F, Tanaka K, Hotta H. 2'-,5'-Oligoadenylate synthetase response ratio predicting virological response to PEG-interferon-alpha2b plus ribavirin therapy in patients with chronic hepatitis C. J Clin Pharm Ther 31:441-446, 2006.
5. Vallet S, Gouriou S, Nkontchou G, Hotta H, Vilerio M, Legrand-Quillien MC, Beaugrand M, Trinchet JC, Nousbaum JB, Deny P, Gaudy C, Goudeau A, Picard B, Payan C. Is hepatitis C virus NS3 protease quasispecies heterogeneity predictive of progression from cirrhosis to hepatocellular carcinoma? J Viral Hepat (in press) 2006.
6. Yonashiro R, Ishido S, Kyo S, Fukuda T, Goto E, Matsuki Y, Ohmura-Hoshino M, Sada K, Hotta H, Yamamura H, Inatome R, Yanagi S. A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J 25:3618-3626, 2006.
7. Ohmura-Hoshino M, Goto E, Matsuki Y, Aoki M, Mito M, Uematsu M, Hotta H, Ishido S. A novel family of membrane-bound e3 ubiquitin ligases. J Biochem 140:147-154, 2006.
8. Ohmura-Hoshino M, Matsuki Y, Aoki M, Goto E, Mito M, Uematsu M, Kakiuchi T, Hotta H, Ishido S. Inhibition of MHC class II expression and immune responses by c-MIR. J Immunol 177:341-354, 2006.
9. Ohgimoto K, Ohgimoto S, Ihara T, Mizuta H, Ishido S, Ayata M, Ogura H, Hotta H. Difference in production of infectious wild-type measles and vaccine viruses in monocyte-derived dendritic cells. Virus Res (in press) 2006.
10. Hotta H, Nihei K, Abe Y, Kato S, Jiang D-P, Nagano-Fujii M, Sada K. Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE. Microbiol Immunol 50:525-534, 2006.
11. Otaki M, Sada K, Kadoya H, Kato S, Nagano-Fujii M, Hotta H. Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference. Antiviral Res 70:105-111, 2006.
12. Inoue M, Uga S, Oda T, Rai SK, Vesey G, Hotta H. Physical and biochemical properties of 　Cryptosporidium oocysts change with incubation period in various circumstances.Water Res 40:881-886, 2006.
13. Hidajat R, Nagano-Fujii M, Deng L, Tanaka M, Takigawa Y, Kitazawa S, Hotta H. Hepatitis C virus NS3 protein interacts with ELKS-δ and ELKS-α, members of a novel protein family involved in intracellular transport and secretory pathways. J Gen Virol 86:2197-2208, 2005.
14. Qu X, Miah SM, Hatani H, Okazaki M, Hori-Tamura N, Yamamura H, Hotta H, Sada K. Selective inhibition of Fc?RI-mediated mast cell activation by the truncation variant of Cbl-b related to the rat model of type 1 diabetes mellitus. J Biochem 137:711-720, 2005.
15. Kadoya H, Nagano-Fujii M, Deng L, Nakazono N, Hotta H. Nonstructural proteins 4A and 4B of hepatitis C virus transactivate the interleukin 8 promoter. Microbiol Immunol 49:265-273, 2005.

トップへ

　
[塩澤]
1. Tsuchida K, Chaki H, Takakura T, Kotsubo H, Tanaka T, Aikawa Y, Shiozawa S, Hirono S. Discovery of nonpeptidic small-molecule AP-1 inhibitors: Lead hopping based on 3D pharmacophore model. J Med Chem 49:80-91, 2006
2. Takami N, Osawa K, Miura Y, Komai K, Taniguchi M, Shiraishi M, Sato K, Iguchi T, Shiozawa K, Hashiramoto A, Shiozawa S. The promoter region of death receptor 3 (DR3) is specifically hypermethylated in rheumatoid synovial cells. Arthritis Rheum 54:779-87, 2006.
3. Tamiya G, Shinya M, Imanishi T, Ikuta T, Makino S, Okamoto K, Furugaki K, Matsumoto T, Mano S, Ando S, Nozaki Y, Yukawa W, Nakashige R, Yamaguchi D, Ishibashi H, Yonekura M, Yoshikawa Y, Fujimoto K, Oka A, Chiku S, Linsen SEV, Giphart MJ, Hoshina Y, Suzuki Y, Hotta T, Mochida J, Minezaki, Komai K, Shiozawa S, Taniguchi A, Yamanaka H, Kamatani N, Gojobori T, Bahram S, Inoko H. Whole genome association study of rheumatoid arthritis using 27039 microsatellites. Human Mol Genet 14:2305-2321, 2005.
4. Mitani M, Miura Y, Saura R, Kitagawa A, Fukuyama T, Hashiramoto A, Shiozawa S, Kurosaka M, Yoshiya S. Estrogen specifically stimulates expression and production of osteoprotegerin from rheumatoid synovial fibroblasts. Int J Mol Med, 5:827-32, 2005.
5. Murata M, Miura Y, Hashiramoto A, Kitamura H, Kawasaki H, Shiozawa K, Yoshiya S, Baba H, Chihara K, Shiozawa S. Heat shock protein 90 is required for increased DNA binding activity of activator protein-1, a heterodimer of Fos/JunD, in rheumatoid synovial cells under inflammatory stimuli. Int J Mol Med 15:649-53, 2005.
6. Kuroki K, Takabayashi C, Nishiyama K, Shimada T, Shiozawa S, Chihara K, Ueba Y. Adrenocorticotropic hormone response to hypoglycemic stress was preserved by a single bedtime 3-mg dose of prednisolone in patients with rheumatoid arthritis. Mod Rheumatol 14:291-95, 2004.
7. Osawa K, Takami N, Shiozawa K, Hashiramoto A, Shiozawa S. Death receptor 3 (DR3) gene duplication in a chromosome region 1p36.3: Gene duplication is more prevalent in rheumatoid arthritis patients. Gene Immunity 5:439-43, 2004.
8. Tsuchiya K, Chaki H, Takakura T, Yokotani J, Aikawa Y, Shiozawa S. Design, synthesis, and biological evaluation of new cyclic disulfide decapeptides that inhibit the binding of AP-1 to DNA. J Med Chem 47:4239-4246, 2004.
9. Sakaki T, Sawada N, Abe D, Komai K, Shiozawa S et al. Metabolism of 26, 26, 26, 27, 27, 27-F6-1a, 25-dihydroxyvitamin D3 by CYP24. Biochem Pharmacol 65:1957-65, 2003.
10. Kawasaki H, Komai K, Nakamura M, Yamamoto E, OuYang Z, Nakashima T, Hashiramoto A, Shiozawa K, Ishikawa H, Kurosaka M, Shiozawa S. Human wee 1 kinase is directly transactivated by and increased in association with c-Fos/AP-1: Rheumatoid synovial cells overexpressing these genes go into aberrant mitosis. Oncogene 22:6839-6844, 2003.
11. Hikasa M, Yamamoto E, Kawasaki H, Komai K, Shiozawa K, Hashiramoto A, Miura Y, Shiozawa S. p21 is down-regulated in conjuction with up-regulation of c-Fos in the lymphocytes of rheumatoid arthritis patients. Biochem Biophys Res Commun 304:143-147, 2003.
12. Muto M, Ohmura A, Hamamoto Y, Konishi Y, Shiozawa S. Generalized pustular psoriasis: strategy for identification of psoriasis susceptibility gene. Arch Dermatol Res 295:S60-62, 2003.
13. Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S. Characterization of novel alternative splicing variants of the mouse MCF-2 (DBL) proto-oncogene. Biochem Biophys Res Commun 309:906-909, 2003.
14. Matsuno H, Yodoh k, Hanyu T, Kano S, Komatsubara Y, Matsubara T, Murata N, Nakai H, Nakamura H, Ozaki S, Shimuzu M, Shiozawa S, et al. Quantitative assessment of hand radiographs of rheumatoid arthritis: interobserver variation in a multicenter radiographic study. J Orthop Sci 8:467 -473, 2003.
15. Shiozawa S, Miura Y, Hashiramoto A, Murata M, Takabayashi C, Shiozawa K, Kuroki Y. Fasciitis: What is the significance of various forms? J Clin Rheumatol 9:1-3, 2003.

トップへ

　
[佐藤]
1. Hironori Edamatsu, Takaya Satoh, and Tohru Kataoka. Ras and Rap activation of PLCε lipase activity. Methods Enzymol. in press (2005)
2. Takaya Satoh, Hironori Edamatsu, and Tohru Kataoka. PLCε GEF activity and activation of Rap. Methods Enzymol. in press (2005)
3. Takaya Satoh. The signaling network of Ras family and Rho family GTP-binding proteins in mammalian cells. Cellular Signaling: New Research. Nova Science Publishers, Hauppauge, NY, USA. in press (2005)
4. 佐藤孝哉．低分子量GTP結合タンパク質と神経．バイオ研究マスターシリーズ「シグナル伝達集中マスター」（山本雅，仙波憲太郎　編，羊土社） p49-p57 (2005)
5. Alam Nur-E-Kamal, Ailing Zhang, Susan M. Keenan, Jabed Seraj, Takaya Satoh, Sally Meiners, and William J. Welsh. Requirement of activated Cdc42-associated kinase (ACK) for survival of v-Ras-transformed mammalian cells. Mol. Cancer Res. in press (2005)
6. Makoto Tadano, Hironori Edamatsu, Susumu Minamisawa, Utako Yokoyama, Yoshihiro Ishikawa, Noboru Suzuki, Hiromitsu Saito, Dongmei Wu, Misa Masago-Toda, Yuriko Yamawaki-Kataoka, Tomiyoshi Setsu, Toshio Terashima, Sakan Maeda, Takaya Satoh, and Tohru Kataoka. Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C?. Mol. Cell. Biol. 25 (6), 2191-2199 (2005)
7. Yunfeng Bai, Hironori Edamatsu, Sakan Maeda, Hiromitsu Saito, Noboru Suzuki, Takaya Satoh, and Tohru Kataoka. Crucial role of phospholipase Cε in chemical carcinogen-induced skin tumor development. Cancer Res. 64 (24), 8808-8810 (2004)
8. Shuji Ueda, Tohru Kataoka, and Takaya Satoh. Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites. Cell. Signal. 16 (8), 899-906 (2004)
9. Kazuhiro Nomura, Hoshimi Kanemura, Takaya Satoh, and Tohru Kataoka. Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations. J. Biol. Chem. 279 (21), 22664-22673 (2004)
10. Honma N, Asada A, Takeshita S, Enomoto M, Yamakawa E, Tsutsumi K, Saito T, Satoh T, Itoh H, Kaziro Y, Kishimoto T, and Hisanaga S. Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. Biochem. Biophys. Res. Commun. 310(2): 398-404, 2003.
11. 佐藤孝哉．Rasによる発癌の分子機構．Biotherapy 17 (6), 515-521 (2003)

トップへ

　
[北澤]
1. Hidajat R, Nagano-Fujii M, Deng L, Tanaka M, Takigawa Y, Kitazawa S, Hotta H, Hepatitis C virus NS3 protein interacts with ELKS-d and ELKS-a, members of a novel protein family involved in intracellular transport and secretory pathways, J Gen Virol (86), 2197-2208, 2005
2. Hirano M, Yamasaki K, Okada H, Kitazawa S, Kitazawa R, Ohno Y, Sakurai T, Kondoh T, Ohbayashi C, Katafuchi T, Maeda S, Sugimura K, Tamura S, Estimation of Contrast of Refraction Contrast Imaging Compared with Absorption Imaging -Basic Approach, Radiation Medicine (23), 89-96, 2005
3. Takeuchi K, Kitazawa S, Wakahashi S, Sugimoto M, Morizane M, Maruo T, A case of virilizing Brenner tumor in a postmenopausal woman with stromal androgenic activity, Int J Gynecol Pathol, in press, 2005
4. Kitazawa S, Kitazawa R, Obayashi C, Yamamoto T, Desmoid Tumor with Ossification in Chest Wall: Possible Involvement of BAMBI Promoter Hypermethylation in Metaplastic Bone Formation, J Bone Miner Res (20), 1472-1477, 2005
5. Kitazawa S, Kondo T, Kitazawa R, Application Trials of in situ Hybridization at Electron Microscopic Level, Neuropathology (25), 274-279, 2005
6. Kobayashi N, Kitazawa R, Maeda S, Schurgers LJ, Kitazawa S, T-138C Polymorphism of Matrix Gla Protein Promoter Alters its Expression but is not Directly Associated with Atherosclerotic Vascular Calcification, Kobe J Med Sci (50), 69-81, 2004
7. Kitazawa R, KitazawaS, In Situ Hybrid zation on Calcified Tissue: Detection of RANKL mRNA in Mouse Osteolytic Bone Lesions, Acta Histochem Cytochem (38), 143-149, 2005
8. Fujimoto M, Kitazawa R, Maeda S, Kitazawa S, Methylation Adjacent to Negatively Regulating AP-1 Site Reactivates TrkA Gene Expression during Cancer Progression, Oncogene (24), 5108-5118, 2005
9. Kondo T, Kitazawa R, Maeda S, Kitazawa S. 1 alpha,25 dihydroxyvitamin D3 Rapidly Regulates the Mouse Osteoprotegerin Gene through Dual Pathways. J Bone Miner Res, 19, 1411-1419, 2004.
10. Takeuchi K, Ohbayashi C, Kitazawa S, Ohara N, Maruo T. Coexistence of Brenner Tumor and Struma Ovarii: Case Report. Eur J Gynaecol Oncol, 26, 109-110, 2005.
11. Ong DB, Colley SM, Norman MR, Kitazawa S, Tobias J. Transcriptional Regulation of a BMP-6 Promoter by Estrogen Receptor Alpha. J Bone Miner Res, 19, 447-454, 2004.
12. Sowa H, Kaji H, Kitazawa R, Kitazawa S, Tsukamoto T, Yano S, Tsukada T, Canaff L, Hendy GN, Sugimoto T, Chihara K. Menin Inactivation Leads to Loss of Transforming Growth Factor Beta Inhibition of Parathyroid Cell Proliferation and Parathyroid Hormone Secretion. Cancer Res, 64, 2222-2228, 2004.
13. Hirano M, Yamasaki K, Kitazawa R, Kitazawa S, Okada H, Katafuchi T, Sakurai T, Kondoh T, Ohbayashi C, Maeda S, Sugimura K, Tamura S. Imaging of Fine Structure of Bone Sample with High Coherent X-Ray Beam and High Spatial Resolution Detector. Radiat Med, 22, 56-59, 2004.
14. Zhang J, Lu Y, Yao Z, Kitazawa R, Kitazawa S, Zhao X, Hall DE, Pienta KJ, Keller ET. In Vivo Real-Time Imaging of TGF-Beta-Induced Transcriptional Activation of the RANK Ligand Gene Promoter in Intraosseous Prostate Cancer. Prostate, 59, 360-369, 2004.
15. Saijo M, Kitazawa R, Nakajima M, Kurosaka M, Maeda S, Kitazawa S. Heparanase mRNA Expression During Fracture Repair in Mouse. Histochem Cell Biol:120, 493-503, 2003.

トップへ

　
[深川]
1. Yamashita H, Yamashita T, Miyamoto M, Shigematsu T, Kazama JJ, Shimada T, Yamazaki Y, Fukumoto S, Fukagawa M, Noguchi S: Fibroblast growth factor (FGF)-23 in patients with Grave’s disease before and after antithyroid therapy: Its important role in serum phosphate regulation. J Clin Endocrinol Metab, in press.
2. Kazama JJ, Omori K, Takahashi N, Ito Y, Maruyama H, Narita I, Gejyo F, Iwasaki Y, Fukagawa M: Maxacalcitol therapy decreases circulating osteoprotegerin levels in dialysis patients with secondary hyperparathyroidism, Clin Nephrol, in press.
3. Nishi H, Nii-Kono T, Nakanishi S, Yamazaki Y, Yamashita T, Fukumoto S, Ikeda K, Fujimori A, Fukagawa M: Intravenous calcitriol therapy increases serum concentrations of fibroblast growth factor-23 in dialysis patients with secondary hyperparathyroidism. Nephron Clin Prac, in press.
4. Koiwa F, Kazama JJ, Tokumoto A, Onoda N, Kato H, Okada T, Nii-Kono T, Fukagawa M, Shigematsu T: Sevelamer hydrochloride and calcium carbonate reduce serum FGF23 levels in dialysis patients. Ther Aphr Dial, in press.
5. Koiwa F, Onoda N, Kato H, Tokumoto A, Okada N, Fukagawa M, Shigematsu T: Prospective randomized multicenter trial of sevelamer hydrochloride and calcium carbonate for the treatment of hyperphosphatemia in hemodialysis patients in Japan. Ther Aphr Dial, in press.
6. Yamashita H, Cantor T, Uchino S, Watanabe S, Ogawa T, Moriyama T, Takamatsu Y, Fukagawa M, Noguchi S: Sequential changes in plasma intact and whole parathyroid hormone levels during parathyroidectomy for secondary hyperparathyroidism. World J Surgery 29: 169-173, 2005.
7. Nakanishi S, Kazama JJ, Nii-Kono T, Omori K, Yamashita T, Fukumoto S, Gejyo F, Shigematsu T, Fukagawa M: Serum fibroblast growth factor-23 levels predict the future refractory hyperparathyroidism in dialysis patients. Kidney Int 67: 1171-1178, 2005.
8. Kazama JJ, Sato F, Omori K, Yamamoto S, Maruyama H, Narita I, Gejyo F, Yamashita T, Fukumoto S, Fukagawa M: Pretreatment serum FGF-23 levels predict the efficacy of calcitriol therapy in dialysis patients, Kidney Int 67: 1120-1125, 2005.
9. Iwasaki-Ishizuka Y, Yamato H, Murayama H, Ezawa I, Kurokawa K, Fukagawa M: Menatetrenone rescues bone loss by improving osteoblast dysfunction in rats immobilized by scialic neurectomy. Life Sci 76: 1721-1734, 2005.
10. Nishi H, Sato T, Kurihara T, Kurosawa T, Fukagawa M: Control of parathyroid function in patients with short history of hemodialysis. Ther Aphr Dial 9: 39-43, 2005.
11. Tanaka M, Itoh K, Matsushita K, Matsushita K, Fukagawa M: Efficacy of percutaneous ethanol injection therapy for secondary hyperparathyroidism in patients on hemodialysis as evaluated by parathyroid hormone levels according to K/DOQI guidelines. Ther Aphr Dial　9: 48-52, 2005.
12. Yamashita H, Gao P, Cantor T, Noguchi S, Uchino S, Watanabe S, Ogawa T, Kawamoto H, Fukagawa M: Comparison of parathyroid hormone levels from the intact and whole parathyroid hormone assays after parathyroidectomy for primary and secondary hyperparathyroidism. Surgery 135: 149-156, 2004.
13. Abe T, Kobata H, Hanba Y, Kitabata Y, Narukawa N, Hasegawa H, Abe T, Fukagawa M: Study of plasma exchange for liver failure: Beneficial and harmful effects. Ther Aphere Dial 8: 180-184, 2004.
14. Yamashita H, Yamashita T, Miyamoto M, Shigematsu T, Kazama JJ, Shimada T, Fukumoto S, Fukagawa M, Noguchi S: Fibroblast growth factor (FGF)-23 in patients with primary hyperparathyroidism. Eur J Endocrinol 151: 55-60, 2004.
15. Shigematsu T, Kazama JJ, Yamashita T, Fukumoto S, Hosoya T, Gejyo F, Fukagawa M: Possible involvement of circulating fibroblast growth factor-23 in the development of secondary hyperparathyroidism associated with renal insufficiency. Am J Kidney Dis 44: 250-256, 2004.
16. Sato T, Tominaga Y, Ueki T, Goto N, Matsuoka S, Katayama A, Haba T, Uchida K, Nakanishi S, Kazama JJ, Gejyo F, Yamashita T, Fukagawa M: Total parathyroidectomy reduces elevated circulating fibroblast growth factor 23 in advanced secondary hyperparathyroidism. Am J Kidney Dis 44: 481-487, 2004.
17. Nakao N, Seno H, Kasuga H, Toriyama T, Kawahara H, Fukagawa M: Effects of combination treatment with losartan and trandolapril on office and ambulatory blood pressures in non-diabetic renal disease: a COOPERATE-ABP substudy. Am J Nephrol 24:543-548, 2004.
18. Fujimori A, Sakai M, Yoshiya K, Shin J, Kim J-I, Inaba Y, Miyamoto T, Inoue S, Fukagawa M: Bio-intact parathyroid hormone (PTH) and intact PTH in patients with secondary hyperparathyroidism receiving intravenous calcitriol therapy. Ther Aphere Dial 8: 474-479, 2004.
19. Hamada Y, Fukagawa M, Nii-kono T, Miyata S, Kitazawa R, Kitazawa S, Kasuga M. Thioredoxin-1 overexpression attenuates diabetic nephropathy in streptozotocin- induced diabetic mice (abstract). J Am Soc Nephrol, 15:30A, 2004.
20. Kazama JJ, Sato F, Omori K, Yamamoto S, Maruyama H, Narita I, Gejyo F, Yamashita T, Fukumoto S, Fukagawa M: Pretreatment serum FGF-23 levels predict the efficacy of calcitriol therapy in dialysis patients, Kidney Int 67: 1120-1125, 2005.
21. Martin KJ, Olgaard K, Coburn J, Cohen GM, Fukagawa M, Langman C, Malluche HH, McCarthy JT, Massry SG, Mehls O, Salusky IB, Silver JM, Smogrorewski MT, Slatopolsky EM, McCann L: Diagnosis, assessment and treatment of bone turnover abnormalities in renal osteodystrophy. Am J Kidney Dis 43: 558-565, 2004.
22. Yamashita H, Gao P, Cantor T, Noguchi S, Uchino S, Watanabe S, Ogawa T, Kawamoto H, Fukagawa M: Comparison of parathyroid hormone levels from the intact and whole parathyroid hormone assays after parathyroidectomy for primary and secondary hyperparathyroidism. Surgery 135: 149-156, 2004.
23. Yamashita H, Yamashita T, Miyamoto M, Shigematsu T, Kazama JJ, Shimada T, Fukumoto S, Fukagawa M, Noguchi S: Fibroblast growth factor (FGF)-23 in patients with primary hyperparathyroidism. Eur J Endocrinol 151: 55-60, 2004.
24. Abe T, Shono M, Kodama T, Kita Y, Fukagawa M, Akizawa T: Extracorporeal albumin dialysis. Ther Apher Dial 8: 217-222, 2004.

トップへ

　
[寺師]
1. 宮村卓、寺師浩人、辻依子、柳英之、田原真也：代替VACシステム作製方法．形成外科，48: 68-71，2005．
2. Hatano Y., Terashi H., Arakawa S., Katagiri K.: Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor necrosis factor-alpha and interferon-gamma in human epidermis. J. Invest. Dermatol., 124: 786-792, 2005.
3. 寺師浩人、北野育郎、辻依子、櫻井敦、司尾和紀、脇田昇、Chugo Rinoie：重症虚血肢の診断・治療におけるレーザードップPV2000の有用性－Skin Perfusion Pressure (SPP、皮膚潅流圧)測定の意義について．形成外科，48: 901-909，2005．
4. Terashi H., Izumi K., Deveci M., Rhodes L.M., Marcelo C.L.: High Glucose Inhibits Human Epidermal Keratinocytes Proliferation for Cellular Studies on Diabetes Mellitus. Int. Wound J., 2: 298-304, 2005.
5. 寺師浩人、北野育郎、辻依子：形成外科における画像診断：下肢血行障害の画像診断．形成外科、49: 17-23、2006.
6. 寺師浩人、辻依子、北野育郎：病態よりみた難治性下腿潰瘍の診断と治療：感染性下腿潰瘍とは．形成外科、49: 181-192、2006.
7. 寺師浩人：特集　新しい創傷管理．８．新鮮外傷の管理．小児外科、38: in press、2006．
8. 寺師浩人：ドレッシング．新しい創傷管理．Ⅵ　様々な創のドレッシング．１０．熱傷のドレッシング（穴澤貞夫編），pp228-234, へるす出版，東京，2005．
9. 寺師浩人：ドレッシング．新しい創傷管理．Ⅵ　様々な創のドレッシング．１０．ドナーサイトのドレッシング（穴澤貞夫編），pp235-239, へるす出版，東京，2005．
10. 寺師浩人：ドレッシング．新しい創傷管理．Ⅵ　様々な創のドレッシング．１０．過形成性瘢痕ならびにケロイド形成を防止するドレッシング（穴澤貞夫編），pp240-245,へるす出版，東京，2005．
11. 寺師浩人：創傷治癒　５．創傷治癒後の病態　２）肥厚性瘢痕とケロイド（塩谷信幸編），pp83-98，ブレーン出版，東京，2005．
12. 寺師浩人、倉田荘太郎：創傷の治療：最近の進歩　形成外科ADVANCEシリーズⅠ-3　Ⅱ創傷の治療15.毛包と毛髪の創傷治癒（森口隆彦編）, pp175-189，克誠堂出版,東京,2005．
13. 寺師浩人：３．創傷治癒（創傷治癒過程、褥瘡、ドレナージ）、第２部外科領域リハビリテーションのための基礎知識．外科領域のリハビリテーション最新マニュアル（宇佐美眞編集），共同医書出版社，東京，2006，印刷中．

トップへ

　
[宮脇]
1. 多留ちえみ、宮脇郁子、矢田真美子、宮田　哲、木戸良明、井上朋子、谷口　洋：2型糖尿病患者の食事療法負担感尺度の開発、糖尿病、48巻６号、2005年

トップへ

　
[岡田]
1. Okada T, Ding G, Sonoda H, Kajimoto T, Haga Y, Khosrowbeygi A, Gao S, Miwa N, Jahangeer S and Nakamura SI. Involvement of N-terminally extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis. J. Biol. Chem. 2005 in press

トップへ

　
[丹羽]
1. Masui, S., Shimosato, D., Toyooka, Y., Yagi, R., Takahashi, K. and Niwa H.: An efficient system to establish multiple embryonic stem cell lines carrying an inducible expression unit. Nucleic Acids Res, 33, 4, e43, 2005.
2. Ogawa, K., Matsui, H., Ohtsuka. S. and Niwa, H. :A novel mechanism for　regulating clonal propagation of mouse ES cells. Genes Cells, 9, 471-477,　2004.
3. Hatano, N., Mori, Y., Oh-hora, M., Kosugi, A., Fujikawa, T., Nakai, N., Niwa, H., Miyazaki, J., Hamaoka, T., Ogata, M :Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells., 8, 847-56, 2003.
4. Ishida, C., Ura, K., Hirao, A., Sasaki, H., Toyoda, A., Sakaki, Y., Niwa, H., Li, E., Kaneda, Y. :Genomic organization and promoter analysis of the Dnmt3b gene. Gene. 22;310, 151-9, 2003.
5. Shimozaki, K., Nakashima, K., Niwa, H. and Taga, T. :Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures. Development, 130, 2505-2512, 2003.
6. Tokuzawa, Y., Kaiho, E., Maruyama, M., Takahashi, K., Mitsui, K., Maeda, M., Niwa, H. and Yamanaka, S. :Fbx15 is a novel target of Oct3/4 but is dispensable for ES cell self -renewal and mouse development. Mol. Cell. Biol., 23, 2699-2708, 2003.
7. Tateishi, S., Niwa, H., Miyazaki, J.-I., Fujimoto, S., Inoue, H. and Yamaizumi, M. :Enhanced genomic instability and defective postreplication repair in RAD18-knockout mouse embryonic stem cells, Mol. Cell. Biol., 23, 474-481, 2003.

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[中江]
1. Yongheng Cao, Yuji Kamioka, Norihide Yokoi, Toshiyuki Kobayashi, Okio Hino,Masafumi Onodera,Naoki Mochizuki, and Jun Nakae. Interaction of FoxO1 and TSC2 induces insulin resistance activation of mTOR/p70S6K pathway J. Biol. Chem. 2006 in press
2. Nakae J, Cao Y, Daitoku H, Fukamizu A, Ogawa W, Yano Y, Hayashi Y. The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. J Clin Invest. 2006 116(9):2473-83
3. Okamoto H, Nakae J, Kitamura T, Park BC, Dragatsis I, Accili D. Transgenic rescue of insulin receptor-deficient mice. J Clin Invest. 2004;114:214-23.
4. Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, Kamon J, Kobayashi M, Suzuki R, Hara K, Kubota N, Terauchi Y, Froguel P, Nakae J, Kasuga M, Accili D, Tobe K, Ueki K, Nagai R, Kadowaki T. Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and Adiponectin sensitivity. J Biol Chem. 2004 279:30817-30822.
5. Kitamura T, Kitamura Y, Nakae J, Giordano A, Cinti S, Kahn CR, Efstratiadis A, Accili D. Mosaic analysis of insulin receptor function. J Clin Invest. 2004;113:209-19.
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